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The map label for this gene is degA [H]

Identifier: 239617552

GI number: 239617552

Start: 1238655

End: 1239644

Strand: Direct

Name: degA [H]

Synonym: Kole_1170

Alternate gene names: 239617552

Gene position: 1238655-1239644 (Clockwise)

Preceding gene: 239617550

Following gene: 239617553

Centisome position: 53.8

GC content: 39.09

Gene sequence:

>990_bases
ATGAAAAAGAAGATAACTATCAGAGAGATCGCTAAAATTGCTGGTGTTGGTGTTGGTACCGTTTCCAGAGTTTTGAATGG
TGGTGCTGTAAAACCTGAAACAAAAAAACTTGTGATGGATACTATTGAGAGGCTTGGTTACATTCCCAATGCTTCTGCAA
GAAAGTTAGCTGGGGGAAAAACTAAGAGTGTAATGATGCTAACCCCGGAGATCAAAACGGAATTTCACTGGCGATTGATA
AAGAGCATGGACAAATATCTTGATGAAATGGATTATCAGACGATTATATATCCCCTAATTTCTAAAAATCGCTTTGAAAA
GTTATTTGCCAGCCATAACATCCACGAAGTTGATGGGGTTGTTCTCTGTACCCTCACATTTGAAAAGACCTTTGGACAAA
AGAAGAATATAGATTTTCCGATTGTTTTACTTGAAGGTTTGGTAGAAAGTTATGACAGTGTTTATCTTGACAATTATCTT
GGTGGGGTTCAAGCTGCGAAAGTGTTGCTTGAGGATGAGGCTAGTGAGTTTTTTGTTCTTTACTATGAGGAGACAAATCC
GCTTTTGTCAAATGACAATATACTGCAGCGTCTCAAAGGATTTCAGGATAGGTTGAGAGAATCGGGGATTGAGTTGCCAG
ATGAGAATGTAATAAACGTAGATTTCTTTCTGGGTTCGGCGCACGAAAAAATCGTGCAAGTACTCACCAAAGTTGAAAAA
CCCGGTATTTTCGCAACGACAGATAACTTTGCCCTCAATGTTCTGGAAACGGCTAAAACTCTCGGTAAAACTCCTGGCAA
GGATTTCTTTCTTATTGGATATGATGATCAGTTTTGGGCAGAGGAACTTGGTTTAACAACAATAGGTCAGCCTATTGAGG
AAATGGGAAAAACTGCGGGAGAACTTATCCTTAAAAGGATAGAAAATCCCATGGGTTCAATCCAACATATTAAATTTCTT
CCTGCCGTCGTTCGAAGAAATACAGCATAA

Upstream 100 bases:

>100_bases
TTTTAAATATTCAGAGCTGAAAACACACAACAAGTTTTCTTGGTGGTGAAACGAATGATTATAATGGAAGCGGTTCCAAA
ATTATTAGTGAGGTATTCAT

Downstream 100 bases:

>100_bases
ATAATTGCCCCACTTTAGGGTTATTTTTTAGGAGGTGTAGGCTGTGAAAAAGGTAGTAGCGGTGTTGTTGGTTGTTCTTT
TGGCTACTTTTGTGGTAGCC

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: Degradation activator [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MKKKITIREIAKIAGVGVGTVSRVLNGGAVKPETKKLVMDTIERLGYIPNASARKLAGGKTKSVMMLTPEIKTEFHWRLI
KSMDKYLDEMDYQTIIYPLISKNRFEKLFASHNIHEVDGVVLCTLTFEKTFGQKKNIDFPIVLLEGLVESYDSVYLDNYL
GGVQAAKVLLEDEASEFFVLYYEETNPLLSNDNILQRLKGFQDRLRESGIELPDENVINVDFFLGSAHEKIVQVLTKVEK
PGIFATTDNFALNVLETAKTLGKTPGKDFFLIGYDDQFWAEELGLTTIGQPIEEMGKTAGELILKRIENPMGSIQHIKFL
PAVVRRNTA

Sequences:

>Translated_329_residues
MKKKITIREIAKIAGVGVGTVSRVLNGGAVKPETKKLVMDTIERLGYIPNASARKLAGGKTKSVMMLTPEIKTEFHWRLI
KSMDKYLDEMDYQTIIYPLISKNRFEKLFASHNIHEVDGVVLCTLTFEKTFGQKKNIDFPIVLLEGLVESYDSVYLDNYL
GGVQAAKVLLEDEASEFFVLYYEETNPLLSNDNILQRLKGFQDRLRESGIELPDENVINVDFFLGSAHEKIVQVLTKVEK
PGIFATTDNFALNVLETAKTLGKTPGKDFFLIGYDDQFWAEELGLTTIGQPIEEMGKTAGELILKRIENPMGSIQHIKFL
PAVVRRNTA
>Mature_329_residues
MKKKITIREIAKIAGVGVGTVSRVLNGGAVKPETKKLVMDTIERLGYIPNASARKLAGGKTKSVMMLTPEIKTEFHWRLI
KSMDKYLDEMDYQTIIYPLISKNRFEKLFASHNIHEVDGVVLCTLTFEKTFGQKKNIDFPIVLLEGLVESYDSVYLDNYL
GGVQAAKVLLEDEASEFFVLYYEETNPLLSNDNILQRLKGFQDRLRESGIELPDENVINVDFFLGSAHEKIVQVLTKVEK
PGIFATTDNFALNVLETAKTLGKTPGKDFFLIGYDDQFWAEELGLTTIGQPIEEMGKTAGELILKRIENPMGSIQHIKFL
PAVVRRNTA

Specific function: Involved in the control of degradation of B.subtilis amidophosphoribosyltransferase (purF). Probably activates the gene for a degradative protease [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787948, Length=335, Percent_Identity=29.5522388059701, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1790369, Length=323, Percent_Identity=26.0061919504644, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790194, Length=334, Percent_Identity=26.3473053892216, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788474, Length=340, Percent_Identity=29.7058823529412, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787580, Length=318, Percent_Identity=25.1572327044025, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI48994940, Length=322, Percent_Identity=23.9130434782609, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786268, Length=176, Percent_Identity=28.9772727272727, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37013; Mature: 37013

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKITIREIAKIAGVGVGTVSRVLNGGAVKPETKKLVMDTIERLGYIPNASARKLAGGK
CCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCCC
TKSVMMLTPEIKTEFHWRLIKSMDKYLDEMDYQTIIYPLISKNRFEKLFASHNIHEVDGV
CCEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCEECCCE
VLCTLTFEKTFGQKKNIDFPIVLLEGLVESYDSVYLDNYLGGVQAAKVLLEDEASEFFVL
EEEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
YYEETNPLLSNDNILQRLKGFQDRLRESGIELPDENVINVDFFLGSAHEKIVQVLTKVEK
EEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHCC
PGIFATTDNFALNVLETAKTLGKTPGKDFFLIGYDDQFWAEELGLTTIGQPIEEMGKTAG
CCEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHH
ELILKRIENPMGSIQHIKFLPAVVRRNTA
HHHHHHHHCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKKITIREIAKIAGVGVGTVSRVLNGGAVKPETKKLVMDTIERLGYIPNASARKLAGGK
CCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCCC
TKSVMMLTPEIKTEFHWRLIKSMDKYLDEMDYQTIIYPLISKNRFEKLFASHNIHEVDGV
CCEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCEECCCE
VLCTLTFEKTFGQKKNIDFPIVLLEGLVESYDSVYLDNYLGGVQAAKVLLEDEASEFFVL
EEEEEEEHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
YYEETNPLLSNDNILQRLKGFQDRLRESGIELPDENVINVDFFLGSAHEKIVQVLTKVEK
EEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHCC
PGIFATTDNFALNVLETAKTLGKTPGKDFFLIGYDDQFWAEELGLTTIGQPIEEMGKTAG
CCEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHH
ELILKRIENPMGSIQHIKFLPAVVRRNTA
HHHHHHHHCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8407808; 9353932; 9384377 [H]