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The map label for this gene is yuxL [H]

Identifier: 239617551

GI number: 239617551

Start: 1236410

End: 1238227

Strand: Reverse

Name: yuxL [H]

Synonym: Kole_1169

Alternate gene names: 239617551

Gene position: 1238227-1236410 (Counterclockwise)

Preceding gene: 239617557

Following gene: 239617549

Centisome position: 53.79

GC content: 41.69

Gene sequence:

>1818_bases
ATGAAAAAACAGGTAAAAAAGTACACAATCCATCAATTTATGAAGAACATAACTATCATCGGTACCGCTTTATCGTCAGA
TGGAAGAAAGATCCTTTTTTCCAGCGATGAAAGTGGAATATTCAACGCACACGAAATTGATCTGGAAACGGGTAAAGCAT
CCAAACTTACAGATTCTCAGGATAGCGTTTTCATCGTAGGATATCTTCCGGAAGGTAATGGATTTTTGTTTGAAAAAGAT
AACGGCGGAAACGAGATTTCCCATATTTATCTTAAAGATGCCGATGGAAATGAAAAGGATCTAACTCCAGATGAAAAAGC
GAAAGCTATGTTCCACAGCTGGAGCGATGACGGCAAGGGATTCTATTTTCTTTCAAATAAAAGGGATCCTAAATATTTCG
ATATTTACTATATGGATATTAAAAGCCTCGAGGCAGATCTGATTCTTGAGAATAACGAAGGGTTTAACCCCGGGCCAGTA
TCTCCCAATGGAAGGTTTATTGCTCTTTCTAAAACAGTTACGATGAACGATGTTGAAATGTACATAAAAGATCTTAAGAC
CGGTGAGCTGACACATATAACACCCCATGAAGGTGAAGTATTCTACGACCCCGTGAGTTTTTCCAGGGATTCAAAGATTC
TATACTTCATTACGGATGAGGATAGGGAATTCAAGTACCTAAAAAAGTACAATTTGAGTTCCGGGACAAGTGAACCCTTC
AAAGTCTTCGCATGGGACGTAGTCTTCGCTAAATTTTCAAAAAACAACAGATTCTTAGCGCTGGCAATAAACAACGATGC
ACGGATAGAACTCAAGATCTACGATCTTAAAAAAGATATTGAAATCGACTTGCCGGAATTACCGAAAGGCGTTGTCTCTG
ATTTTGACTTTTCCCGGGATGAGAGGTTCCTTGCGTTGGTAGCAGACGCATCGAACTCCCCGAGAAATCTTTTCCTTCTG
GATTTCCAGACAGGCGAAATCAAAAAACTCACGGATTCACTCAATCCAGAAATAGATCCAGAAGATCTCGTAGAGGCAGA
GGTTGTAAGATTCAAATCCTTTGATGGATTGGAAATACCGGGAATCTTTTACAAACCGAAAGGGCTTAAAAAAGGTGAAA
AAGTCCCTGCACTTGTTTACGTTCACGGTGGTCCCGGCGGGCAAACGATTCTAAGTTATTCACCGATGTTTCAATATCTT
GTGAATCACGGTTATGCCATATTTGCTGTAAACAACCGCGGAAGCAGCGGTTATGGAAAAACTTTCTTCATGGCCGCTGA
TCATAGGCACGGAGAACTCGACCTGGCAGATTGCGTCGAGGCTAAACGCTTTCTGGAAACACTGGATTTTATCGATGGAA
CAAAGATAGGAATAATCGGTGCCAGCTACGGCGGTTATATGGTTCTGGCCGCCCTCGTTTTCAAACCAGAAGTTTTTAAG
GTCGGTATCGACATTTTCGGTGTTTCCAACTGGTTGCGCACGCTGAAAGAGATTCCACCATGGTGGGGAGCTATGAAAGA
TGCTCTTTACAGGAAAATTGGTGACCCATACAAGGAAGAGGAATATTTAAGAAGCATTTCACCTCTCTTCCATGCAGAGA
AGATTGTCAAACCACTGCTCGTCCTCCAGGGAGCTAACGATCCCAGAGTCCTGAAAATAGAGTCAGATGAAATCGTTGAA
AAGGTCAAGGAAAATGGTGTTCCCGTGGAATACATCGTATTCGAAGATGAAGGTCACGGATTCACGAAGAAGGCTAATCA
ATTAAAAGCCTACAAAAAAATTCTGGAATTCCTTGATAAACACCTCGCAACTGCCTGA

Upstream 100 bases:

>100_bases
TTATCTTTGTATGCCAGAATTAGAGTATAATTAGTTTCGAATATGAAAGCTCAATTCTTTCTGTATAGGTAGAACAGCTG
TTTATAGAGGGGGGAGCATT

Downstream 100 bases:

>100_bases
ACATATGTATAAGCATACGTATTTCAATACTTTTCAGAAATGGATTTCCTCTTTTTTTGCAATTTTGGAAATGGGTTTCC
GGTTCGACACTTCGCGTCGG

Product: peptidase S9 prolyl oligopeptidase active site domain protein

Products: Hydrolyzed protein [C]

Alternate protein names: NA

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MKKQVKKYTIHQFMKNITIIGTALSSDGRKILFSSDESGIFNAHEIDLETGKASKLTDSQDSVFIVGYLPEGNGFLFEKD
NGGNEISHIYLKDADGNEKDLTPDEKAKAMFHSWSDDGKGFYFLSNKRDPKYFDIYYMDIKSLEADLILENNEGFNPGPV
SPNGRFIALSKTVTMNDVEMYIKDLKTGELTHITPHEGEVFYDPVSFSRDSKILYFITDEDREFKYLKKYNLSSGTSEPF
KVFAWDVVFAKFSKNNRFLALAINNDARIELKIYDLKKDIEIDLPELPKGVVSDFDFSRDERFLALVADASNSPRNLFLL
DFQTGEIKKLTDSLNPEIDPEDLVEAEVVRFKSFDGLEIPGIFYKPKGLKKGEKVPALVYVHGGPGGQTILSYSPMFQYL
VNHGYAIFAVNNRGSSGYGKTFFMAADHRHGELDLADCVEAKRFLETLDFIDGTKIGIIGASYGGYMVLAALVFKPEVFK
VGIDIFGVSNWLRTLKEIPPWWGAMKDALYRKIGDPYKEEEYLRSISPLFHAEKIVKPLLVLQGANDPRVLKIESDEIVE
KVKENGVPVEYIVFEDEGHGFTKKANQLKAYKKILEFLDKHLATA

Sequences:

>Translated_605_residues
MKKQVKKYTIHQFMKNITIIGTALSSDGRKILFSSDESGIFNAHEIDLETGKASKLTDSQDSVFIVGYLPEGNGFLFEKD
NGGNEISHIYLKDADGNEKDLTPDEKAKAMFHSWSDDGKGFYFLSNKRDPKYFDIYYMDIKSLEADLILENNEGFNPGPV
SPNGRFIALSKTVTMNDVEMYIKDLKTGELTHITPHEGEVFYDPVSFSRDSKILYFITDEDREFKYLKKYNLSSGTSEPF
KVFAWDVVFAKFSKNNRFLALAINNDARIELKIYDLKKDIEIDLPELPKGVVSDFDFSRDERFLALVADASNSPRNLFLL
DFQTGEIKKLTDSLNPEIDPEDLVEAEVVRFKSFDGLEIPGIFYKPKGLKKGEKVPALVYVHGGPGGQTILSYSPMFQYL
VNHGYAIFAVNNRGSSGYGKTFFMAADHRHGELDLADCVEAKRFLETLDFIDGTKIGIIGASYGGYMVLAALVFKPEVFK
VGIDIFGVSNWLRTLKEIPPWWGAMKDALYRKIGDPYKEEEYLRSISPLFHAEKIVKPLLVLQGANDPRVLKIESDEIVE
KVKENGVPVEYIVFEDEGHGFTKKANQLKAYKKILEFLDKHLATA
>Mature_605_residues
MKKQVKKYTIHQFMKNITIIGTALSSDGRKILFSSDESGIFNAHEIDLETGKASKLTDSQDSVFIVGYLPEGNGFLFEKD
NGGNEISHIYLKDADGNEKDLTPDEKAKAMFHSWSDDGKGFYFLSNKRDPKYFDIYYMDIKSLEADLILENNEGFNPGPV
SPNGRFIALSKTVTMNDVEMYIKDLKTGELTHITPHEGEVFYDPVSFSRDSKILYFITDEDREFKYLKKYNLSSGTSEPF
KVFAWDVVFAKFSKNNRFLALAINNDARIELKIYDLKKDIEIDLPELPKGVVSDFDFSRDERFLALVADASNSPRNLFLL
DFQTGEIKKLTDSLNPEIDPEDLVEAEVVRFKSFDGLEIPGIFYKPKGLKKGEKVPALVYVHGGPGGQTILSYSPMFQYL
VNHGYAIFAVNNRGSSGYGKTFFMAADHRHGELDLADCVEAKRFLETLDFIDGTKIGIIGASYGGYMVLAALVFKPEVFK
VGIDIFGVSNWLRTLKEIPPWWGAMKDALYRKIGDPYKEEEYLRSISPLFHAEKIVKPLLVLQGANDPRVLKIESDEIVE
KVKENGVPVEYIVFEDEGHGFTKKANQLKAYKKILEFLDKHLATA

Specific function: Cleaves Peptide Bonds On The C-Terminal Side Of Lysyl And Argininyl Residues. [C]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI194394146, Length=274, Percent_Identity=28.4671532846715, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI18450280, Length=276, Percent_Identity=28.2608695652174, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI37577089, Length=276, Percent_Identity=28.2608695652174, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI23510451, Length=256, Percent_Identity=22.65625, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI18765694, Length=246, Percent_Identity=25.609756097561, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI295849272, Length=314, Percent_Identity=24.5222929936306, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI16933540, Length=254, Percent_Identity=26.7716535433071, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI52426756, Length=314, Percent_Identity=24.5222929936306, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI85787627, Length=314, Percent_Identity=24.5222929936306, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI295842403, Length=314, Percent_Identity=24.5222929936306, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI295842359, Length=314, Percent_Identity=24.5222929936306, Blast_Score=73, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25144537, Length=637, Percent_Identity=24.8037676609105, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI25144540, Length=339, Percent_Identity=31.5634218289086, Blast_Score=182, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI25144543, Length=546, Percent_Identity=22.1611721611722, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17552908, Length=345, Percent_Identity=25.2173913043478, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI25149159, Length=445, Percent_Identity=25.1685393258427, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17508017, Length=245, Percent_Identity=28.1632653061224, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508019, Length=245, Percent_Identity=28.1632653061224, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17550672, Length=290, Percent_Identity=23.448275862069, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324793, Length=260, Percent_Identity=26.9230769230769, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45550825, Length=250, Percent_Identity=28.4, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45553511, Length=250, Percent_Identity=28.4, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45551969, Length=250, Percent_Identity=28.4, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24582257, Length=253, Percent_Identity=24.901185770751, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR011659
- InterPro:   IPR001375 [H]

Pfam domain/function: PF07676 PD40; PF00326 Peptidase_S9 [H]

EC number: 3.4.21.83 [C]

Molecular weight: Translated: 68467; Mature: 68467

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQVKKYTIHQFMKNITIIGTALSSDGRKILFSSDESGIFNAHEIDLETGKASKLTDSQ
CCCHHHHHHHHHHHCCEEEEEEEECCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCC
DSVFIVGYLPEGNGFLFEKDNGGNEISHIYLKDADGNEKDLTPDEKAKAMFHSWSDDGKG
CCEEEEEEEECCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCE
FYFLSNKRDPKYFDIYYMDIKSLEADLILENNEGFNPGPVSPNGRFIALSKTVTMNDVEM
EEEECCCCCCCEEEEEEEEEECCCEEEEEECCCCCCCCCCCCCCEEEEEEEEEEEHHHHH
YIKDLKTGELTHITPHEGEVFYDPVSFSRDSKILYFITDEDREFKYLKKYNLSSGTSEPF
HHHHCCCCCEEEECCCCCCEEECCCCCCCCCEEEEEEECCCCCCHHHHHCCCCCCCCCCE
KVFAWDVVFAKFSKNNRFLALAINNDARIELKIYDLKKDIEIDLPELPKGVVSDFDFSRD
EEEEEEEEEEEECCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCHHHCCCCCCCC
ERFLALVADASNSPRNLFLLDFQTGEIKKLTDSLNPEIDPEDLVEAEVVRFKSFDGLEIP
CEEEEEEEECCCCCCEEEEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHEECCCCCCCCC
GIFYKPKGLKKGEKVPALVYVHGGPGGQTILSYSPMFQYLVNHGYAIFAVNNRGSSGYGK
CEEECCCCCCCCCCCCEEEEEECCCCCCEEEECCHHHHHHHHCCEEEEEEECCCCCCCCE
TFFMAADHRHGELDLADCVEAKRFLETLDFIDGTKIGIIGASYGGYMVLAALVFKPEVFK
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCEEE
VGIDIFGVSNWLRTLKEIPPWWGAMKDALYRKIGDPYKEEEYLRSISPLFHAEKIVKPLL
EEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHE
VLQGANDPRVLKIESDEIVEKVKENGVPVEYIVFEDEGHGFTKKANQLKAYKKILEFLDK
EEECCCCCEEEEECCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
HLATA
HHCCC
>Mature Secondary Structure
MKKQVKKYTIHQFMKNITIIGTALSSDGRKILFSSDESGIFNAHEIDLETGKASKLTDSQ
CCCHHHHHHHHHHHCCEEEEEEEECCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCC
DSVFIVGYLPEGNGFLFEKDNGGNEISHIYLKDADGNEKDLTPDEKAKAMFHSWSDDGKG
CCEEEEEEEECCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCE
FYFLSNKRDPKYFDIYYMDIKSLEADLILENNEGFNPGPVSPNGRFIALSKTVTMNDVEM
EEEECCCCCCCEEEEEEEEEECCCEEEEEECCCCCCCCCCCCCCEEEEEEEEEEEHHHHH
YIKDLKTGELTHITPHEGEVFYDPVSFSRDSKILYFITDEDREFKYLKKYNLSSGTSEPF
HHHHCCCCCEEEECCCCCCEEECCCCCCCCCEEEEEEECCCCCCHHHHHCCCCCCCCCCE
KVFAWDVVFAKFSKNNRFLALAINNDARIELKIYDLKKDIEIDLPELPKGVVSDFDFSRD
EEEEEEEEEEEECCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCHHHCCCCCCCC
ERFLALVADASNSPRNLFLLDFQTGEIKKLTDSLNPEIDPEDLVEAEVVRFKSFDGLEIP
CEEEEEEEECCCCCCEEEEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHEECCCCCCCCC
GIFYKPKGLKKGEKVPALVYVHGGPGGQTILSYSPMFQYLVNHGYAIFAVNNRGSSGYGK
CEEECCCCCCCCCCCCEEEEEECCCCCCEEEECCHHHHHHHHCCEEEEEEECCCCCCCCE
TFFMAADHRHGELDLADCVEAKRFLETLDFIDGTKIGIIGASYGGYMVLAALVFKPEVFK
EEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCEEE
VGIDIFGVSNWLRTLKEIPPWWGAMKDALYRKIGDPYKEEEYLRSISPLFHAEKIVKPLL
EEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHE
VLQGANDPRVLKIESDEIVEKVKENGVPVEYIVFEDEGHGFTKKANQLKAYKKILEFLDK
EEECCCCCEEEEECCHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
HLATA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): 11820 [C]

Specific activity: NA

Km value (mM): 0.23 {tosyl-Arg} 0.92 {benzoyl-Lys} 0.6 {N-benzoyl-Arg} 0.47 {tosyl-Lys-methyl} 0.33 {N-benzyloxycarbonyl-Lys} 0.31 {N-benzyloxycarbonyl-Lys} 0.5 {benzoyl-Arg} 0.48 {benzoyl-Arg} 0.25 {benzoyl-Arg} 80 {acetyl-tyrosine} [C]

Substrates: Protein; H2O [C]

Specific reaction: Protein + H2O = hydrolyzed protein [C]

General reaction: Peptide bond hydrolysis [C]

Inhibitor: Antipain; Aromaticamidines; Benzamidine; Co2+; DFP; Fe2+; Hg2+; L-Arginine; Leupeptin sulfhydryl agents, trypsin inhibitors, 1, 10-phenanthroline; p-Aminobenzamidine; Tosyl -Leuchloromethyl ketone; Zn2+ [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 3098560 [H]