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The map label for this gene is manC [H]

Identifier: 239617411

GI number: 239617411

Start: 1083926

End: 1084948

Strand: Reverse

Name: manC [H]

Synonym: Kole_1022

Alternate gene names: 239617411

Gene position: 1084948-1083926 (Counterclockwise)

Preceding gene: 239617413

Following gene: 239617410

Centisome position: 47.13

GC content: 37.15

Gene sequence:

>1023_bases
TTGATAATCGCAGTAATAATGGCAGGGGGTATAGGGGAAAGGTTGTGGCCCCTCAGTACCAGAAAAAAGCCAAAGCAATT
TCACATTTTTGGAGCAGAAAAAACTCTAATAGAGCTAACAGTGGAAAGGGCACAGGCATTTGCGGATAAAATCTATATAG
TTACCACCCGAGAACAAAAAGCATTGTTCACGAATTATCTTCCGAATTTTCCGCAACAAAACATATTGATAGAGCCTTTC
AGGCGTAATACTGCTCCTGCAATCGCTCTGGGGTGTTTGCATGCTTCTGATGAAGATATAATAGTAGTTCTACCTTCTGA
TCATATTATAAGAGATAAAGAAACCTTTGAAAGAACCATGAATTCCGCAATCAAAGAAGCATCAAAAAACAATATCCTTG
TCACTATAGGTATTACACCAAATTCACCTCATACAGGTTACGGTTATATTGAAAGAGGTGAGACATTCAATTCAGAAACG
GGAAGTTTCACCGTAAAAAAATTCCACGAAAAGCCTTCTTTTGATGTCGCCCAACGTTATGTAAAAGATGGACGTTTTTA
CTGGAATTCTGGAATGTTTGTATGGAAAAAATCCTCTTTCGATAAAGCTCTTGCTTCGCACTTAAAGGATATCAACTCAG
CTATGAAAGAAATCAAAAATGATTATTCGAAACTTGAGAGCGTTTACAAGGGCATGCCCAACATTTCTGTAGATTATGGG
ATAATGGAAAAAGCAGATAATGTTATTGTAATTCCAGCGAACTTTTATTGGAACGATGTTGGAAGCTGGGATTCCGTTTA
CGATCTGGAAGAAAAGGATGAAAATGGTAACGTCGTTAAGGGAAATTTTATTCTACACAATGTAAGAAATTCTCTTCTAG
TAAATACCACACAGAGGAATATCGGTATTTCTCATGTTGAAGATATGATAGTCGTTGTTTCCAATGAAGGAACTTTACTA
TGTCATCGCGGAGAAACACAATATGTAAGAGAAATCACAAAAAGATTGGAGGAGAAAGCGTGA

Upstream 100 bases:

>100_bases
GACCCCACATATACGAATCATATCCACCTTTAACAATTATACTACATTTTGAAACAACTCCCTTTTTTTCTGATATCCTA
ATATAATGGAGGTGATACTT

Downstream 100 bases:

>100_bases
ATACAAAAATTGACAAAATGGTTCTTGAATTGCGCGACAAAATAGTTGAATCCGTTTCAGAACTTATTAAAATACCCTCC
GTTGAAGGAACGCCAAAACC

Product: Mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MIIAVIMAGGIGERLWPLSTRKKPKQFHIFGAEKTLIELTVERAQAFADKIYIVTTREQKALFTNYLPNFPQQNILIEPF
RRNTAPAIALGCLHASDEDIIVVLPSDHIIRDKETFERTMNSAIKEASKNNILVTIGITPNSPHTGYGYIERGETFNSET
GSFTVKKFHEKPSFDVAQRYVKDGRFYWNSGMFVWKKSSFDKALASHLKDINSAMKEIKNDYSKLESVYKGMPNISVDYG
IMEKADNVIVIPANFYWNDVGSWDSVYDLEEKDENGNVVKGNFILHNVRNSLLVNTTQRNIGISHVEDMIVVVSNEGTLL
CHRGETQYVREITKRLEEKA

Sequences:

>Translated_340_residues
MIIAVIMAGGIGERLWPLSTRKKPKQFHIFGAEKTLIELTVERAQAFADKIYIVTTREQKALFTNYLPNFPQQNILIEPF
RRNTAPAIALGCLHASDEDIIVVLPSDHIIRDKETFERTMNSAIKEASKNNILVTIGITPNSPHTGYGYIERGETFNSET
GSFTVKKFHEKPSFDVAQRYVKDGRFYWNSGMFVWKKSSFDKALASHLKDINSAMKEIKNDYSKLESVYKGMPNISVDYG
IMEKADNVIVIPANFYWNDVGSWDSVYDLEEKDENGNVVKGNFILHNVRNSLLVNTTQRNIGISHVEDMIVVVSNEGTLL
CHRGETQYVREITKRLEEKA
>Mature_340_residues
MIIAVIMAGGIGERLWPLSTRKKPKQFHIFGAEKTLIELTVERAQAFADKIYIVTTREQKALFTNYLPNFPQQNILIEPF
RRNTAPAIALGCLHASDEDIIVVLPSDHIIRDKETFERTMNSAIKEASKNNILVTIGITPNSPHTGYGYIERGETFNSET
GSFTVKKFHEKPSFDVAQRYVKDGRFYWNSGMFVWKKSSFDKALASHLKDINSAMKEIKNDYSKLESVYKGMPNISVDYG
IMEKADNVIVIPANFYWNDVGSWDSVYDLEEKDENGNVVKGNFILHNVRNSLLVNTTQRNIGISHVEDMIVVVSNEGTLL
CHRGETQYVREITKRLEEKA

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=350, Percent_Identity=34.8571428571429, Blast_Score=197, Evalue=9e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR018247
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 38690; Mature: 38690

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIAVIMAGGIGERLWPLSTRKKPKQFHIFGAEKTLIELTVERAQAFADKIYIVTTREQK
CEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHCEEEEEEECCHH
ALFTNYLPNFPQQNILIEPFRRNTAPAIALGCLHASDEDIIVVLPSDHIIRDKETFERTM
HHHHHHCCCCCCCCCEECCCCCCCCCEEEEEEEECCCCCEEEEECCCCEECCHHHHHHHH
NSAIKEASKNNILVTIGITPNSPHTGYGYIERGETFNSETGSFTVKKFHEKPSFDVAQRY
HHHHHHHCCCCEEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEEECCCCCCHHHHHHH
VKDGRFYWNSGMFVWKKSSFDKALASHLKDINSAMKEIKNDYSKLESVYKGMPNISVDYG
HHCCCEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
IMEKADNVIVIPANFYWNDVGSWDSVYDLEEKDENGNVVKGNFILHNVRNSLLVNTTQRN
HHHCCCCEEEEECCCEECCCCCCCCEECCCCCCCCCCEEECCEEEEECCCCEEEEEHHHC
IGISHVEDMIVVVSNEGTLLCHRGETQYVREITKRLEEKA
CCHHCCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIIAVIMAGGIGERLWPLSTRKKPKQFHIFGAEKTLIELTVERAQAFADKIYIVTTREQK
CEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHCEEEEEEECCHH
ALFTNYLPNFPQQNILIEPFRRNTAPAIALGCLHASDEDIIVVLPSDHIIRDKETFERTM
HHHHHHCCCCCCCCCEECCCCCCCCCEEEEEEEECCCCCEEEEECCCCEECCHHHHHHHH
NSAIKEASKNNILVTIGITPNSPHTGYGYIERGETFNSETGSFTVKKFHEKPSFDVAQRY
HHHHHHHCCCCEEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEEECCCCCCHHHHHHH
VKDGRFYWNSGMFVWKKSSFDKALASHLKDINSAMKEIKNDYSKLESVYKGMPNISVDYG
HHCCCEEEECCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
IMEKADNVIVIPANFYWNDVGSWDSVYDLEEKDENGNVVKGNFILHNVRNSLLVNTTQRN
HHHCCCCEEEEECCCEECCCCCCCCEECCCCCCCCCCEEECCEEEEECCCCEEEEEHHHC
IGISHVEDMIVVVSNEGTLLCHRGETQYVREITKRLEEKA
CCHHCCCEEEEEEECCCEEEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1383393 [H]