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The map label for this gene is dxs [C]

Identifier: 239617382

GI number: 239617382

Start: 1047936

End: 1048913

Strand: Reverse

Name: dxs [C]

Synonym: Kole_0992

Alternate gene names: 239617382

Gene position: 1048913-1047936 (Counterclockwise)

Preceding gene: 239617383

Following gene: 239617381

Centisome position: 45.56

GC content: 42.84

Gene sequence:

>978_bases
ATGACAGTAAAAATTGTTAAAAATAGAATCCCCGATACTGAGATGATGAGGGACGTTTATATCCAGAATCTCATAGAACT
GGCAAAAAAGGATAAAAATATCGTCGTTCTGGATGCCGATTTGATGCATTCGAATGCCACCCACAAATTTCTCAAAGAAT
TCCCAGACAGAACAATCAACGTAGGTGTTCAGGAAGCTAATATGATAGGTATCGCCGGAGGGCTTTCCGCTACCGGGAAG
ATTCCTTTCACCCATACTTTCGCCTGTTTCAATACCAGAAGAGCCCTGGATCAGATCTATATTTCGATTGCTTATGCACA
ACTGAATGCGAAACTGATCGGAACAGATCCAGGAATAACCGCTTCTTACAACGGCGGTACTCATATGCCTTTAGAAGATG
TTGGGATAATGCGCGGAATCCCCAACATGACTATTGTTGAACCTGTTGATAACGTCATGATGAAAAACATCCTCAAAGAC
ATAACATACACGTATGGGCCTTTTTACGTCAGGGTTTCCAGAAAGTTCCCGGTGAAGATATACGAAGAAGGTTCCACCTT
TGAAATAGGCAAAGGCATCATCTTACGTAATGGAAAAGACGTGACGATAATAGCCTCAGGCATTATGGTGGCTGAAGCTC
TCGACGCTGCTGACATCCTTGAAAAAGAAGGTATTGACGCCAGAGTGGTGAACATATTCACCATCAAGCCCATCGACAGA
GAACTCATTACTTTATGTGCCGAGGAGACAGGAGCCGTCGTCACCGCAGAAAATCACAACATCCATAACGGTCTTGGTTC
CGCTGTTGCTGAGGTTCTTGTAGAAAATTGTCCTGTTCCTATGGAAAGGGTTGGAGTTTTTGATCTCTTCGGCGAAGTCG
GAAGTGTTGATTATCTCAAGAAACGATTCCAACTTACTTCCAACGATATAGTTAAAAGCGTAAAGAAAGTACTTTCCAGG
AAGAAGAGGTGTATGTAA

Upstream 100 bases:

>100_bases
GTATTGAGTTGAACCATCATATGAAATTCACAGAAGAACAAATAGAACAAGCAATAAAGCCTCTTGAAGAAGAACTCCGC
AGGAAAGAAAGGGATCTCGC

Downstream 100 bases:

>100_bases
TGAGAAAGTACAAAATCGCGGTGATACCGGGTGACGGGATAGGCGTAGATGTTATTAACGAAGGGCTAAAAATCCTCGAA
ACAGCTAAAGAACTCCACGG

Product: Transketolase domain protein

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MTVKIVKNRIPDTEMMRDVYIQNLIELAKKDKNIVVLDADLMHSNATHKFLKEFPDRTINVGVQEANMIGIAGGLSATGK
IPFTHTFACFNTRRALDQIYISIAYAQLNAKLIGTDPGITASYNGGTHMPLEDVGIMRGIPNMTIVEPVDNVMMKNILKD
ITYTYGPFYVRVSRKFPVKIYEEGSTFEIGKGIILRNGKDVTIIASGIMVAEALDAADILEKEGIDARVVNIFTIKPIDR
ELITLCAEETGAVVTAENHNIHNGLGSAVAEVLVENCPVPMERVGVFDLFGEVGSVDYLKKRFQLTSNDIVKSVKKVLSR
KKRCM

Sequences:

>Translated_325_residues
MTVKIVKNRIPDTEMMRDVYIQNLIELAKKDKNIVVLDADLMHSNATHKFLKEFPDRTINVGVQEANMIGIAGGLSATGK
IPFTHTFACFNTRRALDQIYISIAYAQLNAKLIGTDPGITASYNGGTHMPLEDVGIMRGIPNMTIVEPVDNVMMKNILKD
ITYTYGPFYVRVSRKFPVKIYEEGSTFEIGKGIILRNGKDVTIIASGIMVAEALDAADILEKEGIDARVVNIFTIKPIDR
ELITLCAEETGAVVTAENHNIHNGLGSAVAEVLVENCPVPMERVGVFDLFGEVGSVDYLKKRFQLTSNDIVKSVKKVLSR
KKRCM
>Mature_324_residues
TVKIVKNRIPDTEMMRDVYIQNLIELAKKDKNIVVLDADLMHSNATHKFLKEFPDRTINVGVQEANMIGIAGGLSATGKI
PFTHTFACFNTRRALDQIYISIAYAQLNAKLIGTDPGITASYNGGTHMPLEDVGIMRGIPNMTIVEPVDNVMMKNILKDI
TYTYGPFYVRVSRKFPVKIYEEGSTFEIGKGIILRNGKDVTIIASGIMVAEALDAADILEKEGIDARVVNIFTIKPIDRE
LITLCAEETGAVVTAENHNIHNGLGSAVAEVLVENCPVPMERVGVFDLFGEVGSVDYLKKRFQLTSNDIVKSVKKVLSRK
KRCM

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=316, Percent_Identity=33.2278481012658, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4507521, Length=316, Percent_Identity=33.2278481012658, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI225637463, Length=314, Percent_Identity=33.4394904458599, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI225637459, Length=314, Percent_Identity=33.4394904458599, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI225637461, Length=314, Percent_Identity=33.4394904458599, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI133778974, Length=313, Percent_Identity=30.6709265175719, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI291084858, Length=273, Percent_Identity=24.9084249084249, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI156564403, Length=278, Percent_Identity=25.1798561151079, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1786622, Length=306, Percent_Identity=29.4117647058824, Blast_Score=119, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17539652, Length=308, Percent_Identity=32.7922077922078, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17538422, Length=338, Percent_Identity=24.8520710059172, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319698, Length=351, Percent_Identity=24.2165242165242, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551847, Length=270, Percent_Identity=34.4444444444444, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45550715, Length=270, Percent_Identity=34.4444444444444, Blast_Score=142, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24645119, Length=269, Percent_Identity=34.5724907063197, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24666278, Length=274, Percent_Identity=31.7518248175182, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21358145, Length=269, Percent_Identity=25.2788104089219, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650940, Length=269, Percent_Identity=25.2788104089219, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI160714828, Length=137, Percent_Identity=35.036496350365, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI160714832, Length=137, Percent_Identity=35.036496350365, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 35938; Mature: 35807

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKIVKNRIPDTEMMRDVYIQNLIELAKKDKNIVVLDADLMHSNATHKFLKEFPDRTIN
CEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCHHHHHHHCCCCEEE
VGVQEANMIGIAGGLSATGKIPFTHTFACFNTRRALDQIYISIAYAQLNAKLIGTDPGIT
CCEEECCEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHEEEEEECCEEEECCCCCE
ASYNGGTHMPLEDVGIMRGIPNMTIVEPVDNVMMKNILKDITYTYGPFYVRVSRKFPVKI
EECCCCCCCCHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEE
YEEGSTFEIGKGIILRNGKDVTIIASGIMVAEALDAADILEKEGIDARVVNIFTIKPIDR
EECCCEEEECCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCH
ELITLCAEETGAVVTAENHNIHNGLGSAVAEVLVENCPVPMERVGVFDLFGEVGSVDYLK
HHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHH
KRFQLTSNDIVKSVKKVLSRKKRCM
HHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVKIVKNRIPDTEMMRDVYIQNLIELAKKDKNIVVLDADLMHSNATHKFLKEFPDRTIN
EEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCHHHHHHHCCCCEEE
VGVQEANMIGIAGGLSATGKIPFTHTFACFNTRRALDQIYISIAYAQLNAKLIGTDPGIT
CCEEECCEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHHHHHEEEEEECCEEEECCCCCE
ASYNGGTHMPLEDVGIMRGIPNMTIVEPVDNVMMKNILKDITYTYGPFYVRVSRKFPVKI
EECCCCCCCCHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEE
YEEGSTFEIGKGIILRNGKDVTIIASGIMVAEALDAADILEKEGIDARVVNIFTIKPIDR
EECCCEEEECCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCH
ELITLCAEETGAVVTAENHNIHNGLGSAVAEVLVENCPVPMERVGVFDLFGEVGSVDYLK
HHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHH
KRFQLTSNDIVKSVKKVLSRKKRCM
HHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]