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The map label for this gene is tktA [C]

Identifier: 239617383

GI number: 239617383

Start: 1048910

End: 1049764

Strand: Reverse

Name: tktA [C]

Synonym: Kole_0993

Alternate gene names: 239617383

Gene position: 1049764-1048910 (Counterclockwise)

Preceding gene: 239617384

Following gene: 239617382

Centisome position: 45.6

GC content: 44.33

Gene sequence:

>855_bases
ATGCTGACAGAAAAAGAAATCAGGGAACTCGAGAAGTTTGCTCTTGAAATTCGGATACAAACATTAAAAGAATTAGGATA
TCTCGGTTTTGGGCATATCGGTGGTGCCATGTCAATCGTTGAGCTTCTGGCCGTTCTCTATGGGAAGGAAATGAGATACG
ACCCAAAAAACCCAAAATGGGACGGTCGGGATTGGTTCATTCTTTCTAAAGGACATGCAGGGCCGGCACTTTACGCAACG
CTCGCTTTGAAAGGGTTCTTTTCTATTGATCTACTGAAAACGCTGAATCAGGGCGGGACGAACCTTCCAAGTCACTGTGA
CAGAAACAAAACACCCGGTATAGACATGAGCACAGGCTCTCTAGGTCAGGGAATCTCCATGGGAATCGGTGTTGCTCTGG
GTTTTAAGATGGACGGTAAAAGCAATTACGTTTATGTCGTTCTTGGAGATGGAGAATGCCAGGAAGGACAGGTTTGGGAA
GCGGCGCTTTACGGTGGAAATGCCAAACTTGACAACCTTATAGTTTTCGTTGATTACAACAAGCAGCAGCTCGATGGCTA
CATCGACGATATCAACCCATTGGGAGATCTTAGAGAGAAGTGGGAAGTATTCGGATGGCATAGTCAAGAAGTCGATGGCC
ACAACGTTGCAGAGATTTATGATGCCATCCAGAAGGCCAAGAAAACAAAAGGGAAAAGCTCTGTAATTATCCTTCATACA
ATAAAAGGAAAAGGCTGCAGTTTCGCCGAAGGTATTGAGTTGAACCATCATATGAAATTCACAGAAGAACAAATAGAACA
AGCAATAAAGCCTCTTGAAGAAGAACTCCGCAGGAAAGAAAGGGATCTCGCATGA

Upstream 100 bases:

>100_bases
ATCAAAAGCTTTTGAAATGAAAGGTGAGAAGGCTGAGTATGCTGTCTTCCCGCTTGGAGCTTCAACTTTACCGAGAGTTA
AGAGAGGTGAGAACTGAATA

Downstream 100 bases:

>100_bases
CAGTAAAAATTGTTAAAAATAGAATCCCCGATACTGAGATGATGAGGGACGTTTATATCCAGAATCTCATAGAACTGGCA
AAAAAGGATAAAAATATCGT

Product: Transketolase domain protein

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MLTEKEIRELEKFALEIRIQTLKELGYLGFGHIGGAMSIVELLAVLYGKEMRYDPKNPKWDGRDWFILSKGHAGPALYAT
LALKGFFSIDLLKTLNQGGTNLPSHCDRNKTPGIDMSTGSLGQGISMGIGVALGFKMDGKSNYVYVVLGDGECQEGQVWE
AALYGGNAKLDNLIVFVDYNKQQLDGYIDDINPLGDLREKWEVFGWHSQEVDGHNVAEIYDAIQKAKKTKGKSSVIILHT
IKGKGCSFAEGIELNHHMKFTEEQIEQAIKPLEEELRRKERDLA

Sequences:

>Translated_284_residues
MLTEKEIRELEKFALEIRIQTLKELGYLGFGHIGGAMSIVELLAVLYGKEMRYDPKNPKWDGRDWFILSKGHAGPALYAT
LALKGFFSIDLLKTLNQGGTNLPSHCDRNKTPGIDMSTGSLGQGISMGIGVALGFKMDGKSNYVYVVLGDGECQEGQVWE
AALYGGNAKLDNLIVFVDYNKQQLDGYIDDINPLGDLREKWEVFGWHSQEVDGHNVAEIYDAIQKAKKTKGKSSVIILHT
IKGKGCSFAEGIELNHHMKFTEEQIEQAIKPLEEELRRKERDLA
>Mature_284_residues
MLTEKEIRELEKFALEIRIQTLKELGYLGFGHIGGAMSIVELLAVLYGKEMRYDPKNPKWDGRDWFILSKGHAGPALYAT
LALKGFFSIDLLKTLNQGGTNLPSHCDRNKTPGIDMSTGSLGQGISMGIGVALGFKMDGKSNYVYVVLGDGECQEGQVWE
AALYGGNAKLDNLIVFVDYNKQQLDGYIDDINPLGDLREKWEVFGWHSQEVDGHNVAEIYDAIQKAKKTKGKSSVIILHT
IKGKGCSFAEGIELNHHMKFTEEQIEQAIKPLEEELRRKERDLA

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=292, Percent_Identity=34.5890410958904, Blast_Score=158, Evalue=4e-39,
Organism=Homo sapiens, GI4507521, Length=292, Percent_Identity=34.5890410958904, Blast_Score=158, Evalue=4e-39,
Organism=Homo sapiens, GI133778974, Length=281, Percent_Identity=32.7402135231317, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI225637459, Length=269, Percent_Identity=25.2788104089219, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI225637461, Length=238, Percent_Identity=25.6302521008403, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI225637463, Length=165, Percent_Identity=30.3030303030303, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI48994911, Length=282, Percent_Identity=30.1418439716312, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1788808, Length=272, Percent_Identity=31.25, Blast_Score=134, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI17539652, Length=280, Percent_Identity=37.5, Blast_Score=157, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6325331, Length=278, Percent_Identity=35.2517985611511, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6319593, Length=279, Percent_Identity=30.1075268817204, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24666278, Length=280, Percent_Identity=35.7142857142857, Blast_Score=161, Evalue=4e-40,
Organism=Drosophila melanogaster, GI45551847, Length=273, Percent_Identity=36.996336996337, Blast_Score=160, Evalue=7e-40,
Organism=Drosophila melanogaster, GI45550715, Length=273, Percent_Identity=36.996336996337, Blast_Score=160, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24645119, Length=235, Percent_Identity=38.7234042553192, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 31708; Mature: 31708

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTEKEIRELEKFALEIRIQTLKELGYLGFGHIGGAMSIVELLAVLYGKEMRYDPKNPKW
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DGRDWFILSKGHAGPALYATLALKGFFSIDLLKTLNQGGTNLPSHCDRNKTPGIDMSTGS
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
LGQGISMGIGVALGFKMDGKSNYVYVVLGDGECQEGQVWEAALYGGNAKLDNLIVFVDYN
CCCCCHHCEEEEEEEEECCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCEEEEEECC
KQQLDGYIDDINPLGDLREKWEVFGWHSQEVDGHNVAEIYDAIQKAKKTKGKSSVIILHT
HHHHCCHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
IKGKGCSFAEGIELNHHMKFTEEQIEQAIKPLEEELRRKERDLA
ECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTEKEIRELEKFALEIRIQTLKELGYLGFGHIGGAMSIVELLAVLYGKEMRYDPKNPKW
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DGRDWFILSKGHAGPALYATLALKGFFSIDLLKTLNQGGTNLPSHCDRNKTPGIDMSTGS
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
LGQGISMGIGVALGFKMDGKSNYVYVVLGDGECQEGQVWEAALYGGNAKLDNLIVFVDYN
CCCCCHHCEEEEEEEEECCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCEEEEEECC
KQQLDGYIDDINPLGDLREKWEVFGWHSQEVDGHNVAEIYDAIQKAKKTKGKSSVIILHT
HHHHCCHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEE
IKGKGCSFAEGIELNHHMKFTEEQIEQAIKPLEEELRRKERDLA
ECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]