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The map label for this gene is galK [H]

Identifier: 239617341

GI number: 239617341

Start: 1004306

End: 1005409

Strand: Direct

Name: galK [H]

Synonym: Kole_0950

Alternate gene names: 239617341

Gene position: 1004306-1005409 (Clockwise)

Preceding gene: 239617340

Following gene: 239617342

Centisome position: 43.63

GC content: 43.3

Gene sequence:

>1104_bases
ATGGGTAATTTCGAATACTATGTTGCCCCTGGGAGAATCAACATAATAGGAGAGCATACTGATTACAACGATGGCTATGT
TTTACCCGCTGCGATAAACAAATATATTCAGGTCGGGGTCAGAAAAGCACCAGACAACAAGATAACCGTCAGATCCGCAC
AGAAAGGAACCTCTGCATTCTCCACAGATTCTATCGAAAAGGCCAATGACTGGTCAGACTATATAAGAGGCGTTTTCTGG
ATTCTTAAAAAGGAAAAGAACATAGATTTCCCTGGATTGGAACTGGAAATTACCTCGAACATTCCGGAAGGCGCGGGTCT
TTCAAGTTCCGCCGCTCTTGAAGTCGCGGTAATAACCGCGCTAAATGGACTGTTGAACCTTGGCCTTACAGATAAGGAAA
GGATTATTCTCTGCCAAAAAGCAGAAAACGATTTTGTTGGCGTCCAATGCGGAATAATGGACCAGTTTGCAAGCGTAATG
GGAAAAGAAAATAAAGCGATCTTTCTCGATACCTATACGATGGATTACGAATACATCCCTCTTGAGCTAAAAGATTATTC
TTTACTTGTAATAGATTCGGGAGTAAGGCATACCCTCTCATCCGGTGACTACAACAAACGAAGAGAAGAAGCAAAGAAGG
CTCTTGCAGAGCTTGGGAAAACCAGCTATCGCGATGTGAAACTCGCCGACGTTCTTATGGCACGTTCTAAGATAAGCGAG
ATAAGTTACAGGAGAGCTATGCACATCGTTTCCGAGAACATGAGGGTTCTCGAAAGTGTGGATATTTTGAAACACTCAAA
TTTTGAAAACCTTGGCAGACTCTTAATCCAGTCCCATGAATCTCTGGCTTTCGAATACGAGGTATCATGCGAAGAACTCG
ACTTTATGGTCGAAAAGCTCAGGAATCTTCCCGGCGTTTCAGGGTGCAGGATGATCGGCGCCGGATTCGGTGGTTCTGTC
CTCGCAATCTGTGAAAAAACGGCAGTGGACAGCATCATCTCAGAGCTTTCAGAGGTTTATAAAAAAGCATACAATCATGA
ACCAAAATTTTACGATGTTCTTCCATCTGATGGCGCAAGAAAAGTGGAAAAGCCTATTTTATGA

Upstream 100 bases:

>100_bases
CTGAAATGGATGGCCAGCGTTGAAACTGGTAGCTGGACGTTTATAAATCCATCAGAACCCGAAGAAGTAGCAAAAAAACT
CAGAGAGGTGGTGATAGACA

Downstream 100 bases:

>100_bases
AATTAGGCTTTCAAGTGTTGGGTCGGTCTAGCCGACCCTTTTTGTTTTGAATTGAGGGATTGGGCTTGTTAGTAAAAAAC
TTGAATTCCAGAGAGCATTT

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MGNFEYYVAPGRINIIGEHTDYNDGYVLPAAINKYIQVGVRKAPDNKITVRSAQKGTSAFSTDSIEKANDWSDYIRGVFW
ILKKEKNIDFPGLELEITSNIPEGAGLSSSAALEVAVITALNGLLNLGLTDKERIILCQKAENDFVGVQCGIMDQFASVM
GKENKAIFLDTYTMDYEYIPLELKDYSLLVIDSGVRHTLSSGDYNKRREEAKKALAELGKTSYRDVKLADVLMARSKISE
ISYRRAMHIVSENMRVLESVDILKHSNFENLGRLLIQSHESLAFEYEVSCEELDFMVEKLRNLPGVSGCRMIGAGFGGSV
LAICEKTAVDSIISELSEVYKKAYNHEPKFYDVLPSDGARKVEKPIL

Sequences:

>Translated_367_residues
MGNFEYYVAPGRINIIGEHTDYNDGYVLPAAINKYIQVGVRKAPDNKITVRSAQKGTSAFSTDSIEKANDWSDYIRGVFW
ILKKEKNIDFPGLELEITSNIPEGAGLSSSAALEVAVITALNGLLNLGLTDKERIILCQKAENDFVGVQCGIMDQFASVM
GKENKAIFLDTYTMDYEYIPLELKDYSLLVIDSGVRHTLSSGDYNKRREEAKKALAELGKTSYRDVKLADVLMARSKISE
ISYRRAMHIVSENMRVLESVDILKHSNFENLGRLLIQSHESLAFEYEVSCEELDFMVEKLRNLPGVSGCRMIGAGFGGSV
LAICEKTAVDSIISELSEVYKKAYNHEPKFYDVLPSDGARKVEKPIL
>Mature_366_residues
GNFEYYVAPGRINIIGEHTDYNDGYVLPAAINKYIQVGVRKAPDNKITVRSAQKGTSAFSTDSIEKANDWSDYIRGVFWI
LKKEKNIDFPGLELEITSNIPEGAGLSSSAALEVAVITALNGLLNLGLTDKERIILCQKAENDFVGVQCGIMDQFASVMG
KENKAIFLDTYTMDYEYIPLELKDYSLLVIDSGVRHTLSSGDYNKRREEAKKALAELGKTSYRDVKLADVLMARSKISEI
SYRRAMHIVSENMRVLESVDILKHSNFENLGRLLIQSHESLAFEYEVSCEELDFMVEKLRNLPGVSGCRMIGAGFGGSVL
AICEKTAVDSIISELSEVYKKAYNHEPKFYDVLPSDGARKVEKPIL

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=362, Percent_Identity=35.9116022099448, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI48527957, Length=430, Percent_Identity=27.2093023255814, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4503897, Length=430, Percent_Identity=27.2093023255814, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786972, Length=357, Percent_Identity=35.2941176470588, Blast_Score=233, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71989053, Length=391, Percent_Identity=24.5524296675192, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6319494, Length=317, Percent_Identity=26.4984227129338, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320212, Length=184, Percent_Identity=32.6086956521739, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24661292, Length=437, Percent_Identity=25.629290617849, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355577, Length=437, Percent_Identity=25.629290617849, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24661285, Length=437, Percent_Identity=25.629290617849, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 40942; Mature: 40811

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNFEYYVAPGRINIIGEHTDYNDGYVLPAAINKYIQVGVRKAPDNKITVRSAQKGTSAF
CCCCEEEEECCEEEEEECCCCCCCCEEEHHHHHHHHHHCCEECCCCCEEEEECCCCCCCC
STDSIEKANDWSDYIRGVFWILKKEKNIDFPGLELEITSNIPEGAGLSSSAALEVAVITA
CCCCCCCCCCHHHHHHHHHHHEECCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHH
LNGLLNLGLTDKERIILCQKAENDFVGVQCGIMDQFASVMGKENKAIFLDTYTMDYEYIP
HHHHHHCCCCCCCEEEEEEECCCCEEEEEECHHHHHHHHHCCCCCEEEEEEEEECEEEEE
LELKDYSLLVIDSGVRHTLSSGDYNKRREEAKKALAELGKTSYRDVKLADVLMARSKISE
EEECCEEEEEEECCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
ISYRRAMHIVSENMRVLESVDILKHSNFENLGRLLIQSHESLAFEYEVSCEELDFMVEKL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHH
RNLPGVSGCRMIGAGFGGSVLAICEKTAVDSIISELSEVYKKAYNHEPKFYDVLPSDGAR
HCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCH
KVEKPIL
HHHCCCC
>Mature Secondary Structure 
GNFEYYVAPGRINIIGEHTDYNDGYVLPAAINKYIQVGVRKAPDNKITVRSAQKGTSAF
CCCEEEEECCEEEEEECCCCCCCCEEEHHHHHHHHHHCCEECCCCCEEEEECCCCCCCC
STDSIEKANDWSDYIRGVFWILKKEKNIDFPGLELEITSNIPEGAGLSSSAALEVAVITA
CCCCCCCCCCHHHHHHHHHHHEECCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHH
LNGLLNLGLTDKERIILCQKAENDFVGVQCGIMDQFASVMGKENKAIFLDTYTMDYEYIP
HHHHHHCCCCCCCEEEEEEECCCCEEEEEECHHHHHHHHHCCCCCEEEEEEEEECEEEEE
LELKDYSLLVIDSGVRHTLSSGDYNKRREEAKKALAELGKTSYRDVKLADVLMARSKISE
EEECCEEEEEEECCCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
ISYRRAMHIVSENMRVLESVDILKHSNFENLGRLLIQSHESLAFEYEVSCEELDFMVEKL
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHH
RNLPGVSGCRMIGAGFGGSVLAICEKTAVDSIISELSEVYKKAYNHEPKFYDVLPSDGAR
HCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCH
KVEKPIL
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA