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The map label for this gene is arlR [H]

Identifier: 239617306

GI number: 239617306

Start: 967610

End: 968275

Strand: Direct

Name: arlR [H]

Synonym: Kole_0915

Alternate gene names: 239617306

Gene position: 967610-968275 (Clockwise)

Preceding gene: 239617305

Following gene: 239617307

Centisome position: 42.03

GC content: 42.79

Gene sequence:

>666_bases
TTGAAAGCAAAAGTGCTTCTCGTAGAGGATGATCCTCACATAAGAAAATTCATTCAGCTGGAACTCGAACACGAAGGCTA
TGAAGTAAAAACAGCCGTTACCGGTCCACAAGCTCTCGACGAACTTGAAAAGGAGCTTCCAGATGTTGTTTTGCTGGATG
TGATGTTGCCGGAGATGAATGGTTTTACCGTGTTAGAAAGAATCCGGGAAGACTTTTCAACGGAGCTTCCAGTAATTATG
TTGACAGCTCGAGGAGAGCTGGAAGATCGGGTCAGGGGATTGAAAAGTGGTGCTGATGATTACATAGTAAAACCTTTCCA
CATTGAAGAGCTTTTGGCCAGACTGGAAGCAGTCCTGAGAAGAAAGGGCTATTCAGAAAAAATTTTATACGGTAATATAG
AAATGAACCTCTCTTCCAGAGAGGTAAAGGTTAATGGTGAACCTGTCGAGCTTAGTAGGACAGAGTTTGATTTGCTAAAA
GTCCTTCTTACGAATGCAGGAATCGTTATGTCAAAAGATAGGCTGTTAGAGCTGGTATGGGGAACGGAAGAATGGGGGAA
TCCTAACGTTGTGGAAGTGTACATAAATTATCTGCGAAAGAAACTTGGATCAGCGGGGAAGATCATAAAAACGGTAAGAG
GTGTTGGTTACGTTGCGAAGGAGTAA

Upstream 100 bases:

>100_bases
ATGATTGAAGGACTTGGGTTGATAATGATGGTCGTCGGGATAATTCTTGGAAGTTTGTCAACGATTAAAGAAAAAGAACA
GGAAAGTGAGGTGGGATAAC

Downstream 100 bases:

>100_bases
ATCCATACCATTTTCACTTCAGTTATTTATCAGTATTGTTATGATAACCGTGCTCGTCATGGTTTTCTTTGCCCTTTTTG
TTTATAGTCTTTCATCCGAG

Product: two component transcriptional regulator, winged helix family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MKAKVLLVEDDPHIRKFIQLELEHEGYEVKTAVTGPQALDELEKELPDVVLLDVMLPEMNGFTVLERIREDFSTELPVIM
LTARGELEDRVRGLKSGADDYIVKPFHIEELLARLEAVLRRKGYSEKILYGNIEMNLSSREVKVNGEPVELSRTEFDLLK
VLLTNAGIVMSKDRLLELVWGTEEWGNPNVVEVYINYLRKKLGSAGKIIKTVRGVGYVAKE

Sequences:

>Translated_221_residues
MKAKVLLVEDDPHIRKFIQLELEHEGYEVKTAVTGPQALDELEKELPDVVLLDVMLPEMNGFTVLERIREDFSTELPVIM
LTARGELEDRVRGLKSGADDYIVKPFHIEELLARLEAVLRRKGYSEKILYGNIEMNLSSREVKVNGEPVELSRTEFDLLK
VLLTNAGIVMSKDRLLELVWGTEEWGNPNVVEVYINYLRKKLGSAGKIIKTVRGVGYVAKE
>Mature_221_residues
MKAKVLLVEDDPHIRKFIQLELEHEGYEVKTAVTGPQALDELEKELPDVVLLDVMLPEMNGFTVLERIREDFSTELPVIM
LTARGELEDRVRGLKSGADDYIVKPFHIEELLARLEAVLRRKGYSEKILYGNIEMNLSSREVKVNGEPVELSRTEFDLLK
VLLTNAGIVMSKDRLLELVWGTEEWGNPNVVEVYINYLRKKLGSAGKIIKTVRGVGYVAKE

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=41.2556053811659, Blast_Score=163, Evalue=7e-42,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=40.4545454545455, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=34.703196347032, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=40.8256880733945, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=36.5638766519824, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=36.405529953917, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=36.1990950226244, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=37.6681614349776, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=34.0909090909091, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=39.4736842105263, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=30.7017543859649, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=33.9366515837104, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=31.2775330396476, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=32.4675324675325, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1788550, Length=168, Percent_Identity=29.1666666666667, Blast_Score=87, Evalue=7e-19,
Organism=Escherichia coli, GI1790299, Length=132, Percent_Identity=34.0909090909091, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790437, Length=115, Percent_Identity=37.3913043478261, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI145693157, Length=105, Percent_Identity=39.0476190476191, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788713, Length=114, Percent_Identity=32.4561403508772, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1788905, Length=121, Percent_Identity=33.8842975206612, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788191, Length=122, Percent_Identity=31.9672131147541, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25136; Mature: 25136

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAKVLLVEDDPHIRKFIQLELEHEGYEVKTAVTGPQALDELEKELPDVVLLDVMLPEMN
CCEEEEEECCCHHHHHHEEEEECCCCEEEEEEECCHHHHHHHHHHCCCEEEEEHHHCCCC
GFTVLERIREDFSTELPVIMLTARGELEDRVRGLKSGADDYIVKPFHIEELLARLEAVLR
CHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHH
RKGYSEKILYGNIEMNLSSREVKVNGEPVELSRTEFDLLKVLLTNAGIVMSKDRLLELVW
HCCCCCCEEEEEEEEEECCCEEEECCCCEEECHHHHHHHHHHHHCCCEEEEHHHHEEEEE
GTEEWGNPNVVEVYINYLRKKLGSAGKIIKTVRGVGYVAKE
CCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKAKVLLVEDDPHIRKFIQLELEHEGYEVKTAVTGPQALDELEKELPDVVLLDVMLPEMN
CCEEEEEECCCHHHHHHEEEEECCCCEEEEEEECCHHHHHHHHHHCCCEEEEEHHHCCCC
GFTVLERIREDFSTELPVIMLTARGELEDRVRGLKSGADDYIVKPFHIEELLARLEAVLR
CHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHH
RKGYSEKILYGNIEMNLSSREVKVNGEPVELSRTEFDLLKVLLTNAGIVMSKDRLLELVW
HCCCCCCEEEEEEEEEECCCEEEECCCCEEECHHHHHHHHHHHHCCCEEEEHHHHEEEEE
GTEEWGNPNVVEVYINYLRKKLGSAGKIIKTVRGVGYVAKE
CCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA