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The map label for this gene is dxr [H]

Identifier: 239617300

GI number: 239617300

Start: 960504

End: 961637

Strand: Direct

Name: dxr [H]

Synonym: Kole_0909

Alternate gene names: 239617300

Gene position: 960504-961637 (Clockwise)

Preceding gene: 239617299

Following gene: 239617301

Centisome position: 41.72

GC content: 41.45

Gene sequence:

>1134_bases
TTGAAGAAAATAGCGATAGTAGGTTCCACAGGTTCCATTGGAACTCAAACACTTGAAGTGATTAGAAAACTTGATAATTT
TAGAGTTGTGGCCATGGCTTGTGGCCACAACTTTTCACTTTTTGAAAGACAACTCCACGAATTTTCTCCAGAATACGCTG
CTATGCTTGAGCCAAATAGAGAGCTAGAAGTTAATTTTCCATCTGTGAAGTTTTTTTATGGTGCTGAAGGAATTGAAGAG
ATGCTGGAGATAGCCAAACCTGATTACACAGTTCTTGCGGCCAGCGGCGCGATAGGGTTGAGATACAGTCTCAAGGCGAT
TGAGCATTCTAAACGGCTCTGTCTTGCTAATAAAGAGTCCATCGTTTGTGGTGGAAAACTTCTGCTGGAAAAGGCAAAGC
GGTATTCGGCAGAAATTATTCCTGTTGATAGTGAACACAGTGCGCTCTTTCAGTTGCTTCGAGGCGATGTTCGACCAGAG
AAAATATTCATCACCGCTTCAGGTGGTGCACTCAGAGATTATCCGCTCGATAGAATCAATGAAGTTACACTGAAAGATGT
TTTGAATCACCCTGTCTGGTCTATGGGGGTTAGAATAACTGTTGATAGTGCTACTATGGTGAACAAAGGACTTGAGATTA
TAGAAGCCCATTATCTCTTTTCCTATGATGAAAAAGACATTTTGACATATGTTTGCAAGAATAGCGCAATCCATGCCGGA
GTAATCTACTCAGACGGAACAATAAAACTTCACATCGGCAAACCGGACATGAGAATTCCGATAGCTTATTCTTTAACTTA
TCCCCAAAGGGCTGCACTGAAAGACTTCACGGCTTCTCCTCTGGATTATTCCCTTTCTCTGGAGGAAATCGATTATCGAA
GATATCCGGCTTTGAAACTAGCACGTGAAATTATCGGGATACCGTCGAAACAAATCGCGTTCAACGCTGCTGATGAAATA
GCAGTCAAAAACTTTGTGGAGGGTAGAATTTCTTTTGGTAGCATTTATAGGATAATTGAAAAAACTATCGAGCGTATTGA
ACCGATAAGTCCTAAAGACTTCGAAGAGGTTCAGGCTATCGATGTATTGGCAAGAAAAATTGCACAGGAAGAGGTGAGAA
AATGCTCACGTTAG

Upstream 100 bases:

>100_bases
GAAGAATATCAAGGAAAAATCCCCGGAAGAGATTAAAAAAATCGTAGAGGAAGCCAAAGGAGATATAGAGGAACTGAAGA
AAAGATTCGAGGTGTAGCTC

Downstream 100 bases:

>100_bases
TTTACTTTTTTCTTATACTGACGGCGATAGTCGTTGTTCATGAGTTCGGACATTATCTTTTCGCAAGGATTTTTGGTGTT
AGGGCCTTAGAATTTGCTGT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKKIAIVGSTGSIGTQTLEVIRKLDNFRVVAMACGHNFSLFERQLHEFSPEYAAMLEPNRELEVNFPSVKFFYGAEGIEE
MLEIAKPDYTVLAASGAIGLRYSLKAIEHSKRLCLANKESIVCGGKLLLEKAKRYSAEIIPVDSEHSALFQLLRGDVRPE
KIFITASGGALRDYPLDRINEVTLKDVLNHPVWSMGVRITVDSATMVNKGLEIIEAHYLFSYDEKDILTYVCKNSAIHAG
VIYSDGTIKLHIGKPDMRIPIAYSLTYPQRAALKDFTASPLDYSLSLEEIDYRRYPALKLAREIIGIPSKQIAFNAADEI
AVKNFVEGRISFGSIYRIIEKTIERIEPISPKDFEEVQAIDVLARKIAQEEVRKCSR

Sequences:

>Translated_377_residues
MKKIAIVGSTGSIGTQTLEVIRKLDNFRVVAMACGHNFSLFERQLHEFSPEYAAMLEPNRELEVNFPSVKFFYGAEGIEE
MLEIAKPDYTVLAASGAIGLRYSLKAIEHSKRLCLANKESIVCGGKLLLEKAKRYSAEIIPVDSEHSALFQLLRGDVRPE
KIFITASGGALRDYPLDRINEVTLKDVLNHPVWSMGVRITVDSATMVNKGLEIIEAHYLFSYDEKDILTYVCKNSAIHAG
VIYSDGTIKLHIGKPDMRIPIAYSLTYPQRAALKDFTASPLDYSLSLEEIDYRRYPALKLAREIIGIPSKQIAFNAADEI
AVKNFVEGRISFGSIYRIIEKTIERIEPISPKDFEEVQAIDVLARKIAQEEVRKCSR
>Mature_377_residues
MKKIAIVGSTGSIGTQTLEVIRKLDNFRVVAMACGHNFSLFERQLHEFSPEYAAMLEPNRELEVNFPSVKFFYGAEGIEE
MLEIAKPDYTVLAASGAIGLRYSLKAIEHSKRLCLANKESIVCGGKLLLEKAKRYSAEIIPVDSEHSALFQLLRGDVRPE
KIFITASGGALRDYPLDRINEVTLKDVLNHPVWSMGVRITVDSATMVNKGLEIIEAHYLFSYDEKDILTYVCKNSAIHAG
VIYSDGTIKLHIGKPDMRIPIAYSLTYPQRAALKDFTASPLDYSLSLEEIDYRRYPALKLAREIIGIPSKQIAFNAADEI
AVKNFVEGRISFGSIYRIIEKTIERIEPISPKDFEEVQAIDVLARKIAQEEVRKCSR

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=398, Percent_Identity=36.6834170854271, Blast_Score=238, Evalue=4e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42338; Mature: 42338

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIAIVGSTGSIGTQTLEVIRKLDNFRVVAMACGHNFSLFERQLHEFSPEYAAMLEPNR
CCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHCCCCC
ELEVNFPSVKFFYGAEGIEEMLEIAKPDYTVLAASGAIGLRYSLKAIEHSKRLCLANKES
EEEEECCCEEEEECHHHHHHHHHHCCCCEEEEEECCCCEEEEHHHHHHCCCCEEECCCCC
IVCGGKLLLEKAKRYSAEIIPVDSEHSALFQLLRGDVRPEKIFITASGGALRDYPLDRIN
EEECHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHH
EVTLKDVLNHPVWSMGVRITVDSATMVNKGLEIIEAHYLFSYDEKDILTYVCKNSAIHAG
HHHHHHHHCCCHHHCCEEEEECCHHHHHCCHHHEEEEEEEECCCHHHHHHHHCCCCEEEE
VIYSDGTIKLHIGKPDMRIPIAYSLTYPQRAALKDFTASPLDYSLSLEEIDYRRYPALKL
EEEECCEEEEEECCCCCEEEEEEEECCCCHHHHHHCCCCCCCCEEEHHHHCCCCCHHHHH
AREIIGIPSKQIAFNAADEIAVKNFVEGRISFGSIYRIIEKTIERIEPISPKDFEEVQAI
HHHHHCCCCHHEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
DVLARKIAQEEVRKCSR
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKIAIVGSTGSIGTQTLEVIRKLDNFRVVAMACGHNFSLFERQLHEFSPEYAAMLEPNR
CCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHCCCCC
ELEVNFPSVKFFYGAEGIEEMLEIAKPDYTVLAASGAIGLRYSLKAIEHSKRLCLANKES
EEEEECCCEEEEECHHHHHHHHHHCCCCEEEEEECCCCEEEEHHHHHHCCCCEEECCCCC
IVCGGKLLLEKAKRYSAEIIPVDSEHSALFQLLRGDVRPEKIFITASGGALRDYPLDRIN
EEECHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHH
EVTLKDVLNHPVWSMGVRITVDSATMVNKGLEIIEAHYLFSYDEKDILTYVCKNSAIHAG
HHHHHHHHCCCHHHCCEEEEECCHHHHHCCHHHEEEEEEEECCCHHHHHHHHCCCCEEEE
VIYSDGTIKLHIGKPDMRIPIAYSLTYPQRAALKDFTASPLDYSLSLEEIDYRRYPALKL
EEEECCEEEEEECCCCCEEEEEEEECCCCHHHHHHCCCCCCCCEEEHHHHCCCCCHHHHH
AREIIGIPSKQIAFNAADEIAVKNFVEGRISFGSIYRIIEKTIERIEPISPKDFEEVQAI
HHHHHCCCCHHEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
DVLARKIAQEEVRKCSR
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA