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The map label for this gene is hexR [C]

Identifier: 239617208

GI number: 239617208

Start: 866559

End: 867386

Strand: Direct

Name: hexR [C]

Synonym: Kole_0815

Alternate gene names: 239617208

Gene position: 866559-867386 (Clockwise)

Preceding gene: 239617207

Following gene: 239617210

Centisome position: 37.64

GC content: 42.15

Gene sequence:

>828_bases
GTGATAATCGTTCAGCTAAAAGGTATATACGATTCTTTGAGTGAATCAGAAAGGCGTGTTGCTAAGTATATTATTGAGAG
GCCGGACGATGTTATACATTACACTATAACAGAGCTGGCAAAGTTTTCTCATTCCAGTGAAGCTACTGTATACCGATTGG
TTAAAAAGTTAGGGTTTAGTGGATACCAGAGCTTTAAGATATCTCTTGCTAGAGAGTTGAGCATACCCCAGGAAGTAATA
GAAGAAGGTAGCGAAGGTAGTTACCAAAACTTTGTAGAAAGAATCGTTCAGGAAAACATATCACTGGCAAAAGAAACCAT
GGCTGTTCTGGATCTTGATGCGTTGAAAAAAGCTGTGGAACTGATAATTAACGCCAGGAGGTTGGTCTTTTTTGGTGTTG
GTAGATCTGCCGTGGTAGCTCAAAGTGGAAGTTTTAATTTTGCTTTGCTGGGTTTTTCCAGCACTCATTACATCGATCCG
CATGCTCAGGTTATGGTTGCCTCTGGTTTAACGAATGAAGACGTTGTTGTTGGAATCTCACACACAGGAACGATAAGAGA
TACTGTGAAATCTGTGCAGGTAGCCCATGCAGCGGGGGCGAAAACAATCGTCATAACCTCCGGTATAAACTCCCCGATAA
CGGAGGTAGGAGATGTGGTTCTCTACACTGCGGCCGGGAAACCATCAACAAGCGAATTCACTGTCAGCAGGATCGGTGAA
TTTCTGATTCTTGATATCCTTTACAAAACAGTTGTAGCACGCATGAGCGAACGTCTCAGTAAGCATTTCGACAAACTGGA
AGAAATATTGAAACCAAAAAGGTTCTAA

Upstream 100 bases:

>100_bases
TCGATCTAGATTCCCGGAAAGCTGAAACATTAGTAGAAGACCTTGTTCAGGTTTTCCTGAAGAAAAAATCCGAACTGGTT
GATAGGTGGTGATAAACTCC

Downstream 100 bases:

>100_bases
TCTCTCATTTTCTGGGACCGAAAAGGATTGTTCCAAGCCTTATCATATTTGCGCCTTCTTTAATGGCTATTTTATATGAA
TCTGACATACCCATAGATAA

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MIIVQLKGIYDSLSESERRVAKYIIERPDDVIHYTITELAKFSHSSEATVYRLVKKLGFSGYQSFKISLARELSIPQEVI
EEGSEGSYQNFVERIVQENISLAKETMAVLDLDALKKAVELIINARRLVFFGVGRSAVVAQSGSFNFALLGFSSTHYIDP
HAQVMVASGLTNEDVVVGISHTGTIRDTVKSVQVAHAAGAKTIVITSGINSPITEVGDVVLYTAAGKPSTSEFTVSRIGE
FLILDILYKTVVARMSERLSKHFDKLEEILKPKRF

Sequences:

>Translated_275_residues
MIIVQLKGIYDSLSESERRVAKYIIERPDDVIHYTITELAKFSHSSEATVYRLVKKLGFSGYQSFKISLARELSIPQEVI
EEGSEGSYQNFVERIVQENISLAKETMAVLDLDALKKAVELIINARRLVFFGVGRSAVVAQSGSFNFALLGFSSTHYIDP
HAQVMVASGLTNEDVVVGISHTGTIRDTVKSVQVAHAAGAKTIVITSGINSPITEVGDVVLYTAAGKPSTSEFTVSRIGE
FLILDILYKTVVARMSERLSKHFDKLEEILKPKRF
>Mature_275_residues
MIIVQLKGIYDSLSESERRVAKYIIERPDDVIHYTITELAKFSHSSEATVYRLVKKLGFSGYQSFKISLARELSIPQEVI
EEGSEGSYQNFVERIVQENISLAKETMAVLDLDALKKAVELIINARRLVFFGVGRSAVVAQSGSFNFALLGFSSTHYIDP
HAQVMVASGLTNEDVVVGISHTGTIRDTVKSVQVAHAAGAKTIVITSGINSPITEVGDVVLYTAAGKPSTSEFTVSRIGE
FLILDILYKTVVARMSERLSKHFDKLEEILKPKRF

Specific function: Represses The Expression Of The Hex Regulon (Zwf, Eda, Glp And Gap) (By Similarity). [C]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=282, Percent_Identity=28.3687943262411, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI87082130, Length=258, Percent_Identity=23.6434108527132, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87082369, Length=244, Percent_Identity=25.4098360655738, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1788767, Length=245, Percent_Identity=24.8979591836735, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 30345; Mature: 30345

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIVQLKGIYDSLSESERRVAKYIIERPDDVIHYTITELAKFSHSSEATVYRLVKKLGFS
CEEEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
GYQSFKISLARELSIPQEVIEEGSEGSYQNFVERIVQENISLAKETMAVLDLDALKKAVE
CCHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIINARRLVFFGVGRSAVVAQSGSFNFALLGFSSTHYIDPHAQVMVASGLTNEDVVVGIS
HHHCCCCEEEEECCCCEEEEECCCCEEEEEECCCCCEECCCHHEEEECCCCCCCEEEEEC
HTGTIRDTVKSVQVAHAAGAKTIVITSGINSPITEVGDVVLYTAAGKPSTSEFTVSRIGE
CCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCEEEEEECCCCCCCCHHHHHHHH
FLILDILYKTVVARMSERLSKHFDKLEEILKPKRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIIVQLKGIYDSLSESERRVAKYIIERPDDVIHYTITELAKFSHSSEATVYRLVKKLGFS
CEEEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
GYQSFKISLARELSIPQEVIEEGSEGSYQNFVERIVQENISLAKETMAVLDLDALKKAVE
CCHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIINARRLVFFGVGRSAVVAQSGSFNFALLGFSSTHYIDPHAQVMVASGLTNEDVVVGIS
HHHCCCCEEEEECCCCEEEEECCCCEEEEEECCCCCEECCCHHEEEECCCCCCCEEEEEC
HTGTIRDTVKSVQVAHAAGAKTIVITSGINSPITEVGDVVLYTAAGKPSTSEFTVSRIGE
CCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCEEEEEECCCCCCCCHHHHHHHH
FLILDILYKTVVARMSERLSKHFDKLEEILKPKRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8177218; 11792842 [H]