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The map label for this gene is lysC [H]

Identifier: 239616513

GI number: 239616513

Start: 119046

End: 120245

Strand: Reverse

Name: lysC [H]

Synonym: Kole_0103

Alternate gene names: 239616513

Gene position: 120245-119046 (Counterclockwise)

Preceding gene: 239616514

Following gene: 239616512

Centisome position: 5.22

GC content: 44.17

Gene sequence:

>1200_bases
ATGCTGGTTCAGAAATATGGCGGCTCATCGGTAGCAACGTTGGAGCGAATAGCTAATGTGGCAAATAGAATCAAAGCAAG
GGTTGACACCGGAGAGAAAATCATTGTTGTAGTTTCCGCCATGGGGGAAACGACCAACAAGCTTATCTCTGTCGCTAAAA
AGATATCAGATGATCCTGATCCAAGAGAACTGGATATGTTACTGGCCACTGGAGAACAGAAATCCGCTGCCCTTCTATCA
ATGATGTTGTTGAAAATGGGAGTCAAAGCGGTCTCATATAATGCCTTTCAGCTCAATATTCTGACCACCGACAACCATAC
CGATGCCCGCATAATGGACATGAACCTTGAAAAGGTCAAAAAGGAATTGCTGGATAAGGACGTTATAGTGGTAACCGGTT
TCCAGGGTATAACCCCCGAAGGAAACCTAACAACCCTTGGAAGAGGGGGTTCCGATACTTCAGCGGTAGCAATAGCCGCC
AAGCTCGGTACCCGTTGCGAAATATACAGCGATGTCGCGGGGATATACACCACCGATCCCAAATTCTATAGCAAAGCAAA
AAAGCTTGAATATATAACCTACGACGAAATGTTAGAACTGGCTGCTCAGGGCTCACGGGTCCTTCATTCAAGGGCAGTGG
AAATTGCAAAAAAGTACAATGTTGAAGTAGTATGTCTATCCTCATTTTCAGATGAAGGAGGTACTACCATAGTGAATACA
CTTCCAGAATGGCTTGAACAACCGGTGGTCACGGGTGTCGCCATGGATTCGAACCAGATAAAAATAACAATTAACAATAT
TCCCAACAACGTAGACCTTATAAGCGGTATCTTCAATGCTGTAGCAGAAGCCCGAATAAATATTGACATGATCTCCATAG
TAAACGACAATTCCCATACCCACATAACCTTTACAGCGGTAGCCGGTAATCCCGATAGAGTAGAAGAGGTTATAAAAACG
GTTCTGAAGGATGAAAAGGGCTGGAAAATAACTGCCGACACAAATGTTACAAAGGTATCCGCCATAGGTGTCGGAATGAG
GTCTAATTCAGGAGTAGCCTCTCGTTTCTTCTCTGCTTTGCAGCGAGAAGGTATCAGGATAATAGCCACAACTACTTCCG
AGATAAAGATTTCGGTGCTTGTTCCAAAGGAAGAATCGGGAAGAGCTTTGAAGGCTCTGATAGATGAGTTTGAGCTTTGA

Upstream 100 bases:

>100_bases
ATACCGGCGAAGGTAATTAAAGCCTTTGATGCTACTACTGCTGACAAGACAAAGATAGTTCAAGACTTGAGAGAACTATA
AATATAGAGGAGTTGCTGAA

Downstream 100 bases:

>100_bases
GGGTGGTTCGTATGCTGTGCAAGGTATATACACCATATGAATTTAAGGTTGAGAAGGCCCGGGGAATAGAGATATTCACA
GACAAGGGTGTATTTCTCGA

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MLVQKYGGSSVATLERIANVANRIKARVDTGEKIIVVVSAMGETTNKLISVAKKISDDPDPRELDMLLATGEQKSAALLS
MMLLKMGVKAVSYNAFQLNILTTDNHTDARIMDMNLEKVKKELLDKDVIVVTGFQGITPEGNLTTLGRGGSDTSAVAIAA
KLGTRCEIYSDVAGIYTTDPKFYSKAKKLEYITYDEMLELAAQGSRVLHSRAVEIAKKYNVEVVCLSSFSDEGGTTIVNT
LPEWLEQPVVTGVAMDSNQIKITINNIPNNVDLISGIFNAVAEARINIDMISIVNDNSHTHITFTAVAGNPDRVEEVIKT
VLKDEKGWKITADTNVTKVSAIGVGMRSNSGVASRFFSALQREGIRIIATTTSEIKISVLVPKEESGRALKALIDEFEL

Sequences:

>Translated_399_residues
MLVQKYGGSSVATLERIANVANRIKARVDTGEKIIVVVSAMGETTNKLISVAKKISDDPDPRELDMLLATGEQKSAALLS
MMLLKMGVKAVSYNAFQLNILTTDNHTDARIMDMNLEKVKKELLDKDVIVVTGFQGITPEGNLTTLGRGGSDTSAVAIAA
KLGTRCEIYSDVAGIYTTDPKFYSKAKKLEYITYDEMLELAAQGSRVLHSRAVEIAKKYNVEVVCLSSFSDEGGTTIVNT
LPEWLEQPVVTGVAMDSNQIKITINNIPNNVDLISGIFNAVAEARINIDMISIVNDNSHTHITFTAVAGNPDRVEEVIKT
VLKDEKGWKITADTNVTKVSAIGVGMRSNSGVASRFFSALQREGIRIIATTTSEIKISVLVPKEESGRALKALIDEFEL
>Mature_399_residues
MLVQKYGGSSVATLERIANVANRIKARVDTGEKIIVVVSAMGETTNKLISVAKKISDDPDPRELDMLLATGEQKSAALLS
MMLLKMGVKAVSYNAFQLNILTTDNHTDARIMDMNLEKVKKELLDKDVIVVTGFQGITPEGNLTTLGRGGSDTSAVAIAA
KLGTRCEIYSDVAGIYTTDPKFYSKAKKLEYITYDEMLELAAQGSRVLHSRAVEIAKKYNVEVVCLSSFSDEGGTTIVNT
LPEWLEQPVVTGVAMDSNQIKITINNIPNNVDLISGIFNAVAEARINIDMISIVNDNSHTHITFTAVAGNPDRVEEVIKT
VLKDEKGWKITADTNVTKVSAIGVGMRSNSGVASRFFSALQREGIRIIATTTSEIKISVLVPKEESGRALKALIDEFEL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=268, Percent_Identity=29.1044776119403, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790455, Length=274, Percent_Identity=27.7372262773723, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1790376, Length=439, Percent_Identity=25.0569476082005, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320893, Length=380, Percent_Identity=24.4736842105263, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 43302; Mature: 43302

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVQKYGGSSVATLERIANVANRIKARVDTGEKIIVVVSAMGETTNKLISVAKKISDDPD
CEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCC
PRELDMLLATGEQKSAALLSMMLLKMGVKAVSYNAFQLNILTTDNHTDARIMDMNLEKVK
CHHEEEEEECCCCHHHHHHHHHHHHHCCHHEEECEEEEEEEEECCCCCCEEEECCHHHHH
KELLDKDVIVVTGFQGITPEGNLTTLGRGGSDTSAVAIAAKLGTRCEIYSDVAGIYTTDP
HHHCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHEEEEECCCCCEEEHHCCCCEEECCH
KFYSKAKKLEYITYDEMLELAAQGSRVLHSRAVEIAKKYNVEVVCLSSFSDEGGTTIVNT
HHHHHHHHEEEECHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHH
LPEWLEQPVVTGVAMDSNQIKITINNIPNNVDLISGIFNAVAEARINIDMISIVNDNSHT
HHHHHHCCHHEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHEEEEEEEEEEECCCCE
HITFTAVAGNPDRVEEVIKTVLKDEKGWKITADTNVTKVSAIGVGMRSNSGVASRFFSAL
EEEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEEECCCCCCCHHHHHHHHH
QREGIRIIATTTSEIKISVLVPKEESGRALKALIDEFEL
HHCCEEEEEEECCEEEEEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MLVQKYGGSSVATLERIANVANRIKARVDTGEKIIVVVSAMGETTNKLISVAKKISDDPD
CEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCC
PRELDMLLATGEQKSAALLSMMLLKMGVKAVSYNAFQLNILTTDNHTDARIMDMNLEKVK
CHHEEEEEECCCCHHHHHHHHHHHHHCCHHEEECEEEEEEEEECCCCCCEEEECCHHHHH
KELLDKDVIVVTGFQGITPEGNLTTLGRGGSDTSAVAIAAKLGTRCEIYSDVAGIYTTDP
HHHCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHEEEEECCCCCEEEHHCCCCEEECCH
KFYSKAKKLEYITYDEMLELAAQGSRVLHSRAVEIAKKYNVEVVCLSSFSDEGGTTIVNT
HHHHHHHHEEEECHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHH
LPEWLEQPVVTGVAMDSNQIKITINNIPNNVDLISGIFNAVAEARINIDMISIVNDNSHT
HHHHHHCCHHEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHEEEEEEEEEEECCCCE
HITFTAVAGNPDRVEEVIKTVLKDEKGWKITADTNVTKVSAIGVGMRSNSGVASRFFSAL
EEEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCEEEEEEEECCCCCCCHHHHHHHHH
QREGIRIIATTTSEIKISVLVPKEESGRALKALIDEFEL
HHCCEEEEEEECCEEEEEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]