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The map label for this gene is comEA [H]

Identifier: 239616446

GI number: 239616446

Start: 42089

End: 42883

Strand: Reverse

Name: comEA [H]

Synonym: Kole_0035

Alternate gene names: 239616446

Gene position: 42883-42089 (Counterclockwise)

Preceding gene: 239616447

Following gene: 239616445

Centisome position: 1.86

GC content: 42.64

Gene sequence:

>795_bases
ATGAAACGACTTTCTTCAAAAGAAGCGCAATTACTTGGGTCCGTGATTTTCATCGTTGTTATTGGTTTTATAGCTTTATT
GAACATGGGTGAGACCAATGACGTAACCAAAAACAGCGAGGCCCTTTTTGATGTAAAAGAGCGATTTCCAATAGACTTGA
ACACCGCTACTGTAGAAATATTGCAGTTACTTCCGGGAATCGGCGAGACCAGGGCAAAGGCGATTGTTACGTTCAGAGAA
AGCAATGGCGGTTTTTCGTCAACCGAAGAGTTGCTTCAAGTTAAGGGAATAGGTAACTCTACCTACGAAAAGCTAAAGGA
TCTGGTTACCATTACGAACGCTGCAAAAAGTAAGGCGGAAAACACCAGAGATACCAGACTGGATTTAAACACAGCATCGA
AAGTAGATTTGACTTCACTTCCCGGCATAGGGGAAGTCAAGGCAGCAGAGATAGTGAAATACCGGGAAGAGCATGGTGGT
TTTAAGGCCATAGATGAACTTATAAATGTGAAGGGGATAGGAAGAGCCACTCTGGACAAAATAAGAAATCTGGTAAGAGT
TGGGAGCGTTTCAACAAATGTTCCGGATAAAAGCGAGAATTCCGGAAAGATAAATGTCAATACCGCGACTCTTCAGGAGT
TAGTAGCGCTTCCAGGGATAGGACCTGTCCTGGCAGAAAGGATAATTGATTACAGAGAACACAATGGAAAATTCCATAAA
CCGGAAGACCTGCTTAAAGTAAGCGGAATAGGAATCAAGACGTTGAGCAAGTTCAGGGAGATGATCGATTTTTGA

Upstream 100 bases:

>100_bases
ATCTCGAAACCGCGAGAGATTATTCTGAAGCTTTGAATGTTTTCAAGGTTGAGGAAATAACAGGCTGGGATATTTCCGGA
AGGTACTTGAGGAGAATCAA

Downstream 100 bases:

>100_bases
AACTCCTTTTGCATGTGTGCTGTGGCCCTGATTTAGCTGTTACTATGGAACACCTGAAAAGCGATTTCAACGGCAAAATA
ACCGCTTTCTTTTACAATCC

Product: competence protein ComEA helix-hairpin-helix repeat protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKRLSSKEAQLLGSVIFIVVIGFIALLNMGETNDVTKNSEALFDVKERFPIDLNTATVEILQLLPGIGETRAKAIVTFRE
SNGGFSSTEELLQVKGIGNSTYEKLKDLVTITNAAKSKAENTRDTRLDLNTASKVDLTSLPGIGEVKAAEIVKYREEHGG
FKAIDELINVKGIGRATLDKIRNLVRVGSVSTNVPDKSENSGKINVNTATLQELVALPGIGPVLAERIIDYREHNGKFHK
PEDLLKVSGIGIKTLSKFREMIDF

Sequences:

>Translated_264_residues
MKRLSSKEAQLLGSVIFIVVIGFIALLNMGETNDVTKNSEALFDVKERFPIDLNTATVEILQLLPGIGETRAKAIVTFRE
SNGGFSSTEELLQVKGIGNSTYEKLKDLVTITNAAKSKAENTRDTRLDLNTASKVDLTSLPGIGEVKAAEIVKYREEHGG
FKAIDELINVKGIGRATLDKIRNLVRVGSVSTNVPDKSENSGKINVNTATLQELVALPGIGPVLAERIIDYREHNGKFHK
PEDLLKVSGIGIKTLSKFREMIDF
>Mature_264_residues
MKRLSSKEAQLLGSVIFIVVIGFIALLNMGETNDVTKNSEALFDVKERFPIDLNTATVEILQLLPGIGETRAKAIVTFRE
SNGGFSSTEELLQVKGIGNSTYEKLKDLVTITNAAKSKAENTRDTRLDLNTASKVDLTSLPGIGEVKAAEIVKYREEHGG
FKAIDELINVKGIGRATLDKIRNLVRVGSVSTNVPDKSENSGKINVNTATLQELVALPGIGPVLAERIIDYREHNGKFHK
PEDLLKVSGIGIKTLSKFREMIDF

Specific function: Needed for both DNA binding and transport. It is absolutely required for the uptake of transforming DNA but not for binding. Its role in binding may be indirect [H]

COG id: COG1555

COG function: function code L; DNA uptake protein and related DNA-binding proteins

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HhH domains [H]

Homologues:

Organism=Homo sapiens, GI71043966, Length=169, Percent_Identity=33.1360946745562, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004787
- InterPro:   IPR004509
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR019554 [H]

Pfam domain/function: PF00633 HHH; PF10531 SLBB [H]

EC number: NA

Molecular weight: Translated: 28836; Mature: 28836

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLSSKEAQLLGSVIFIVVIGFIALLNMGETNDVTKNSEALFDVKERFPIDLNTATVEI
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHH
LQLLPGIGETRAKAIVTFRESNGGFSSTEELLQVKGIGNSTYEKLKDLVTITNAAKSKAE
HHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
NTRDTRLDLNTASKVDLTSLPGIGEVKAAEIVKYREEHGGFKAIDELINVKGIGRATLDK
CCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHH
IRNLVRVGSVSTNVPDKSENSGKINVNTATLQELVALPGIGPVLAERIIDYREHNGKFHK
HHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
PEDLLKVSGIGIKTLSKFREMIDF
HHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKRLSSKEAQLLGSVIFIVVIGFIALLNMGETNDVTKNSEALFDVKERFPIDLNTATVEI
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHH
LQLLPGIGETRAKAIVTFRESNGGFSSTEELLQVKGIGNSTYEKLKDLVTITNAAKSKAE
HHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
NTRDTRLDLNTASKVDLTSLPGIGEVKAAEIVKYREEHGGFKAIDELINVKGIGRATLDK
CCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHH
IRNLVRVGSVSTNVPDKSENSGKINVNTATLQELVALPGIGPVLAERIIDYREHNGKFHK
HHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
PEDLLKVSGIGIKTLSKFREMIDF
HHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377; 7768800 [H]