Click here to switch to the map view.

The map label for this gene is 239616443

Identifier: 239616443

GI number: 239616443

Start: 40080

End: 40973

Strand: Reverse

Name: 239616443

Synonym: Kole_0032

Alternate gene names: NA

Gene position: 40973-40080 (Counterclockwise)

Preceding gene: 239616444

Following gene: 239616442

Centisome position: 1.78

GC content: 41.61

Gene sequence:

>894_bases
ATGATAAAGTTTTCCCTGAAGCTCGACACAGCTTTCGATCTTGATACCACACTCGATTGTGGTCAGACATTCAGATGGGA
AAAGACTGATGGCTGGTGGAAAGGTGTTGTAAGGGATACTGTGCTTTTTCTCAAACAGTCTGGGAAAAAGCTTGATGTGA
TAGCTTCCAGAGATACATTACTTGGAATGGACATAGATGAAGGATTACGAAAATATCTTGGGTTTGAGGATGATTTAGAA
GAGGTTCATTCTACCCTGGAAATGATCATCCGGAGTCTTCCAGAGCGAACAAAGGAACTCTCTCTAAATGCGGTTAAACA
GGCCAGAGGCTTGAGAATTCTCAGGCAGGATGCCCTTGAGATGACAGTGGAATACATTATCTCAACGAGAAACAGTATTC
CTACAATACGTAAAATATCCGACCTGCTTTCTGCAAAGTTTCCGGAAAATCGAGTTGAAATGGATGATGAGGTGTTCTAC
ACCTTTCCTTCATTGGAACAGCTGAAGCATTTAAAGCTTGAGGATCTCCTTGAAATCAAGCTTGGTTTTAGAGCGGATTG
GTTGTACGAACTCTTCCAGAATCTTGAGGATGAAATGTTTTTTGAAGAGCTTTATGATAAACCCTTGATGGAAAAACTCG
AGGAGCTGATGAAAATAAAGGGGATCGGATACAAGGTTGGAAGTTGTATTACGCTTTTCGCATATGCTGAACTGAACTCG
TTCCCCGTTGATGTATGGATAAAGAGAGTGATGAAGGATCTCTTCGGTGTAAATGGTAGCACAAAAAAGGTAATGGAGTT
TGGCATGGAAACCTTTGCCCCTTACGCAGGTTACTATCAGGAAGCTGTGTTCAGATACTATAGAACGCACAAATTGGGGA
GAGATAAACAGTGA

Upstream 100 bases:

>100_bases
ATATAGGAGGAAATGCCCTCGTTCTCGTGGTTATTGGAGAATTCAGAGAAGACAACGCTTTCAGGCTTTTGAAGGTTGTC
ACAGAGAGGATGCTGACTAA

Downstream 100 bases:

>100_bases
AGGTGAAGATAAATATAGTCGGTGGTGGGCTGGCCGGGTCTGAAGCGGCCCTGAGCCTAGCTGAAAAGGGAATAGAAGTA
ACATTATACGAGATGAGACC

Product: 8-oxoguanine DNA glycosylase domain protein

Products: NA

Alternate protein names: 8-oxoguanine DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase; AP lyase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MIKFSLKLDTAFDLDTTLDCGQTFRWEKTDGWWKGVVRDTVLFLKQSGKKLDVIASRDTLLGMDIDEGLRKYLGFEDDLE
EVHSTLEMIIRSLPERTKELSLNAVKQARGLRILRQDALEMTVEYIISTRNSIPTIRKISDLLSAKFPENRVEMDDEVFY
TFPSLEQLKHLKLEDLLEIKLGFRADWLYELFQNLEDEMFFEELYDKPLMEKLEELMKIKGIGYKVGSCITLFAYAELNS
FPVDVWIKRVMKDLFGVNGSTKKVMEFGMETFAPYAGYYQEAVFRYYRTHKLGRDKQ

Sequences:

>Translated_297_residues
MIKFSLKLDTAFDLDTTLDCGQTFRWEKTDGWWKGVVRDTVLFLKQSGKKLDVIASRDTLLGMDIDEGLRKYLGFEDDLE
EVHSTLEMIIRSLPERTKELSLNAVKQARGLRILRQDALEMTVEYIISTRNSIPTIRKISDLLSAKFPENRVEMDDEVFY
TFPSLEQLKHLKLEDLLEIKLGFRADWLYELFQNLEDEMFFEELYDKPLMEKLEELMKIKGIGYKVGSCITLFAYAELNS
FPVDVWIKRVMKDLFGVNGSTKKVMEFGMETFAPYAGYYQEAVFRYYRTHKLGRDKQ
>Mature_297_residues
MIKFSLKLDTAFDLDTTLDCGQTFRWEKTDGWWKGVVRDTVLFLKQSGKKLDVIASRDTLLGMDIDEGLRKYLGFEDDLE
EVHSTLEMIIRSLPERTKELSLNAVKQARGLRILRQDALEMTVEYIISTRNSIPTIRKISDLLSAKFPENRVEMDDEVFY
TFPSLEQLKHLKLEDLLEIKLGFRADWLYELFQNLEDEMFFEELYDKPLMEKLEELMKIKGIGYKVGSCITLFAYAELNS
FPVDVWIKRVMKDLFGVNGSTKKVMEFGMETFAPYAGYYQEAVFRYYRTHKLGRDKQ

Specific function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-1 OGG1 family [H]

Homologues:

Organism=Homo sapiens, GI4505495, Length=296, Percent_Identity=27.027027027027, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI8670542, Length=294, Percent_Identity=27.2108843537415, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI8670532, Length=298, Percent_Identity=26.8456375838926, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI8670534, Length=307, Percent_Identity=26.7100977198697, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI8670530, Length=292, Percent_Identity=27.0547945205479, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI8670540, Length=292, Percent_Identity=27.0547945205479, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI8670536, Length=226, Percent_Identity=27.4336283185841, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI8670538, Length=164, Percent_Identity=29.8780487804878, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6323580, Length=171, Percent_Identity=25.7309941520468, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640654, Length=295, Percent_Identity=28.135593220339, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR004577
- InterPro:   IPR012904 [H]

Pfam domain/function: PF00730 HhH-GPD; PF07934 OGG_N [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 34828; Mature: 34828

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKFSLKLDTAFDLDTTLDCGQTFRWEKTDGWWKGVVRDTVLFLKQSGKKLDVIASRDTL
CEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCE
LGMDIDEGLRKYLGFEDDLEEVHSTLEMIIRSLPERTKELSLNAVKQARGLRILRQDALE
ECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTVEYIISTRNSIPTIRKISDLLSAKFPENRVEMDDEVFYTFPSLEQLKHLKLEDLLEIK
HHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHCCHHHHHHHH
LGFRADWLYELFQNLEDEMFFEELYDKPLMEKLEELMKIKGIGYKVGSCITLFAYAELNS
HCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCC
FPVDVWIKRVMKDLFGVNGSTKKVMEFGMETFAPYAGYYQEAVFRYYRTHKLGRDKQ
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIKFSLKLDTAFDLDTTLDCGQTFRWEKTDGWWKGVVRDTVLFLKQSGKKLDVIASRDTL
CEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCE
LGMDIDEGLRKYLGFEDDLEEVHSTLEMIIRSLPERTKELSLNAVKQARGLRILRQDALE
ECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTVEYIISTRNSIPTIRKISDLLSAKFPENRVEMDDEVFYTFPSLEQLKHLKLEDLLEIK
HHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCHHHHHHCCHHHHHHHH
LGFRADWLYELFQNLEDEMFFEELYDKPLMEKLEELMKIKGIGYKVGSCITLFAYAELNS
HCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCC
FPVDVWIKRVMKDLFGVNGSTKKVMEFGMETFAPYAGYYQEAVFRYYRTHKLGRDKQ
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]