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The map label for this gene is yclK [H]

Identifier: 238925263

GI number: 238925263

Start: 2797187

End: 2798626

Strand: Direct

Name: yclK [H]

Synonym: EUBREC_2917

Alternate gene names: 238925263

Gene position: 2797187-2798626 (Clockwise)

Preceding gene: 238925262

Following gene: 238925264

Centisome position: 81.09

GC content: 43.68

Gene sequence:

>1440_bases
ATGAAACATACCATCTACACTAAGCTGTTAATCAGCTACCTGATTTACGGTGTCATCGCTTTTTTCATTATATGCACATT
TACACAGCATCTCACCACAGACTATATTGAAAAGCAGGAGGCATCCAATCTCTACAGGGAAGCCTCCATCATTGCAGGTG
ATTACGCCGCCGAATACTTTGACTCATCCATGTCGCTTAGCGATTTCCAGAATCACATGAAAATCGTAGCCGACTATATG
GATGCCAAGGTATGGGTGGTCAGCCCTGACGGTGAGCTGCTCATGGACTCAGATGATCCGTCAATAGGCATTGATATCCA
AAATGACAGTTCTAAGCCTGTAGTGATAAATGGCTTTGATGTCACCGATTTTGGCAGCAACAACTATATGATTGGAGATT
TTTATGGCTCCTTCAAGCATAAGATGCTGTCCGTATTTTCCCCGGTAAATGTCTCGTACCAGAATATCGGCTACATAGTC
ATTCACAAGACAATGAGCCATATCACGGCAGGTGTAAACGGTTTTATGAATATCTCCTTTTACACTGTAGCGCTCATTTT
TGCCTTTGCATTTGTTCTGCTTTTCATGATGAGCCGCTCCATTTACCGTCCTATCTCCAAAATCACAAAGACCGCAAAGA
AGTATGCAAAGGGTGATTTCACTGCCCAGATTGATGTACATTCCAATGACGAAATCGGCTATCTGGCAAACACACTAAAC
TACATGGCAACTGAGCTTGATACGCTTGAGGAGGATCAGCGCAAGTTTGTTTCCAACGTGTCACACGACTTCCGCTCCCC
TCTTACCTCGATAAAGGGCTACGTGGAGGCCATGCTGGACGGAACCATCCCTGTTGAGATGCAGGATAAGTATTTAAATA
TCATACTTTTTGAAACCGAGAGGCTTAATAAGCTCACCAAGAGTCTTATTGATCTGAACCAGTTCGGTCATCACGGCATA
CACCTGGATATTGCTGATTTTGACATCAATACAATGATCCGCACGACAATCCTCACCTTCGAGGGTAAATGCAGTGAAAA
GGGCTTAAGCTTTGACCTGCTGCTCACCGGAAAAGAGCTTTTCGTGCGCGGTGATATGGTCAAAATCCAGCAGATTCTTT
ACAACCTGATAGACAACGCTGTGAAGTTTTCAAATAATGATTCGAGTATCAAGATTGAGACGAGTATCAGAAATGAAAAG
GTGTTTATATCAGTAAAGGATCACGGTATCGGTATACCAAAGGACAGCCTTTCAAAGATCTGGGAGCGCTTCTACAAGAG
TGATTTATCCCGCGGAAAGGATAAGCGCGGTACGGGACTTGGCCTGTCTATAGTTAAAGAAATCGTGCAGGCGCATGGTG
AGAATATAAATGTGATAAGTACTGAGGGTGTGGGAACTGAGTTTATATTTACGCTGCCGCTCAGCAAAAAAGAAGGGTGA

Upstream 100 bases:

>100_bases
TGTGCATGTAAAGCGTCTCCGCGAGAAAATCAAGGACAAGCCAACCTGGCGCATCGCAACTGTCTGGGGCATCGGATACA
AGTTTGAGGTAAAATAAATA

Downstream 100 bases:

>100_bases
GGCGCAGCTCATCAAATGATTGGTGGTGGTGGGCGCCTCGCTTTTTAGGTTGTGAGGTTGCCGGCATAGCACACAGTATA
TTCCTCAGAAAAATGTGAAG

Product: sensory transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MKHTIYTKLLISYLIYGVIAFFIICTFTQHLTTDYIEKQEASNLYREASIIAGDYAAEYFDSSMSLSDFQNHMKIVADYM
DAKVWVVSPDGELLMDSDDPSIGIDIQNDSSKPVVINGFDVTDFGSNNYMIGDFYGSFKHKMLSVFSPVNVSYQNIGYIV
IHKTMSHITAGVNGFMNISFYTVALIFAFAFVLLFMMSRSIYRPISKITKTAKKYAKGDFTAQIDVHSNDEIGYLANTLN
YMATELDTLEEDQRKFVSNVSHDFRSPLTSIKGYVEAMLDGTIPVEMQDKYLNIILFETERLNKLTKSLIDLNQFGHHGI
HLDIADFDINTMIRTTILTFEGKCSEKGLSFDLLLTGKELFVRGDMVKIQQILYNLIDNAVKFSNNDSSIKIETSIRNEK
VFISVKDHGIGIPKDSLSKIWERFYKSDLSRGKDKRGTGLGLSIVKEIVQAHGENINVISTEGVGTEFIFTLPLSKKEG

Sequences:

>Translated_479_residues
MKHTIYTKLLISYLIYGVIAFFIICTFTQHLTTDYIEKQEASNLYREASIIAGDYAAEYFDSSMSLSDFQNHMKIVADYM
DAKVWVVSPDGELLMDSDDPSIGIDIQNDSSKPVVINGFDVTDFGSNNYMIGDFYGSFKHKMLSVFSPVNVSYQNIGYIV
IHKTMSHITAGVNGFMNISFYTVALIFAFAFVLLFMMSRSIYRPISKITKTAKKYAKGDFTAQIDVHSNDEIGYLANTLN
YMATELDTLEEDQRKFVSNVSHDFRSPLTSIKGYVEAMLDGTIPVEMQDKYLNIILFETERLNKLTKSLIDLNQFGHHGI
HLDIADFDINTMIRTTILTFEGKCSEKGLSFDLLLTGKELFVRGDMVKIQQILYNLIDNAVKFSNNDSSIKIETSIRNEK
VFISVKDHGIGIPKDSLSKIWERFYKSDLSRGKDKRGTGLGLSIVKEIVQAHGENINVISTEGVGTEFIFTLPLSKKEG
>Mature_479_residues
MKHTIYTKLLISYLIYGVIAFFIICTFTQHLTTDYIEKQEASNLYREASIIAGDYAAEYFDSSMSLSDFQNHMKIVADYM
DAKVWVVSPDGELLMDSDDPSIGIDIQNDSSKPVVINGFDVTDFGSNNYMIGDFYGSFKHKMLSVFSPVNVSYQNIGYIV
IHKTMSHITAGVNGFMNISFYTVALIFAFAFVLLFMMSRSIYRPISKITKTAKKYAKGDFTAQIDVHSNDEIGYLANTLN
YMATELDTLEEDQRKFVSNVSHDFRSPLTSIKGYVEAMLDGTIPVEMQDKYLNIILFETERLNKLTKSLIDLNQFGHHGI
HLDIADFDINTMIRTTILTFEGKCSEKGLSFDLLLTGKELFVRGDMVKIQQILYNLIDNAVKFSNNDSSIKIETSIRNEK
VFISVKDHGIGIPKDSLSKIWERFYKSDLSRGKDKRGTGLGLSIVKEIVQAHGENINVISTEGVGTEFIFTLPLSKKEG

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=28.0575539568345, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI1786600, Length=280, Percent_Identity=28.2142857142857, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1790861, Length=463, Percent_Identity=22.8941684665227, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1786783, Length=316, Percent_Identity=24.3670886075949, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI48994928, Length=232, Percent_Identity=31.4655172413793, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1789149, Length=365, Percent_Identity=24.3835616438356, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1787894, Length=297, Percent_Identity=23.5690235690236, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87082128, Length=295, Percent_Identity=22.0338983050847, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788549, Length=237, Percent_Identity=27.8481012658228, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788713, Length=295, Percent_Identity=23.3898305084746, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI87081816, Length=350, Percent_Identity=23.4285714285714, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=27.7272727272727, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789808, Length=303, Percent_Identity=25.4125412541254, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1789403, Length=289, Percent_Identity=25.6055363321799, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=22.4066390041494, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790346, Length=289, Percent_Identity=23.5294117647059, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790551, Length=293, Percent_Identity=23.2081911262799, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788279, Length=274, Percent_Identity=25.1824817518248, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=26.890756302521, Blast_Score=79, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54084; Mature: 54084

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHTIYTKLLISYLIYGVIAFFIICTFTQHLTTDYIEKQEASNLYREASIIAGDYAAEYF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
DSSMSLSDFQNHMKIVADYMDAKVWVVSPDGELLMDSDDPSIGIDIQNDSSKPVVINGFD
CCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCEEEEEEECCCCCCEEEECCE
VTDFGSNNYMIGDFYGSFKHKMLSVFSPVNVSYQNIGYIVIHKTMSHITAGVNGFMNISF
EEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHCCCHHEEHHH
YTVALIFAFAFVLLFMMSRSIYRPISKITKTAKKYAKGDFTAQIDVHSNDEIGYLANTLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHH
YMATELDTLEEDQRKFVSNVSHDFRSPLTSIKGYVEAMLDGTIPVEMQDKYLNIILFETE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEEEHH
RLNKLTKSLIDLNQFGHHGIHLDIADFDINTMIRTTILTFEGKCSEKGLSFDLLLTGKEL
HHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHEEEEEEECCCCCCCCCEEEEEEECCHH
FVRGDMVKIQQILYNLIDNAVKFSNNDSSIKIETSIRNEKVFISVKDHGIGIPKDSLSKI
EEECCHHHHHHHHHHHHHHHHEECCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHH
WERFYKSDLSRGKDKRGTGLGLSIVKEIVQAHGENINVISTEGVGTEFIFTLPLSKKEG
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MKHTIYTKLLISYLIYGVIAFFIICTFTQHLTTDYIEKQEASNLYREASIIAGDYAAEYF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
DSSMSLSDFQNHMKIVADYMDAKVWVVSPDGELLMDSDDPSIGIDIQNDSSKPVVINGFD
CCCCCHHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCCEEEEEEECCCCCCEEEECCE
VTDFGSNNYMIGDFYGSFKHKMLSVFSPVNVSYQNIGYIVIHKTMSHITAGVNGFMNISF
EEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHCCCHHEEHHH
YTVALIFAFAFVLLFMMSRSIYRPISKITKTAKKYAKGDFTAQIDVHSNDEIGYLANTLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHH
YMATELDTLEEDQRKFVSNVSHDFRSPLTSIKGYVEAMLDGTIPVEMQDKYLNIILFETE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEEEEEHH
RLNKLTKSLIDLNQFGHHGIHLDIADFDINTMIRTTILTFEGKCSEKGLSFDLLLTGKEL
HHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHEEEEEEECCCCCCCCCEEEEEEECCHH
FVRGDMVKIQQILYNLIDNAVKFSNNDSSIKIETSIRNEKVFISVKDHGIGIPKDSLSKI
EEECCHHHHHHHHHHHHHHHHEECCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHH
WERFYKSDLSRGKDKRGTGLGLSIVKEIVQAHGENINVISTEGVGTEFIFTLPLSKKEG
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]