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The map label for this gene is pyrC [H]

Identifier: 238925256

GI number: 238925256

Start: 2786449

End: 2787732

Strand: Direct

Name: pyrC [H]

Synonym: EUBREC_2910

Alternate gene names: 238925256

Gene position: 2786449-2787732 (Clockwise)

Preceding gene: 238925255

Following gene: 238925261

Centisome position: 80.77

GC content: 47.51

Gene sequence:

>1284_bases
ATGATAATAAAAAACGGCATTATAGCAGACCCTGCTTCAGGTCTCTACGAACATATGGATATACTTGTAAAAGATGGGAA
AATAGTAAAAATATCACCTGACATCTCATGTGCGTCAGACGCTGCTGCAACTGAAAAAGAAGAAATAATAGATGCATCCG
GAATGATTGTCGGACCGGGACTTATCGACACACATGTGCATTTCCGTGATCCGGGCTTCACATACAAGGAGGATATCCAC
ACCGGTTCCCTGGCTGCCGCAAAGGGTGGCTTCACAACTGTTGTATGCATGGCAAACACAAAGCCTACAGTGGACAATGT
GGATACTCTAAAGGACAACCTCACACGTGGAAAGCAGGAAAAAATCCGTATGTATCAGGCCGCTGCAATATCGCACTCCC
TCAAAGGACAGGATGAGGTTGACATGGCAGCTTTAAAGGAAGCCGGAGCATGTGGCTTTACCGATGACGGCATCCCGCTT
ACAAATGCCGCTTTCTGCTACAGAGCCATGCAAAATGCTGCAAAGCTGGATATGCCGATAAGTCTCCATGAGGAGGACCC
TGCATTTATCAAAAACAACGGCATCAACCATGGAAAAATATCTGACGCTCTCGGTATCTACGGCTCACCATCCATCGCTG
AGGAAGCCCTTGTCGCAAGAGACTGTCTGCTTGCGCTGCGCAGTGGTGCTGATGTTGTAATACAGCACATCAGCTCCGGT
GTATCTGTTGATATAGTCCGCACCTACAAAAAGCTTGGTGCAAGGCTCCATGCCGAGGCCACTCCACATCACTTCACGCT
GACTGAGGATGCTGTCTTAGAGCACGGCACCCTTGCCAAGATGAATCCGCCTCTGCGCACTGAAGCAGACCGTCAAAAGA
TTATAGAGGGACTTATCGATGGCACAATAGACCTTATCGCAACAGATCATGCGCCTCACAGCACTGAGGAAAAATCAAAG
CCTGTAACCGAAGCTCCAAGCGGTATCATCGGTCTTGAGACATCTCTTGCTCTTGGTATCACAAGCCTTGTCAAACCGGG
CCATCTGAGCATGCTTGAGCTTTTGGAAAAGATGACTATCAATCCTGCCAGGCTGTACCACATGCCTTACGGTACTATCT
CAGAGGGTGCTGCTGCAGATTTTGTCATCTTTGATCCTGACGAAAAATGGGTACCATGCGAATATGCATCAAAATCATCA
AACACACCTTTCACCGGCATGGAACTGACCGGAAAGGTTAAATACACCGTATGCGGTGGAAATGTGATTTATTCGGATAA
ATAA

Upstream 100 bases:

>100_bases
GGCACTGAACAATTACGAAATTTATTTGCAAATTCGTACGCTTCATTATACTATATACTCATAGTATCAGAAAATAAGTA
CAATCTACAGGAGGATTATC

Downstream 100 bases:

>100_bases
ATTGTGTATGCACTATTAAAAAAGCAGATTGTGAACTCATATGTCCACAATCTGCTTATTTCTACTTCTCCACCAGCTCC
AGGCAGTCTCCATAGTGCCT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MIIKNGIIADPASGLYEHMDILVKDGKIVKISPDISCASDAAATEKEEIIDASGMIVGPGLIDTHVHFRDPGFTYKEDIH
TGSLAAAKGGFTTVVCMANTKPTVDNVDTLKDNLTRGKQEKIRMYQAAAISHSLKGQDEVDMAALKEAGACGFTDDGIPL
TNAAFCYRAMQNAAKLDMPISLHEEDPAFIKNNGINHGKISDALGIYGSPSIAEEALVARDCLLALRSGADVVIQHISSG
VSVDIVRTYKKLGARLHAEATPHHFTLTEDAVLEHGTLAKMNPPLRTEADRQKIIEGLIDGTIDLIATDHAPHSTEEKSK
PVTEAPSGIIGLETSLALGITSLVKPGHLSMLELLEKMTINPARLYHMPYGTISEGAAADFVIFDPDEKWVPCEYASKSS
NTPFTGMELTGKVKYTVCGGNVIYSDK

Sequences:

>Translated_427_residues
MIIKNGIIADPASGLYEHMDILVKDGKIVKISPDISCASDAAATEKEEIIDASGMIVGPGLIDTHVHFRDPGFTYKEDIH
TGSLAAAKGGFTTVVCMANTKPTVDNVDTLKDNLTRGKQEKIRMYQAAAISHSLKGQDEVDMAALKEAGACGFTDDGIPL
TNAAFCYRAMQNAAKLDMPISLHEEDPAFIKNNGINHGKISDALGIYGSPSIAEEALVARDCLLALRSGADVVIQHISSG
VSVDIVRTYKKLGARLHAEATPHHFTLTEDAVLEHGTLAKMNPPLRTEADRQKIIEGLIDGTIDLIATDHAPHSTEEKSK
PVTEAPSGIIGLETSLALGITSLVKPGHLSMLELLEKMTINPARLYHMPYGTISEGAAADFVIFDPDEKWVPCEYASKSS
NTPFTGMELTGKVKYTVCGGNVIYSDK
>Mature_427_residues
MIIKNGIIADPASGLYEHMDILVKDGKIVKISPDISCASDAAATEKEEIIDASGMIVGPGLIDTHVHFRDPGFTYKEDIH
TGSLAAAKGGFTTVVCMANTKPTVDNVDTLKDNLTRGKQEKIRMYQAAAISHSLKGQDEVDMAALKEAGACGFTDDGIPL
TNAAFCYRAMQNAAKLDMPISLHEEDPAFIKNNGINHGKISDALGIYGSPSIAEEALVARDCLLALRSGADVVIQHISSG
VSVDIVRTYKKLGARLHAEATPHHFTLTEDAVLEHGTLAKMNPPLRTEADRQKIIEGLIDGTIDLIATDHAPHSTEEKSK
PVTEAPSGIIGLETSLALGITSLVKPGHLSMLELLEKMTINPARLYHMPYGTISEGAAADFVIFDPDEKWVPCEYASKSS
NTPFTGMELTGKVKYTVCGGNVIYSDK

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=219, Percent_Identity=32.4200913242009, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1786722, Length=444, Percent_Identity=30.1801801801802, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87082175, Length=457, Percent_Identity=27.3522975929978, Blast_Score=111, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI193204318, Length=366, Percent_Identity=28.9617486338798, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI86575075, Length=422, Percent_Identity=24.8815165876777, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6322218, Length=393, Percent_Identity=26.4631043256997, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24642586, Length=375, Percent_Identity=29.3333333333333, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI18859883, Length=420, Percent_Identity=27.1428571428571, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45768; Mature: 45768

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIKNGIIADPASGLYEHMDILVKDGKIVKISPDISCASDAAATEKEEIIDASGMIVGPG
CEECCCCCCCCHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCHHHHHCCCCEEECCC
LIDTHVHFRDPGFTYKEDIHTGSLAAAKGGFTTVVCMANTKPTVDNVDTLKDNLTRGKQE
EEECEEEECCCCCCHHHCCCCCCEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHCCHHH
KIRMYQAAAISHSLKGQDEVDMAALKEAGACGFTDDGIPLTNAAFCYRAMQNAAKLDMPI
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
SLHEEDPAFIKNNGINHGKISDALGIYGSPSIAEEALVARDCLLALRSGADVVIQHISSG
EECCCCCCEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
VSVDIVRTYKKLGARLHAEATPHHFTLTEDAVLEHGTLAKMNPPLRTEADRQKIIEGLID
CEEHHHHHHHHHCCEEECCCCCCEEEECHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHC
GTIDLIATDHAPHSTEEKSKPVTEAPSGIIGLETSLALGITSLVKPGHLSMLELLEKMTI
CCEEEEEECCCCCCCCHHCCCCCCCCCCEEEECHHHHHHHHHHCCCCCHHHHHHHHHHCC
NPARLYHMPYGTISEGAAADFVIFDPDEKWVPCEYASKSSNTPFTGMELTGKVKYTVCGG
CCHHEEECCCCCCCCCCCCEEEEECCCCCEECCCCCCCCCCCCCCCEEEECEEEEEEECC
NVIYSDK
EEEECCC
>Mature Secondary Structure
MIIKNGIIADPASGLYEHMDILVKDGKIVKISPDISCASDAAATEKEEIIDASGMIVGPG
CEECCCCCCCCHHHHHHHHHEEEECCEEEEECCCCCCCCCCCCCCHHHHHCCCCEEECCC
LIDTHVHFRDPGFTYKEDIHTGSLAAAKGGFTTVVCMANTKPTVDNVDTLKDNLTRGKQE
EEECEEEECCCCCCHHHCCCCCCEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHCCHHH
KIRMYQAAAISHSLKGQDEVDMAALKEAGACGFTDDGIPLTNAAFCYRAMQNAAKLDMPI
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
SLHEEDPAFIKNNGINHGKISDALGIYGSPSIAEEALVARDCLLALRSGADVVIQHISSG
EECCCCCCEEECCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
VSVDIVRTYKKLGARLHAEATPHHFTLTEDAVLEHGTLAKMNPPLRTEADRQKIIEGLID
CEEHHHHHHHHHCCEEECCCCCCEEEECHHHHHCCCCEECCCCCCCCCHHHHHHHHHHHC
GTIDLIATDHAPHSTEEKSKPVTEAPSGIIGLETSLALGITSLVKPGHLSMLELLEKMTI
CCEEEEEECCCCCCCCHHCCCCCCCCCCEEEECHHHHHHHHHHCCCCCHHHHHHHHHHCC
NPARLYHMPYGTISEGAAADFVIFDPDEKWVPCEYASKSSNTPFTGMELTGKVKYTVCGG
CCHHEEECCCCCCCCCCCCEEEEECCCCCEECCCCCCCCCCCCCCCEEEECEEEEEEECC
NVIYSDK
EEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA