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The map label for this gene is mutS2

Identifier: 238925261

GI number: 238925261

Start: 2794052

End: 2796430

Strand: Direct

Name: mutS2

Synonym: EUBREC_2915

Alternate gene names: 238925261

Gene position: 2794052-2796430 (Clockwise)

Preceding gene: 238925256

Following gene: 238925262

Centisome position: 80.99

GC content: 47.54

Gene sequence:

>2379_bases
ATGAATAAAAAAGTTTACAAAACATTGGAATATAACAAAATCCTCACCATGCTAAGCAGCTACGCAGCATGTGATGAGAC
AAAGAAGCGGTGTCTTTCGCTTGAGCCTATCACCGATTTATACGAAATCAGACATCTGCAGACCACCACTGCCGATGCAC
TAAGCCGCCTGTACAAGGACAGCGGAGTGTCCTTCGTTGGCATACACAATGTACATGCTTCTCTAAAGAGGCTTGATATC
GGTGGTGCACTGAATACGACCGAGCTTCTTCGCATCTGCAGTCTTTTGGAGGTTGCAAAGCGCGTGAAGGCTTATGGCAG
AAGCGCCATGGACAATGAGAAGCAGGATTCTCTCTCCGGTCTGTTTGCAGGGATTGAACCGGTTTCTGCGCTCTGCGATG
AGATTAAGAGGTGCATTTTATCTGAGGAAGAGATTGCCGATGATGCGAGTCCTGAGCTTTTTAAGATAAGAAAGAGCATA
CGCGGCATGAACGACAGAATCCATGCGCAGCTCACCAAGCTCATGAACAACAGCACAACGAGGACATATCTGCAGGATGC
GGTTGTGACCATGCGTGACGGCAGATATTGTCTGCCTGTAAAGGCTGAGGCAAAGGGCAATGTACCCGGCATGATGCACG
ACCAGTCATCTACCGGCTCTACCCTTTTTATCGAGCCGATGGCTGTCGTCAATTTGAATAATGAGCTCAAGGAGCTTTTC
ATAAAGGAGCAGGAGGAGATTGAAAAAATCCTTGCAGCGCTCAGCGACAAGGTTGCCATGAATGCGGCTGCCTTGGAGCA
GGACTATGAGATTCTTTCAGAGCTTGACTTCATTTTTGCAAAGGCAAATCTGGCTAAATCATATAACGGTGTGGCACCGG
ATTTCAACACCGATGGGCATATCAATATCAGAAAGGGCCGTCATCCGCTTTTGGATGCTAAAAAGGTGGTCCCTATAGAT
GTACGGCTCGGCGAGGACTATAAGCAGCTCATCATCACCGGACCAAATACCGGTGGTAAGACGGTTTCACTAAAGACTGT
CGGACTTTTGACTCTCATGGGTCAGGCAGGTCTTCACATTCCTGCGGCTGACAGGTCAAAGCTCGCCATCTTTGAAGATG
TCTTTGCGGATATAGGCGATGAGCAGAGTATTGAACAAAGTCTCAGTACCTTCTCGTCTCACATGACCAATATCGTAAAA
ATTCTTGAAAAAGCCGATGACAGAAGCCTTTGCCTGTTCGATGAGCTCTGCTCGGGAACCGACCCGACAGAGGGTGCGGC
ACTTGCCATCTCAATTTTAAACAGACTGCACCAGTATGGTGCCATCACCATGGCCACCACACACTACAGTGAGCTGAAGG
TATATGCGCTTTCCACAGACGGTGTGGAAAATGCCTGCTGTGAGTTCAATGTGGAGACTTTAAGCCCTACCTACCGCCTG
TTAATCGGTATTCCTGGAAAGAGTAACGCATTTGCAATCTCATCAAAGCTTGGTCTGGACGAAAACATCATCGAGGATGC
AAAAAGCAGAATTAATGATAACGACCTTGATTTTGAAGATCTGATTGCAAGCCTCGAGTCACAGCGACAAACCATCGAAA
AGGAACAGCTTGAAATCAACAGCTACAAGGCCGAGATTGAAAAGCTCAAGAAACAGCTCGAAGAGAAAAACGAGCGTATA
GACAAGAGCAAAGACAAGATTTTACGCGAGGCAAATGAGGAAGCCTACAAGATACTGCAGGATGCAAAGGAACTTGCCGA
CAAAACCATCCGCAATTTCAACAAATACGGACAGGGACAGGCTCCTATGAGCCAGATGGAAAAGGAGCGCTCTGCCCTTC
GTGACAAGATGAATGACAAGGAAAAGAAGCTGTCAGACATCAAGAAAAACACTGCCAAGGCAAATCACAAGGCGCCTAAG
AAGCTGCGCATCGGTGATTCTGTGCTTGTGCTCTCCCTCAATCTGAAGGGAACTGTCCACACTCTGCCAAACGCCAAGGG
CGATTTGTATGTGCAGATGGGTATACTGCGCTCGCTGGTTAATATTAATGACCTCGTGCTCTTAAACGACGATGTCTCTC
CTGCCAAGAAGTACGGCGGCAGCGGAAGCAAGATAAAGATGAGCAAATCGCTGTCAGTTTCATCCGAAATCAACCTGATA
GGAAAGACTACGGATGAGGCGCTTGCTCTCTTAGATAAATACTTAGACGACGCATATATCGCTCATCTTTCATCAGTGCG
CATTGTCCACGGAAAAGGCACCGGTGCTCTGCGAAAGGCTGTGCATGGACTCCTTAAGAGGACAAAAACTATTGCGGAAT
ACCATCTCGGTGAGTTTGGTGAGGGCGATGCCGGAGTAACCATCGCAACCTTTAAATAA

Upstream 100 bases:

>100_bases
TATTTATTATGGTTTTTTTGAAGATTTTCAGCTATAATATGATAAGCTATACAGTAAATATGAATTTAATATTCAACTAC
CGAAATATAAGGATATAGAA

Downstream 100 bases:

>100_bases
CGACAATTTACTTTTACGGAATATAAATAATTTTTAAGAAGGAGATTAGAAATGGCTGTTAAACAGAAAATACTGATAGT
AGACGACGACAACAATATAG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 792; Mature: 792

Protein sequence:

>792_residues
MNKKVYKTLEYNKILTMLSSYAACDETKKRCLSLEPITDLYEIRHLQTTTADALSRLYKDSGVSFVGIHNVHASLKRLDI
GGALNTTELLRICSLLEVAKRVKAYGRSAMDNEKQDSLSGLFAGIEPVSALCDEIKRCILSEEEIADDASPELFKIRKSI
RGMNDRIHAQLTKLMNNSTTRTYLQDAVVTMRDGRYCLPVKAEAKGNVPGMMHDQSSTGSTLFIEPMAVVNLNNELKELF
IKEQEEIEKILAALSDKVAMNAAALEQDYEILSELDFIFAKANLAKSYNGVAPDFNTDGHINIRKGRHPLLDAKKVVPID
VRLGEDYKQLIITGPNTGGKTVSLKTVGLLTLMGQAGLHIPAADRSKLAIFEDVFADIGDEQSIEQSLSTFSSHMTNIVK
ILEKADDRSLCLFDELCSGTDPTEGAALAISILNRLHQYGAITMATTHYSELKVYALSTDGVENACCEFNVETLSPTYRL
LIGIPGKSNAFAISSKLGLDENIIEDAKSRINDNDLDFEDLIASLESQRQTIEKEQLEINSYKAEIEKLKKQLEEKNERI
DKSKDKILREANEEAYKILQDAKELADKTIRNFNKYGQGQAPMSQMEKERSALRDKMNDKEKKLSDIKKNTAKANHKAPK
KLRIGDSVLVLSLNLKGTVHTLPNAKGDLYVQMGILRSLVNINDLVLLNDDVSPAKKYGGSGSKIKMSKSLSVSSEINLI
GKTTDEALALLDKYLDDAYIAHLSSVRIVHGKGTGALRKAVHGLLKRTKTIAEYHLGEFGEGDAGVTIATFK

Sequences:

>Translated_792_residues
MNKKVYKTLEYNKILTMLSSYAACDETKKRCLSLEPITDLYEIRHLQTTTADALSRLYKDSGVSFVGIHNVHASLKRLDI
GGALNTTELLRICSLLEVAKRVKAYGRSAMDNEKQDSLSGLFAGIEPVSALCDEIKRCILSEEEIADDASPELFKIRKSI
RGMNDRIHAQLTKLMNNSTTRTYLQDAVVTMRDGRYCLPVKAEAKGNVPGMMHDQSSTGSTLFIEPMAVVNLNNELKELF
IKEQEEIEKILAALSDKVAMNAAALEQDYEILSELDFIFAKANLAKSYNGVAPDFNTDGHINIRKGRHPLLDAKKVVPID
VRLGEDYKQLIITGPNTGGKTVSLKTVGLLTLMGQAGLHIPAADRSKLAIFEDVFADIGDEQSIEQSLSTFSSHMTNIVK
ILEKADDRSLCLFDELCSGTDPTEGAALAISILNRLHQYGAITMATTHYSELKVYALSTDGVENACCEFNVETLSPTYRL
LIGIPGKSNAFAISSKLGLDENIIEDAKSRINDNDLDFEDLIASLESQRQTIEKEQLEINSYKAEIEKLKKQLEEKNERI
DKSKDKILREANEEAYKILQDAKELADKTIRNFNKYGQGQAPMSQMEKERSALRDKMNDKEKKLSDIKKNTAKANHKAPK
KLRIGDSVLVLSLNLKGTVHTLPNAKGDLYVQMGILRSLVNINDLVLLNDDVSPAKKYGGSGSKIKMSKSLSVSSEINLI
GKTTDEALALLDKYLDDAYIAHLSSVRIVHGKGTGALRKAVHGLLKRTKTIAEYHLGEFGEGDAGVTIATFK
>Mature_792_residues
MNKKVYKTLEYNKILTMLSSYAACDETKKRCLSLEPITDLYEIRHLQTTTADALSRLYKDSGVSFVGIHNVHASLKRLDI
GGALNTTELLRICSLLEVAKRVKAYGRSAMDNEKQDSLSGLFAGIEPVSALCDEIKRCILSEEEIADDASPELFKIRKSI
RGMNDRIHAQLTKLMNNSTTRTYLQDAVVTMRDGRYCLPVKAEAKGNVPGMMHDQSSTGSTLFIEPMAVVNLNNELKELF
IKEQEEIEKILAALSDKVAMNAAALEQDYEILSELDFIFAKANLAKSYNGVAPDFNTDGHINIRKGRHPLLDAKKVVPID
VRLGEDYKQLIITGPNTGGKTVSLKTVGLLTLMGQAGLHIPAADRSKLAIFEDVFADIGDEQSIEQSLSTFSSHMTNIVK
ILEKADDRSLCLFDELCSGTDPTEGAALAISILNRLHQYGAITMATTHYSELKVYALSTDGVENACCEFNVETLSPTYRL
LIGIPGKSNAFAISSKLGLDENIIEDAKSRINDNDLDFEDLIASLESQRQTIEKEQLEINSYKAEIEKLKKQLEEKNERI
DKSKDKILREANEEAYKILQDAKELADKTIRNFNKYGQGQAPMSQMEKERSALRDKMNDKEKKLSDIKKNTAKANHKAPK
KLRIGDSVLVLSLNLKGTVHTLPNAKGDLYVQMGILRSLVNINDLVLLNDDVSPAKKYGGSGSKIKMSKSLSVSSEINLI
GKTTDEALALLDKYLDDAYIAHLSSVRIVHGKGTGALRKAVHGLLKRTKTIAEYHLGEFGEGDAGVTIATFK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain

Homologues:

Organism=Homo sapiens, GI284813531, Length=316, Percent_Identity=30.0632911392405, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI36949366, Length=323, Percent_Identity=31.2693498452012, Blast_Score=116, Evalue=9e-26,
Organism=Homo sapiens, GI26638666, Length=332, Percent_Identity=28.0120481927711, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI4505253, Length=332, Percent_Identity=28.0120481927711, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI26638664, Length=333, Percent_Identity=27.9279279279279, Blast_Score=100, Evalue=1e-20,
Organism=Homo sapiens, GI262231786, Length=227, Percent_Identity=31.2775330396476, Blast_Score=97, Evalue=8e-20,
Organism=Homo sapiens, GI4504191, Length=305, Percent_Identity=26.8852459016393, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI4557761, Length=208, Percent_Identity=30.2884615384615, Blast_Score=89, Evalue=2e-17,
Organism=Escherichia coli, GI1789089, Length=256, Percent_Identity=28.90625, Blast_Score=111, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17534743, Length=349, Percent_Identity=25.214899713467, Blast_Score=110, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17508445, Length=305, Percent_Identity=23.9344262295082, Blast_Score=99, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17508447, Length=276, Percent_Identity=24.2753623188406, Blast_Score=73, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17539736, Length=247, Percent_Identity=24.6963562753036, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6319935, Length=386, Percent_Identity=27.720207253886, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324482, Length=268, Percent_Identity=27.6119402985075, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321912, Length=248, Percent_Identity=25.8064516129032, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320302, Length=228, Percent_Identity=27.1929824561404, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321109, Length=220, Percent_Identity=28.1818181818182, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320047, Length=202, Percent_Identity=25.2475247524752, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24664545, Length=270, Percent_Identity=29.2592592592593, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24584320, Length=263, Percent_Identity=27.3764258555133, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTS2_EUBR3 (C4ZI07)

Other databases:

- EMBL:   CP001107
- RefSeq:   YP_002938778.1
- GeneID:   7963414
- GenomeReviews:   CP001107_GR
- KEGG:   ere:EUBREC_2915
- ProtClustDB:   CLSK2506010
- HAMAP:   MF_00092
- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625
- PANTHER:   PTHR11361
- PIRSF:   PIRSF005814
- SMART:   SM00534
- SMART:   SM00533
- TIGRFAMs:   TIGR01069

Pfam domain/function: PF00488 MutS_V; PF01713 Smr; SSF48334 DNA_repair_MutS_domIII

EC number: NA

Molecular weight: Translated: 87575; Mature: 87575

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2; PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKVYKTLEYNKILTMLSSYAACDETKKRCLSLEPITDLYEIRHLQTTTADALSRLYKD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SGVSFVGIHNVHASLKRLDIGGALNTTELLRICSLLEVAKRVKAYGRSAMDNEKQDSLSG
CCCEEEEEHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHH
LFAGIEPVSALCDEIKRCILSEEEIADDASPELFKIRKSIRGMNDRIHAQLTKLMNNSTT
HHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCH
RTYLQDAVVTMRDGRYCLPVKAEAKGNVPGMMHDQSSTGSTLFIEPMAVVNLNNELKELF
HHHHHHHHHEECCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEECCEEEEECCHHHHHHH
IKEQEEIEKILAALSDKVAMNAAALEQDYEILSELDFIFAKANLAKSYNGVAPDFNTDGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
INIRKGRHPLLDAKKVVPIDVRLGEDYKQLIITGPNTGGKTVSLKTVGLLTLMGQAGLHI
EEEECCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCEEEEEHHHHHHHHCCCCCCC
PAADRSKLAIFEDVFADIGDEQSIEQSLSTFSSHMTNIVKILEKADDRSLCLFDELCSGT
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCC
DPTEGAALAISILNRLHQYGAITMATTHYSELKVYALSTDGVENACCEFNVETLSPTYRL
CCCCCHHHHHHHHHHHHHHCCEEEEEEECCEEEEEEEECCCCCCHHHCCCCHHCCCCEEE
LIGIPGKSNAFAISSKLGLDENIIEDAKSRINDNDLDFEDLIASLESQRQTIEKEQLEIN
EEECCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SYKAEIEKLKKQLEEKNERIDKSKDKILREANEEAYKILQDAKELADKTIRNFNKYGQGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
APMSQMEKERSALRDKMNDKEKKLSDIKKNTAKANHKAPKKLRIGDSVLVLSLNLKGTVH
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEEEEECCEEEE
TLPNAKGDLYVQMGILRSLVNINDLVLLNDDVSPAKKYGGSGSKIKMSKSLSVSSEINLI
ECCCCCCCEEEHHHHHHHHHCCCCEEEECCCCCHHHHCCCCCCEEEEECCCCCCCCCEEE
GKTTDEALALLDKYLDDAYIAHLSSVRIVHGKGTGALRKAVHGLLKRTKTIAEYHLGEFG
ECCHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
EGDAGVTIATFK
CCCCCEEEEEEC
>Mature Secondary Structure
MNKKVYKTLEYNKILTMLSSYAACDETKKRCLSLEPITDLYEIRHLQTTTADALSRLYKD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SGVSFVGIHNVHASLKRLDIGGALNTTELLRICSLLEVAKRVKAYGRSAMDNEKQDSLSG
CCCEEEEEHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHH
LFAGIEPVSALCDEIKRCILSEEEIADDASPELFKIRKSIRGMNDRIHAQLTKLMNNSTT
HHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCH
RTYLQDAVVTMRDGRYCLPVKAEAKGNVPGMMHDQSSTGSTLFIEPMAVVNLNNELKELF
HHHHHHHHHEECCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEECCEEEEECCHHHHHHH
IKEQEEIEKILAALSDKVAMNAAALEQDYEILSELDFIFAKANLAKSYNGVAPDFNTDGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
INIRKGRHPLLDAKKVVPIDVRLGEDYKQLIITGPNTGGKTVSLKTVGLLTLMGQAGLHI
EEEECCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCEEEEEHHHHHHHHCCCCCCC
PAADRSKLAIFEDVFADIGDEQSIEQSLSTFSSHMTNIVKILEKADDRSLCLFDELCSGT
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCC
DPTEGAALAISILNRLHQYGAITMATTHYSELKVYALSTDGVENACCEFNVETLSPTYRL
CCCCCHHHHHHHHHHHHHHCCEEEEEEECCEEEEEEEECCCCCCHHHCCCCHHCCCCEEE
LIGIPGKSNAFAISSKLGLDENIIEDAKSRINDNDLDFEDLIASLESQRQTIEKEQLEIN
EEECCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SYKAEIEKLKKQLEEKNERIDKSKDKILREANEEAYKILQDAKELADKTIRNFNKYGQGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
APMSQMEKERSALRDKMNDKEKKLSDIKKNTAKANHKAPKKLRIGDSVLVLSLNLKGTVH
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEEEEECCEEEE
TLPNAKGDLYVQMGILRSLVNINDLVLLNDDVSPAKKYGGSGSKIKMSKSLSVSSEINLI
ECCCCCCCEEEHHHHHHHHHCCCCEEEECCCCCHHHHCCCCCCEEEEECCCCCCCCCEEE
GKTTDEALALLDKYLDDAYIAHLSSVRIVHGKGTGALRKAVHGLLKRTKTIAEYHLGEFG
ECCHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
EGDAGVTIATFK
CCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA