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The map label for this gene is hisA [H]

Identifier: 238924893

GI number: 238924893

Start: 2417437

End: 2418222

Strand: Reverse

Name: hisA [H]

Synonym: EUBREC_2544

Alternate gene names: 238924893

Gene position: 2418222-2417437 (Counterclockwise)

Preceding gene: 238924895

Following gene: 238924892

Centisome position: 70.1

GC content: 46.44

Gene sequence:

>786_bases
ATGGAATTTCGACCATGCATCGACATTCACAATGGAAAAGTAAAGCAGATTGTCGGTGGTTCATTAAAAGATAGGGGCGA
TTTTGCCAGTGAGAACTTCGTCTCAGAGCAGGACAGCCGGTTTTATGCAGATATGTATAGGAAATCGGGCATAAAGGGCG
GTCATATCATTCTGCTCAATTCTGTGGACAGCGAGTATTATGAGGATACAAAGGAGCAGGCTGTTATGGCGCTTGAAGCG
TATCCGCAGGGCTTGCAGGTAGGTGGCGGCATCACCGCAGACAATGCGATGGAGTTTATAGATGCCGGTGCAGCAGCAGT
TATTGTGACATCCTACGTATTTAAAGACGGCAGGATAAACTATGCAAATCTAAACAGGCTTAAAGATACTGTGGGCAGTG
ACAGGCTGGTGCTTGATCTGTCATGTCGCAAAAAGGATGGACAGTATTATATAGTGACTGACCGCTGGCAAAACTTCACG
GATGAGGCAGTGACCACAGAGCTTTTGGATAAGCTATCCTCATATTGCTGCGAGTTTCTGGTACATGCAGTGGATGTTGA
GGGCAGGGTGAACGGCATTGAAAAGGAGCTTGTCGCCATGCTTGGCAGCTGGGGAAGGATACCGGTCACATATGCAGGCG
GTGTGTCATCCTTTGACGATTTAAAATGCATCAGGCAGCTTGGGCAGAACCATCTGAATGTGACAATAGGCAGTGCTCTT
GATTTGTTTGGCGGTGAGATGGAGTACGATAAGGTTATAGCTTTTTGCAATAATAAGGAGATTTAA

Upstream 100 bases:

>100_bases
ATTTTATATTAAGTGGCTTTAAGGCAATGTTTGCATGTCACACTAAGGCGTGGACAGTAACGATTTTTGTGCCACAATAA
ACTAAACCAGGGAGAAAAAT

Downstream 100 bases:

>100_bases
AATGGCAAAATACAGTAAGAATGATATTATCCGCATAGTGGATGAGGAGGATATTGAGTTTATCCGTTTACAGTTTACGG
ACATCTTTGGAACATTAAAA

Product: APG10 (albino and pale green 10); 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imid azole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MEFRPCIDIHNGKVKQIVGGSLKDRGDFASENFVSEQDSRFYADMYRKSGIKGGHIILLNSVDSEYYEDTKEQAVMALEA
YPQGLQVGGGITADNAMEFIDAGAAAVIVTSYVFKDGRINYANLNRLKDTVGSDRLVLDLSCRKKDGQYYIVTDRWQNFT
DEAVTTELLDKLSSYCCEFLVHAVDVEGRVNGIEKELVAMLGSWGRIPVTYAGGVSSFDDLKCIRQLGQNHLNVTIGSAL
DLFGGEMEYDKVIAFCNNKEI

Sequences:

>Translated_261_residues
MEFRPCIDIHNGKVKQIVGGSLKDRGDFASENFVSEQDSRFYADMYRKSGIKGGHIILLNSVDSEYYEDTKEQAVMALEA
YPQGLQVGGGITADNAMEFIDAGAAAVIVTSYVFKDGRINYANLNRLKDTVGSDRLVLDLSCRKKDGQYYIVTDRWQNFT
DEAVTTELLDKLSSYCCEFLVHAVDVEGRVNGIEKELVAMLGSWGRIPVTYAGGVSSFDDLKCIRQLGQNHLNVTIGSAL
DLFGGEMEYDKVIAFCNNKEI
>Mature_261_residues
MEFRPCIDIHNGKVKQIVGGSLKDRGDFASENFVSEQDSRFYADMYRKSGIKGGHIILLNSVDSEYYEDTKEQAVMALEA
YPQGLQVGGGITADNAMEFIDAGAAAVIVTSYVFKDGRINYANLNRLKDTVGSDRLVLDLSCRKKDGQYYIVTDRWQNFT
DEAVTTELLDKLSSYCCEFLVHAVDVEGRVNGIEKELVAMLGSWGRIPVTYAGGVSSFDDLKCIRQLGQNHLNVTIGSAL
DLFGGEMEYDKVIAFCNNKEI

Specific function: Unknown

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322169, Length=253, Percent_Identity=41.501976284585, Blast_Score=194, Evalue=8e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 28965; Mature: 28965

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFRPCIDIHNGKVKQIVGGSLKDRGDFASENFVSEQDSRFYADMYRKSGIKGGHIILLN
CCCCCCEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEE
SVDSEYYEDTKEQAVMALEAYPQGLQVGGGITADNAMEFIDAGAAAVIVTSYVFKDGRIN
CCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCC
YANLNRLKDTVGSDRLVLDLSCRKKDGQYYIVTDRWQNFTDEAVTTELLDKLSSYCCEFL
HHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
VHAVDVEGRVNGIEKELVAMLGSWGRIPVTYAGGVSSFDDLKCIRQLGQNHLNVTIGSAL
HHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCHH
DLFGGEMEYDKVIAFCNNKEI
HHCCCCCCHHHEEEECCCCCC
>Mature Secondary Structure
MEFRPCIDIHNGKVKQIVGGSLKDRGDFASENFVSEQDSRFYADMYRKSGIKGGHIILLN
CCCCCCEECCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEE
SVDSEYYEDTKEQAVMALEAYPQGLQVGGGITADNAMEFIDAGAAAVIVTSYVFKDGRIN
CCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCC
YANLNRLKDTVGSDRLVLDLSCRKKDGQYYIVTDRWQNFTDEAVTTELLDKLSSYCCEFL
HHHHHHHHHHCCCCEEEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
VHAVDVEGRVNGIEKELVAMLGSWGRIPVTYAGGVSSFDDLKCIRQLGQNHLNVTIGSAL
HHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEECCHH
DLFGGEMEYDKVIAFCNNKEI
HHCCCCCCHHHEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA