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The map label for this gene is pyrD [H]

Identifier: 238924828

GI number: 238924828

Start: 2348161

End: 2349069

Strand: Reverse

Name: pyrD [H]

Synonym: EUBREC_2479

Alternate gene names: 238924828

Gene position: 2349069-2348161 (Counterclockwise)

Preceding gene: 238924829

Following gene: 238924827

Centisome position: 68.1

GC content: 46.42

Gene sequence:

>909_bases
ATGAGTAATATGTCAGTAAATGTGGCCGGTGTTGAGTGGAAAAATCCTGTTACAGTTGCATCCGGCACATTCGGCTCCGG
TGCAGAGTACAGCGAGTTTGTTGATTTAAACAGACTTGGTGCAGTCACTACAAAGGGTGTTGCGAATAAGCCGTGGGAGG
GGAATCCTACACCGAGAGTAGCAGAGGTGTACGGCGGCATGCTCAATGCAGTCGGACTTCAAAATCCCGGCATCGAGCTT
TTCTGCAAGAGGGATATTCCTTTTTTAAAGCAGTTTGATACAAGGATTGTGGTAAATGTCTGCGGTCATTCGCTTGACGA
GTATCTTGATGTGGTAAAGCGTCTTGCAGATGAGCCTATTGATATGATGGAAATAAATATCTCATGCCCTAATGTTAAGG
AGGGCGGAATTGCCTTCGGAACAGATCCAAAGGGTGTTGAGACAATCACAAGCGAGATTAAAAAATATGCAAAGCAGCCT
GTTATCATGAAGCTTTCTCCAAATGTCACAAGTATTGCAGAGATAGCAAGGGCGGCAGAGGCCGGTGGAGCTGATGCGGT
TTCGCTCATCAATACAATTACAGGCATGAAGATTGATATAAACAGAAGAAGCTTTGTGTTAGCAAACAAGACAGGCGGCA
TGAGCGGTCCGGCGGTTCATCCGGTTGCAGTGCGCATGGTTTATGAGACAGCACATGCAGTCAATATTCCGATTATCGGA
ATGGGCGGTATCACAAATGCTGCCGATGCTATAGAGATGATACTTGCCGGAGCTACGGCTGTTTCAGTCGGCACAGCAAA
CTTTGTAAATCCAAAGACCACAGAGCAGATAGTGGATGGCATCGCAGAGTATATGGACAGGTATGGAGTAAAGGATATTT
CAGAGCTTGTCGGCGCAGTTGACAGATAG

Upstream 100 bases:

>100_bases
GCGTATGCAAAACAAAGGACAAGGATGCCCACAGCAATGTAAACAACAAGCGTATATGCAAAGAGGGACCTGTTTTTGAT
GCGAAGGAGGTGGAGCTGTA

Downstream 100 bases:

>100_bases
AGCATAATGGATAGACGGAGGATAAAATAATGATTCTGGCAGCAGAATACGTGCCTTCTATGTATGCCACAGTCTGGGCA
CTTGTTCCACCTGTTGTGGC

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSNMSVNVAGVEWKNPVTVASGTFGSGAEYSEFVDLNRLGAVTTKGVANKPWEGNPTPRVAEVYGGMLNAVGLQNPGIEL
FCKRDIPFLKQFDTRIVVNVCGHSLDEYLDVVKRLADEPIDMMEINISCPNVKEGGIAFGTDPKGVETITSEIKKYAKQP
VIMKLSPNVTSIAEIARAAEAGGADAVSLINTITGMKIDINRRSFVLANKTGGMSGPAVHPVAVRMVYETAHAVNIPIIG
MGGITNAADAIEMILAGATAVSVGTANFVNPKTTEQIVDGIAEYMDRYGVKDISELVGAVDR

Sequences:

>Translated_302_residues
MSNMSVNVAGVEWKNPVTVASGTFGSGAEYSEFVDLNRLGAVTTKGVANKPWEGNPTPRVAEVYGGMLNAVGLQNPGIEL
FCKRDIPFLKQFDTRIVVNVCGHSLDEYLDVVKRLADEPIDMMEINISCPNVKEGGIAFGTDPKGVETITSEIKKYAKQP
VIMKLSPNVTSIAEIARAAEAGGADAVSLINTITGMKIDINRRSFVLANKTGGMSGPAVHPVAVRMVYETAHAVNIPIIG
MGGITNAADAIEMILAGATAVSVGTANFVNPKTTEQIVDGIAEYMDRYGVKDISELVGAVDR
>Mature_301_residues
SNMSVNVAGVEWKNPVTVASGTFGSGAEYSEFVDLNRLGAVTTKGVANKPWEGNPTPRVAEVYGGMLNAVGLQNPGIELF
CKRDIPFLKQFDTRIVVNVCGHSLDEYLDVVKRLADEPIDMMEINISCPNVKEGGIAFGTDPKGVETITSEIKKYAKQPV
IMKLSPNVTSIAEIARAAEAGGADAVSLINTITGMKIDINRRSFVLANKTGGMSGPAVHPVAVRMVYETAHAVNIPIIGM
GGITNAADAIEMILAGATAVSVGTANFVNPKTTEQIVDGIAEYMDRYGVKDISELVGAVDR

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=289, Percent_Identity=29.757785467128, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI45006951, Length=324, Percent_Identity=24.6913580246914, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI87082059, Length=318, Percent_Identity=25.7861635220126, Blast_Score=105, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71984108, Length=289, Percent_Identity=28.719723183391, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322633, Length=301, Percent_Identity=29.2358803986711, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24640763, Length=287, Percent_Identity=28.9198606271777, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI18858217, Length=287, Percent_Identity=28.9198606271777, Blast_Score=107, Evalue=8e-24,
Organism=Drosophila melanogaster, GI281361352, Length=319, Percent_Identity=26.0188087774295, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17137316, Length=319, Percent_Identity=26.0188087774295, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32017; Mature: 31886

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNMSVNVAGVEWKNPVTVASGTFGSGAEYSEFVDLNRLGAVTTKGVANKPWEGNPTPRV
CCCCEEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHH
AEVYGGMLNAVGLQNPGIELFCKRDIPFLKQFDTRIVVNVCGHSLDEYLDVVKRLADEPI
HHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHCCCC
DMMEINISCPNVKEGGIAFGTDPKGVETITSEIKKYAKQPVIMKLSPNVTSIAEIARAAE
CEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHH
AGGADAVSLINTITGMKIDINRRSFVLANKTGGMSGPAVHPVAVRMVYETAHAVNIPIIG
CCCHHHHHHHHHHCCCEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHEECCCEEE
MGGITNAADAIEMILAGATAVSVGTANFVNPKTTEQIVDGIAEYMDRYGVKDISELVGAV
CCCCCHHHHHHHHHHHCCHHEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHC
DR
CC
>Mature Secondary Structure 
SNMSVNVAGVEWKNPVTVASGTFGSGAEYSEFVDLNRLGAVTTKGVANKPWEGNPTPRV
CCCEEEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHH
AEVYGGMLNAVGLQNPGIELFCKRDIPFLKQFDTRIVVNVCGHSLDEYLDVVKRLADEPI
HHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHCCCC
DMMEINISCPNVKEGGIAFGTDPKGVETITSEIKKYAKQPVIMKLSPNVTSIAEIARAAE
CEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHH
AGGADAVSLINTITGMKIDINRRSFVLANKTGGMSGPAVHPVAVRMVYETAHAVNIPIIG
CCCHHHHHHHHHHCCCEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHEECCCEEE
MGGITNAADAIEMILAGATAVSVGTANFVNPKTTEQIVDGIAEYMDRYGVKDISELVGAV
CCCCCHHHHHHHHHHHCCHHEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHC
DR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA