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The map label for this gene is purE [H]

Identifier: 238924814

GI number: 238924814

Start: 2332851

End: 2333363

Strand: Reverse

Name: purE [H]

Synonym: EUBREC_2465

Alternate gene names: 238924814

Gene position: 2333363-2332851 (Counterclockwise)

Preceding gene: 238924815

Following gene: 238924813

Centisome position: 67.64

GC content: 46.78

Gene sequence:

>513_bases
ATGGCAAAGGTTGGAATAGTTATGGGCAGCGACTCAGATTTAAAGGTGATGAGTAAGGCGGCAGATATGCTTGAAGAGCT
CGGCATAGAGTATGAGCTCACCATCATCTCGGCACACCGTGAGCCGGATGAGCTTATTGAGTGGACAAGAGGCGCTGAGA
ATAGAGATGTAAAGGTAATAATAGCAGGAGCGGGAATGGCAGCAGCACTTCCGGGAATGTGTGCAGCGCTTTTTGCACTT
CCTGTTATCGGAGTACCGCTTTCAGGAAAGAATCTGGATGGAATGGATGCAGTGTTCTCAATCATGCAGATGCCACCTGG
AGTGCCTGTTGCCACAGTTGCAATTGACGGTGCGAAAAATGCAGCAATCCTTGCAGCAAAGATACTCGCAGCAGGTGATG
ATGCAATCCTTGAGAAAATCAAAAACTATACAGCAGATATGAAGGCTCAGGTTGTAGCAAAGGATGCGAAACTGAAACAG
GTTGGATATAAGCAGTATCTTGCTGAGAAATAG

Upstream 100 bases:

>100_bases
GATGGCAGATTTGTGCTTGAGGGCGTAGAAGAGTTGAACAAACCGCTCGATACGCTTGATGCAGAAAGCAAATAATTGTT
AGACGTATAAGGAGGATAAA

Downstream 100 bases:

>100_bases
ATTGTATTGTCATCTATAGGAGGGTTTTTATGGGTATATTGCAAAAGGCAGACAGATGTATGGATGAGGCAGCAGCCTTA
TTTGGCGAGAATAAGCTTTT

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MAKVGIVMGSDSDLKVMSKAADMLEELGIEYELTIISAHREPDELIEWTRGAENRDVKVIIAGAGMAAALPGMCAALFAL
PVIGVPLSGKNLDGMDAVFSIMQMPPGVPVATVAIDGAKNAAILAAKILAAGDDAILEKIKNYTADMKAQVVAKDAKLKQ
VGYKQYLAEK

Sequences:

>Translated_170_residues
MAKVGIVMGSDSDLKVMSKAADMLEELGIEYELTIISAHREPDELIEWTRGAENRDVKVIIAGAGMAAALPGMCAALFAL
PVIGVPLSGKNLDGMDAVFSIMQMPPGVPVATVAIDGAKNAAILAAKILAAGDDAILEKIKNYTADMKAQVVAKDAKLKQ
VGYKQYLAEK
>Mature_169_residues
AKVGIVMGSDSDLKVMSKAADMLEELGIEYELTIISAHREPDELIEWTRGAENRDVKVIIAGAGMAAALPGMCAALFALP
VIGVPLSGKNLDGMDAVFSIMQMPPGVPVATVAIDGAKNAAILAAKILAAGDDAILEKIKNYTADMKAQVVAKDAKLKQV
GYKQYLAEK

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=112, Percent_Identity=49.1071428571429, Blast_Score=112, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324702, Length=167, Percent_Identity=51.497005988024, Blast_Score=172, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17872; Mature: 17741

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVGIVMGSDSDLKVMSKAADMLEELGIEYELTIISAHREPDELIEWTRGAENRDVKVI
CCEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHCCCCCCCEEEE
IAGAGMAAALPGMCAALFALPVIGVPLSGKNLDGMDAVFSIMQMPPGVPVATVAIDGAKN
EECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCC
AAILAAKILAAGDDAILEKIKNYTADMKAQVVAKDAKLKQVGYKQYLAEK
HHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKVGIVMGSDSDLKVMSKAADMLEELGIEYELTIISAHREPDELIEWTRGAENRDVKVI
CEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHCCCCCCCEEEE
IAGAGMAAALPGMCAALFALPVIGVPLSGKNLDGMDAVFSIMQMPPGVPVATVAIDGAKN
EECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCC
AAILAAKILAAGDDAILEKIKNYTADMKAQVVAKDAKLKQVGYKQYLAEK
HHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]