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The map label for this gene is hisB [H]

Identifier: 238924050

GI number: 238924050

Start: 1571122

End: 1571712

Strand: Direct

Name: hisB [H]

Synonym: EUBREC_1688

Alternate gene names: 238924050

Gene position: 1571122-1571712 (Clockwise)

Preceding gene: 238924049

Following gene: 238924051

Centisome position: 45.54

GC content: 43.15

Gene sequence:

>591_bases
ATGGCAGATAGATGCGCTAAGCTTAGTAGAAAAACAAAAGAGACTGATATTTCGGTCGGTTTAAATATAGACGGAACCGG
AAAATCAAATATAGACACGGGCATAGGCTTCTTTAACCATATGCTGGAGGGCTTTTCAAAGCATGGGTTTTTTGACCTCG
ATATGACATGCGACGGTGACTTAAATGTGGACTGTCATCATACTATAGAGGACTGCGGCATAGTGCTTGGCAATGCTATA
GCACAGGCTGTCGGAGACAAAAAGGGCATAAAGAGATTTGGAAGCTTTATTTTACCGATGGATGAGGTGCTGGTGCTTTG
TGCCATTGACTTATCAGGCAGACCGTACCTGCAGTTTGACGGTGAGTTTACCTGCGAGAGAGTCGGAGATATGGATACAG
AGATGGTTAGAGAGTTTTTCTATGCCGTTTCTTACTCTGCTGCGATGAATCTGCATATAAAGGTTTTGACACCGGGAAAT
AATCATCATATGATAGAAGCTATGTTTAAGGCATTTGCCAAGGCGCTTGACGATGCCTGCACCTATGATAGCAGAATAAA
GGACGTGATGTCCACGAAAGGAAGTTTGTAA

Upstream 100 bases:

>100_bases
AATACATACAGATATTGAGCAGTTTGCAGAGTGTGAGAAGCTTACGGCACATGCAAATTCAATCAAGGTTAGATTTGAGG
ATTAGTCAAAGGAGTAAGAA

Downstream 100 bases:

>100_bases
TTTGACTGGTTTTAAGAACATCGTTGCTACACTGTATTTAAAAAACGGCCAGGCCGTGAAATCAGCGTCTGATATGACAG
TTATGGGCGACGTCTACAAT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MADRCAKLSRKTKETDISVGLNIDGTGKSNIDTGIGFFNHMLEGFSKHGFFDLDMTCDGDLNVDCHHTIEDCGIVLGNAI
AQAVGDKKGIKRFGSFILPMDEVLVLCAIDLSGRPYLQFDGEFTCERVGDMDTEMVREFFYAVSYSAAMNLHIKVLTPGN
NHHMIEAMFKAFAKALDDACTYDSRIKDVMSTKGSL

Sequences:

>Translated_196_residues
MADRCAKLSRKTKETDISVGLNIDGTGKSNIDTGIGFFNHMLEGFSKHGFFDLDMTCDGDLNVDCHHTIEDCGIVLGNAI
AQAVGDKKGIKRFGSFILPMDEVLVLCAIDLSGRPYLQFDGEFTCERVGDMDTEMVREFFYAVSYSAAMNLHIKVLTPGN
NHHMIEAMFKAFAKALDDACTYDSRIKDVMSTKGSL
>Mature_195_residues
ADRCAKLSRKTKETDISVGLNIDGTGKSNIDTGIGFFNHMLEGFSKHGFFDLDMTCDGDLNVDCHHTIEDCGIVLGNAIA
QAVGDKKGIKRFGSFILPMDEVLVLCAIDLSGRPYLQFDGEFTCERVGDMDTEMVREFFYAVSYSAAMNLHIKVLTPGNN
HHMIEAMFKAFAKALDDACTYDSRIKDVMSTKGSL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=195, Percent_Identity=48.7179487179487, Blast_Score=190, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6324776, Length=220, Percent_Identity=36.8181818181818, Blast_Score=148, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21613; Mature: 21482

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00954 IGP_DEHYDRATASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
8.7 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADRCAKLSRKTKETDISVGLNIDGTGKSNIDTGIGFFNHMLEGFSKHGFFDLDMTCDGD
CCCHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCC
LNVDCHHTIEDCGIVLGNAIAQAVGDKKGIKRFGSFILPMDEVLVLCAIDLSGRPYLQFD
CCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHEECCCCCCEEEEC
GEFTCERVGDMDTEMVREFFYAVSYSAAMNLHIKVLTPGNNHHMIEAMFKAFAKALDDAC
CCCHHHHHCCCCHHHHHHHHHHHHHHEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
TYDSRIKDVMSTKGSL
CHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ADRCAKLSRKTKETDISVGLNIDGTGKSNIDTGIGFFNHMLEGFSKHGFFDLDMTCDGD
CCHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCC
LNVDCHHTIEDCGIVLGNAIAQAVGDKKGIKRFGSFILPMDEVLVLCAIDLSGRPYLQFD
CCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHEECCCCCCEEEEC
GEFTCERVGDMDTEMVREFFYAVSYSAAMNLHIKVLTPGNNHHMIEAMFKAFAKALDDAC
CCCHHHHHCCCCHHHHHHHHHHHHHHEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
TYDSRIKDVMSTKGSL
CHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA