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The map label for this gene is hisD [H]

Identifier: 238924049

GI number: 238924049

Start: 1569817

End: 1571106

Strand: Direct

Name: hisD [H]

Synonym: EUBREC_1687

Alternate gene names: 238924049

Gene position: 1569817-1571106 (Clockwise)

Preceding gene: 238924048

Following gene: 238924050

Centisome position: 45.51

GC content: 41.63

Gene sequence:

>1290_bases
ATGAGAACTTTAAAACTTACAAAGGATTCACAGAAGAACATATTGGAGAGCCTGCTTAAGAGAAGCCCTAACAACTATAC
AGAGTATGAGAGCACGGTAAATGAGATTATAAACAATGTAAAGGAAAACCGTGATAAGGCTGTTTTTGAATACACAAAGA
AATTTGATAAAGCGGATGTGGATGCATCAAATATCCGTGTCACAGAGGAAGAAATAAAGGAAGCATATGAGCTGGTTGAT
GAGAAGCTTCTTGCCGTTATAAAAAAAGCTCTTGTAAATATCAGAAAATATCATGAGAAGCAGCTGCAGAACTCATGGTT
TACAACAGAGGACGGCATCATTTTAGGACAGAAGGTCACACCTATAGCAAAGGCAGGAGTATATGTGCCGGGCGGCAAGG
CTGTCTATCCTTCATCTGTGCTGATGAACGTGCTTCCTGCAAAGGTAGCAGGCGTTGAAAAGATTGTTATGTGTACACCA
TGTGGAGCTGACGGCAAGGTATATCCTTCCACACTTGTAGCCGCAAACGAGGCCGGAGTAGATGAAATCTACAAGGTAGG
TGGTGCACAGGCTATCGCTGCAATGGCATTTGGTACAGAGAGTGTGCCAAAGGTAGACAAGATTGTTGGACCGGGAAATA
TTTTTGTTGCCCTTGCCAAAAAGGCTGTGTTTGGATATGTCAGCATTGATTCAATCGCAGGACCTAGCGAGATTCTGGTG
CTTGCAGATGAGACTGCAAATCCACGTTATGTGGCAGCGGATTTACTTTCACAGGCCGAGCATGATGAGATGGCATCAGC
TATCTTGATCACAACAAGTGAGGAGCTTGCAAAGAAAGTATCAGAGGAAGTTGATAAGTTTGTTGAGGTCCTCTCAAGAA
AAGAAATCATTGAGAAATCTCTTGAAAACTACGGATATATACTTGTTGCAGAGGATATGGATGAGGCAATTGATGCAGTA
AACGATATCGCTTCAGAGCATATGGAGATTGTCACAAGAGATCCTTTCTCAGTCATGACAAAAATCAAAAATGCAGGAGC
AATTTTTATCGGAGAGTACTCATCAGAGCCTTTGGGAGACTATTTTGCAGGACCAAACCATGTTCTGCCTACAAACGGAA
CAGCAAAATTCTTCTCAGCCTTATCTGTAGATGACTTTATCAAAAAGTCAAGCATCATCTCATATTCAAGAGAAGCACTT
GAGAGAATACATACAGATATTGAGCAGTTTGCAGAGTGTGAGAAGCTTACGGCACATGCAAATTCAATCAAGGTTAGATT
TGAGGATTAG

Upstream 100 bases:

>100_bases
GATGGACAATGAGCGTATCACAAAGCTCATAAGTGATTTGAAGACTGTTATCAAATAGCGTATAATTTATATCAATACAT
GATTTTAGACGGAGGCTGTA

Downstream 100 bases:

>100_bases
TCAAAGGAGTAAGAAATGGCAGATAGATGCGCTAAGCTTAGTAGAAAAACAAAAGAGACTGATATTTCGGTCGGTTTAAA
TATAGACGGAACCGGAAAAT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MRTLKLTKDSQKNILESLLKRSPNNYTEYESTVNEIINNVKENRDKAVFEYTKKFDKADVDASNIRVTEEEIKEAYELVD
EKLLAVIKKALVNIRKYHEKQLQNSWFTTEDGIILGQKVTPIAKAGVYVPGGKAVYPSSVLMNVLPAKVAGVEKIVMCTP
CGADGKVYPSTLVAANEAGVDEIYKVGGAQAIAAMAFGTESVPKVDKIVGPGNIFVALAKKAVFGYVSIDSIAGPSEILV
LADETANPRYVAADLLSQAEHDEMASAILITTSEELAKKVSEEVDKFVEVLSRKEIIEKSLENYGYILVAEDMDEAIDAV
NDIASEHMEIVTRDPFSVMTKIKNAGAIFIGEYSSEPLGDYFAGPNHVLPTNGTAKFFSALSVDDFIKKSSIISYSREAL
ERIHTDIEQFAECEKLTAHANSIKVRFED

Sequences:

>Translated_429_residues
MRTLKLTKDSQKNILESLLKRSPNNYTEYESTVNEIINNVKENRDKAVFEYTKKFDKADVDASNIRVTEEEIKEAYELVD
EKLLAVIKKALVNIRKYHEKQLQNSWFTTEDGIILGQKVTPIAKAGVYVPGGKAVYPSSVLMNVLPAKVAGVEKIVMCTP
CGADGKVYPSTLVAANEAGVDEIYKVGGAQAIAAMAFGTESVPKVDKIVGPGNIFVALAKKAVFGYVSIDSIAGPSEILV
LADETANPRYVAADLLSQAEHDEMASAILITTSEELAKKVSEEVDKFVEVLSRKEIIEKSLENYGYILVAEDMDEAIDAV
NDIASEHMEIVTRDPFSVMTKIKNAGAIFIGEYSSEPLGDYFAGPNHVLPTNGTAKFFSALSVDDFIKKSSIISYSREAL
ERIHTDIEQFAECEKLTAHANSIKVRFED
>Mature_429_residues
MRTLKLTKDSQKNILESLLKRSPNNYTEYESTVNEIINNVKENRDKAVFEYTKKFDKADVDASNIRVTEEEIKEAYELVD
EKLLAVIKKALVNIRKYHEKQLQNSWFTTEDGIILGQKVTPIAKAGVYVPGGKAVYPSSVLMNVLPAKVAGVEKIVMCTP
CGADGKVYPSTLVAANEAGVDEIYKVGGAQAIAAMAFGTESVPKVDKIVGPGNIFVALAKKAVFGYVSIDSIAGPSEILV
LADETANPRYVAADLLSQAEHDEMASAILITTSEELAKKVSEEVDKFVEVLSRKEIIEKSLENYGYILVAEDMDEAIDAV
NDIASEHMEIVTRDPFSVMTKIKNAGAIFIGEYSSEPLGDYFAGPNHVLPTNGTAKFFSALSVDDFIKKSSIISYSREAL
ERIHTDIEQFAECEKLTAHANSIKVRFED

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=399, Percent_Identity=41.8546365914787, Blast_Score=307, Evalue=8e-85,
Organism=Saccharomyces cerevisiae, GI6319819, Length=433, Percent_Identity=37.1824480369515, Blast_Score=262, Evalue=8e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47126; Mature: 47126

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLKLTKDSQKNILESLLKRSPNNYTEYESTVNEIINNVKENRDKAVFEYTKKFDKADV
CCCEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
DASNIRVTEEEIKEAYELVDEKLLAVIKKALVNIRKYHEKQLQNSWFTTEDGIILGQKVT
CCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCC
PIAKAGVYVPGGKAVYPSSVLMNVLPAKVAGVEKIVMCTPCGADGKVYPSTLVAANEAGV
CHHHCCEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHEECCCCCH
DEIYKVGGAQAIAAMAFGTESVPKVDKIVGPGNIFVALAKKAVFGYVSIDSIAGPSEILV
HHHHHHCCHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHEEEECCCCCCCCEEEE
LADETANPRYVAADLLSQAEHDEMASAILITTSEELAKKVSEEVDKFVEVLSRKEIIEKS
EECCCCCCCHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LENYGYILVAEDMDEAIDAVNDIASEHMEIVTRDPFSVMTKIKNAGAIFIGEYSSEPLGD
HHHCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCCCCHH
YFAGPNHVLPTNGTAKFFSALSVDDFIKKSSIISYSREALERIHTDIEQFAECEKLTAHA
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NSIKVRFED
CEEEEEECC
>Mature Secondary Structure
MRTLKLTKDSQKNILESLLKRSPNNYTEYESTVNEIINNVKENRDKAVFEYTKKFDKADV
CCCEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
DASNIRVTEEEIKEAYELVDEKLLAVIKKALVNIRKYHEKQLQNSWFTTEDGIILGQKVT
CCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCC
PIAKAGVYVPGGKAVYPSSVLMNVLPAKVAGVEKIVMCTPCGADGKVYPSTLVAANEAGV
CHHHCCEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHEECCCCCH
DEIYKVGGAQAIAAMAFGTESVPKVDKIVGPGNIFVALAKKAVFGYVSIDSIAGPSEILV
HHHHHHCCHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHHEEEECCCCCCCCEEEE
LADETANPRYVAADLLSQAEHDEMASAILITTSEELAKKVSEEVDKFVEVLSRKEIIEKS
EECCCCCCCHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LENYGYILVAEDMDEAIDAVNDIASEHMEIVTRDPFSVMTKIKNAGAIFIGEYSSEPLGD
HHHCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCCCCHH
YFAGPNHVLPTNGTAKFFSALSVDDFIKKSSIISYSREALERIHTDIEQFAECEKLTAHA
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NSIKVRFED
CEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]