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The map label for this gene is ygfA [C]

Identifier: 238924012

GI number: 238924012

Start: 1536610

End: 1537185

Strand: Direct

Name: ygfA [C]

Synonym: EUBREC_1650

Alternate gene names: 238924012

Gene position: 1536610-1537185 (Clockwise)

Preceding gene: 238924011

Following gene: 238924013

Centisome position: 44.54

GC content: 39.93

Gene sequence:

>576_bases
ATGGAAACAAAAAAAGAAATTCGTAGCAGGCTTAAAAAGCAAAGAGGCCTTCTGGGGGTTGATGAGTGCCACAACATGAG
CCATGAAATTTATAAAAGGCTCATAGCTTTAGAGCTCGACAGGGAATATGACAACATACTTTTGTATTCAGCTATCAGAA
ATGAAGTGAATACTGATGAGTATTTTGCCTATTTAATAAACAAAGCAAAAAGGATATATTATCCGAGGGTTTCGGGCAAT
ACAATGTCCTTTTACAGGGTAAGAAGCCTTGATGAGCTTAATTGTGGTTCATTTAATATTAAAGAGCCTGATATGACGAA
GGAGTATACGCAGGCGGATGGCAGGGCGCTTATGATAGTGCCGGGGCTTGCATTTTCGGATACCGGTTACAGAATCGGCT
ATGGAAAGGGCTTTTATGACAGATATTTATCGTCTTTTACAAAAAGAGACACTGTTATGGCAGTTGGAGTGGGCTACGAT
TTCCAGTTACTTAGCGGCATGACGTTTGAAGATGAATATGACGTACCCTTAGATGGGGTGATAACAGATAAGAGAGAGGT
GTTTATTGATGAATGA

Upstream 100 bases:

>100_bases
AAGGAGTATATAGCAAACGTGAAGAAGAATTTAAGAAACCAGCTCAACAATATCGATATGGTAAACGATGACGGTTCGGT
TGAGAATCTCGGCGAGAAAT

Downstream 100 bases:

>100_bases
TTTAGAAAAAATTTGTGCGGATGCATATGAGGCCAGAGTAAAGATAGGAACACTGGATACTGATATCAAGAATAAGGTAT
TAAACGATGCAGCGGACAAT

Product: putative ligase

Products: NA

Alternate protein names: 5,10-methenyl-tetrahydrofolate synthetase; MTHFS; Methenyl-THF synthetase [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
METKKEIRSRLKKQRGLLGVDECHNMSHEIYKRLIALELDREYDNILLYSAIRNEVNTDEYFAYLINKAKRIYYPRVSGN
TMSFYRVRSLDELNCGSFNIKEPDMTKEYTQADGRALMIVPGLAFSDTGYRIGYGKGFYDRYLSSFTKRDTVMAVGVGYD
FQLLSGMTFEDEYDVPLDGVITDKREVFIDE

Sequences:

>Translated_191_residues
METKKEIRSRLKKQRGLLGVDECHNMSHEIYKRLIALELDREYDNILLYSAIRNEVNTDEYFAYLINKAKRIYYPRVSGN
TMSFYRVRSLDELNCGSFNIKEPDMTKEYTQADGRALMIVPGLAFSDTGYRIGYGKGFYDRYLSSFTKRDTVMAVGVGYD
FQLLSGMTFEDEYDVPLDGVITDKREVFIDE
>Mature_191_residues
METKKEIRSRLKKQRGLLGVDECHNMSHEIYKRLIALELDREYDNILLYSAIRNEVNTDEYFAYLINKAKRIYYPRVSGN
TMSFYRVRSLDELNCGSFNIKEPDMTKEYTQADGRALMIVPGLAFSDTGYRIGYGKGFYDRYLSSFTKRDTVMAVGVGYD
FQLLSGMTFEDEYDVPLDGVITDKREVFIDE

Specific function: Unknown

COG id: COG0212

COG function: function code H; 5-formyltetrahydrofolate cyclo-ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family [H]

Homologues:

Organism=Homo sapiens, GI5453746, Length=168, Percent_Identity=26.1904761904762, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1789278, Length=179, Percent_Identity=25.1396648044693, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17510857, Length=200, Percent_Identity=24.5, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161077430, Length=193, Percent_Identity=26.9430051813472, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002698 [H]

Pfam domain/function: PF01812 5-FTHF_cyc-lig [H]

EC number: =6.3.3.2 [H]

Molecular weight: Translated: 22243; Mature: 22243

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKKEIRSRLKKQRGLLGVDECHNMSHEIYKRLIALELDREYDNILLYSAIRNEVNTDE
CCCHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEHHHHCCCCHHH
YFAYLINKAKRIYYPRVSGNTMSFYRVRSLDELNCGSFNIKEPDMTKEYTQADGRALMIV
HHHHHHHHHHHEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEE
PGLAFSDTGYRIGYGKGFYDRYLSSFTKRDTVMAVGVGYDFQLLSGMTFEDEYDVPLDGV
CCCEECCCCEEEECCCCHHHHHHHHHHCCCEEEEEECCCCHHHHCCCCCCCCCCCCCCCE
ITDKREVFIDE
EECCCEEEECC
>Mature Secondary Structure
METKKEIRSRLKKQRGLLGVDECHNMSHEIYKRLIALELDREYDNILLYSAIRNEVNTDE
CCCHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEHHHHCCCCHHH
YFAYLINKAKRIYYPRVSGNTMSFYRVRSLDELNCGSFNIKEPDMTKEYTQADGRALMIV
HHHHHHHHHHHEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEE
PGLAFSDTGYRIGYGKGFYDRYLSSFTKRDTVMAVGVGYDFQLLSGMTFEDEYDVPLDGV
CCCEECCCCEEEECCCCHHHHHHHHHHCCCEEEEEECCCCHHHHCCCCCCCCCCCCCCCE
ITDKREVFIDE
EECCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]