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The map label for this gene is proA

Identifier: 238924013

GI number: 238924013

Start: 1537178

End: 1538434

Strand: Direct

Name: proA

Synonym: EUBREC_1651

Alternate gene names: 238924013

Gene position: 1537178-1538434 (Clockwise)

Preceding gene: 238924012

Following gene: 238924014

Centisome position: 44.56

GC content: 43.12

Gene sequence:

>1257_bases
ATGAATGATTTAGAAAAAATTTGTGCGGATGCATATGAGGCCAGAGTAAAGATAGGAACACTGGATACTGATATCAAGAA
TAAGGTATTAAACGATGCAGCGGACAATCTTCTTAAGGCAGAAAAAGAAATCCTTGAGGCAAACAAAAGGGATGTGGCCA
CAGCAGAGGAAAATATGAAGGCAAAGAGCATGATTGACAGGCTCTCGCTTGACCATGACAGGCTCCTTGGCATGGCTGAC
GGACTCAGACAGATAGCAAAGCTTGCAGACCCTATTGGGGAAGTGATGTCTATGGCAAAGCGTCCTAATGGCCTTATTAT
CGGAAAAAGAAGAGTTGCAATCGGTGTTGTTGGCATTATCTTTGAGGCGCGCCCAAATGTCACATCAGATGCCTTTGGTC
TGTGCTTTAAGACAGGCAACTGTGTCATATTGAAGGGTGGAAGTGATGCGATAAATACCAATATCGCAATAGTTAAGGCA
CTAAAAAAGGCTTTAACGGACAATTTGGTTTCTGATGCTGCACTTGCACTTATTGAGTCAACAGACAGAGAGACAACAAA
TGCGTTTATGAAGATGGATCAGTATGTGGATGTGCTCATACCAAGAGGTGGTGCAGGACTCATCCAGAATGTTGTCAAAA
ATGCTACAATTCCTGTCATCCAGACCGGTACAGGCAACTGCCATGTATATGTGGACAAGGATGCAGACTTTGATATGGCT
GTTAATATTATTAACAATGCAAAGACACAAAGAATCAGTGTCTGCAATGCATGTGAGTCGATTGTAGTACACAGTGCCAT
AGCGGAGGAGTTTCTGCCAAAGCTGTACGATAAGCTAAGAGAGCATCATGTACAGCTGCACTGTGATGAAAGAGCGCAGG
CAATTCTTGCCGGAAGAGATGATGTGACAGAGGCCACTGCCGATGACTGGGGTATGGAGTACCTTGATTACATTATGTCT
GTAAAGATTGTTGACAGTATTGATGAGGCAATCGAGCATATCAACAGATACAACACATCACATTCTGAGGCAATCGTCAC
AAATGATTATGACAACGCACAGAAGTTCTTAAATGAGATAGATGCTGCATGCGTTTATGTAAATGCCTCAACCAGATTTT
CTGATGGAAATGAATTCGGCTTTGGAGCTGAGATAGGAATCAGCACACAGAAGCTTCACGCAAGGGGACCTATGGGGCTT
GAAGCACTGACTAGCTACAAATATATTATTTACGGCAGTGGTCAGATCAGGGAATAG

Upstream 100 bases:

>100_bases
GTGGGCTACGATTTCCAGTTACTTAGCGGCATGACGTTTGAAGATGAATATGACGTACCCTTAGATGGGGTGATAACAGA
TAAGAGAGAGGTGTTTATTG

Downstream 100 bases:

>100_bases
TCAGGTAAAGTATCATAGAATTAATTTGAGAGGAAATATAATATAACATGAGCTACGATATAGATATAACAAAGACACCA
CCGGCACATGAGCCTGAGAG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MNDLEKICADAYEARVKIGTLDTDIKNKVLNDAADNLLKAEKEILEANKRDVATAEENMKAKSMIDRLSLDHDRLLGMAD
GLRQIAKLADPIGEVMSMAKRPNGLIIGKRRVAIGVVGIIFEARPNVTSDAFGLCFKTGNCVILKGGSDAINTNIAIVKA
LKKALTDNLVSDAALALIESTDRETTNAFMKMDQYVDVLIPRGGAGLIQNVVKNATIPVIQTGTGNCHVYVDKDADFDMA
VNIINNAKTQRISVCNACESIVVHSAIAEEFLPKLYDKLREHHVQLHCDERAQAILAGRDDVTEATADDWGMEYLDYIMS
VKIVDSIDEAIEHINRYNTSHSEAIVTNDYDNAQKFLNEIDAACVYVNASTRFSDGNEFGFGAEIGISTQKLHARGPMGL
EALTSYKYIIYGSGQIRE

Sequences:

>Translated_418_residues
MNDLEKICADAYEARVKIGTLDTDIKNKVLNDAADNLLKAEKEILEANKRDVATAEENMKAKSMIDRLSLDHDRLLGMAD
GLRQIAKLADPIGEVMSMAKRPNGLIIGKRRVAIGVVGIIFEARPNVTSDAFGLCFKTGNCVILKGGSDAINTNIAIVKA
LKKALTDNLVSDAALALIESTDRETTNAFMKMDQYVDVLIPRGGAGLIQNVVKNATIPVIQTGTGNCHVYVDKDADFDMA
VNIINNAKTQRISVCNACESIVVHSAIAEEFLPKLYDKLREHHVQLHCDERAQAILAGRDDVTEATADDWGMEYLDYIMS
VKIVDSIDEAIEHINRYNTSHSEAIVTNDYDNAQKFLNEIDAACVYVNASTRFSDGNEFGFGAEIGISTQKLHARGPMGL
EALTSYKYIIYGSGQIRE
>Mature_418_residues
MNDLEKICADAYEARVKIGTLDTDIKNKVLNDAADNLLKAEKEILEANKRDVATAEENMKAKSMIDRLSLDHDRLLGMAD
GLRQIAKLADPIGEVMSMAKRPNGLIIGKRRVAIGVVGIIFEARPNVTSDAFGLCFKTGNCVILKGGSDAINTNIAIVKA
LKKALTDNLVSDAALALIESTDRETTNAFMKMDQYVDVLIPRGGAGLIQNVVKNATIPVIQTGTGNCHVYVDKDADFDMA
VNIINNAKTQRISVCNACESIVVHSAIAEEFLPKLYDKLREHHVQLHCDERAQAILAGRDDVTEATADDWGMEYLDYIMS
VKIVDSIDEAIEHINRYNTSHSEAIVTNDYDNAQKFLNEIDAACVYVNASTRFSDGNEFGFGAEIGISTQKLHARGPMGL
EALTSYKYIIYGSGQIRE

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=402, Percent_Identity=34.8258706467662, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI21361368, Length=402, Percent_Identity=34.8258706467662, Blast_Score=257, Evalue=1e-68,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=46.7469879518072, Blast_Score=376, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17569969, Length=419, Percent_Identity=32.9355608591885, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17569967, Length=419, Percent_Identity=32.9355608591885, Blast_Score=246, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6324899, Length=434, Percent_Identity=34.331797235023, Blast_Score=248, Evalue=1e-66,
Organism=Drosophila melanogaster, GI21357643, Length=412, Percent_Identity=33.7378640776699, Blast_Score=248, Evalue=7e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_EUBR3 (C4Z9V4)

Other databases:

- EMBL:   CP001107
- RefSeq:   YP_002937529.1
- ProteinModelPortal:   C4Z9V4
- GeneID:   7964727
- GenomeReviews:   CP001107_GR
- KEGG:   ere:EUBREC_1651
- ProtClustDB:   PRK00197
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45807; Mature: 45807

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLEKICADAYEARVKIGTLDTDIKNKVLNDAADNLLKAEKEILEANKRDVATAEENMK
CCHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AKSMIDRLSLDHDRLLGMADGLRQIAKLADPIGEVMSMAKRPNGLIIGKRRVAIGVVGII
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHEEEEEEE
FEARPNVTSDAFGLCFKTGNCVILKGGSDAINTNIAIVKALKKALTDNLVSDAALALIES
EECCCCCCCCHHHHEEECCCEEEEECCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHC
TDRETTNAFMKMDQYVDVLIPRGGAGLIQNVVKNATIPVIQTGTGNCHVYVDKDADFDMA
CCCHHHHHHHHHHHHHHEEECCCCHHHHHHHHCCCCCCEEEECCCCEEEEEECCCCCHHH
VNIINNAKTQRISVCNACESIVVHSAIAEEFLPKLYDKLREHHVQLHCDERAQAILAGRD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHEECCCCC
DVTEATADDWGMEYLDYIMSVKIVDSIDEAIEHINRYNTSHSEAIVTNDYDNAQKFLNEI
CHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHH
DAACVYVNASTRFSDGNEFGFGAEIGISTQKLHARGPMGLEALTSYKYIIYGSGQIRE
CCEEEEEECCCCCCCCCCCCCCCEECCCHHHHHCCCCCCHHHHHCEEEEEEECCCCCC
>Mature Secondary Structure
MNDLEKICADAYEARVKIGTLDTDIKNKVLNDAADNLLKAEKEILEANKRDVATAEENMK
CCHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
AKSMIDRLSLDHDRLLGMADGLRQIAKLADPIGEVMSMAKRPNGLIIGKRRVAIGVVGII
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHEEEEEEE
FEARPNVTSDAFGLCFKTGNCVILKGGSDAINTNIAIVKALKKALTDNLVSDAALALIES
EECCCCCCCCHHHHEEECCCEEEEECCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHC
TDRETTNAFMKMDQYVDVLIPRGGAGLIQNVVKNATIPVIQTGTGNCHVYVDKDADFDMA
CCCHHHHHHHHHHHHHHEEECCCCHHHHHHHHCCCCCCEEEECCCCEEEEEECCCCCHHH
VNIINNAKTQRISVCNACESIVVHSAIAEEFLPKLYDKLREHHVQLHCDERAQAILAGRD
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHEECCCCC
DVTEATADDWGMEYLDYIMSVKIVDSIDEAIEHINRYNTSHSEAIVTNDYDNAQKFLNEI
CHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHH
DAACVYVNASTRFSDGNEFGFGAEIGISTQKLHARGPMGLEALTSYKYIIYGSGQIRE
CCEEEEEECCCCCCCCCCCCCCCEECCCHHHHHCCCCCCHHHHHCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA