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The map label for this gene is hemN [H]

Identifier: 238923984

GI number: 238923984

Start: 1512430

End: 1513623

Strand: Direct

Name: hemN [H]

Synonym: EUBREC_1622

Alternate gene names: 238923984

Gene position: 1512430-1513623 (Clockwise)

Preceding gene: 238923983

Following gene: 238923985

Centisome position: 43.84

GC content: 43.22

Gene sequence:

>1194_bases
ATGAAGAATCTTGAGATTTATATTCATATACCATTTTGTGTGAGAAAATGTGAATATTGTGATTTTTTATCATTTCCCGC
AGACGATGATGCAAAGCTTCGCTATGTCAAGGGGCTTATGGCGGAAATGATATTTTACGGCCCGCTTATGAAGAACTATC
AGGTGTCATCTGTCTATATCGGAGGAGGTACACCAAGCTCTATAGATGAGCAGTGGATTGCTGCTTTGATGGAGGGTGTG
TTTGACTGCTTTAATGTGCTGCCTGATGCTGAGATATCCATAGAGTGCAATCCCGGTACGCTTAGCAGAGAAAAGCTTTT
AGCATACAGGGATGCGGGAATCAACCGCCTGTCCATAGGACTGCAGTCGGCAAATAATGATGAGCTTAAGCTGCTCGGGC
GTATACATACCTTTGAACAGTTTGTGACGAATTACGAGGTGGCCAGAAACGTGGGCTTTAAAAATATCAATGTAGATTTG
ATGTATGGTCTGCCGGGACAGTCAGCGTCACAGTATATGGCGACAGTAAACAAGATTATAAGGCTTCATCCGGATCATAT
ATCGGCGTATTCTCTTATAGTGGAAAAGGGTACTCCTTTCTATGAAAAGTACAAGTTTGACATGGTGCGCCAGGAGGCGG
GCATGAGAACAGAGTTTCTGCCTAATGAGGACGAGTTATATGATATGGAAAAGGCGGGACAGAAGGCGTTTATGGATGCC
GGCTACAGGCAGTATGAGACATCTAACTATGCTAAAAGAGGTATGGAGTGCCGCCATAATATAGGCTACTGGACCAGAGC
TGACTATTTAGGACTTGGAATAGGGGCGGCATCGCTTATATCAAATGTCAGATATACCAATACATCAGATATGGATGAAT
ATCTGTCGCGATGCCGTCATATACATGATGTGGGTGATGATATATTTAAGGCCAATCTGCATGTGTCAGCTGATGTTATA
GACAAAAAGGGACAGATGGAGGAGTTTATGTTTCTTGGACTTCGTATGAATGAGGGGGTCACAAGAGAAGCCTTTGAGAG
GGCATTTGGTATTTCGATAGATGCAATCTACAAGGATACGATAGACAGCCTGAAAAAACAGGAGCTGCTCGTGGTAAAGG
CCGGGCATATCTATTTATCGGAGAGAGGAAAAGATGTAGCCAATTACGTTATGGCACAGTTTTTGAAGGATTAA

Upstream 100 bases:

>100_bases
AGAAGGAAGGAAAGAAGAGGATGCGTCAGGTGGGCAATGTAGAGATACCACAGGAGGCATTCATGAGTGTGCTTAAGCTG
GATGAGGAGTAATCGCACAT

Downstream 100 bases:

>100_bases
CGGAGAGTAAATTATGGATATGACTTTTAAGCTTCAGGTGTTTGAGGGACCGCTTGACCTGCTTTTATACCTGATAGAGA
AAAATAAAGTAAATATTTAT

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MKNLEIYIHIPFCVRKCEYCDFLSFPADDDAKLRYVKGLMAEMIFYGPLMKNYQVSSVYIGGGTPSSIDEQWIAALMEGV
FDCFNVLPDAEISIECNPGTLSREKLLAYRDAGINRLSIGLQSANNDELKLLGRIHTFEQFVTNYEVARNVGFKNINVDL
MYGLPGQSASQYMATVNKIIRLHPDHISAYSLIVEKGTPFYEKYKFDMVRQEAGMRTEFLPNEDELYDMEKAGQKAFMDA
GYRQYETSNYAKRGMECRHNIGYWTRADYLGLGIGAASLISNVRYTNTSDMDEYLSRCRHIHDVGDDIFKANLHVSADVI
DKKGQMEEFMFLGLRMNEGVTREAFERAFGISIDAIYKDTIDSLKKQELLVVKAGHIYLSERGKDVANYVMAQFLKD

Sequences:

>Translated_397_residues
MKNLEIYIHIPFCVRKCEYCDFLSFPADDDAKLRYVKGLMAEMIFYGPLMKNYQVSSVYIGGGTPSSIDEQWIAALMEGV
FDCFNVLPDAEISIECNPGTLSREKLLAYRDAGINRLSIGLQSANNDELKLLGRIHTFEQFVTNYEVARNVGFKNINVDL
MYGLPGQSASQYMATVNKIIRLHPDHISAYSLIVEKGTPFYEKYKFDMVRQEAGMRTEFLPNEDELYDMEKAGQKAFMDA
GYRQYETSNYAKRGMECRHNIGYWTRADYLGLGIGAASLISNVRYTNTSDMDEYLSRCRHIHDVGDDIFKANLHVSADVI
DKKGQMEEFMFLGLRMNEGVTREAFERAFGISIDAIYKDTIDSLKKQELLVVKAGHIYLSERGKDVANYVMAQFLKD
>Mature_397_residues
MKNLEIYIHIPFCVRKCEYCDFLSFPADDDAKLRYVKGLMAEMIFYGPLMKNYQVSSVYIGGGTPSSIDEQWIAALMEGV
FDCFNVLPDAEISIECNPGTLSREKLLAYRDAGINRLSIGLQSANNDELKLLGRIHTFEQFVTNYEVARNVGFKNINVDL
MYGLPGQSASQYMATVNKIIRLHPDHISAYSLIVEKGTPFYEKYKFDMVRQEAGMRTEFLPNEDELYDMEKAGQKAFMDA
GYRQYETSNYAKRGMECRHNIGYWTRADYLGLGIGAASLISNVRYTNTSDMDEYLSRCRHIHDVGDDIFKANLHVSADVI
DKKGQMEEFMFLGLRMNEGVTREAFERAFGISIDAIYKDTIDSLKKQELLVVKAGHIYLSERGKDVANYVMAQFLKD

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=275, Percent_Identity=32.3636363636364, Blast_Score=169, Evalue=6e-42,
Organism=Escherichia coli, GI1789325, Length=405, Percent_Identity=33.0864197530864, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI87082341, Length=306, Percent_Identity=28.4313725490196, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 45304; Mature: 45304

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLEIYIHIPFCVRKCEYCDFLSFPADDDAKLRYVKGLMAEMIFYGPLMKNYQVSSVYI
CCCEEEEEECHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEE
GGGTPSSIDEQWIAALMEGVFDCFNVLPDAEISIECNPGTLSREKLLAYRDAGINRLSIG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEE
LQSANNDELKLLGRIHTFEQFVTNYEVARNVGFKNINVDLMYGLPGQSASQYMATVNKII
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCEEEEECCCCCCHHHHHHHHHHHH
RLHPDHISAYSLIVEKGTPFYEKYKFDMVRQEAGMRTEFLPNEDELYDMEKAGQKAFMDA
HCCCCHHCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHC
GYRQYETSNYAKRGMECRHNIGYWTRADYLGLGIGAASLISNVRYTNTSDMDEYLSRCRH
CCHHHCCHHHHHHCCHHHHCCCCEECCCHHCCCCCHHHHHCCCCCCCCCCHHHHHHHHHH
IHDVGDDIFKANLHVSADVIDKKGQMEEFMFLGLRMNEGVTREAFERAFGISIDAIYKDT
HHHCCHHHEEECCEEEHHHHCCCCCHHHHHHEEEECCCCCCHHHHHHHHCCCHHHHHHHH
IDSLKKQELLVVKAGHIYLSERGKDVANYVMAQFLKD
HHHHHHCEEEEEEECEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKNLEIYIHIPFCVRKCEYCDFLSFPADDDAKLRYVKGLMAEMIFYGPLMKNYQVSSVYI
CCCEEEEEECHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEE
GGGTPSSIDEQWIAALMEGVFDCFNVLPDAEISIECNPGTLSREKLLAYRDAGINRLSIG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEE
LQSANNDELKLLGRIHTFEQFVTNYEVARNVGFKNINVDLMYGLPGQSASQYMATVNKII
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEECCEEEEECCCCCCHHHHHHHHHHHH
RLHPDHISAYSLIVEKGTPFYEKYKFDMVRQEAGMRTEFLPNEDELYDMEKAGQKAFMDA
HCCCCHHCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHC
GYRQYETSNYAKRGMECRHNIGYWTRADYLGLGIGAASLISNVRYTNTSDMDEYLSRCRH
CCHHHCCHHHHHHCCHHHHCCCCEECCCHHCCCCCHHHHHCCCCCCCCCCHHHHHHHHHH
IHDVGDDIFKANLHVSADVIDKKGQMEEFMFLGLRMNEGVTREAFERAFGISIDAIYKDT
HHHCCHHHEEECCEEEHHHHCCCCCHHHHHHEEEECCCCCCHHHHHHHHCCCHHHHHHHH
IDSLKKQELLVVKAGHIYLSERGKDVANYVMAQFLKD
HHHHHHCEEEEEEECEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]