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The map label for this gene is hemK [H]

Identifier: 238923859

GI number: 238923859

Start: 1367907

End: 1368758

Strand: Direct

Name: hemK [H]

Synonym: EUBREC_1487

Alternate gene names: 238923859

Gene position: 1367907-1368758 (Clockwise)

Preceding gene: 238923858

Following gene: 238923860

Centisome position: 39.65

GC content: 45.42

Gene sequence:

>852_bases
ATGACATATAGAGAAGCAATTTTACTTGGGGAAAGCATATTACAAAAAGCAAAGATAGTTGATGCAAAAAACGATGCATG
GCTGCTTTTAGCCATGGCATGCAGGATAAATCACACATATTACTATGTGCATATGGATGAGGAAATGTCGCAGGAGCAGA
TAGGGGAATATCAAGCATTGCTGAGTAAGCGCGCTGAGCGTATTCCGCTCCAGTACATAGTCGGAGAGCAGGAGTTTATG
GGACTCAAATTCCGTGTGAACAGCAATGTGCTCATACCGCGTCAGGATACAGAGACTCTTGTAGAGGAGGCACTCAAGGT
GATAGAGCCGGGTATGAGAGTGCTTGATATGTGTACAGGAAGCGGCTGCATAATTATAAGCATCTTAAAGAATACGACTA
ATGTGGACGGTGCAGCCTGTGATATCTCAAAGCAGGCGCTCAATGTGGCAAAGGAAAACGCAAGGATTAACGGCGTGTTT
GTTGATTTTGAGAGAAGCGATCTGTTTGAGCATGTCGATGAGATGTATGATGTGATAGTATCCAATCCACCATATATAAG
AAGCGACGAGATACCGCATCTGATGCCTGAGGTGTCTGTGTTTGAGCCGCATGAGGCTCTTGACGGCTCTGAGGATGGAC
TTTTATTTTACAGGCGCATCATAAAGGATTGCAGAGCAAATCTAAAGCCACAGGGCAGGCTGCTTTTTGAGATAGGCTGT
GACCAGGGCAGACAGGTGTCAGAGATGATGCAGTTTGCCGGATTTAGCGATGTACATGTGATAAAGGACCTGGCGGGAAA
TGACAGGGTAGTATCGGGAGTGTTTGACAGCAAGGAGGAAAAACATGTTTGA

Upstream 100 bases:

>100_bases
TAGAGGTTGGCATCGCATCGGTTGAGGCCGTGTTTGACTGGAAGAAATGGCAGGAGGAAAACAATGTGTGTGCACATTGA
CCGCCGGATAGAAGGTATAT

Downstream 100 bases:

>100_bases
TAAGTTAGAAGATCTTATACACCATTATGAAGAGCTGATGAATCTGCTCAGCGAGCCGGATGTGGCAAATGATGCAAACA
GATTTAAAAAGCTTATGAAG

Product: putative rRNA or tRNA methylase

Products: NA

Alternate protein names: M.XfaHemK2P [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MTYREAILLGESILQKAKIVDAKNDAWLLLAMACRINHTYYYVHMDEEMSQEQIGEYQALLSKRAERIPLQYIVGEQEFM
GLKFRVNSNVLIPRQDTETLVEEALKVIEPGMRVLDMCTGSGCIIISILKNTTNVDGAACDISKQALNVAKENARINGVF
VDFERSDLFEHVDEMYDVIVSNPPYIRSDEIPHLMPEVSVFEPHEALDGSEDGLLFYRRIIKDCRANLKPQGRLLFEIGC
DQGRQVSEMMQFAGFSDVHVIKDLAGNDRVVSGVFDSKEEKHV

Sequences:

>Translated_283_residues
MTYREAILLGESILQKAKIVDAKNDAWLLLAMACRINHTYYYVHMDEEMSQEQIGEYQALLSKRAERIPLQYIVGEQEFM
GLKFRVNSNVLIPRQDTETLVEEALKVIEPGMRVLDMCTGSGCIIISILKNTTNVDGAACDISKQALNVAKENARINGVF
VDFERSDLFEHVDEMYDVIVSNPPYIRSDEIPHLMPEVSVFEPHEALDGSEDGLLFYRRIIKDCRANLKPQGRLLFEIGC
DQGRQVSEMMQFAGFSDVHVIKDLAGNDRVVSGVFDSKEEKHV
>Mature_282_residues
TYREAILLGESILQKAKIVDAKNDAWLLLAMACRINHTYYYVHMDEEMSQEQIGEYQALLSKRAERIPLQYIVGEQEFMG
LKFRVNSNVLIPRQDTETLVEEALKVIEPGMRVLDMCTGSGCIIISILKNTTNVDGAACDISKQALNVAKENARINGVFV
DFERSDLFEHVDEMYDVIVSNPPYIRSDEIPHLMPEVSVFEPHEALDGSEDGLLFYRRIIKDCRANLKPQGRLLFEIGCD
QGRQVSEMMQFAGFSDVHVIKDLAGNDRVVSGVFDSKEEKHV

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=281, Percent_Identity=27.0462633451957, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1787463, Length=270, Percent_Identity=32.5925925925926, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082085, Length=179, Percent_Identity=36.3128491620112, Blast_Score=101, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6324266, Length=187, Percent_Identity=29.4117647058824, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24582226, Length=230, Percent_Identity=33.0434782608696, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 32095; Mature: 31964

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYREAILLGESILQKAKIVDAKNDAWLLLAMACRINHTYYYVHMDEEMSQEQIGEYQAL
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCEEEEEEECHHHCHHHHHHHHHH
LSKRAERIPLQYIVGEQEFMGLKFRVNSNVLIPRQDTETLVEEALKVIEPGMRVLDMCTG
HHHHHHHCCHHEEECCHHHEEEEEEECCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHCC
SGCIIISILKNTTNVDGAACDISKQALNVAKENARINGVFVDFERSDLFEHVDEMYDVIV
CCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHHHHHH
SNPPYIRSDEIPHLMPEVSVFEPHEALDGSEDGLLFYRRIIKDCRANLKPQGRLLFEIGC
CCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECC
DQGRQVSEMMQFAGFSDVHVIKDLAGNDRVVSGVFDSKEEKHV
CCCHHHHHHHHHCCCCHHHHHHHCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure 
TYREAILLGESILQKAKIVDAKNDAWLLLAMACRINHTYYYVHMDEEMSQEQIGEYQAL
CHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCEEEEEEECHHHCHHHHHHHHHH
LSKRAERIPLQYIVGEQEFMGLKFRVNSNVLIPRQDTETLVEEALKVIEPGMRVLDMCTG
HHHHHHHCCHHEEECCHHHEEEEEEECCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHCC
SGCIIISILKNTTNVDGAACDISKQALNVAKENARINGVFVDFERSDLFEHVDEMYDVIV
CCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHHHHHH
SNPPYIRSDEIPHLMPEVSVFEPHEALDGSEDGLLFYRRIIKDCRANLKPQGRLLFEIGC
CCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECC
DQGRQVSEMMQFAGFSDVHVIKDLAGNDRVVSGVFDSKEEKHV
CCCHHHHHHHHHCCCCHHHHHHHCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]