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The map label for this gene is serA [H]

Identifier: 238923585

GI number: 238923585

Start: 1113905

End: 1114894

Strand: Direct

Name: serA [H]

Synonym: EUBREC_1207

Alternate gene names: 238923585

Gene position: 1113905-1114894 (Clockwise)

Preceding gene: 238923584

Following gene: 238923586

Centisome position: 32.29

GC content: 45.05

Gene sequence:

>990_bases
ATGAAGTTTGTAATGACACAGGCTGTATGCCCTGAAGGAATGCAGCTTTTAGATGGAATAGCTGATGTATATGTAGCTGA
CAATCAGGATCCGAACAATTATCTTGACGAGATGAGGGATGCAGCTGCTCTTATTGTAAGAATTGCAAAATGTGATGCAA
ATGCTATAGAAAACAGCCCGAAGCTCAAGGTAATTGGACGTACAGGCGTAGGATATGATTCGGTTGATGTAAAAAAAGCA
ACAGAGCTTGGTATCCCGGTGGTCATCACACCGGGAGCCAACAACAGAAGTGTTGCTGAGCATGCGGTAGCAATGATTTT
TGCATTGTCAAAGAATCTTATCGAGGCACAGAACGAGATGTGCAAAGGAAACTGGGAAATCCGTGGAGCAAAGAAGGCTT
TCGAGCTTGAGAGAAAGACAGTCGGAATCCTTGGGCTTGGAGCAATCGGAAGAGAAACAGCCAAAATCTGCAAAGGCTGC
GGAATGAGAATTGCAGCGTATGATCCTTTTATGACAAAAGAGCAGGTAGAAGGCTATGGTGCTAAATATTATGAAGATTA
TGTGGAGCTGTTAAAGGACAGCGATGTGGTATCAATCCATGTACCGCTCACAGATCAGACCAGGAACATGATCTCAAAGA
AGGAGCTTTCTGTTATGAAGCCGACGGCACTTATAATAAACTGCAGCCGTGGAGGAATCATCAACGAAGCAGATCTCGTA
GAAGCATTAAATAACGGAGTTATCGCCGGTGCGGGAACAGACGTATTCTGCAGCGAGCCACCAAAAACAGATGATCCGTT
ATTGAACTGCAGAAATCTTATCGTAAGTCCGCACTCAGCAGCCCAGACAAGAGAGGCAGTTATCAAGATGGCACAGATGT
GTATCAAGGGCTGTCTGGCAGTCGTAGAGGGTAAAAAGTGGCCATATGTAGCCGACAAGTCAGTATATGAGCACGAGAAA
TGGAAGGGTGCTGACTGGGCAGAGATTTAA

Upstream 100 bases:

>100_bases
ATTCAACTATCTGTGCGATGAGGGTGTGGAAGCGCTTGCAAAGGTATTAAAAGAGAATGCTGACAAAGGAATGAACTAAC
TCTGGGGAGGATGAATTAAT

Downstream 100 bases:

>100_bases
AATAAAAATATATCGGGGGATATAATATGGATTCTAGTATTATTTCAATTATAATTGTATTAATTACAATGGGCTTGTTT
GTCTGGAATAGACTGCCGAT

Product: phosphoglycerate dehydrogenase, putative

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MKFVMTQAVCPEGMQLLDGIADVYVADNQDPNNYLDEMRDAAALIVRIAKCDANAIENSPKLKVIGRTGVGYDSVDVKKA
TELGIPVVITPGANNRSVAEHAVAMIFALSKNLIEAQNEMCKGNWEIRGAKKAFELERKTVGILGLGAIGRETAKICKGC
GMRIAAYDPFMTKEQVEGYGAKYYEDYVELLKDSDVVSIHVPLTDQTRNMISKKELSVMKPTALIINCSRGGIINEADLV
EALNNGVIAGAGTDVFCSEPPKTDDPLLNCRNLIVSPHSAAQTREAVIKMAQMCIKGCLAVVEGKKWPYVADKSVYEHEK
WKGADWAEI

Sequences:

>Translated_329_residues
MKFVMTQAVCPEGMQLLDGIADVYVADNQDPNNYLDEMRDAAALIVRIAKCDANAIENSPKLKVIGRTGVGYDSVDVKKA
TELGIPVVITPGANNRSVAEHAVAMIFALSKNLIEAQNEMCKGNWEIRGAKKAFELERKTVGILGLGAIGRETAKICKGC
GMRIAAYDPFMTKEQVEGYGAKYYEDYVELLKDSDVVSIHVPLTDQTRNMISKKELSVMKPTALIINCSRGGIINEADLV
EALNNGVIAGAGTDVFCSEPPKTDDPLLNCRNLIVSPHSAAQTREAVIKMAQMCIKGCLAVVEGKKWPYVADKSVYEHEK
WKGADWAEI
>Mature_329_residues
MKFVMTQAVCPEGMQLLDGIADVYVADNQDPNNYLDEMRDAAALIVRIAKCDANAIENSPKLKVIGRTGVGYDSVDVKKA
TELGIPVVITPGANNRSVAEHAVAMIFALSKNLIEAQNEMCKGNWEIRGAKKAFELERKTVGILGLGAIGRETAKICKGC
GMRIAAYDPFMTKEQVEGYGAKYYEDYVELLKDSDVVSIHVPLTDQTRNMISKKELSVMKPTALIINCSRGGIINEADLV
EALNNGVIAGAGTDVFCSEPPKTDDPLLNCRNLIVSPHSAAQTREAVIKMAQMCIKGCLAVVEGKKWPYVADKSVYEHEK
WKGADWAEI

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=272, Percent_Identity=38.2352941176471, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI61743967, Length=305, Percent_Identity=28.5245901639344, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4557497, Length=305, Percent_Identity=28.5245901639344, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI145580578, Length=292, Percent_Identity=30.4794520547945, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI4557499, Length=292, Percent_Identity=30.4794520547945, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI6912396, Length=252, Percent_Identity=32.5396825396825, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI145580575, Length=310, Percent_Identity=28.3870967741935, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI87082289, Length=269, Percent_Identity=31.9702602230483, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1789279, Length=294, Percent_Identity=31.9727891156463, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1787645, Length=260, Percent_Identity=31.1538461538462, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87081824, Length=234, Percent_Identity=24.7863247863248, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788660, Length=229, Percent_Identity=26.2008733624454, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=275, Percent_Identity=38.9090909090909, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI25147481, Length=287, Percent_Identity=33.4494773519164, Blast_Score=127, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6320925, Length=266, Percent_Identity=31.5789473684211, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322116, Length=266, Percent_Identity=30.8270676691729, Blast_Score=129, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6324055, Length=309, Percent_Identity=29.126213592233, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324964, Length=311, Percent_Identity=29.5819935691318, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6325144, Length=191, Percent_Identity=30.8900523560209, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=168, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921140, Length=260, Percent_Identity=36.5384615384615, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24585516, Length=247, Percent_Identity=29.9595141700405, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574286, Length=313, Percent_Identity=29.3929712460064, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24585514, Length=250, Percent_Identity=32.8, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI28574282, Length=250, Percent_Identity=32.8, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI45552429, Length=250, Percent_Identity=32.8, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI28574284, Length=250, Percent_Identity=32.8, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45551003, Length=250, Percent_Identity=32.8, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646446, Length=294, Percent_Identity=28.5714285714286, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646448, Length=294, Percent_Identity=28.5714285714286, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646452, Length=294, Percent_Identity=28.5714285714286, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646450, Length=294, Percent_Identity=28.5714285714286, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571528, Length=250, Percent_Identity=30.8, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI62472511, Length=294, Percent_Identity=28.5714285714286, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 35873; Mature: 35873

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVMTQAVCPEGMQLLDGIADVYVADNQDPNNYLDEMRDAAALIVRIAKCDANAIENSP
CCEEECHHCCHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC
KLKVIGRTGVGYDSVDVKKATELGIPVVITPGANNRSVAEHAVAMIFALSKNLIEAQNEM
CEEEEECCCCCCCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
CKGNWEIRGAKKAFELERKTVGILGLGAIGRETAKICKGCGMRIAAYDPFMTKEQVEGYG
HCCCCEEECCHHHHHHHHHHEEEEEECCCCHHHHHHHHHCCCEEEECCCCCCHHHHHCCC
AKYYEDYVELLKDSDVVSIHVPLTDQTRNMISKKELSVMKPTALIINCSRGGIINEADLV
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHH
EALNNGVIAGAGTDVFCSEPPKTDDPLLNCRNLIVSPHSAAQTREAVIKMAQMCIKGCLA
HHHHCCEEEECCCCCEECCCCCCCCHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHH
VVEGKKWPYVADKSVYEHEKWKGADWAEI
HHCCCCCCCCCCCHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKFVMTQAVCPEGMQLLDGIADVYVADNQDPNNYLDEMRDAAALIVRIAKCDANAIENSP
CCEEECHHCCHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC
KLKVIGRTGVGYDSVDVKKATELGIPVVITPGANNRSVAEHAVAMIFALSKNLIEAQNEM
CEEEEECCCCCCCCCCHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
CKGNWEIRGAKKAFELERKTVGILGLGAIGRETAKICKGCGMRIAAYDPFMTKEQVEGYG
HCCCCEEECCHHHHHHHHHHEEEEEECCCCHHHHHHHHHCCCEEEECCCCCCHHHHHCCC
AKYYEDYVELLKDSDVVSIHVPLTDQTRNMISKKELSVMKPTALIINCSRGGIINEADLV
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHH
EALNNGVIAGAGTDVFCSEPPKTDDPLLNCRNLIVSPHSAAQTREAVIKMAQMCIKGCLA
HHHHCCEEEECCCCCEECCCCCCCCHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHH
VVEGKKWPYVADKSVYEHEKWKGADWAEI
HHCCCCCCCCCCCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]