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The map label for this gene is pdxA [H]

Identifier: 238923582

GI number: 238923582

Start: 1110631

End: 1111671

Strand: Direct

Name: pdxA [H]

Synonym: EUBREC_1204

Alternate gene names: 238923582

Gene position: 1110631-1111671 (Clockwise)

Preceding gene: 238923581

Following gene: 238923583

Centisome position: 32.2

GC content: 42.17

Gene sequence:

>1041_bases
ATGAAAAAGCCAATTATCGGAATTACAATGGGAGATCCTGCAGGAAACGGTTCTGAGATTTCAGTAAAAGCGTTATCAAG
ATCGGAAATATATGAGCAGTGTCGTCCGGTGATTATCGGTGATGCTGCATGCATGGAAGAGGCAGTAAAAATCGCAGGAA
AAGAAGGACAAATAAAGATTCATGCGATTAACGATATTAAAGCTGCAAAGTTTGAGTACGGAACGATTGATGTGTACGAC
ATGAATCTTGTGAACATGGACAGACACATATTCGGAAAAGTATCAAAGATGTGTGGAGAGGCTGCTTTTCAGTATGTCGT
AAAGGTAATAGAGCTTGCGCAGAGCGGCGAGATTGACGCAACTGTCACAAATGCCTTAAATAAAGAGGCAATAAATATGG
CAGGACATCATTATTCGGGACATACAGAGATTTATGCAGAGTACACCCATACAGACAAGTACACAATGATGCTTGCGCAC
GAGGATTTGAGGGTTGTACACGTATCGACGCATGTTTCTCTCAGGCAGGCATGTGACAAGGTAAAGAAGGACAGAGTCCT
TGAAGTTATAAGAATTGCAAATGATGCCTGCAAGGCGATAGGCATTGAGAATCCAAAGATTGGTGTGGCAGGTCTTAACC
CACACTGCGGAGAAAACGGACTGTTTGGAACAGAGGAAATTGAGGAAATCCAGCCGGCAATAGATGAGGCAATGGCAGAA
GGAATCAATATTCCTGAGAAAAAACCGACACCGCCTGACAGCATATTCTCTAAGGCAATCGGAGGCTGGTATGATATAGT
TGTAGCAATGTACCATGATCAGGGACATATTCCTCTGAAGGTTAAAGGTTTTGTATACAACAAAGAATTAAAGAAATGGG
ATGCGGTAGCAGGTGTAAATGTAACACTCGGAATTCCTGTAATAAGGGTATCGGTAGACCATGGTACAGGCTTTGACCTT
GCAGGAAAAGGCGAATCGAATGAGTTAAGCCTTGTAAATTCAATTGACTATGCGACAAAGCTTGCAGTAAACAAAAAATA
G

Upstream 100 bases:

>100_bases
GGAAGCAAACAGCAGAGACTTCTTGTAAACAATATGAAAGAATTAAGTCTTGACGATATCAGAAACATATATCTTAAGGT
GTTAAAATAAAGGAGGACCT

Downstream 100 bases:

>100_bases
CGGGAGGAAATGCGATGGTAAAGCTGTTGATCATAGCAGATGACTTTACCGGTGCATTGGATACCGGAATCCAGTTTGTG
AATAAGGGAATTGCCACCCA

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKKPIIGITMGDPAGNGSEISVKALSRSEIYEQCRPVIIGDAACMEEAVKIAGKEGQIKIHAINDIKAAKFEYGTIDVYD
MNLVNMDRHIFGKVSKMCGEAAFQYVVKVIELAQSGEIDATVTNALNKEAINMAGHHYSGHTEIYAEYTHTDKYTMMLAH
EDLRVVHVSTHVSLRQACDKVKKDRVLEVIRIANDACKAIGIENPKIGVAGLNPHCGENGLFGTEEIEEIQPAIDEAMAE
GINIPEKKPTPPDSIFSKAIGGWYDIVVAMYHDQGHIPLKVKGFVYNKELKKWDAVAGVNVTLGIPVIRVSVDHGTGFDL
AGKGESNELSLVNSIDYATKLAVNKK

Sequences:

>Translated_346_residues
MKKPIIGITMGDPAGNGSEISVKALSRSEIYEQCRPVIIGDAACMEEAVKIAGKEGQIKIHAINDIKAAKFEYGTIDVYD
MNLVNMDRHIFGKVSKMCGEAAFQYVVKVIELAQSGEIDATVTNALNKEAINMAGHHYSGHTEIYAEYTHTDKYTMMLAH
EDLRVVHVSTHVSLRQACDKVKKDRVLEVIRIANDACKAIGIENPKIGVAGLNPHCGENGLFGTEEIEEIQPAIDEAMAE
GINIPEKKPTPPDSIFSKAIGGWYDIVVAMYHDQGHIPLKVKGFVYNKELKKWDAVAGVNVTLGIPVIRVSVDHGTGFDL
AGKGESNELSLVNSIDYATKLAVNKK
>Mature_346_residues
MKKPIIGITMGDPAGNGSEISVKALSRSEIYEQCRPVIIGDAACMEEAVKIAGKEGQIKIHAINDIKAAKFEYGTIDVYD
MNLVNMDRHIFGKVSKMCGEAAFQYVVKVIELAQSGEIDATVTNALNKEAINMAGHHYSGHTEIYAEYTHTDKYTMMLAH
EDLRVVHVSTHVSLRQACDKVKKDRVLEVIRIANDACKAIGIENPKIGVAGLNPHCGENGLFGTEEIEEIQPAIDEAMAE
GINIPEKKPTPPDSIFSKAIGGWYDIVVAMYHDQGHIPLKVKGFVYNKELKKWDAVAGVNVTLGIPVIRVSVDHGTGFDL
AGKGESNELSLVNSIDYATKLAVNKK

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=347, Percent_Identity=35.1585014409222, Blast_Score=184, Evalue=7e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 37746; Mature: 37746

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPIIGITMGDPAGNGSEISVKALSRSEIYEQCRPVIIGDAACMEEAVKIAGKEGQIKI
CCCCEEEEEECCCCCCCCEEEEEECCHHHHHHHCCCEEEECHHHHHHHHHHCCCCCCEEE
HAINDIKAAKFEYGTIDVYDMNLVNMDRHIFGKVSKMCGEAAFQYVVKVIELAQSGEIDA
EEECCCEECEEECCEEEEEECEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TVTNALNKEAINMAGHHYSGHTEIYAEYTHTDKYTMMLAHEDLRVVHVSTHVSLRQACDK
HHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCEEEEEEEECCEEEEEEECHHHHHHHHHH
VKKDRVLEVIRIANDACKAIGIENPKIGVAGLNPHCGENGLFGTEEIEEIQPAIDEAMAE
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GINIPEKKPTPPDSIFSKAIGGWYDIVVAMYHDQGHIPLKVKGFVYNKELKKWDAVAGVN
CCCCCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEEEEECCHHHHHHHHCCCE
VTLGIPVIRVSVDHGTGFDLAGKGESNELSLVNSIDYATKLAVNKK
EEECCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCHHHEEEECCC
>Mature Secondary Structure
MKKPIIGITMGDPAGNGSEISVKALSRSEIYEQCRPVIIGDAACMEEAVKIAGKEGQIKI
CCCCEEEEEECCCCCCCCEEEEEECCHHHHHHHCCCEEEECHHHHHHHHHHCCCCCCEEE
HAINDIKAAKFEYGTIDVYDMNLVNMDRHIFGKVSKMCGEAAFQYVVKVIELAQSGEIDA
EEECCCEECEEECCEEEEEECEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TVTNALNKEAINMAGHHYSGHTEIYAEYTHTDKYTMMLAHEDLRVVHVSTHVSLRQACDK
HHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCEEEEEEEECCEEEEEEECHHHHHHHHHH
VKKDRVLEVIRIANDACKAIGIENPKIGVAGLNPHCGENGLFGTEEIEEIQPAIDEAMAE
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GINIPEKKPTPPDSIFSKAIGGWYDIVVAMYHDQGHIPLKVKGFVYNKELKKWDAVAGVN
CCCCCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCEEEEEEEECCHHHHHHHHCCCE
VTLGIPVIRVSVDHGTGFDLAGKGESNELSLVNSIDYATKLAVNKK
EEECCEEEEEEECCCCCCCCCCCCCCCCEEEEECCCHHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]