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The map label for this gene is purM

Identifier: 238923505

GI number: 238923505

Start: 1037121

End: 1038146

Strand: Direct

Name: purM

Synonym: EUBREC_1125

Alternate gene names: 238923505

Gene position: 1037121-1038146 (Clockwise)

Preceding gene: 238923503

Following gene: 238923506

Centisome position: 30.06

GC content: 46.2

Gene sequence:

>1026_bases
ATGGATTACAAGAATTCAGGTGTTGATATCGAGGCAGGTTACAAGTCAGTAGAGCTTATGAAAAAGCATGTAAAGGAGAC
TATGAGACCGGAGGTGTTAGGTGGTCTCGGAGGCTTCTCAGGAGCGTTCTCACTTGCTTCCATCAAGGATATGGAGGATC
CGGTGCTTTTATCGGGAACAGATGGCTGCGGAACTAAGGTAAAGCTTGCTTTCATCATGGACAAGCATGATACAATCGGA
ATCGATGCAGTTGCCATGTGTGTAAATGATGTGGCATGTGCAGGCGGTGAGCCATTATTTTTCCTTGATTATATAGCATG
TGGAAAGAACTATCCGGAGAAGATTGCTACAATCGTAAGCGGTGTGGCAGAGGGCTGTAAGCAGTCAGGCTGTGCACTCG
TTGGTGGTGAGACAGCAGAGCATCCGGGTCTTATGCCTGAGGACGAGTATGACCTTGCAGGCTTTGCAGTTGGTGTGGTT
GACAGAAAGGACATCATTACAGGCGAGGGATTAAAGGATGGTGATGTACTTATCGGAATGGCATCAACAGGCGTACACTC
AAATGGATTTTCACTTGTCAGAAAGATTTTCAAGATGGACAAGGAGACATTAAATACATATCATGAGGAGCTTGGCACTA
CACTTGGAGAGGCACTTCTTGCCCCTACAAGAATCTATGTAAAGGCTCTTAAGGCTGTAAAGGACGCAGGAGTCACAGTA
AAGGCCTGCAGTCATATTACAGGTGGCGGCTTCTATGAGAATATCCCACGTATGCTCATCGATGGCAAACGTGCCGTAGT
TGAGAAAAACAGCTACCCTGTTCCACCAATCTTTAAAATGATGGCTAGAGAGGGAAATGTTGAGGAGCAGATGATGTACA
ATACCTACAACATGGGACTTGGAATGATTGTCGCAGTTGACCCTGCAGACGTGGACAAGACTATGGAGGCTATGAAGTCT
GCCGGAGATACACCATACGTAGTCGGAAAGATTATTGACGGCGAGAAGGGTGTAGATCTCGTATAA

Upstream 100 bases:

>100_bases
AAACTAATAAGAATAATTACAATATATAATTGGAAAATTTAGCACTATGAAGGTATACTATAGGTATTGAACGAATTGCA
GATTATTAGGAGGAACAATA

Downstream 100 bases:

>100_bases
TAACATTCAATATATTGTTAATAACGTATACATCGTTGCGAGGAAAAAGAATGAAAATTGCAGTATGTGTATCGGGTGGC
GGCACCAATCTTCAGGCCAT

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MDYKNSGVDIEAGYKSVELMKKHVKETMRPEVLGGLGGFSGAFSLASIKDMEDPVLLSGTDGCGTKVKLAFIMDKHDTIG
IDAVAMCVNDVACAGGEPLFFLDYIACGKNYPEKIATIVSGVAEGCKQSGCALVGGETAEHPGLMPEDEYDLAGFAVGVV
DRKDIITGEGLKDGDVLIGMASTGVHSNGFSLVRKIFKMDKETLNTYHEELGTTLGEALLAPTRIYVKALKAVKDAGVTV
KACSHITGGGFYENIPRMLIDGKRAVVEKNSYPVPPIFKMMAREGNVEEQMMYNTYNMGLGMIVAVDPADVDKTMEAMKS
AGDTPYVVGKIIDGEKGVDLV

Sequences:

>Translated_341_residues
MDYKNSGVDIEAGYKSVELMKKHVKETMRPEVLGGLGGFSGAFSLASIKDMEDPVLLSGTDGCGTKVKLAFIMDKHDTIG
IDAVAMCVNDVACAGGEPLFFLDYIACGKNYPEKIATIVSGVAEGCKQSGCALVGGETAEHPGLMPEDEYDLAGFAVGVV
DRKDIITGEGLKDGDVLIGMASTGVHSNGFSLVRKIFKMDKETLNTYHEELGTTLGEALLAPTRIYVKALKAVKDAGVTV
KACSHITGGGFYENIPRMLIDGKRAVVEKNSYPVPPIFKMMAREGNVEEQMMYNTYNMGLGMIVAVDPADVDKTMEAMKS
AGDTPYVVGKIIDGEKGVDLV
>Mature_341_residues
MDYKNSGVDIEAGYKSVELMKKHVKETMRPEVLGGLGGFSGAFSLASIKDMEDPVLLSGTDGCGTKVKLAFIMDKHDTIG
IDAVAMCVNDVACAGGEPLFFLDYIACGKNYPEKIATIVSGVAEGCKQSGCALVGGETAEHPGLMPEDEYDLAGFAVGVV
DRKDIITGEGLKDGDVLIGMASTGVHSNGFSLVRKIFKMDKETLNTYHEELGTTLGEALLAPTRIYVKALKAVKDAGVTV
KACSHITGGGFYENIPRMLIDGKRAVVEKNSYPVPPIFKMMAREGNVEEQMMYNTYNMGLGMIVAVDPADVDKTMEAMKS
AGDTPYVVGKIIDGEKGVDLV

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=340, Percent_Identity=43.8235294117647, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI209869995, Length=340, Percent_Identity=43.8235294117647, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI209869993, Length=340, Percent_Identity=43.8235294117647, Blast_Score=275, Evalue=4e-74,
Organism=Escherichia coli, GI1788845, Length=331, Percent_Identity=50.1510574018127, Blast_Score=325, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17567511, Length=342, Percent_Identity=35.9649122807018, Blast_Score=215, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6321203, Length=343, Percent_Identity=42.8571428571429, Blast_Score=258, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24582400, Length=284, Percent_Identity=42.2535211267606, Blast_Score=218, Evalue=5e-57,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_EUBR3 (C4ZH75)

Other databases:

- EMBL:   CP001107
- RefSeq:   YP_002937021.1
- GeneID:   7964138
- GenomeReviews:   CP001107_GR
- KEGG:   ere:EUBREC_1125
- ProtClustDB:   CLSK2506417
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36348; Mature: 36348

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKNSGVDIEAGYKSVELMKKHVKETMRPEVLGGLGGFSGAFSLASIKDMEDPVLLSGT
CCCCCCCCEECCCHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHCCCCCEEEECC
DGCGTKVKLAFIMDKHDTIGIDAVAMCVNDVACAGGEPLFFLDYIACGKNYPEKIATIVS
CCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHCCCCHHHHHHHHH
GVAEGCKQSGCALVGGETAEHPGLMPEDEYDLAGFAVGVVDRKDIITGEGLKDGDVLIGM
HHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEE
ASTGVHSNGFSLVRKIFKMDKETLNTYHEELGTTLGEALLAPTRIYVKALKAVKDAGVTV
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
KACSHITGGGFYENIPRMLIDGKRAVVEKNSYPVPPIFKMMAREGNVEEQMMYNTYNMGL
EHHCCCCCCCHHHHHHHHHHCCCHHEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCC
GMIVAVDPADVDKTMEAMKSAGDTPYVVGKIIDGEKGVDLV
EEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure
MDYKNSGVDIEAGYKSVELMKKHVKETMRPEVLGGLGGFSGAFSLASIKDMEDPVLLSGT
CCCCCCCCEECCCHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHCCCCCEEEECC
DGCGTKVKLAFIMDKHDTIGIDAVAMCVNDVACAGGEPLFFLDYIACGKNYPEKIATIVS
CCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHCCCCHHHHHHHHH
GVAEGCKQSGCALVGGETAEHPGLMPEDEYDLAGFAVGVVDRKDIITGEGLKDGDVLIGM
HHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEE
ASTGVHSNGFSLVRKIFKMDKETLNTYHEELGTTLGEALLAPTRIYVKALKAVKDAGVTV
ECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
KACSHITGGGFYENIPRMLIDGKRAVVEKNSYPVPPIFKMMAREGNVEEQMMYNTYNMGL
EHHCCCCCCCHHHHHHHHHHCCCHHEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCC
GMIVAVDPADVDKTMEAMKSAGDTPYVVGKIIDGEKGVDLV
EEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA