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The map label for this gene is purN [H]

Identifier: 238923506

GI number: 238923506

Start: 1038197

End: 1038823

Strand: Direct

Name: purN [H]

Synonym: EUBREC_1126

Alternate gene names: 238923506

Gene position: 1038197-1038823 (Clockwise)

Preceding gene: 238923505

Following gene: 238923507

Centisome position: 30.1

GC content: 45.93

Gene sequence:

>627_bases
ATGAAAATTGCAGTATGTGTATCGGGTGGCGGCACCAATCTTCAGGCCATCATAGATGCAATAGATAACGGAACAATTAC
AAACACACAGATAGAGGTTGTTATCAGCAACAACGCAGATGCATATGCGCTTGAGAGAGCTAAAAAGGCTGGAATAAAGG
CAGTATGCATCTCGCCAAAGAGCTATGAAAGCAGAGCTGCCTTCAATGAAGATTTCTTAAAGCAGCTTAACTCATATCAT
GTGGATTTAGTCGTACTGGCAGGTTTTCTGGTAGTGATTCCACCTGAGATGATAAAGCAGTACAGAAACAGAATCATAAA
TATCCATCCATCGCTCATACCATCTTTCTGCGGCACAGGCTACTATGGTCTTAAGGTGCATGAGGGAGTGCTTGCACGCG
GTGTGAAGGTGACAGGTGCAACCTGCCACTTTGTGGATGAAGGCACAGACACAGGCCCTATTATTTTACAGAAGGCAGTC
GAGGTAAAGCAGGGCGACACACCTGAGGTGCTCCAGCGCAGGGTTATGGAGCAGGCTGAGTGGAAAATCATGCCACACGC
TATCGACCTGATAGCAAATGGCAGGGTGTCAGTAGAAGACGGACATGTTATTATAGATGAGAAGTAA

Upstream 100 bases:

>100_bases
ACGTAGTCGGAAAGATTATTGACGGCGAGAAGGGTGTAGATCTCGTATAATAACATTCAATATATTGTTAATAACGTATA
CATCGTTGCGAGGAAAAAGA

Downstream 100 bases:

>100_bases
TGACAGTGCTGTAAGTAATTAGTATGTAAACACAGGTAGATTATGATTACCGGACAATGAAAAGCTTATGTATAGCTTAG
GTATAGGAGGCAAAAATGAA

Product: folate-dependent phosphoribosylglycinamide formyltransferase

Products: NA

Alternate protein names: 5'-phosphoribosylglycinamide transformylase; GAR transformylase; GART [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKIAVCVSGGGTNLQAIIDAIDNGTITNTQIEVVISNNADAYALERAKKAGIKAVCISPKSYESRAAFNEDFLKQLNSYH
VDLVVLAGFLVVIPPEMIKQYRNRIINIHPSLIPSFCGTGYYGLKVHEGVLARGVKVTGATCHFVDEGTDTGPIILQKAV
EVKQGDTPEVLQRRVMEQAEWKIMPHAIDLIANGRVSVEDGHVIIDEK

Sequences:

>Translated_208_residues
MKIAVCVSGGGTNLQAIIDAIDNGTITNTQIEVVISNNADAYALERAKKAGIKAVCISPKSYESRAAFNEDFLKQLNSYH
VDLVVLAGFLVVIPPEMIKQYRNRIINIHPSLIPSFCGTGYYGLKVHEGVLARGVKVTGATCHFVDEGTDTGPIILQKAV
EVKQGDTPEVLQRRVMEQAEWKIMPHAIDLIANGRVSVEDGHVIIDEK
>Mature_208_residues
MKIAVCVSGGGTNLQAIIDAIDNGTITNTQIEVVISNNADAYALERAKKAGIKAVCISPKSYESRAAFNEDFLKQLNSYH
VDLVVLAGFLVVIPPEMIKQYRNRIINIHPSLIPSFCGTGYYGLKVHEGVLARGVKVTGATCHFVDEGTDTGPIILQKAV
EVKQGDTPEVLQRRVMEQAEWKIMPHAIDLIANGRVSVEDGHVIIDEK

Specific function: De novo purine biosynthesis; third step. [C]

COG id: COG0299

COG function: function code F; Folate-dependent phosphoribosylglycinamide formyltransferase PurN

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GART family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=203, Percent_Identity=42.3645320197044, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI209869995, Length=203, Percent_Identity=42.3645320197044, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI209869993, Length=203, Percent_Identity=42.3645320197044, Blast_Score=153, Evalue=1e-37,
Organism=Escherichia coli, GI1788846, Length=206, Percent_Identity=39.3203883495146, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1787483, Length=137, Percent_Identity=32.8467153284672, Blast_Score=84, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17567511, Length=192, Percent_Identity=33.8541666666667, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320616, Length=191, Percent_Identity=29.3193717277487, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24582400, Length=194, Percent_Identity=39.6907216494845, Blast_Score=147, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002376
- InterPro:   IPR001555
- InterPro:   IPR004607 [H]

Pfam domain/function: PF00551 Formyl_trans_N [H]

EC number: =2.1.2.2 [H]

Molecular weight: Translated: 22668; Mature: 22668

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAVCVSGGGTNLQAIIDAIDNGTITNTQIEVVISNNADAYALERAKKAGIKAVCISPK
CEEEEEECCCCCCHHHHHHHHCCCEEECEEEEEEEECCCCHHHHHHHHHCCCEEEEECCC
SYESRAAFNEDFLKQLNSYHVDLVVLAGFLVVIPPEMIKQYRNRIINIHPSLIPSFCGTG
CCCHHHHCCHHHHHHHHCCCCHHHHHHHHHEEECHHHHHHHHHHEEEECHHHHHHHHCCC
YYGLKVHEGVLARGVKVTGATCHFVDEGTDTGPIILQKAVEVKQGDTPEVLQRRVMEQAE
EEEEEECCCHHHCCEEEECCEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHC
WKIMPHAIDLIANGRVSVEDGHVIIDEK
CEECCHHHHHEECCEEEEECCEEEEECC
>Mature Secondary Structure
MKIAVCVSGGGTNLQAIIDAIDNGTITNTQIEVVISNNADAYALERAKKAGIKAVCISPK
CEEEEEECCCCCCHHHHHHHHCCCEEECEEEEEEEECCCCHHHHHHHHHCCCEEEEECCC
SYESRAAFNEDFLKQLNSYHVDLVVLAGFLVVIPPEMIKQYRNRIINIHPSLIPSFCGTG
CCCHHHHCCHHHHHHHHCCCCHHHHHHHHHEEECHHHHHHHHHHEEEECHHHHHHHHCCC
YYGLKVHEGVLARGVKVTGATCHFVDEGTDTGPIILQKAVEVKQGDTPEVLQRRVMEQAE
EEEEEECCCHHHCCEEEECCEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHC
WKIMPHAIDLIANGRVSVEDGHVIIDEK
CEECCHHHHHEECCEEEEECCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3301838; 9205837; 9278503; 10954745; 2204419; 1522592; 1631098; 9698564; 10606510 [H]