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The map label for this gene is clpP

Identifier: 238923369

GI number: 238923369

Start: 883766

End: 884347

Strand: Direct

Name: clpP

Synonym: EUBREC_0989

Alternate gene names: 238923369

Gene position: 883766-884347 (Clockwise)

Preceding gene: 238923368

Following gene: 238923370

Centisome position: 25.62

GC content: 42.61

Gene sequence:

>582_bases
ATGAGTTTAGTACCATATGTCATTGAACAGACCAGCAGAGGAGAGCGCAACTACGACATTTACTCCAGATTATTAAAAGA
TCGTATCATTTTCCTTGGAGAGGAAGTAAATGAGACAACAGCCAGCCTTGTTGTTGCCCAGCTTTTATTCCTTGAGTCCG
AGGATCCGAATAAGGATATCCACCTTTACATCAATTCACCGGGTGGAATGGTTACAGCAGGACTTGCTATTTACGATACT
ATGCAGTACATCAAGTGTGATGTTTCAACAATCTGTATCGGTCTTGCAGCAAGCATGGGAGCTTTCCTTCTTGCAGGCGG
TGCAAAGGGCAAGAGATATGCTCTTCCAAATGCAGAGATTATGATTCATCAGCCATCTGGCGGTGCAAAGGGTCAGGCTA
CTGAGATTCAGATTGCTGCAGAAAATATTTTAAAGACAAAGAAGAGATTAAACGAAATTTTAGCAGCCAATACAGGCAAG
CCATACGAGACAATTGCAGCTGATACAGAGCGAGACAACTATATGTCAGCACAGGAAGCCGCAGAGTATGGTCTCATAGA
CAGTGTAATAACAAACAGATAA

Upstream 100 bases:

>100_bases
CTACAGAAGAATAAGATTTTTGAATCAAGATTTGATTGACTGGCTCAGAAGCCTATTTTCTGAGCCGGTCTTTTGAGCTT
TTATAAAGGAGGTATTTTAT

Downstream 100 bases:

>100_bases
TCAGAAGTTAGATGAATTTAAGAGGGTACCCCATATGGGATGCCCTCATGCAATAAAAGGAGTTAATAATGGCAGGAAAA
AACGACGGAAAGATTCGCTG

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MSLVPYVIEQTSRGERNYDIYSRLLKDRIIFLGEEVNETTASLVVAQLLFLESEDPNKDIHLYINSPGGMVTAGLAIYDT
MQYIKCDVSTICIGLAASMGAFLLAGGAKGKRYALPNAEIMIHQPSGGAKGQATEIQIAAENILKTKKRLNEILAANTGK
PYETIAADTERDNYMSAQEAAEYGLIDSVITNR

Sequences:

>Translated_193_residues
MSLVPYVIEQTSRGERNYDIYSRLLKDRIIFLGEEVNETTASLVVAQLLFLESEDPNKDIHLYINSPGGMVTAGLAIYDT
MQYIKCDVSTICIGLAASMGAFLLAGGAKGKRYALPNAEIMIHQPSGGAKGQATEIQIAAENILKTKKRLNEILAANTGK
PYETIAADTERDNYMSAQEAAEYGLIDSVITNR
>Mature_192_residues
SLVPYVIEQTSRGERNYDIYSRLLKDRIIFLGEEVNETTASLVVAQLLFLESEDPNKDIHLYINSPGGMVTAGLAIYDTM
QYIKCDVSTICIGLAASMGAFLLAGGAKGKRYALPNAEIMIHQPSGGAKGQATEIQIAAENILKTKKRLNEILAANTGKP
YETIAADTERDNYMSAQEAAEYGLIDSVITNR

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=58.3333333333333, Blast_Score=239, Evalue=1e-63,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=66.3212435233161, Blast_Score=280, Evalue=5e-77,
Organism=Caenorhabditis elegans, GI17538017, Length=189, Percent_Identity=56.0846560846561, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=59.4736842105263, Blast_Score=237, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_EUBR3 (C4ZGF4)

Other databases:

- EMBL:   CP001107
- RefSeq:   YP_002936885.1
- GeneID:   7964963
- GenomeReviews:   CP001107_GR
- KEGG:   ere:EUBREC_0989
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21054; Mature: 20923

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVPYVIEQTSRGERNYDIYSRLLKDRIIFLGEEVNETTASLVVAQLLFLESEDPNKDI
CCCCCHHHHHCCCCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
HLYINSPGGMVTAGLAIYDTMQYIKCDVSTICIGLAASMGAFLLAGGAKGKRYALPNAEI
EEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEECCCCEE
MIHQPSGGAKGQATEIQIAAENILKTKKRLNEILAANTGKPYETIAADTERDNYMSAQEA
EEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHCHHHH
AEYGLIDSVITNR
HHHCHHHHHHCCC
>Mature Secondary Structure 
SLVPYVIEQTSRGERNYDIYSRLLKDRIIFLGEEVNETTASLVVAQLLFLESEDPNKDI
CCCCHHHHHCCCCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
HLYINSPGGMVTAGLAIYDTMQYIKCDVSTICIGLAASMGAFLLAGGAKGKRYALPNAEI
EEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEECCCCEE
MIHQPSGGAKGQATEIQIAAENILKTKKRLNEILAANTGKPYETIAADTERDNYMSAQEA
EEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCHHCHHHH
AEYGLIDSVITNR
HHHCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA