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The map label for this gene is fba [H]

Identifier: 238923108

GI number: 238923108

Start: 643199

End: 644065

Strand: Direct

Name: fba [H]

Synonym: EUBREC_0700

Alternate gene names: 238923108

Gene position: 643199-644065 (Clockwise)

Preceding gene: 238923107

Following gene: 238923109

Centisome position: 18.65

GC content: 46.71

Gene sequence:

>867_bases
ATGTTAGTATCTGCAACAGAAATGCTTAAGAAAGCAAAAGAAGGACATTACGCAGTAGGTCAGTTCAACATCAACAACCT
TGAGTGGACAAAATCAGTACTTTTAACAGCAGAGGAGCTTAAGAGCCCTGTAATCCTTGGTGTATCTGAGGGTGCCGGAA
AGTACATGACAGGCTTCGGTACAGTAGCAGCAATGGTTAAGGCTATGCATGACGAGCTCGGTATCACAGTACCTGTAGCA
CTTCACCTTGATCACGGCACATACGAAGGATGCTACAAGTGCATCAAGGCCGGCTTCACATCAATCATGTTCGACGGATC
TCATTATCCAATCGATGAGAACGTTGCAAAGACAAAAGAGTTAGTAGCAGTTGCTCATGCAATGGGCATGTCTATCGAGG
CTGAAGTTGGTTCAATCGGTGGCGAGGAAGACGGAGTTGTTGGAATGGGCGAGTGCGCTGATCCTGACGAGTGCAAGAGA
GTTGCTGATCTTGGTGTAGATATGCTTGCAGCAGGAATCGGAAACATCCACGGAAAATATCCTGCAAACTGGCAGGGACT
CAGCTTTGAGACTCTTGATGCTATCCAGCAGAAGACTGGTGTTATGCCATTAGTACTTCACGGTGGTACAGGAATCCCAG
CTGACATGATCAAGAAAGCAATCGACCTTGGAGTATCTAAGATCAACGTTAACACAGAGTGCCAGCTTTCATTCGCAGAT
GCAACACGTAAATACATCGAGGCCGGAAAGGATCTTGAGGGCAAGGGATTTGACCCTCGTAAGCTTCTTGCTCCAGGTGC
TGAGGCAATCAAGGCAACAGTTAAGGAGAAGATGGAGCTTTTCGGATCAGTTGGAAAGGCTGAATAA

Upstream 100 bases:

>100_bases
GTACACAATTTTTTGTCTGATTGTGTTAAAAATTTAACTTTATTTTTATAAGGTTATGTAATATAATAACATTAGCTTTT
AATTAACAGGAGGAAAAAAT

Downstream 100 bases:

>100_bases
TATTATTGCAATTTAGTATTTTTGCACATACTACTTTACAAAATATTTATATCTTGTAGTAAAATTTTATAAAACTTAAC
TTTTTTAACATAAACACTTG

Product: fructose-1,6-bisphosphate aldolase, class II

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MLVSATEMLKKAKEGHYAVGQFNINNLEWTKSVLLTAEELKSPVILGVSEGAGKYMTGFGTVAAMVKAMHDELGITVPVA
LHLDHGTYEGCYKCIKAGFTSIMFDGSHYPIDENVAKTKELVAVAHAMGMSIEAEVGSIGGEEDGVVGMGECADPDECKR
VADLGVDMLAAGIGNIHGKYPANWQGLSFETLDAIQQKTGVMPLVLHGGTGIPADMIKKAIDLGVSKINVNTECQLSFAD
ATRKYIEAGKDLEGKGFDPRKLLAPGAEAIKATVKEKMELFGSVGKAE

Sequences:

>Translated_288_residues
MLVSATEMLKKAKEGHYAVGQFNINNLEWTKSVLLTAEELKSPVILGVSEGAGKYMTGFGTVAAMVKAMHDELGITVPVA
LHLDHGTYEGCYKCIKAGFTSIMFDGSHYPIDENVAKTKELVAVAHAMGMSIEAEVGSIGGEEDGVVGMGECADPDECKR
VADLGVDMLAAGIGNIHGKYPANWQGLSFETLDAIQQKTGVMPLVLHGGTGIPADMIKKAIDLGVSKINVNTECQLSFAD
ATRKYIEAGKDLEGKGFDPRKLLAPGAEAIKATVKEKMELFGSVGKAE
>Mature_288_residues
MLVSATEMLKKAKEGHYAVGQFNINNLEWTKSVLLTAEELKSPVILGVSEGAGKYMTGFGTVAAMVKAMHDELGITVPVA
LHLDHGTYEGCYKCIKAGFTSIMFDGSHYPIDENVAKTKELVAVAHAMGMSIEAEVGSIGGEEDGVVGMGECADPDECKR
VADLGVDMLAAGIGNIHGKYPANWQGLSFETLDAIQQKTGVMPLVLHGGTGIPADMIKKAIDLGVSKINVNTECQLSFAD
ATRKYIEAGKDLEGKGFDPRKLLAPGAEAIKATVKEKMELFGSVGKAE

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=290, Percent_Identity=36.2068965517241, Blast_Score=175, Evalue=3e-45,
Organism=Escherichia coli, GI87082041, Length=297, Percent_Identity=36.026936026936, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1788072, Length=295, Percent_Identity=37.6271186440678, Blast_Score=146, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 30523; Mature: 30523

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVSATEMLKKAKEGHYAVGQFNINNLEWTKSVLLTAEELKSPVILGVSEGAGKYMTGFG
CCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHH
TVAAMVKAMHDELGITVPVALHLDHGTYEGCYKCIKAGFTSIMFDGSHYPIDENVAKTKE
HHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHH
LVAVAHAMGMSIEAEVGSIGGEEDGVVGMGECADPDECKRVADLGVDMLAAGIGNIHGKY
HHHHHHHHCCEEEEHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PANWQGLSFETLDAIQQKTGVMPLVLHGGTGIPADMIKKAIDLGVSKINVNTECQLSFAD
CCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCEEEECCCEEEEEHHH
ATRKYIEAGKDLEGKGFDPRKLLAPGAEAIKATVKEKMELFGSVGKAE
HHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLVSATEMLKKAKEGHYAVGQFNINNLEWTKSVLLTAEELKSPVILGVSEGAGKYMTGFG
CCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHH
TVAAMVKAMHDELGITVPVALHLDHGTYEGCYKCIKAGFTSIMFDGSHYPIDENVAKTKE
HHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHH
LVAVAHAMGMSIEAEVGSIGGEEDGVVGMGECADPDECKRVADLGVDMLAAGIGNIHGKY
HHHHHHHHCCEEEEHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PANWQGLSFETLDAIQQKTGVMPLVLHGGTGIPADMIKKAIDLGVSKINVNTECQLSFAD
CCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCEEEECCCEEEEEHHH
ATRKYIEAGKDLEGKGFDPRKLLAPGAEAIKATVKEKMELFGSVGKAE
HHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8948633 [H]