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The map label for this gene is uvrC [H]

Identifier: 238923101

GI number: 238923101

Start: 635185

End: 637059

Strand: Direct

Name: uvrC [H]

Synonym: EUBREC_0693

Alternate gene names: 238923101

Gene position: 635185-637059 (Clockwise)

Preceding gene: 238923100

Following gene: 238923102

Centisome position: 18.41

GC content: 45.97

Gene sequence:

>1875_bases
ATGGAAAAAACATTTGATATCAAAGAAGAATTAAAAAAACTCCCGGATGCCCCGGGAGTTTATATTATGCATGACAAGGA
TGATGTAATCATATATATCGGCAAAGCCAAAAGCCTGACGAAGCGAGTACATCAGTACTTTCAGGCGAGCCACAATGAGG
GCATCAAGAAAAAACAGATGGTAGAGCATATAGATCATTTTGAGTATATAGTCACCGACTCTGAACTTGAGGCCCTTGTT
TTGGAGTGCAATCTGATAAAGGAGCACACACCAAAGTATAATACTATGCTTCGTGATGACAAGACATATCCGTACATCAA
GGTGACACTGGGAGAGGACTATCCGAGGGTGCTGTTTTCGCGCCAGATGAAAAAGGACAAATCCCGTTACTTTGGTCCGT
ATACGAGTGCCTCTGCGGTGAAAAGCTCGATAGATTTGATAAACAAAATCTATAAGCTTCGCACCTGCAACCGCAGGCTG
CCGCGTGATATAGGAGCAGACCGGCCGTGCCTCAACTATCATATACACCAGTGCAATGCACCATGCCAGGGGTATGTAAC
GAAGGAAGAGTATGCCATATCTGTAAAGGGCGCGATAGATTTCTTAAACGGCGACTATGAGCAGACAATAAAGGCTCTTA
GCGATAAAATGCTAAAGGCTTCAGAGAGCATGGAGTTTGAAAAAGCGGCTGAATACAGGGATCTGATAAACAGTGTGAAA
CAGGTAGCACAGAAGCAGAAGATAACAAATGCCGACGGCGAGGATAAGGATATCATAGCACTGGCAAATGACGATACTGA
TGCAGTGGTGCAGGTATTTTTCATAAGAAACGGAAAGCTGATAGGCAGAGATCATTTCCATGTGAGGGTCGGAAGCGAGG
AGGCTGCGGATGATGTGTTAAATAACTTTGTGAAGCAGTTTTATTCAGGAACACCTTTTATACCGCGCGAGGTCATGCTG
CAGAGTGAGATAGAGGATATGGCTGTTTTGGAGCAGTGGCTCAGTGAAAAGCGAGGCAGGCGTGTAAATATAAAGGTGCC
GCAGAAGGGCATGAAGGAAAAGCTTGTTGAGCTTGCCTACAAGAACGCACTCTTAGTGCTCAGCCAGGATAAGGAGCGGA
TAAAGAGAGAAGAGGGGCGCACAATAGGAGCTGTAAAGGAAATCGAGGGACTTTTGGGCTTACATGGATTAAACCGTATG
GAGGCCTATGATATTTCCAATATCAACGGCTTTGAGACTGTCGGCTCCATGATAGTGTATGAGAAGGGCAAGCCTAAAAA
GAGCGATTACAGAAAGTTTAAGCTTCGCACAGTTACAGGACCTGATGATTATGCGTCAATGCACGAGGTGCTCACACGCC
GCTTTACACATGGCATGGAAGAACAGAAGCAGCTTGAAAAAGATGGCTCTCCACAGGAAATAGGCAGCTTCAACCGTTTT
CCGGATATTATAATGATGGATGGTGGAAGAGGTCAGGTAAATATATGCCTTCAGGTGCTTTCCGAGCTGGGACTCGACAT
ACCTGTGTGTGGTATGGTGAAGGATGATTTTCACCGCACAAGAGGTCTTTATTACAACAATGTGGAGATACCTATCGACC
GCCACGGCGAAGGCTTCAAGCTCATCACGAGAATACAGGATGAGGCACACCGCTTTGCAATAGAGTTTCATAGGTCACTG
CGCTCAAAAAGTCAGGTACATTCGGTGCTTGATGATATTGAAGGCATAGGGCCGGCACGCAGAAAGGCGCTCATGCGCCG
CTACCAGTCGCTAGAGAAGATAAAGGAAGCAGATGTCGAAGACCTTATGCAGACAGAGACCATGAACGAAAAAGCAGCAC
AGGCAGTGTATGCATTTTTCCACTCTGCCACGTAG

Upstream 100 bases:

>100_bases
GCTGACTTCATATTTTCCTGAGGAATACACTGTGTGCCATGCCGGCAACCACACAACCTAAAAGTGCGAAACTCCACCAC
AACCAACCCAAAGAGCGAAT

Downstream 100 bases:

>100_bases
ATTTTGAAGCTAATCTGTGGTATACTAAAAAACAAATATACATCAAGGGGGACCGCGAATGGATGCATTACACTCAGTAT
CAGTTGCAAAGGTAGCAGAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MEKTFDIKEELKKLPDAPGVYIMHDKDDVIIYIGKAKSLTKRVHQYFQASHNEGIKKKQMVEHIDHFEYIVTDSELEALV
LECNLIKEHTPKYNTMLRDDKTYPYIKVTLGEDYPRVLFSRQMKKDKSRYFGPYTSASAVKSSIDLINKIYKLRTCNRRL
PRDIGADRPCLNYHIHQCNAPCQGYVTKEEYAISVKGAIDFLNGDYEQTIKALSDKMLKASESMEFEKAAEYRDLINSVK
QVAQKQKITNADGEDKDIIALANDDTDAVVQVFFIRNGKLIGRDHFHVRVGSEEAADDVLNNFVKQFYSGTPFIPREVML
QSEIEDMAVLEQWLSEKRGRRVNIKVPQKGMKEKLVELAYKNALLVLSQDKERIKREEGRTIGAVKEIEGLLGLHGLNRM
EAYDISNINGFETVGSMIVYEKGKPKKSDYRKFKLRTVTGPDDYASMHEVLTRRFTHGMEEQKQLEKDGSPQEIGSFNRF
PDIIMMDGGRGQVNICLQVLSELGLDIPVCGMVKDDFHRTRGLYYNNVEIPIDRHGEGFKLITRIQDEAHRFAIEFHRSL
RSKSQVHSVLDDIEGIGPARRKALMRRYQSLEKIKEADVEDLMQTETMNEKAAQAVYAFFHSAT

Sequences:

>Translated_624_residues
MEKTFDIKEELKKLPDAPGVYIMHDKDDVIIYIGKAKSLTKRVHQYFQASHNEGIKKKQMVEHIDHFEYIVTDSELEALV
LECNLIKEHTPKYNTMLRDDKTYPYIKVTLGEDYPRVLFSRQMKKDKSRYFGPYTSASAVKSSIDLINKIYKLRTCNRRL
PRDIGADRPCLNYHIHQCNAPCQGYVTKEEYAISVKGAIDFLNGDYEQTIKALSDKMLKASESMEFEKAAEYRDLINSVK
QVAQKQKITNADGEDKDIIALANDDTDAVVQVFFIRNGKLIGRDHFHVRVGSEEAADDVLNNFVKQFYSGTPFIPREVML
QSEIEDMAVLEQWLSEKRGRRVNIKVPQKGMKEKLVELAYKNALLVLSQDKERIKREEGRTIGAVKEIEGLLGLHGLNRM
EAYDISNINGFETVGSMIVYEKGKPKKSDYRKFKLRTVTGPDDYASMHEVLTRRFTHGMEEQKQLEKDGSPQEIGSFNRF
PDIIMMDGGRGQVNICLQVLSELGLDIPVCGMVKDDFHRTRGLYYNNVEIPIDRHGEGFKLITRIQDEAHRFAIEFHRSL
RSKSQVHSVLDDIEGIGPARRKALMRRYQSLEKIKEADVEDLMQTETMNEKAAQAVYAFFHSAT
>Mature_624_residues
MEKTFDIKEELKKLPDAPGVYIMHDKDDVIIYIGKAKSLTKRVHQYFQASHNEGIKKKQMVEHIDHFEYIVTDSELEALV
LECNLIKEHTPKYNTMLRDDKTYPYIKVTLGEDYPRVLFSRQMKKDKSRYFGPYTSASAVKSSIDLINKIYKLRTCNRRL
PRDIGADRPCLNYHIHQCNAPCQGYVTKEEYAISVKGAIDFLNGDYEQTIKALSDKMLKASESMEFEKAAEYRDLINSVK
QVAQKQKITNADGEDKDIIALANDDTDAVVQVFFIRNGKLIGRDHFHVRVGSEEAADDVLNNFVKQFYSGTPFIPREVML
QSEIEDMAVLEQWLSEKRGRRVNIKVPQKGMKEKLVELAYKNALLVLSQDKERIKREEGRTIGAVKEIEGLLGLHGLNRM
EAYDISNINGFETVGSMIVYEKGKPKKSDYRKFKLRTVTGPDDYASMHEVLTRRFTHGMEEQKQLEKDGSPQEIGSFNRF
PDIIMMDGGRGQVNICLQVLSELGLDIPVCGMVKDDFHRTRGLYYNNVEIPIDRHGEGFKLITRIQDEAHRFAIEFHRSL
RSKSQVHSVLDDIEGIGPARRKALMRRYQSLEKIKEADVEDLMQTETMNEKAAQAVYAFFHSAT

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=634, Percent_Identity=34.5425867507886, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1788037, Length=199, Percent_Identity=26.6331658291457, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 71738; Mature: 71738

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKTFDIKEELKKLPDAPGVYIMHDKDDVIIYIGKAKSLTKRVHQYFQASHNEGIKKKQM
CCCCCCHHHHHHHCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHH
VEHIDHFEYIVTDSELEALVLECNLIKEHTPKYNTMLRDDKTYPYIKVTLGEDYPRVLFS
HHHHHHHHEEEECCHHHHHHHHHHHHHHCCCCHHCEECCCCCCCEEEEEECCCHHHHHHH
RQMKKDKSRYFGPYTSASAVKSSIDLINKIYKLRTCNRRLPRDIGADRPCLNYHIHQCNA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHCEEHCCCC
PCQGYVTKEEYAISVKGAIDFLNGDYEQTIKALSDKMLKASESMEFEKAAEYRDLINSVK
CCCCCEECCCEEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QVAQKQKITNADGEDKDIIALANDDTDAVVQVFFIRNGKLIGRDHFHVRVGSEEAADDVL
HHHHHHHCCCCCCCCCCEEEEECCCCHHHEEEEEEECCEEECCCEEEEEECCHHHHHHHH
NNFVKQFYSGTPFIPREVMLQSEIEDMAVLEQWLSEKRGRRVNIKVPQKGMKEKLVELAY
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHH
KNALLVLSQDKERIKREEGRTIGAVKEIEGLLGLHGLNRMEAYDISNINGFETVGSMIVY
CCEEEEEECCHHHHHHHCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCEEEE
EKGKPKKSDYRKFKLRTVTGPDDYASMHEVLTRRFTHGMEEQKQLEKDGSPQEIGSFNRF
ECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHCCCCCC
PDIIMMDGGRGQVNICLQVLSELGLDIPVCGMVKDDFHRTRGLYYNNVEIPIDRHGEGFK
CCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEECCEEEEECCCCCCHH
LITRIQDEAHRFAIEFHRSLRSKSQVHSVLDDIEGIGPARRKALMRRYQSLEKIKEADVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHH
DLMQTETMNEKAAQAVYAFFHSAT
HHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKTFDIKEELKKLPDAPGVYIMHDKDDVIIYIGKAKSLTKRVHQYFQASHNEGIKKKQM
CCCCCCHHHHHHHCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHH
VEHIDHFEYIVTDSELEALVLECNLIKEHTPKYNTMLRDDKTYPYIKVTLGEDYPRVLFS
HHHHHHHHEEEECCHHHHHHHHHHHHHHCCCCHHCEECCCCCCCEEEEEECCCHHHHHHH
RQMKKDKSRYFGPYTSASAVKSSIDLINKIYKLRTCNRRLPRDIGADRPCLNYHIHQCNA
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHCEEHCCCC
PCQGYVTKEEYAISVKGAIDFLNGDYEQTIKALSDKMLKASESMEFEKAAEYRDLINSVK
CCCCCEECCCEEEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
QVAQKQKITNADGEDKDIIALANDDTDAVVQVFFIRNGKLIGRDHFHVRVGSEEAADDVL
HHHHHHHCCCCCCCCCCEEEEECCCCHHHEEEEEEECCEEECCCEEEEEECCHHHHHHHH
NNFVKQFYSGTPFIPREVMLQSEIEDMAVLEQWLSEKRGRRVNIKVPQKGMKEKLVELAY
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHH
KNALLVLSQDKERIKREEGRTIGAVKEIEGLLGLHGLNRMEAYDISNINGFETVGSMIVY
CCEEEEEECCHHHHHHHCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCEEEE
EKGKPKKSDYRKFKLRTVTGPDDYASMHEVLTRRFTHGMEEQKQLEKDGSPQEIGSFNRF
ECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHCCCCCC
PDIIMMDGGRGQVNICLQVLSELGLDIPVCGMVKDDFHRTRGLYYNNVEIPIDRHGEGFK
CCEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEECCEEEEECCCCCCHH
LITRIQDEAHRFAIEFHRSLRSKSQVHSVLDDIEGIGPARRKALMRRYQSLEKIKEADVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHH
DLMQTETMNEKAAQAVYAFFHSAT
HHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA