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The map label for this gene is adk

Identifier: 238922850

GI number: 238922850

Start: 394369

End: 395013

Strand: Direct

Name: adk

Synonym: EUBREC_0438

Alternate gene names: 238922850

Gene position: 394369-395013 (Clockwise)

Preceding gene: 238922849

Following gene: 238922851

Centisome position: 11.43

GC content: 43.1

Gene sequence:

>645_bases
ATGAAGATCATCATGTTAGGGGCACCTGGTGCCGGCAAAGGTACACAGGCAAAACAGATAGCTGCAAAATATTCTATACC
ACATATCTCTACAGGAGATATATTCCGTGCAAACATCAAGAACGGAACAGAGCTTGGTAAGAAGGCAAAGACTTACATGG
ATCAGGGAGCACTTGTTCCGGATGAGCTTACCTGTGACCTTGTTATGGATAGAATACAGCAGGATGATTGCAAAAACGGA
TTTGTATTAGACGGTTTCCCAAGAACAATTCCACAGGCAAAGGCGCTTGATGATGCTCTCACAAAGATTGGGGAGAAGAT
GGATTATGCCATCGATGTAGATGTTCCTGATGAGAACATTGTTAACCGTATGGGTGGAAGAAGAGCCTGCCTCAATTGTG
GTGCAACATATCATATCGTTTTCAATCCAACAAAGGTTGAGGGCAAATGTGATGCATGTGGCGCTGACACAGTACTTAGA
GATGACGATAAGCCGGAGACAGTTCAGAAGCGCTTAGCTGTATATCATGAGCAGACACAGCCACTTATCGAGTATTATGA
CAAGCAGGGCATTTTAAAGTCTGTAGACGGAACAAAGCCTATGGATGAAGTTTTTTCAGCCATTGTAGGTATTTTAGGTG
AATAA

Upstream 100 bases:

>100_bases
TATAAAGGATTTTTAGATGATTAATTGTACATTGGAGATACTGAATTCAGTATCTCCATTCGTGCTATCAACAAGTTTTG
TATAAAAGGAGAAAATTTTT

Downstream 100 bases:

>100_bases
TAATGTCTGTAACTATAAAATCAGAGCATGAGATAGAGCTGATGAGGGAGGCCGGCAGGATTCTGGCGGCCGTTCATCAG
CAGCTCGGTAAAGAAATCAA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MKIIMLGAPGAGKGTQAKQIAAKYSIPHISTGDIFRANIKNGTELGKKAKTYMDQGALVPDELTCDLVMDRIQQDDCKNG
FVLDGFPRTIPQAKALDDALTKIGEKMDYAIDVDVPDENIVNRMGGRRACLNCGATYHIVFNPTKVEGKCDACGADTVLR
DDDKPETVQKRLAVYHEQTQPLIEYYDKQGILKSVDGTKPMDEVFSAIVGILGE

Sequences:

>Translated_214_residues
MKIIMLGAPGAGKGTQAKQIAAKYSIPHISTGDIFRANIKNGTELGKKAKTYMDQGALVPDELTCDLVMDRIQQDDCKNG
FVLDGFPRTIPQAKALDDALTKIGEKMDYAIDVDVPDENIVNRMGGRRACLNCGATYHIVFNPTKVEGKCDACGADTVLR
DDDKPETVQKRLAVYHEQTQPLIEYYDKQGILKSVDGTKPMDEVFSAIVGILGE
>Mature_214_residues
MKIIMLGAPGAGKGTQAKQIAAKYSIPHISTGDIFRANIKNGTELGKKAKTYMDQGALVPDELTCDLVMDRIQQDDCKNG
FVLDGFPRTIPQAKALDDALTKIGEKMDYAIDVDVPDENIVNRMGGRRACLNCGATYHIVFNPTKVEGKCDACGADTVLR
DDDKPETVQKRLAVYHEQTQPLIEYYDKQGILKSVDGTKPMDEVFSAIVGILGE

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=43.4579439252336, Blast_Score=197, Evalue=8e-51,
Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=43.4579439252336, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI19923437, Length=216, Percent_Identity=40.7407407407407, Blast_Score=175, Evalue=3e-44,
Organism=Homo sapiens, GI310110345, Length=199, Percent_Identity=38.6934673366834, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI53832003, Length=199, Percent_Identity=38.6934673366834, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI8051579, Length=199, Percent_Identity=38.6934673366834, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI53832001, Length=199, Percent_Identity=38.6934673366834, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI4502011, Length=207, Percent_Identity=31.8840579710145, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI7706497, Length=215, Percent_Identity=29.3023255813954, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI28144899, Length=208, Percent_Identity=25.9615384615385, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI28144897, Length=208, Percent_Identity=25.9615384615385, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI22749187, Length=143, Percent_Identity=28.6713286713287, Blast_Score=81, Evalue=5e-16,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=55.9633027522936, Blast_Score=236, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI17552384, Length=208, Percent_Identity=42.7884615384615, Blast_Score=189, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17567503, Length=212, Percent_Identity=29.2452830188679, Blast_Score=113, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17533833, Length=213, Percent_Identity=28.169014084507, Blast_Score=100, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17537943, Length=214, Percent_Identity=26.1682242990654, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17550688, Length=212, Percent_Identity=27.8301886792453, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=43.2558139534884, Blast_Score=196, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=38.4615384615385, Blast_Score=142, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6322828, Length=206, Percent_Identity=28.1553398058252, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI22026816, Length=209, Percent_Identity=42.5837320574163, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI17737899, Length=210, Percent_Identity=40.9523809523809, Blast_Score=157, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24645822, Length=210, Percent_Identity=40.9523809523809, Blast_Score=157, Evalue=7e-39,
Organism=Drosophila melanogaster, GI221459597, Length=211, Percent_Identity=27.4881516587678, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21356893, Length=211, Percent_Identity=27.4881516587678, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24663208, Length=208, Percent_Identity=26.4423076923077, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17647141, Length=208, Percent_Identity=26.4423076923077, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_EUBR3 (C4ZBT9)

Other databases:

- EMBL:   CP001107
- RefSeq:   YP_002936363.1
- GeneID:   7966606
- GenomeReviews:   CP001107_GR
- KEGG:   ere:EUBREC_0438
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23383; Mature: 23383

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIMLGAPGAGKGTQAKQIAAKYSIPHISTGDIFRANIKNGTELGKKAKTYMDQGALVP
CEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCC
DELTCDLVMDRIQQDDCKNGFVLDGFPRTIPQAKALDDALTKIGEKMDYAIDVDVPDENI
CHHHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHH
VNRMGGRRACLNCGATYHIVFNPTKVEGKCDACGADTVLRDDDKPETVQKRLAVYHEQTQ
HHHCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCH
PLIEYYDKQGILKSVDGTKPMDEVFSAIVGILGE
HHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIIMLGAPGAGKGTQAKQIAAKYSIPHISTGDIFRANIKNGTELGKKAKTYMDQGALVP
CEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCC
DELTCDLVMDRIQQDDCKNGFVLDGFPRTIPQAKALDDALTKIGEKMDYAIDVDVPDENI
CHHHHHHHHHHHHHHCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHH
VNRMGGRRACLNCGATYHIVFNPTKVEGKCDACGADTVLRDDDKPETVQKRLAVYHEQTQ
HHHCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCH
PLIEYYDKQGILKSVDGTKPMDEVFSAIVGILGE
HHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA