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The map label for this gene is tktA [C]

Identifier: 238922755

GI number: 238922755

Start: 301545

End: 302399

Strand: Direct

Name: tktA [C]

Synonym: EUBREC_0331

Alternate gene names: 238922755

Gene position: 301545-302399 (Clockwise)

Preceding gene: 238922754

Following gene: 238922756

Centisome position: 8.74

GC content: 47.25

Gene sequence:

>855_bases
ATGATAGAAGGAGACATCATGAACAATCTTGAACTTGAGAAGATGGCGAATGAAATTCGCAAGGACATTGTGACAGCAGT
TCACAGTGCCAAATCCGGACATCCGGGTGGATCACTTTCATCAGCAGATATTTTTACATATCTGTATTTTGAGGAGATGA
ATGTAGACCCTGCCAATCCTAAATGGGAGGACAGGGACCGTTTCGTGCTCTCAAAGGGACACGTAGCACCGGGACTTTAC
TCTACACTCGCAGAGAAAGGATATTTTCCAAAGGAGGATTTAAAGACACTCCGTCATACAGGCTCATATCTGCAGGGACA
TCCTGATATGAAGCACATCCCTGGCATTGATATGTCAAGCGGCTCTCTCGGACAGGGTGTATCTGTCGCAGTAGGAATGG
CTGCAGCAGGAAAATATGACAAGAAGGATTACCGTGTATACACACTCACAGGAGATGGCGAGATTCAGGAGGGACAGATC
TGGGAGGCAGCCATGTGGGCAGGCCACCGCAAGCTCGACAACCTCGTAGTCATCGTTGACAACAACAACCTCCAGATAGA
CGGTTCTGTTGAGGATGTATGCTCACCATACCCAATCGACAAGAAGTTTGAGGCATTCAATTTCCACGTAATCAATATCG
ATGGCAACGATTTTGACCAGATCAGGGCAGCCTTCAAGGAAGCCCGTGAGACAAAGGGCATGCCTACAGCCATTATCGCA
AAGACTGTAAAGGGCAAGGGCGTATCCTTCATGGAAAATGCCGCAGGATGGCATGGAAAGGCTCCAAATGACGAGGAGTA
TGAAATTGCAATGGCAGACTTAGAAAAGGCAGGTGAAGCATTATGTCAGAAGTAA

Upstream 100 bases:

>100_bases
AGTGACACGAATCGCAAGCGGAGTTCCCGTAGGAGGCGATTTGGAATATATTGACGAGGTGACCCTGCTTAGGGCGCTTC
AGGGAAGAACAGAGATATAA

Downstream 100 bases:

>100_bases
AGAAAATCGCTACAAGAGATAGCTACGGAAACGCACTCGTAGAGCTTGGAAAAGCACACGATGACCTTATTGTACTTGAT
GCTGACCTGGCAGGTGCCAC

Product: transketolase domain protein

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MIEGDIMNNLELEKMANEIRKDIVTAVHSAKSGHPGGSLSSADIFTYLYFEEMNVDPANPKWEDRDRFVLSKGHVAPGLY
STLAEKGYFPKEDLKTLRHTGSYLQGHPDMKHIPGIDMSSGSLGQGVSVAVGMAAAGKYDKKDYRVYTLTGDGEIQEGQI
WEAAMWAGHRKLDNLVVIVDNNNLQIDGSVEDVCSPYPIDKKFEAFNFHVINIDGNDFDQIRAAFKEARETKGMPTAIIA
KTVKGKGVSFMENAAGWHGKAPNDEEYEIAMADLEKAGEALCQK

Sequences:

>Translated_284_residues
MIEGDIMNNLELEKMANEIRKDIVTAVHSAKSGHPGGSLSSADIFTYLYFEEMNVDPANPKWEDRDRFVLSKGHVAPGLY
STLAEKGYFPKEDLKTLRHTGSYLQGHPDMKHIPGIDMSSGSLGQGVSVAVGMAAAGKYDKKDYRVYTLTGDGEIQEGQI
WEAAMWAGHRKLDNLVVIVDNNNLQIDGSVEDVCSPYPIDKKFEAFNFHVINIDGNDFDQIRAAFKEARETKGMPTAIIA
KTVKGKGVSFMENAAGWHGKAPNDEEYEIAMADLEKAGEALCQK
>Mature_284_residues
MIEGDIMNNLELEKMANEIRKDIVTAVHSAKSGHPGGSLSSADIFTYLYFEEMNVDPANPKWEDRDRFVLSKGHVAPGLY
STLAEKGYFPKEDLKTLRHTGSYLQGHPDMKHIPGIDMSSGSLGQGVSVAVGMAAAGKYDKKDYRVYTLTGDGEIQEGQI
WEAAMWAGHRKLDNLVVIVDNNNLQIDGSVEDVCSPYPIDKKFEAFNFHVINIDGNDFDQIRAAFKEARETKGMPTAIIA
KTVKGKGVSFMENAAGWHGKAPNDEEYEIAMADLEKAGEALCQK

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=258, Percent_Identity=44.5736434108527, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI4507521, Length=258, Percent_Identity=44.5736434108527, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI133778974, Length=278, Percent_Identity=39.2086330935252, Blast_Score=191, Evalue=4e-49,
Organism=Homo sapiens, GI225637459, Length=252, Percent_Identity=34.5238095238095, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI225637461, Length=252, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI225637463, Length=218, Percent_Identity=33.9449541284404, Blast_Score=122, Evalue=3e-28,
Organism=Escherichia coli, GI48994911, Length=258, Percent_Identity=39.922480620155, Blast_Score=167, Evalue=5e-43,
Organism=Escherichia coli, GI1788808, Length=272, Percent_Identity=37.1323529411765, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1786304, Length=264, Percent_Identity=27.6515151515151, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539652, Length=254, Percent_Identity=47.244094488189, Blast_Score=221, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6325331, Length=256, Percent_Identity=39.84375, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319593, Length=270, Percent_Identity=37.4074074074074, Blast_Score=154, Evalue=2e-38,
Organism=Drosophila melanogaster, GI45551847, Length=263, Percent_Identity=44.106463878327, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI45550715, Length=263, Percent_Identity=44.106463878327, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24666278, Length=266, Percent_Identity=42.1052631578947, Blast_Score=207, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24645119, Length=228, Percent_Identity=45.6140350877193, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 31306; Mature: 31306

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEGDIMNNLELEKMANEIRKDIVTAVHSAKSGHPGGSLSSADIFTYLYFEEMNVDPANP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCCCCCC
KWEDRDRFVLSKGHVAPGLYSTLAEKGYFPKEDLKTLRHTGSYLQGHPDMKHIPGIDMSS
CCCCCCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHCCHHHCCCCCCCCCCCCCCCC
GSLGQGVSVAVGMAAAGKYDKKDYRVYTLTGDGEIQEGQIWEAAMWAGHRKLDNLVVIVD
CCCCCCCEEEEEHHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCEEEEEE
NNNLQIDGSVEDVCSPYPIDKKFEAFNFHVINIDGNDFDQIRAAFKEARETKGMPTAIIA
CCCEEECCCHHHHCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHH
KTVKGKGVSFMENAAGWHGKAPNDEEYEIAMADLEKAGEALCQK
EHHCCCCCHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIEGDIMNNLELEKMANEIRKDIVTAVHSAKSGHPGGSLSSADIFTYLYFEEMNVDPANP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEECCCCCCCC
KWEDRDRFVLSKGHVAPGLYSTLAEKGYFPKEDLKTLRHTGSYLQGHPDMKHIPGIDMSS
CCCCCCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHCCHHHCCCCCCCCCCCCCCCC
GSLGQGVSVAVGMAAAGKYDKKDYRVYTLTGDGEIQEGQIWEAAMWAGHRKLDNLVVIVD
CCCCCCCEEEEEHHHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCEEEEEE
NNNLQIDGSVEDVCSPYPIDKKFEAFNFHVINIDGNDFDQIRAAFKEARETKGMPTAIIA
CCCEEECCCHHHHCCCCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHH
KTVKGKGVSFMENAAGWHGKAPNDEEYEIAMADLEKAGEALCQK
EHHCCCCCHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]