Click here to switch to the map view.

The map label for this gene is dxs [C]

Identifier: 238922756

GI number: 238922756

Start: 302387

End: 303328

Strand: Direct

Name: dxs [C]

Synonym: EUBREC_0332

Alternate gene names: 238922756

Gene position: 302387-303328 (Clockwise)

Preceding gene: 238922755

Following gene: 238922757

Centisome position: 8.77

GC content: 47.35

Gene sequence:

>942_bases
ATGTCAGAAGTAAAGAAAATCGCTACAAGAGATAGCTACGGAAACGCACTCGTAGAGCTTGGAAAAGCACACGATGACCT
TATTGTACTTGATGCTGACCTGGCAGGTGCCACAAAGACCTGTATCTTCCAGAAGGAGTTTCCTGAGCGTCACTGGGACT
GCGGAATCGCAGAGTGTAATATGACAGGTATCGCAGCAGGACTTGCTACATGCGGCAAGGTGCCTTTTATCAGCTCATTT
GCCATGTTTGCAGCAGGAAGAAACTATGACCAGGTAAGAAACTCAATCGGATATCCTCATCTCAATGTCAAGATAGGTGC
CACACATGCAGGAATCTCTGTAGGTGAGGACGGAGCTACACATCAGTGCCTCGAGGACCTTTCGCTCATGAGAGAAATCC
CGGGCATGGTTGTAATAAACCCATCAGACGATGTGGAGGCAAGAGCCGCAGTAAAGGCTGCATATGACCATGTGGGCCCT
GTATACCTTAGATTCGGCAGACTTGCAGTGCCTGTAATCAACGACACACCGGACTACAAGTTTGAAATCGGAAAGGGTAT
TGTACTCAAGGAAGGCAAGGATGTATCTATATTTGCAACAGGACTTGAGGTATCAGAGACACTTGAGGCAGCAAAAATGC
TCGCAGCAGACGGCATAGATGCTGAGGTTATCAATATCCATACAATCAAGCCAATCGATAGAGAGCTGATTGTTAAATCT
GTATCAAAGACAGGCAAGGCAGTTACAGTAGAGGAACATTCTATCAATGGAGGACTCGGAAGTGCTGTGGCAGAGGTACT
CTGTGAGGAGCAGCCTGCAAAGCTTCTGCGTATCGGTGTTGAGGACCGTTTCGGCGAGTCAGGACCGGCAGTGGAGCTTA
TCCACAAGTATGGACTGGATGCAGAGGGCATCTACAACAAAGTAAAGAATTATATGAAGTAG

Upstream 100 bases:

>100_bases
TATCCTTCATGGAAAATGCCGCAGGATGGCATGGAAAGGCTCCAAATGACGAGGAGTATGAAATTGCAATGGCAGACTTA
GAAAAGGCAGGTGAAGCATT

Downstream 100 bases:

>100_bases
TGGATTTTATGTGCTTCGCACTTGGAGGCTGTGTTCACCGGTGCAGCATACAGTATATTCCTCAGAAAAATATGAAGTCA
GCCGCAGGATTTCGTGTGGA

Product: transketolase, C-terminal subunit

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSEVKKIATRDSYGNALVELGKAHDDLIVLDADLAGATKTCIFQKEFPERHWDCGIAECNMTGIAAGLATCGKVPFISSF
AMFAAGRNYDQVRNSIGYPHLNVKIGATHAGISVGEDGATHQCLEDLSLMREIPGMVVINPSDDVEARAAVKAAYDHVGP
VYLRFGRLAVPVINDTPDYKFEIGKGIVLKEGKDVSIFATGLEVSETLEAAKMLAADGIDAEVINIHTIKPIDRELIVKS
VSKTGKAVTVEEHSINGGLGSAVAEVLCEEQPAKLLRIGVEDRFGESGPAVELIHKYGLDAEGIYNKVKNYMK

Sequences:

>Translated_313_residues
MSEVKKIATRDSYGNALVELGKAHDDLIVLDADLAGATKTCIFQKEFPERHWDCGIAECNMTGIAAGLATCGKVPFISSF
AMFAAGRNYDQVRNSIGYPHLNVKIGATHAGISVGEDGATHQCLEDLSLMREIPGMVVINPSDDVEARAAVKAAYDHVGP
VYLRFGRLAVPVINDTPDYKFEIGKGIVLKEGKDVSIFATGLEVSETLEAAKMLAADGIDAEVINIHTIKPIDRELIVKS
VSKTGKAVTVEEHSINGGLGSAVAEVLCEEQPAKLLRIGVEDRFGESGPAVELIHKYGLDAEGIYNKVKNYMK
>Mature_312_residues
SEVKKIATRDSYGNALVELGKAHDDLIVLDADLAGATKTCIFQKEFPERHWDCGIAECNMTGIAAGLATCGKVPFISSFA
MFAAGRNYDQVRNSIGYPHLNVKIGATHAGISVGEDGATHQCLEDLSLMREIPGMVVINPSDDVEARAAVKAAYDHVGPV
YLRFGRLAVPVINDTPDYKFEIGKGIVLKEGKDVSIFATGLEVSETLEAAKMLAADGIDAEVINIHTIKPIDRELIVKSV
SKTGKAVTVEEHSINGGLGSAVAEVLCEEQPAKLLRIGVEDRFGESGPAVELIHKYGLDAEGIYNKVKNYMK

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=309, Percent_Identity=38.5113268608414, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4507521, Length=309, Percent_Identity=38.5113268608414, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI225637459, Length=308, Percent_Identity=37.987012987013, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI225637463, Length=308, Percent_Identity=37.987012987013, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI225637461, Length=308, Percent_Identity=37.987012987013, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI133778974, Length=302, Percent_Identity=35.7615894039735, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI291084858, Length=275, Percent_Identity=26.9090909090909, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI156564403, Length=283, Percent_Identity=26.8551236749117, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786622, Length=302, Percent_Identity=35.4304635761589, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1788808, Length=320, Percent_Identity=32.8125, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI48994911, Length=321, Percent_Identity=28.0373831775701, Blast_Score=88, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17539652, Length=312, Percent_Identity=37.5, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17538422, Length=294, Percent_Identity=29.2517006802721, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17506935, Length=143, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319698, Length=288, Percent_Identity=29.8611111111111, Blast_Score=86, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6325331, Length=271, Percent_Identity=31.3653136531365, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319593, Length=337, Percent_Identity=27.5964391691395, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24645119, Length=314, Percent_Identity=35.6687898089172, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI45551847, Length=314, Percent_Identity=35.6687898089172, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI45550715, Length=314, Percent_Identity=35.6687898089172, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24666278, Length=314, Percent_Identity=35.6687898089172, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI21358145, Length=286, Percent_Identity=30.7692307692308, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24650940, Length=286, Percent_Identity=30.7692307692308, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 33629; Mature: 33498

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVKKIATRDSYGNALVELGKAHDDLIVLDADLAGATKTCIFQKEFPERHWDCGIAECN
CCHHHHHHHCCCCCHHHHHHCCCCCCEEEEECCCCCCCHHEEEEHHCCCCCCCCCCEECC
MTGIAAGLATCGKVPFISSFAMFAAGRNYDQVRNSIGYPHLNVKIGATHAGISVGEDGAT
HHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCH
HQCLEDLSLMREIPGMVVINPSDDVEARAAVKAAYDHVGPVYLRFGRLAVPVINDTPDYK
HHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCHHHEEECCEEEEEECCCCCCE
FEIGKGIVLKEGKDVSIFATGLEVSETLEAAKMLAADGIDAEVINIHTIKPIDRELIVKS
EECCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHH
VSKTGKAVTVEEHSINGGLGSAVAEVLCEEQPAKLLRIGVEDRFGESGPAVELIHKYGLD
HHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCHHHEEECCHHHCCCCCCHHHHHHHHCCC
AEGIYNKVKNYMK
HHHHHHHHHHHCC
>Mature Secondary Structure 
SEVKKIATRDSYGNALVELGKAHDDLIVLDADLAGATKTCIFQKEFPERHWDCGIAECN
CHHHHHHHCCCCCHHHHHHCCCCCCEEEEECCCCCCCHHEEEEHHCCCCCCCCCCEECC
MTGIAAGLATCGKVPFISSFAMFAAGRNYDQVRNSIGYPHLNVKIGATHAGISVGEDGAT
HHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCH
HQCLEDLSLMREIPGMVVINPSDDVEARAAVKAAYDHVGPVYLRFGRLAVPVINDTPDYK
HHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCHHHEEECCEEEEEECCCCCCE
FEIGKGIVLKEGKDVSIFATGLEVSETLEAAKMLAADGIDAEVINIHTIKPIDRELIVKS
EECCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHH
VSKTGKAVTVEEHSINGGLGSAVAEVLCEEQPAKLLRIGVEDRFGESGPAVELIHKYGLD
HHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCHHHEEECCHHHCCCCCCHHHHHHHHCCC
AEGIYNKVKNYMK
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]