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The map label for this gene is dnaX [H]

Identifier: 238922752

GI number: 238922752

Start: 298985

End: 300556

Strand: Direct

Name: dnaX [H]

Synonym: EUBREC_0328

Alternate gene names: 238922752

Gene position: 298985-300556 (Clockwise)

Preceding gene: 238922751

Following gene: 238922753

Centisome position: 8.67

GC content: 48.22

Gene sequence:

>1572_bases
GTGTCTTATCAGGCCCTATACCGTAAGTTCCGTCCACAGGAGTTCGAGGACGTAAAGGGACAGGAACACATTGTAACAAC
ACTGAAAAACCAGATAAAAGCTGACAGAATAGGGCATGCCTATTTATTTTGCGGTACGAGAGGTACGGGAAAGACCACTG
TGGCCAAGATATTTGCAAAGGCAGTCAACTGTGAGCACCCTGTAGACGGAAGCCCGTGCGGCGAATGTCCGTCGTGCAGG
GCAATCACTGAGGGCTCATCCATGAATGTCATAGAGATAGATGCAGCGTCAAACAACGGCGTGGACAATATCAGACAGAT
TCGTGAGGAGGTCACATACCGCCCGACAGAGGGCAGGTACAAGGTCTATATCATCGACGAGGTTCACATGCTTTCGGCAG
GAGCCTTCAATGCACTTTTAAAAACACTCGAGGAGCCGCCGAGCTACGTTATATTTATACTGGCGACCACCGAGGCACAC
AAGATACCGATTACTATCCTGTCCAGATGCCAGCGCTATGATTTTCACAGGATTTCCATAGATACGATTGCATCTAGACT
CAGCGATTTGATGGAACAGGAGCATGTGGAGGTTGAGGAGCGCGCCATAAGGTACGTGGCCAAGGCAGGAGACGGCTCCA
TGAGAGATGCGTTAAGTCTCCTTGACCAGTGCATTGCTTTCCATCTGGGAGAGAAGCTCACCTATGAAAATGTGCTCGAG
GTGCTTGGAGCGGTGGACACAGAGGTGTTTTCAAGGCTCTTAAGGCGCATACTCGACGAGGATGTGACAGGCGCCATCCG
CATACTGGGCGAGCTCATAGATGAGGGCAGGGAGCTGTCGCAGCTTGTCAATGATTTCACCTGGTATATGAGGAATCTTT
TGCTTTTGCAGAGCTCAGACGATATGGAGGAGGTGCTCGACATCTCCAAGGACAATCTTGAGGCACTTAAGGAAGAGGCA
GCGCTTGTAAAGCCTGAGACACTCATCAGGTATATCAGGGTATTTTCCGAGTTGTCCAGCCAGGTAAAGTTTGCATCGCA
AAAGCGTATTATGGTCGAGATAGCCATAATAAAGCTGTGCAGGCCGCAGATGGAAAAGAGCTATGATTCGGTGCTTGACC
GCATAAACAGCATAGAGAAAAAGCTTGAAAAGGGTATACCTATAGCGGCACAGGCTGCGCAGACACAGGATATGCAGCAG
GCCGCAGCAAGCGAGCCTATAGTGAAAAAGGAGCTTCCCAAAGCAATACCACAGGATATCTCAGAGCTCATGAAGCACTG
GAAATCCATACTTTCGGAGATGGGAGCAACATCAAAGGTTTATCTGAACAAGGCTGTGACATCGCTGGGCAATTCATCTG
ACCTGATTTTAATGTTTGATGATGAGAATGCGTATGAGTATCTCTCTGAAAACCGTGCAGGCTGTATGGATACGCTGGCT
TCGCTTATAGAAAAGCGTATAGGCAAAAAAGTCGAGGTGACGGTCAAGAAAAATAATTCCGCAGTCAGCGCAAAGGAAGC
GGTTGTGGACTTGACAGATATGATAAATTTTGATATAGAGGAAGAAAACTAA

Upstream 100 bases:

>100_bases
ACTGTAGATCCAAAGAGCCAGATGATCAAGGAAGCAAAGCGCACCGGCATCTGCTTCGGAGATTAAGCAGCAATATTAGA
TATAAGGAAGGTGAAAAGGC

Downstream 100 bases:

>100_bases
GTTATAAACAGGGCTGGGATTAGCCCATCAAAAACAAGGAGGACGCCAGAATGGCAAGAAGAGGTGGATTCCCTGGAGGA
ATGCCGGGAAACATGAACAA

Product: DNA polymerase III, subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MSYQALYRKFRPQEFEDVKGQEHIVTTLKNQIKADRIGHAYLFCGTRGTGKTTVAKIFAKAVNCEHPVDGSPCGECPSCR
AITEGSSMNVIEIDAASNNGVDNIRQIREEVTYRPTEGRYKVYIIDEVHMLSAGAFNALLKTLEEPPSYVIFILATTEAH
KIPITILSRCQRYDFHRISIDTIASRLSDLMEQEHVEVEERAIRYVAKAGDGSMRDALSLLDQCIAFHLGEKLTYENVLE
VLGAVDTEVFSRLLRRILDEDVTGAIRILGELIDEGRELSQLVNDFTWYMRNLLLLQSSDDMEEVLDISKDNLEALKEEA
ALVKPETLIRYIRVFSELSSQVKFASQKRIMVEIAIIKLCRPQMEKSYDSVLDRINSIEKKLEKGIPIAAQAAQTQDMQQ
AAASEPIVKKELPKAIPQDISELMKHWKSILSEMGATSKVYLNKAVTSLGNSSDLILMFDDENAYEYLSENRAGCMDTLA
SLIEKRIGKKVEVTVKKNNSAVSAKEAVVDLTDMINFDIEEEN

Sequences:

>Translated_523_residues
MSYQALYRKFRPQEFEDVKGQEHIVTTLKNQIKADRIGHAYLFCGTRGTGKTTVAKIFAKAVNCEHPVDGSPCGECPSCR
AITEGSSMNVIEIDAASNNGVDNIRQIREEVTYRPTEGRYKVYIIDEVHMLSAGAFNALLKTLEEPPSYVIFILATTEAH
KIPITILSRCQRYDFHRISIDTIASRLSDLMEQEHVEVEERAIRYVAKAGDGSMRDALSLLDQCIAFHLGEKLTYENVLE
VLGAVDTEVFSRLLRRILDEDVTGAIRILGELIDEGRELSQLVNDFTWYMRNLLLLQSSDDMEEVLDISKDNLEALKEEA
ALVKPETLIRYIRVFSELSSQVKFASQKRIMVEIAIIKLCRPQMEKSYDSVLDRINSIEKKLEKGIPIAAQAAQTQDMQQ
AAASEPIVKKELPKAIPQDISELMKHWKSILSEMGATSKVYLNKAVTSLGNSSDLILMFDDENAYEYLSENRAGCMDTLA
SLIEKRIGKKVEVTVKKNNSAVSAKEAVVDLTDMINFDIEEEN
>Mature_522_residues
SYQALYRKFRPQEFEDVKGQEHIVTTLKNQIKADRIGHAYLFCGTRGTGKTTVAKIFAKAVNCEHPVDGSPCGECPSCRA
ITEGSSMNVIEIDAASNNGVDNIRQIREEVTYRPTEGRYKVYIIDEVHMLSAGAFNALLKTLEEPPSYVIFILATTEAHK
IPITILSRCQRYDFHRISIDTIASRLSDLMEQEHVEVEERAIRYVAKAGDGSMRDALSLLDQCIAFHLGEKLTYENVLEV
LGAVDTEVFSRLLRRILDEDVTGAIRILGELIDEGRELSQLVNDFTWYMRNLLLLQSSDDMEEVLDISKDNLEALKEEAA
LVKPETLIRYIRVFSELSSQVKFASQKRIMVEIAIIKLCRPQMEKSYDSVLDRINSIEKKLEKGIPIAAQAAQTQDMQQA
AASEPIVKKELPKAIPQDISELMKHWKSILSEMGATSKVYLNKAVTSLGNSSDLILMFDDENAYEYLSENRAGCMDTLAS
LIEKRIGKKVEVTVKKNNSAVSAKEAVVDLTDMINFDIEEEN

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=287, Percent_Identity=24.7386759581882, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI31881687, Length=287, Percent_Identity=24.7386759581882, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI6677723, Length=266, Percent_Identity=28.9473684210526, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI194306571, Length=266, Percent_Identity=28.9473684210526, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI194306567, Length=266, Percent_Identity=28.9473684210526, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI31563534, Length=282, Percent_Identity=23.758865248227, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI194306569, Length=185, Percent_Identity=29.1891891891892, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786676, Length=363, Percent_Identity=39.3939393939394, Blast_Score=278, Evalue=6e-76,
Organism=Escherichia coli, GI1787119, Length=232, Percent_Identity=25.4310344827586, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1787341, Length=142, Percent_Identity=30.9859154929577, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17541988, Length=273, Percent_Identity=26.7399267399267, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17554730, Length=267, Percent_Identity=23.2209737827715, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI71986063, Length=299, Percent_Identity=24.0802675585284, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=258, Percent_Identity=25.1937984496124, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322528, Length=309, Percent_Identity=22.9773462783171, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324478, Length=314, Percent_Identity=24.5222929936306, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17647857, Length=283, Percent_Identity=25.7950530035336, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921076, Length=219, Percent_Identity=28.7671232876712, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI18859927, Length=226, Percent_Identity=24.3362831858407, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 58864; Mature: 58733

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQALYRKFRPQEFEDVKGQEHIVTTLKNQIKADRIGHAYLFCGTRGTGKTTVAKIFAK
CCHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
AVNCEHPVDGSPCGECPSCRAITEGSSMNVIEIDAASNNGVDNIRQIREEVTYRPTEGRY
HHCCCCCCCCCCCCCCCCCCEECCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCE
KVYIIDEVHMLSAGAFNALLKTLEEPPSYVIFILATTEAHKIPITILSRCQRYDFHRISI
EEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCEEEH
DTIASRLSDLMEQEHVEVEERAIRYVAKAGDGSMRDALSLLDQCIAFHLGEKLTYENVLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHH
VLGAVDTEVFSRLLRRILDEDVTGAIRILGELIDEGRELSQLVNDFTWYMRNLLLLQSSD
HHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
DMEEVLDISKDNLEALKEEAALVKPETLIRYIRVFSELSSQVKFASQKRIMVEIAIIKLC
CHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPQMEKSYDSVLDRINSIEKKLEKGIPIAAQAAQTQDMQQAAASEPIVKKELPKAIPQDI
CHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SELMKHWKSILSEMGATSKVYLNKAVTSLGNSSDLILMFDDENAYEYLSENRAGCMDTLA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHCCCCCHHHHHH
SLIEKRIGKKVEVTVKKNNSAVSAKEAVVDLTDMINFDIEEEN
HHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SYQALYRKFRPQEFEDVKGQEHIVTTLKNQIKADRIGHAYLFCGTRGTGKTTVAKIFAK
CHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
AVNCEHPVDGSPCGECPSCRAITEGSSMNVIEIDAASNNGVDNIRQIREEVTYRPTEGRY
HHCCCCCCCCCCCCCCCCCCEECCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCE
KVYIIDEVHMLSAGAFNALLKTLEEPPSYVIFILATTEAHKIPITILSRCQRYDFHRISI
EEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCEEEH
DTIASRLSDLMEQEHVEVEERAIRYVAKAGDGSMRDALSLLDQCIAFHLGEKLTYENVLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHH
VLGAVDTEVFSRLLRRILDEDVTGAIRILGELIDEGRELSQLVNDFTWYMRNLLLLQSSD
HHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
DMEEVLDISKDNLEALKEEAALVKPETLIRYIRVFSELSSQVKFASQKRIMVEIAIIKLC
CHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPQMEKSYDSVLDRINSIEKKLEKGIPIAAQAAQTQDMQQAAASEPIVKKELPKAIPQDI
CHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SELMKHWKSILSEMGATSKVYLNKAVTSLGNSSDLILMFDDENAYEYLSENRAGCMDTLA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHCCCCCHHHHHH
SLIEKRIGKKVEVTVKKNNSAVSAKEAVVDLTDMINFDIEEEN
HHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]