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The map label for this gene is cdd [H]

Identifier: 238922719

GI number: 238922719

Start: 275447

End: 275866

Strand: Direct

Name: cdd [H]

Synonym: EUBREC_0294

Alternate gene names: 238922719

Gene position: 275447-275866 (Clockwise)

Preceding gene: 238922718

Following gene: 238922720

Centisome position: 7.98

GC content: 44.76

Gene sequence:

>420_bases
ATGGATAAAAAAACAATTGAAAAACTGATTGATACAGCCATTGCACAGCTTGATTTTTCATATGCGCCGTACTCAGGCTT
CAATGTCGGTGCGGCTCTTTTAGCAAAAAATCAGGCAGTCTACACCGGCTGCAATATAGAAAATGCAGCCTACACACCGA
CAAATTGTGCGGAAAGGACAGCATTTTTCAAGGCAGTGAGTGAAGGTGTGCGGGATTTTGAGGCAATATGTATCGTGGGC
GGAAAGAACCAAAAACCGACAGGTTATACAGCGCCATGCGGAGTATGCCGCCAGGTTATGATGGAGTTTTGTAATCCGAA
GACCTTTAAAATAATACTGGCGATTGACAGGGAAAATTATAGGATTTTTACGCTTGAGGATATGCTCCCGCAGGGGTTCG
GACCTGCGAACCTTGAGTAG

Upstream 100 bases:

>100_bases
TTGAGCTTGGCGCTGACAGGCTTGGGACAAGCCGTGTGGTGAAGCTTATTAAGGCTATGGAATGAATTTTCGTATACAAT
AAATAACCGGGGAATTATAT

Downstream 100 bases:

>100_bases
AGCGACCTGTAGCTGTACCTTTAAGGGGCTGCATAATGGTCTGTAATAGTTGTTGATTATATGGTCGTGTGAACATTAGC
CGCCTCAACAGGAAGTGGGA

Product: cytidine deaminase

Products: NA

Alternate protein names: CDA; Cytidine aminohydrolase [H]

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MDKKTIEKLIDTAIAQLDFSYAPYSGFNVGAALLAKNQAVYTGCNIENAAYTPTNCAERTAFFKAVSEGVRDFEAICIVG
GKNQKPTGYTAPCGVCRQVMMEFCNPKTFKIILAIDRENYRIFTLEDMLPQGFGPANLE

Sequences:

>Translated_139_residues
MDKKTIEKLIDTAIAQLDFSYAPYSGFNVGAALLAKNQAVYTGCNIENAAYTPTNCAERTAFFKAVSEGVRDFEAICIVG
GKNQKPTGYTAPCGVCRQVMMEFCNPKTFKIILAIDRENYRIFTLEDMLPQGFGPANLE
>Mature_139_residues
MDKKTIEKLIDTAIAQLDFSYAPYSGFNVGAALLAKNQAVYTGCNIENAAYTPTNCAERTAFFKAVSEGVRDFEAICIVG
GKNQKPTGYTAPCGVCRQVMMEFCNPKTFKIILAIDRENYRIFTLEDMLPQGFGPANLE

Specific function: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis [H]

COG id: COG0295

COG function: function code F; Cytidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI11386157, Length=139, Percent_Identity=39.568345323741, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17540514, Length=133, Percent_Identity=37.593984962406, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17551074, Length=134, Percent_Identity=38.8059701492537, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323274, Length=138, Percent_Identity=32.6086956521739, Blast_Score=94, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24582741, Length=136, Percent_Identity=44.1176470588235, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24582744, Length=96, Percent_Identity=50, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI19920920, Length=102, Percent_Identity=49.0196078431373, Blast_Score=99, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002125
- InterPro:   IPR006262
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.5 [H]

Molecular weight: Translated: 15311; Mature: 15311

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKTIEKLIDTAIAQLDFSYAPYSGFNVGAALLAKNQAVYTGCNIENAAYTPTNCAERT
CCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHH
AFFKAVSEGVRDFEAICIVGGKNQKPTGYTAPCGVCRQVMMEFCNPKTFKIILAIDRENY
HHHHHHHHHHHCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCE
RIFTLEDMLPQGFGPANLE
EEEEEHHHCCCCCCCCCCC
>Mature Secondary Structure
MDKKTIEKLIDTAIAQLDFSYAPYSGFNVGAALLAKNQAVYTGCNIENAAYTPTNCAERT
CCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHH
AFFKAVSEGVRDFEAICIVGGKNQKPTGYTAPCGVCRQVMMEFCNPKTFKIILAIDRENY
HHHHHHHHHHHCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCE
RIFTLEDMLPQGFGPANLE
EEEEEHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11739901 [H]