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The map label for this gene is rsmA [H]

Identifier: 238922667

GI number: 238922667

Start: 224170

End: 225036

Strand: Direct

Name: rsmA [H]

Synonym: EUBREC_0242

Alternate gene names: 238922667

Gene position: 224170-225036 (Clockwise)

Preceding gene: 238922666

Following gene: 238922668

Centisome position: 6.5

GC content: 43.71

Gene sequence:

>867_bases
ATGGCATATTTGGGAAATCCTAAGAACACAATCGAGGTTCTGCAGAAATACAATTTCAATTTTCAAAAGAAATTCGGACA
GAACTTCCTTATTGATACAGGCATTTTGGAGGAAATCATAGACTCGGCCGGCATCACAAAGGACGATATGATACTTGAGA
TAGGCCCGGGAATAGGTACGATGACACAGTATCTGTGTGAGTCGGCGCGCCAGGTAATAGCAGTCGAGATAGATACAAAT
CTGATACCTATACTTAAGGATACTCTGAGTGAATATGATAATGTAAAGGTCATAAATGATGATATATTAAAGGTAGACAT
AAATGCTCTGGCAGAAGAATATAATAATGGTAAGCCGATAAAGGTTGTTGCAAACCTGCCATATTACATAACGACACCTA
TTATTATGGGGCTGTTCGAGAGTCATGTGCCGATAGACAGTATTACAATTATGGTGCAGAAGGAGGTCGCAGACCGTATG
CAGGCAGCTCCCGGCAAGAAGGATTACGGAGCTCTGTCACTTGCTGTGCAGTATTATTCGCACCCTGAGATAGTGGTAAA
TGTGCCGCCAAGCTGTTTCATGCCACAGCCAAAGGTAGGAAGCTCTGTTATATCGCTCAAGCGATACGAAAAGCCGGTGG
TTGACGTAGAGGATGAAAAGCTGATGTTCAAAATCATCAGGGCATCCTTCAACCAGCGCAGGAAAACTCTTGCAAACGGG
CTCAACAATTTCGGTGGTATGGGACTGACCAAGGAGCAGATACAGCAGAGCATAGAGGCTCTCGGAGTCCCTGTAAATGT
GCGTGGTGAGGCTCTAAGTCTTGCACAGTTTGCACAATTATCAAATATAATTGGTGCCGCAAAATAG

Upstream 100 bases:

>100_bases
CGAATATAATTGAAATAAAGGCATTTCATGTGATAATATAAAAAATAAAGACAGCAGTTAGACTGTCGCATCAGATGAAA
CGACACAAGGAGTGCATATC

Downstream 100 bases:

>100_bases
AAAAAGCATGAATAAATCCATGCAGACAGGACATACTATCATCAGAACAATTCAGATGATGGAGGTAATGTCCTATGAAA
AAACAACAAATTGCAGCAGC

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MAYLGNPKNTIEVLQKYNFNFQKKFGQNFLIDTGILEEIIDSAGITKDDMILEIGPGIGTMTQYLCESARQVIAVEIDTN
LIPILKDTLSEYDNVKVINDDILKVDINALAEEYNNGKPIKVVANLPYYITTPIIMGLFESHVPIDSITIMVQKEVADRM
QAAPGKKDYGALSLAVQYYSHPEIVVNVPPSCFMPQPKVGSSVISLKRYEKPVVDVEDEKLMFKIIRASFNQRRKTLANG
LNNFGGMGLTKEQIQQSIEALGVPVNVRGEALSLAQFAQLSNIIGAAK

Sequences:

>Translated_288_residues
MAYLGNPKNTIEVLQKYNFNFQKKFGQNFLIDTGILEEIIDSAGITKDDMILEIGPGIGTMTQYLCESARQVIAVEIDTN
LIPILKDTLSEYDNVKVINDDILKVDINALAEEYNNGKPIKVVANLPYYITTPIIMGLFESHVPIDSITIMVQKEVADRM
QAAPGKKDYGALSLAVQYYSHPEIVVNVPPSCFMPQPKVGSSVISLKRYEKPVVDVEDEKLMFKIIRASFNQRRKTLANG
LNNFGGMGLTKEQIQQSIEALGVPVNVRGEALSLAQFAQLSNIIGAAK
>Mature_287_residues
AYLGNPKNTIEVLQKYNFNFQKKFGQNFLIDTGILEEIIDSAGITKDDMILEIGPGIGTMTQYLCESARQVIAVEIDTNL
IPILKDTLSEYDNVKVINDDILKVDINALAEEYNNGKPIKVVANLPYYITTPIIMGLFESHVPIDSITIMVQKEVADRMQ
AAPGKKDYGALSLAVQYYSHPEIVVNVPPSCFMPQPKVGSSVISLKRYEKPVVDVEDEKLMFKIIRASFNQRRKTLANGL
NNFGGMGLTKEQIQQSIEALGVPVNVRGEALSLAQFAQLSNIIGAAK

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI156415992, Length=289, Percent_Identity=25.6055363321799, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI7657198, Length=250, Percent_Identity=29.2, Blast_Score=104, Evalue=9e-23,
Organism=Escherichia coli, GI1786236, Length=264, Percent_Identity=33.7121212121212, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI25146882, Length=230, Percent_Identity=34.3478260869565, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI25141369, Length=294, Percent_Identity=26.1904761904762, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324989, Length=229, Percent_Identity=27.5109170305677, Blast_Score=96, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21358017, Length=230, Percent_Identity=33.0434782608696, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21357273, Length=294, Percent_Identity=26.1904761904762, Blast_Score=94, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 31857; Mature: 31726

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS01131 RRNA_A_DIMETH ; PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYLGNPKNTIEVLQKYNFNFQKKFGQNFLIDTGILEEIIDSAGITKDDMILEIGPGIGT
CCCCCCCHHHHHHHHHHCCCHHHHHCCCCEECHHHHHHHHHHCCCCCCCEEEEECCCHHH
MTQYLCESARQVIAVEIDTNLIPILKDTLSEYDNVKVINDDILKVDINALAEEYNNGKPI
HHHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCEEEECCCEEEEEHHHHHHHHCCCCCE
KVVANLPYYITTPIIMGLFESHVPIDSITIMVQKEVADRMQAAPGKKDYGALSLAVQYYS
EEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHCCCCCCCCCHHEEEEEECC
HPEIVVNVPPSCFMPQPKVGSSVISLKRYEKPVVDVEDEKLMFKIIRASFNQRRKTLANG
CCEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LNNFGGMGLTKEQIQQSIEALGVPVNVRGEALSLAQFAQLSNIIGAAK
HHHCCCCCCCHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AYLGNPKNTIEVLQKYNFNFQKKFGQNFLIDTGILEEIIDSAGITKDDMILEIGPGIGT
CCCCCCHHHHHHHHHHCCCHHHHHCCCCEECHHHHHHHHHHCCCCCCCEEEEECCCHHH
MTQYLCESARQVIAVEIDTNLIPILKDTLSEYDNVKVINDDILKVDINALAEEYNNGKPI
HHHHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCEEEECCCEEEEEHHHHHHHHCCCCCE
KVVANLPYYITTPIIMGLFESHVPIDSITIMVQKEVADRMQAAPGKKDYGALSLAVQYYS
EEEECCCHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHCCCCCCCCCHHEEEEEECC
HPEIVVNVPPSCFMPQPKVGSSVISLKRYEKPVVDVEDEKLMFKIIRASFNQRRKTLANG
CCEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LNNFGGMGLTKEQIQQSIEALGVPVNVRGEALSLAQFAQLSNIIGAAK
HHHCCCCCCCHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA