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The map label for this gene is mutT [H]

Identifier: 238922597

GI number: 238922597

Start: 167749

End: 168171

Strand: Direct

Name: mutT [H]

Synonym: EUBREC_0171

Alternate gene names: 238922597

Gene position: 167749-168171 (Clockwise)

Preceding gene: 238922596

Following gene: 238922598

Centisome position: 4.86

GC content: 47.52

Gene sequence:

>423_bases
ATGAAAACAGTACGCGTAGTGGCTGCCGTCATAAGAGCAGTCAATAAAGAAAATAAACCGATTATATTTGCAACCCAAAG
AGGCTACGGAGAGTTCAAGGGCGGCTGGGAGTTTCCTGGAGGCAAGATTGAGTCTGGCGAGACACCGCAGCAGGCGCTAA
AGTGGGAGATAATGGAGGAACTGGACACAGAAATTGCTGTCGGAGAATTAATAGATACGATAGAATACGATTATCCTAAT
TTCCATCTCTCTATGGATTGCTTCTGGTGTGAGGTAATTCACGGTGAGCTTATCCTAAAGGAGGCTGAGGACGCAAAGTG
GCTTACAAAGGAGCATCTGGCGGACGTGGAGTGGCTGCCGGCGGATGTGACACTGATTGAGAAGATTGGAGAGGAGTTGC
ATGAAACCAAGGACAGCAAATAG

Upstream 100 bases:

>100_bases
AGATGAAGATGCACCACCCTGTAAGAGAGGATCTGCTTCGATATCTGCAGAGCAATTTACAACAAAGATTACAAAATAAT
ACACAGGAGCTTAAGGCAAT

Downstream 100 bases:

>100_bases
CATGAACATACAAATTTTCGGAACAAAGAAATGTAATGACACAAAGAAAGCACAGCGATTTTTCAAGGAGCGTGGGATAA
AGTTTCAGTTTATCGACATG

Product: mutator MutT protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MKTVRVVAAVIRAVNKENKPIIFATQRGYGEFKGGWEFPGGKIESGETPQQALKWEIMEELDTEIAVGELIDTIEYDYPN
FHLSMDCFWCEVIHGELILKEAEDAKWLTKEHLADVEWLPADVTLIEKIGEELHETKDSK

Sequences:

>Translated_140_residues
MKTVRVVAAVIRAVNKENKPIIFATQRGYGEFKGGWEFPGGKIESGETPQQALKWEIMEELDTEIAVGELIDTIEYDYPN
FHLSMDCFWCEVIHGELILKEAEDAKWLTKEHLADVEWLPADVTLIEKIGEELHETKDSK
>Mature_140_residues
MKTVRVVAAVIRAVNKENKPIIFATQRGYGEFKGGWEFPGGKIESGETPQQALKWEIMEELDTEIAVGELIDTIEYDYPN
FHLSMDCFWCEVIHGELILKEAEDAKWLTKEHLADVEWLPADVTLIEKIGEELHETKDSK

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=130, Percent_Identity=33.0769230769231, Blast_Score=68, Evalue=2e-13,
Organism=Escherichia coli, GI1788056, Length=127, Percent_Identity=32.2834645669291, Blast_Score=63, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 16020; Mature: 16020

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVRVVAAVIRAVNKENKPIIFATQRGYGEFKGGWEFPGGKIESGETPQQALKWEIMEE
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LDTEIAVGELIDTIEYDYPNFHLSMDCFWCEVIHGELILKEAEDAKWLTKEHLADVEWLP
HCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCCCC
ADVTLIEKIGEELHETKDSK
CCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKTVRVVAAVIRAVNKENKPIIFATQRGYGEFKGGWEFPGGKIESGETPQQALKWEIMEE
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
LDTEIAVGELIDTIEYDYPNFHLSMDCFWCEVIHGELILKEAEDAKWLTKEHLADVEWLP
HCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCCCCCC
ADVTLIEKIGEELHETKDSK
CCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]