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The map label for this gene is ywlC [H]

Identifier: 238922539

GI number: 238922539

Start: 110515

End: 112023

Strand: Direct

Name: ywlC [H]

Synonym: EUBREC_0113

Alternate gene names: 238922539

Gene position: 110515-112023 (Clockwise)

Preceding gene: 238922538

Following gene: 238922540

Centisome position: 3.2

GC content: 49.44

Gene sequence:

>1509_bases
ATGGAAACAAAAATTATAAAAATAGATCAGGACAATTTAGACCATAAGCTCATGCAGGAGGCAGGTGATTTGATTGCAGC
CGGTGAGCTTGTAGCGTTTCCGACAGAGACAGTGTATGGGCTTGGCGGTGATGCTTTAGATCCGGAGGCATCAAAGAAGA
TATACAGTGCAAAGGGGCGTCCGTCGGACAATCCGCTTATCGTACACATATCAGATTTTTCGGATTTGGAGCGCATCGCA
AAGACAGTGCCGGAGGATGCAAGGAAGCTTTCGGATGCTTTCTGGCCGGGACCTCTTACCATGATAGTGGAGAAGGGCGA
TGCAGTGCCTTATGCCACAACAGGCGGCATGGACACGGTAGCTGTGCGCATGCCGAATCATCCTATAGCGCTAGATCTTA
TAAGAAGAAGCGGCTGCCTTATCGCGGCGCCAAGCGCCAATACATCCGGCAGACCTAGCCCTACAGAGGCTGCACATGTG
GCTGAGGATCTAAGCGGCAAAATAGCCATGATTATAGACGGAGGACCGGTTGGCATAGGTATAGAGTCCACCATCATTGA
CCTGACAGAGGATACACCTATGGTGCTGCGTCCGGGCTATATTACACCACAGATGCTTTCAAAGGTATTAGGCAAAGAGG
TTATCATAGATCCGGGAATCATAGCGGCAGATGACACGAGAAAGCCCAAGGCCCCAGGCATGAAGTACAAGCACTATGCG
CCAAAGGCTGACATGGTTATCGTGGACGGTACCAGAAAGCATGTGATTGCAAAGATAAATGAGCTTGTGGCTTCGCACAG
GGATGATGGCAAAAAGATAGCAGTCATCGCAACAGAGGAGACAAAGCAGTTTTACGATGCAGATGTTGTCCTGTCGATGG
GAAGCAGGGCGGATGAGGATTCGATAGCGCATGAGCTTTACCGTATATTAAGGGACTGTGATGAGCTCGATGTGGATGTG
ATTTTCTCGGAGAGCTTCTCCACACCGCGTATAGGACAGGCCATCATGAACCGTATGCTAAAGGCGGCAGGCCATCAGGT
GATAGACACACATGTGAAGTATGACAAAATCATTTTTGTCGCACAGACCGGCACATGCAGGGAACAGATGGCAAAGGGCA
TCATGAACGACTTTGTACTCAAGGTGCCGATGGAGATTGAGGCGAGAGGACTTGTTGTCCAGTTTCCGGAGCCGGTCAAT
CAGAAGGCAGAGGCAGTGCTCATAAGCAATGGTATTTCCACGGAGGGCATGGTGTCAACGCAGCTTGAGGAATCGGATAT
CACGGAGAGTACTATGGTATTTACTATGGAGTCATCACAGCGCGAGCGCATTATAGAAAGCTTTGCCGATATCGACCCGG
AGCAGGTCTTTGTGCTTTCGCAGTATGTGGGCGATGAGCTTGAGATACTGGATCCTTACGGTGGCACACTTCAAAGCTAC
GGACTGTGCTATGAAAGCCTTAGGGCTACGCTTAAGAAGCTGGTAAAGCTCTTAAATGCAAATACATAA

Upstream 100 bases:

>100_bases
GAGGTAGCTCTGAAGTGTTACAATAAAAACACATGATTATTTAGAAAAACTGGTGTTTGCACATGGTATATTACTGTAGT
ATGTGCGGTGAGGATATAAA

Downstream 100 bases:

>100_bases
AAGACAAACAAATATAACACAATATAAGACAAAGGAGAACAAATATTATGGGTAAGGTAGTAGTTATGGATCATCCGCTT
ATTCAGCACAAGATTGGAAT

Product: putative translation factor (SUA5)

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
METKIIKIDQDNLDHKLMQEAGDLIAAGELVAFPTETVYGLGGDALDPEASKKIYSAKGRPSDNPLIVHISDFSDLERIA
KTVPEDARKLSDAFWPGPLTMIVEKGDAVPYATTGGMDTVAVRMPNHPIALDLIRRSGCLIAAPSANTSGRPSPTEAAHV
AEDLSGKIAMIIDGGPVGIGIESTIIDLTEDTPMVLRPGYITPQMLSKVLGKEVIIDPGIIAADDTRKPKAPGMKYKHYA
PKADMVIVDGTRKHVIAKINELVASHRDDGKKIAVIATEETKQFYDADVVLSMGSRADEDSIAHELYRILRDCDELDVDV
IFSESFSTPRIGQAIMNRMLKAAGHQVIDTHVKYDKIIFVAQTGTCREQMAKGIMNDFVLKVPMEIEARGLVVQFPEPVN
QKAEAVLISNGISTEGMVSTQLEESDITESTMVFTMESSQRERIIESFADIDPEQVFVLSQYVGDELEILDPYGGTLQSY
GLCYESLRATLKKLVKLLNANT

Sequences:

>Translated_502_residues
METKIIKIDQDNLDHKLMQEAGDLIAAGELVAFPTETVYGLGGDALDPEASKKIYSAKGRPSDNPLIVHISDFSDLERIA
KTVPEDARKLSDAFWPGPLTMIVEKGDAVPYATTGGMDTVAVRMPNHPIALDLIRRSGCLIAAPSANTSGRPSPTEAAHV
AEDLSGKIAMIIDGGPVGIGIESTIIDLTEDTPMVLRPGYITPQMLSKVLGKEVIIDPGIIAADDTRKPKAPGMKYKHYA
PKADMVIVDGTRKHVIAKINELVASHRDDGKKIAVIATEETKQFYDADVVLSMGSRADEDSIAHELYRILRDCDELDVDV
IFSESFSTPRIGQAIMNRMLKAAGHQVIDTHVKYDKIIFVAQTGTCREQMAKGIMNDFVLKVPMEIEARGLVVQFPEPVN
QKAEAVLISNGISTEGMVSTQLEESDITESTMVFTMESSQRERIIESFADIDPEQVFVLSQYVGDELEILDPYGGTLQSY
GLCYESLRATLKKLVKLLNANT
>Mature_502_residues
METKIIKIDQDNLDHKLMQEAGDLIAAGELVAFPTETVYGLGGDALDPEASKKIYSAKGRPSDNPLIVHISDFSDLERIA
KTVPEDARKLSDAFWPGPLTMIVEKGDAVPYATTGGMDTVAVRMPNHPIALDLIRRSGCLIAAPSANTSGRPSPTEAAHV
AEDLSGKIAMIIDGGPVGIGIESTIIDLTEDTPMVLRPGYITPQMLSKVLGKEVIIDPGIIAADDTRKPKAPGMKYKHYA
PKADMVIVDGTRKHVIAKINELVASHRDDGKKIAVIATEETKQFYDADVVLSMGSRADEDSIAHELYRILRDCDELDVDV
IFSESFSTPRIGQAIMNRMLKAAGHQVIDTHVKYDKIIFVAQTGTCREQMAKGIMNDFVLKVPMEIEARGLVVQFPEPVN
QKAEAVLISNGISTEGMVSTQLEESDITESTMVFTMESSQRERIIESFADIDPEQVFVLSQYVGDELEILDPYGGTLQSY
GLCYESLRATLKKLVKLLNANT

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=183, Percent_Identity=31.1475409836066, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI2367210, Length=145, Percent_Identity=31.7241379310345, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081864, Length=199, Percent_Identity=27.1356783919598, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17537239, Length=209, Percent_Identity=28.7081339712919, Blast_Score=85, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6321269, Length=363, Percent_Identity=37.7410468319559, Blast_Score=205, Evalue=1e-53,
Organism=Drosophila melanogaster, GI78707274, Length=202, Percent_Identity=28.2178217821782, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 54818; Mature: 54818

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKIIKIDQDNLDHKLMQEAGDLIAAGELVAFPTETVYGLGGDALDPEASKKIYSAKGR
CCCEEEEECCCCCHHHHHHHHCCEEECCCEEECCCHHEEECCCCCCCCHHHHHHEECCCC
PSDNPLIVHISDFSDLERIAKTVPEDARKLSDAFWPGPLTMIVEKGDAVPYATTGGMDTV
CCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEECCCCCCEEECCCCCEE
AVRMPNHPIALDLIRRSGCLIAAPSANTSGRPSPTEAAHVAEDLSGKIAMIIDGGPVGIG
EEECCCCCEEHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCC
IESTIIDLTEDTPMVLRPGYITPQMLSKVLGKEVIIDPGIIAADDTRKPKAPGMKYKHYA
CCCEEEEECCCCCEEEECCCCCHHHHHHHCCCEEEECCCEEECCCCCCCCCCCCCCCCCC
PKADMVIVDGTRKHVIAKINELVASHRDDGKKIAVIATEETKQFYDADVVLSMGSRADED
CCCCEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHCCCEEEECCCCCCHH
SIAHELYRILRDCDELDVDVIFSESFSTPRIGQAIMNRMLKAAGHQVIDTHVKYDKIIFV
HHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEECCCCCEEEEEEE
AQTGTCREQMAKGIMNDFVLKVPMEIEARGLVVQFPEPVNQKAEAVLISNGISTEGMVST
ECCCCHHHHHHHHHHHHHEEECCCEECCCEEEEECCCCCCCCCCEEEEECCCCCCCEEEE
QLEESDITESTMVFTMESSQRERIIESFADIDPEQVFVLSQYVGDELEILDPYGGTLQSY
CCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCHHHEEEEHHHCCCCEEEECCCCCCHHHH
GLCYESLRATLKKLVKLLNANT
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
METKIIKIDQDNLDHKLMQEAGDLIAAGELVAFPTETVYGLGGDALDPEASKKIYSAKGR
CCCEEEEECCCCCHHHHHHHHCCEEECCCEEECCCHHEEECCCCCCCCHHHHHHEECCCC
PSDNPLIVHISDFSDLERIAKTVPEDARKLSDAFWPGPLTMIVEKGDAVPYATTGGMDTV
CCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEECCCCCCEEECCCCCEE
AVRMPNHPIALDLIRRSGCLIAAPSANTSGRPSPTEAAHVAEDLSGKIAMIIDGGPVGIG
EEECCCCCEEHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCC
IESTIIDLTEDTPMVLRPGYITPQMLSKVLGKEVIIDPGIIAADDTRKPKAPGMKYKHYA
CCCEEEEECCCCCEEEECCCCCHHHHHHHCCCEEEECCCEEECCCCCCCCCCCCCCCCCC
PKADMVIVDGTRKHVIAKINELVASHRDDGKKIAVIATEETKQFYDADVVLSMGSRADED
CCCCEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHCCCEEEECCCCCCHH
SIAHELYRILRDCDELDVDVIFSESFSTPRIGQAIMNRMLKAAGHQVIDTHVKYDKIIFV
HHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEECCCCCEEEEEEE
AQTGTCREQMAKGIMNDFVLKVPMEIEARGLVVQFPEPVNQKAEAVLISNGISTEGMVST
ECCCCHHHHHHHHHHHHHEEECCCEECCCEEEEECCCCCCCCCCEEEEECCCCCCCEEEE
QLEESDITESTMVFTMESSQRERIIESFADIDPEQVFVLSQYVGDELEILDPYGGTLQSY
CCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCHHHEEEEHHHCCCCEEEECCCCCCHHHH
GLCYESLRATLKKLVKLLNANT
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]