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The map label for this gene is upp

Identifier: 238922540

GI number: 238922540

Start: 112071

End: 112700

Strand: Direct

Name: upp

Synonym: EUBREC_0114

Alternate gene names: 238922540

Gene position: 112071-112700 (Clockwise)

Preceding gene: 238922539

Following gene: 238922541

Centisome position: 3.25

GC content: 47.3

Gene sequence:

>630_bases
ATGGGTAAGGTAGTAGTTATGGATCATCCGCTTATTCAGCACAAGATTGGAATTATGAGAAGAACCGACACAGGTTCAAA
GGATTTCAGAACACTCGTCAGCGAGGTTGCGATGCTTGAGTGCTACGAGGCAACAAGAGATCTGGAGCTTACAGATGTGG
AGATTGAGACTCCTATCTGTAAGGCCACTGTAAAGGAATTAAAGGGCAAAAAGCTTGCAGTTGTTCCTATCTTAAGAGCC
GGACTTGGTATGGTGGAGGGCATGCTTGAGCTCATCCCTGCCGCAAAGGTTGGACACATCGGCATGTATCGTGACCCGGA
GACAGCAGAGCCTATCGAGTACTATTGCAAGCTTCCGGCAGACTGCGCAAATAGAGAGGTATTTGTGGTAGATCCGATGC
TCGCAACAGGTGGTTCAGCAGTTGCAGCGCTTGATATGCTCAAAAAGCGCGGTGTGAAAAACATCCACTTTATGTGCATA
ATTGCAGCTCCTGAGGGAGTAAAGAGACTCACAGAGGCACATCCTGATGTGGATGTATATATAGGAGCGCTCGATGATCA
TCTCAATGAGCACAAATATATTGTGCCGGGACTCGGAGATGCAGGAGACAGAATTTTCGGAACCAAGTAA

Upstream 100 bases:

>100_bases
GCCTTAGGGCTACGCTTAAGAAGCTGGTAAAGCTCTTAAATGCAAATACATAAAAGACAAACAAATATAACACAATATAA
GACAAAGGAGAACAAATATT

Downstream 100 bases:

>100_bases
TAATAATGATGATAATAGCTGCAGGTTGCCCTGAGGTGTAAACAGTGATATAAAACTGTAAAGTAACAGACAGTGTGATA
GACCATATTGAATGGAGGTG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MGKVVVMDHPLIQHKIGIMRRTDTGSKDFRTLVSEVAMLECYEATRDLELTDVEIETPICKATVKELKGKKLAVVPILRA
GLGMVEGMLELIPAAKVGHIGMYRDPETAEPIEYYCKLPADCANREVFVVDPMLATGGSAVAALDMLKKRGVKNIHFMCI
IAAPEGVKRLTEAHPDVDVYIGALDDHLNEHKYIVPGLGDAGDRIFGTK

Sequences:

>Translated_209_residues
MGKVVVMDHPLIQHKIGIMRRTDTGSKDFRTLVSEVAMLECYEATRDLELTDVEIETPICKATVKELKGKKLAVVPILRA
GLGMVEGMLELIPAAKVGHIGMYRDPETAEPIEYYCKLPADCANREVFVVDPMLATGGSAVAALDMLKKRGVKNIHFMCI
IAAPEGVKRLTEAHPDVDVYIGALDDHLNEHKYIVPGLGDAGDRIFGTK
>Mature_208_residues
GKVVVMDHPLIQHKIGIMRRTDTGSKDFRTLVSEVAMLECYEATRDLELTDVEIETPICKATVKELKGKKLAVVPILRAG
LGMVEGMLELIPAAKVGHIGMYRDPETAEPIEYYCKLPADCANREVFVVDPMLATGGSAVAALDMLKKRGVKNIHFMCII
AAPEGVKRLTEAHPDVDVYIGALDDHLNEHKYIVPGLGDAGDRIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=207, Percent_Identity=28.5024154589372, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI57863312, Length=207, Percent_Identity=28.5024154589372, Blast_Score=80, Evalue=9e-16,
Organism=Escherichia coli, GI87082118, Length=207, Percent_Identity=53.1400966183575, Blast_Score=235, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17539892, Length=207, Percent_Identity=26.5700483091787, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17539894, Length=207, Percent_Identity=26.5700483091787, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6321920, Length=195, Percent_Identity=40, Blast_Score=129, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45550449, Length=147, Percent_Identity=34.0136054421769, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573516, Length=147, Percent_Identity=34.0136054421769, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573514, Length=147, Percent_Identity=34.0136054421769, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28573512, Length=147, Percent_Identity=34.0136054421769, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_EUBR3 (C4Z9S1)

Other databases:

- EMBL:   CP001107
- RefSeq:   YP_002936053.1
- GeneID:   7965576
- GenomeReviews:   CP001107_GR
- KEGG:   ere:EUBREC_0114
- ProtClustDB:   CLSK2813824
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22898; Mature: 22767

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 104-104 BINDING 194-194 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVVVMDHPLIQHKIGIMRRTDTGSKDFRTLVSEVAMLECYEATRDLELTDVEIETPIC
CCEEEEECCCHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHH
KATVKELKGKKLAVVPILRAGLGMVEGMLELIPAAKVGHIGMYRDPETAEPIEYYCKLPA
HHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCC
DCANREVFVVDPMLATGGSAVAALDMLKKRGVKNIHFMCIIAAPEGVKRLTEAHPDVDVY
CCCCCEEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHCCCCEEEE
IGALDDHLNEHKYIVPGLGDAGDRIFGTK
EECHHHCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
GKVVVMDHPLIQHKIGIMRRTDTGSKDFRTLVSEVAMLECYEATRDLELTDVEIETPIC
CEEEEECCCHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHH
KATVKELKGKKLAVVPILRAGLGMVEGMLELIPAAKVGHIGMYRDPETAEPIEYYCKLPA
HHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCC
DCANREVFVVDPMLATGGSAVAALDMLKKRGVKNIHFMCIIAAPEGVKRLTEAHPDVDVY
CCCCCEEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHCCCCEEEE
IGALDDHLNEHKYIVPGLGDAGDRIFGTK
EECHHHCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA