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The map label for this gene is fruA [H]

Identifier: 238922445

GI number: 238922445

Start: 19607

End: 21535

Strand: Direct

Name: fruA [H]

Synonym: EUBREC_0019

Alternate gene names: 238922445

Gene position: 19607-21535 (Clockwise)

Preceding gene: 238922444

Following gene: 238922446

Centisome position: 0.57

GC content: 44.12

Gene sequence:

>1929_bases
ATGACAATCAGGGATTTATTGGCAGCTGAGAGTATCAATTTGAATGGTACGCCTGCCGGAAAAACCGAAGCATTGAATCA
GTGTATTGATTTGATGGCAAAAAGTGGCAAAATAGCCGATGTGGAGAAGTATCGCAAGGGTGTTTTTGCAAGAGAGGAGG
AAGGCACAACAGGAATTGGAATGGGTATAGCAATTCCTCATTGCAAGTCTGATGCTGTTACTAAAGCAGGTCTTGCGGCA
ATGGTTGTAAAGGATGGGGTTGACTTTGAATCACTCGATGGTACACCTGCAAAGATTATTTTCCTTATAGCTGCACCAAA
CACAGAGGATAATGTGCATCTTCAGGTGCTTAGCAAGCTCTCTGTTATGCTGATGGACGAGCAGTTTACAAATTCTCTTA
TCAATGCCGGTTCAGTTGATGAGTTTTTAAATATCATCGATAGCGCTGAAAAAGCAAAGGATGAGAAAGAGGCTGCCAAA
GAGGCAAAGGCTAAAGAGCCTGTTGAGGTGAAGAAGGACGATGTATTTATCGTTGCAGTTACAGCCTGTCCTACAGGAAT
TGCCCATACTTATATGGCTGCTGAGGCTATCGAGAAAAAAGCCAAGGAGCTTGGATATCAGGTAAAGGTTGAGACAAGAG
GCTCAGGCGGAGCCAAAAATGTGCTCACAGATGATGAAATCGCAAAGGCTGCAGGTGTTATAGTTGCCTGTGATACAAAT
GTACCTACAGACCGCTTTGACGGAAAGAAGGTTATTGAGTGTCAGGTTTCTGACGGAATCAATAAGGCAGAAGAGCTCAT
AAAGAGAATTGCTGCCGGTGATGCTCCTGTATTTAAGGCATCAGGTAAAAAGGAGGCTTCACATTCATCAGTTGGTGGAA
AGGAGAGCGTTGGACATCAGATTTACAAGCACCTGATGAATGGTGTTTCACATATGCTTCCATTCGTAGTTGGTGGTGGT
ATTCTTATCGCAATCGCATTCCTTATCGATGGATTCAGTGTTGACCTTAATTCACTGCCGGCTGACCAGAGAGCAAATTT
CGGTACTATTACACAGGCCGCAGCAATGTTTAAGGGAATCGGTGGAACAGCATTTGGATTTATGCTTCCAATTCTTGCAG
GCTTTATCGCTATGAGTATTGCTGACCGTCCGGGTCTTGCAGTTGGTTTTGTAGGCGGTTCAATCGCAGCAAACGGTACA
TCAGGCTTCCTTGGAGCACTTGTAGCAGGTTTCGTTGCAGGATATATTGTGCTCCTCTTAAAGAAGGTATTTTCTAAACT
TCCGGAGAGTCTTGATGGTATGAAGCCGGTTCTGCTTTATCCGCTGCTTGGTATATTCCTGGTAGGCGTTATAATGCAGT
TTGTAGTTGAGCCTCCAATCGGAGCTTTAAATACAGCTATCAACAATGGTCTTAATGGACTTAACGGTGCAAGCGCAGTA
GTGCTCGGAGTACTTCTCGGAGGAATGATGTCAGTAGATATGGGTGGCCCTGTAAACAAAGCCGCTTATGTATTTGGTAC
AGCTTCAATCGCTGCCGGAAACTACAATATTATGGCAGCAGTTATGATTGGCGGTATGGTTCCACCAATCGCAATCGCTC
TTGCAACAATCTTCTTCAAGAACAAGTTCACAGCAGATGAGAGAAAGGCAGGACCTACAAACTTTATCATGGGATTATCA
TTTATCACAGAGGGTGCAATCCCATTCGCAGCATCTGATCCGCTTCATGTCCTTCCGGCATGTGTAGTCGGTTCAGCAGT
GGCAGGTGGACTTTCAATGGCATTTGGATGTACACTCATGGCACCTCACGGAGGAATCTTCGTAGTTCCTACAATCGGAA
ATCCGTTAATGTATCTTGTTGCATTAGTAATCGGATCTTTCATTGCATGTGGATTACTCGGATTACTCAAAAAGAAAGTA
AGTGAATAA

Upstream 100 bases:

>100_bases
ACTTATTGATAAATGGGACAGTGCTTCCAATTAAACAAACGGTATCAAAAAGGTTGATATAAATAATTAAATTAATACAT
TCTATTAGGAGGAATGATGT

Downstream 100 bases:

>100_bases
GCAATCCTCAATTATCATTTAATCCAACCTATAAACTAATCAACAAAGGCACTGCTTCGGCGGTGCCTTTGTTGTTATGT
TGTGATATAAAAATTAAAAG

Product: PTS system, fructose-specific, IIABC component

Products: NA

Alternate protein names: EIIABC-Fru; Fructose-specific phosphotransferase enzyme IIA component; EII-Fru; PTS system fructose-specific EIIA component; Fructose-specific phosphotransferase enzyme IIB component; EIII-Fru; PTS system fructose-specific EIIB component; Fructose permease IIC component; PTS system fructose-specific EIIC component [H]

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MTIRDLLAAESINLNGTPAGKTEALNQCIDLMAKSGKIADVEKYRKGVFAREEEGTTGIGMGIAIPHCKSDAVTKAGLAA
MVVKDGVDFESLDGTPAKIIFLIAAPNTEDNVHLQVLSKLSVMLMDEQFTNSLINAGSVDEFLNIIDSAEKAKDEKEAAK
EAKAKEPVEVKKDDVFIVAVTACPTGIAHTYMAAEAIEKKAKELGYQVKVETRGSGGAKNVLTDDEIAKAAGVIVACDTN
VPTDRFDGKKVIECQVSDGINKAEELIKRIAAGDAPVFKASGKKEASHSSVGGKESVGHQIYKHLMNGVSHMLPFVVGGG
ILIAIAFLIDGFSVDLNSLPADQRANFGTITQAAAMFKGIGGTAFGFMLPILAGFIAMSIADRPGLAVGFVGGSIAANGT
SGFLGALVAGFVAGYIVLLLKKVFSKLPESLDGMKPVLLYPLLGIFLVGVIMQFVVEPPIGALNTAINNGLNGLNGASAV
VLGVLLGGMMSVDMGGPVNKAAYVFGTASIAAGNYNIMAAVMIGGMVPPIAIALATIFFKNKFTADERKAGPTNFIMGLS
FITEGAIPFAASDPLHVLPACVVGSAVAGGLSMAFGCTLMAPHGGIFVVPTIGNPLMYLVALVIGSFIACGLLGLLKKKV
SE

Sequences:

>Translated_642_residues
MTIRDLLAAESINLNGTPAGKTEALNQCIDLMAKSGKIADVEKYRKGVFAREEEGTTGIGMGIAIPHCKSDAVTKAGLAA
MVVKDGVDFESLDGTPAKIIFLIAAPNTEDNVHLQVLSKLSVMLMDEQFTNSLINAGSVDEFLNIIDSAEKAKDEKEAAK
EAKAKEPVEVKKDDVFIVAVTACPTGIAHTYMAAEAIEKKAKELGYQVKVETRGSGGAKNVLTDDEIAKAAGVIVACDTN
VPTDRFDGKKVIECQVSDGINKAEELIKRIAAGDAPVFKASGKKEASHSSVGGKESVGHQIYKHLMNGVSHMLPFVVGGG
ILIAIAFLIDGFSVDLNSLPADQRANFGTITQAAAMFKGIGGTAFGFMLPILAGFIAMSIADRPGLAVGFVGGSIAANGT
SGFLGALVAGFVAGYIVLLLKKVFSKLPESLDGMKPVLLYPLLGIFLVGVIMQFVVEPPIGALNTAINNGLNGLNGASAV
VLGVLLGGMMSVDMGGPVNKAAYVFGTASIAAGNYNIMAAVMIGGMVPPIAIALATIFFKNKFTADERKAGPTNFIMGLS
FITEGAIPFAASDPLHVLPACVVGSAVAGGLSMAFGCTLMAPHGGIFVVPTIGNPLMYLVALVIGSFIACGLLGLLKKKV
SE
>Mature_641_residues
TIRDLLAAESINLNGTPAGKTEALNQCIDLMAKSGKIADVEKYRKGVFAREEEGTTGIGMGIAIPHCKSDAVTKAGLAAM
VVKDGVDFESLDGTPAKIIFLIAAPNTEDNVHLQVLSKLSVMLMDEQFTNSLINAGSVDEFLNIIDSAEKAKDEKEAAKE
AKAKEPVEVKKDDVFIVAVTACPTGIAHTYMAAEAIEKKAKELGYQVKVETRGSGGAKNVLTDDEIAKAAGVIVACDTNV
PTDRFDGKKVIECQVSDGINKAEELIKRIAAGDAPVFKASGKKEASHSSVGGKESVGHQIYKHLMNGVSHMLPFVVGGGI
LIAIAFLIDGFSVDLNSLPADQRANFGTITQAAAMFKGIGGTAFGFMLPILAGFIAMSIADRPGLAVGFVGGSIAANGTS
GFLGALVAGFVAGYIVLLLKKVFSKLPESLDGMKPVLLYPLLGIFLVGVIMQFVVEPPIGALNTAINNGLNGLNGASAVV
LGVLLGGMMSVDMGGPVNKAAYVFGTASIAAGNYNIMAAVMIGGMVPPIAIALATIFFKNKFTADERKAGPTNFIMGLSF
ITEGAIPFAASDPLHVLPACVVGSAVAGGLSMAFGCTLMAPHGGIFVVPTIGNPLMYLVALVIGSFIACGLLGLLKKKVS
E

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1788492, Length=466, Percent_Identity=46.137339055794, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1786951, Length=610, Percent_Identity=33.6065573770492, Blast_Score=321, Evalue=1e-88,
Organism=Escherichia coli, GI87082348, Length=474, Percent_Identity=35.0210970464135, Blast_Score=247, Evalue=2e-66,
Organism=Escherichia coli, GI1790386, Length=318, Percent_Identity=38.3647798742138, Blast_Score=199, Evalue=7e-52,
Organism=Escherichia coli, GI1788729, Length=403, Percent_Identity=27.7915632754342, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1790387, Length=97, Percent_Identity=47.4226804123711, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788730, Length=96, Percent_Identity=43.75, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI48994992, Length=142, Percent_Identity=30.2816901408451, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789597, Length=111, Percent_Identity=32.4324324324324, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790390, Length=82, Percent_Identity=37.8048780487805, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 66458; Mature: 66326

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRDLLAAESINLNGTPAGKTEALNQCIDLMAKSGKIADVEKYRKGVFAREEEGTTGIG
CCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCC
MGIAIPHCKSDAVTKAGLAAMVVKDGVDFESLDGTPAKIIFLIAAPNTEDNVHLQVLSKL
CCEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHH
SVMLMDEQFTNSLINAGSVDEFLNIIDSAEKAKDEKEAAKEAKAKEPVEVKKDDVFIVAV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
TACPTGIAHTYMAAEAIEKKAKELGYQVKVETRGSGGAKNVLTDDEIAKAAGVIVACDTN
ECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHCCEEEEECCC
VPTDRFDGKKVIECQVSDGINKAEELIKRIAAGDAPVFKASGKKEASHSSVGGKESVGHQ
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHH
IYKHLMNGVSHMLPFVVGGGILIAIAFLIDGFSVDLNSLPADQRANFGTITQAAAMFKGI
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
GGTAFGFMLPILAGFIAMSIADRPGLAVGFVGGSIAANGTSGFLGALVAGFVAGYIVLLL
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KKVFSKLPESLDGMKPVLLYPLLGIFLVGVIMQFVVEPPIGALNTAINNGLNGLNGASAV
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHH
VLGVLLGGMMSVDMGGPVNKAAYVFGTASIAAGNYNIMAAVMIGGMVPPIAIALATIFFK
HHHHHHHHHHEECCCCCCCCCEEEEEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHH
NKFTADERKAGPTNFIMGLSFITEGAIPFAASDPLHVLPACVVGSAVAGGLSMAFGCTLM
CCCCCCHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEE
APHGGIFVVPTIGNPLMYLVALVIGSFIACGLLGLLKKKVSE
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TIRDLLAAESINLNGTPAGKTEALNQCIDLMAKSGKIADVEKYRKGVFAREEEGTTGIG
CHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCCCCCCC
MGIAIPHCKSDAVTKAGLAAMVVKDGVDFESLDGTPAKIIFLIAAPNTEDNVHLQVLSKL
CCEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHH
SVMLMDEQFTNSLINAGSVDEFLNIIDSAEKAKDEKEAAKEAKAKEPVEVKKDDVFIVAV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
TACPTGIAHTYMAAEAIEKKAKELGYQVKVETRGSGGAKNVLTDDEIAKAAGVIVACDTN
ECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHCCEEEEECCC
VPTDRFDGKKVIECQVSDGINKAEELIKRIAAGDAPVFKASGKKEASHSSVGGKESVGHQ
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHHHHH
IYKHLMNGVSHMLPFVVGGGILIAIAFLIDGFSVDLNSLPADQRANFGTITQAAAMFKGI
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
GGTAFGFMLPILAGFIAMSIADRPGLAVGFVGGSIAANGTSGFLGALVAGFVAGYIVLLL
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KKVFSKLPESLDGMKPVLLYPLLGIFLVGVIMQFVVEPPIGALNTAINNGLNGLNGASAV
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHH
VLGVLLGGMMSVDMGGPVNKAAYVFGTASIAAGNYNIMAAVMIGGMVPPIAIALATIFFK
HHHHHHHHHHEECCCCCCCCCEEEEEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHH
NKFTADERKAGPTNFIMGLSFITEGAIPFAASDPLHVLPACVVGSAVAGGLSMAFGCTLM
CCCCCCHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEE
APHGGIFVVPTIGNPLMYLVALVIGSFIACGLLGLLKKKVSE
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]