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The map label for this gene is hssR [H]

Identifier: 238922420

GI number: 238922420

Start: 615038

End: 615748

Strand: Reverse

Name: hssR [H]

Synonym: EUBELI_20656

Alternate gene names: 238922420

Gene position: 615748-615038 (Counterclockwise)

Preceding gene: 238922421

Following gene: 238922419

Centisome position: 98.25

GC content: 38.82

Gene sequence:

>711_bases
ATGGGCAAGGTATCTGTTTTAATAAGGAGGAAGGAAAACGTGTTTCAAATATTGATTGTAGAAGATGATAAAGAATTAAG
CCAGCTATTCCAAAAAGTGCTTGAGAAGAATGGATATCAAGTCAAAAGTGCATCGGATGGAGCACAGGCATTAGAAGTAT
TGGATAAGGAATATATTGATCTGATCATTTCTGATATTATGATGCCGGTTATGGATGGCTATGAACTGGTGTCAGAACTT
CGTTCAGCAGGATATCAGATACCAGTGCTTATGATCACTGCGAAAGGTTCCTTTGATGATATGCGCCAGGGATTTCTTTC
GGGAAGTGACGATTATATGGTAAAACCGGTAAATGTGAATGAAATGGTTTTAAGAGTCGGAGCACTGCTTCGCCGTGCAC
AGATACTGAATGAACACAAAATTGTGATCGGTTCAACAGAGTTTGATTATGATGCAATGACGGTTACAACTGATAAGGAA
AGTCTTGTTTTGCCTAAAAAAGAATTCCTGCTTTTATATAAGCTTGCAGCTTCGCCAGACAGAACATTTACAAAACAACA
GTTGATGGATGAAGTATGGGGATACGAGACGGAGGCAGACCCACATACGATAGAGGTACATATAGGAAGAATCAGAGAGC
GTTTTAAAGATAACCCTGATTTTGAAATCGTAACAATGCGTGGAATTGGATACAAGGTGGTGAAAAAATAA

Upstream 100 bases:

>100_bases
TATTGGAAGATGGAACCTATCGTGATCCGTATCATGTAGAGCCAATTGAATTGACAAAGAAGCGTCAGAGAAAAATATTT
TTGGTACAGCATCTGCTTGG

Downstream 100 bases:

>100_bases
TGGAACAAAAGAAAGAAAAAGGATTGCGGATCCGATCCTGTCTGACTGGTGCAATCTGGCTGGCACTTGTATTTTCAACA
GTTATATCTGCTTTATTATT

Product: two-component system, OmpR family, response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MGKVSVLIRRKENVFQILIVEDDKELSQLFQKVLEKNGYQVKSASDGAQALEVLDKEYIDLIISDIMMPVMDGYELVSEL
RSAGYQIPVLMITAKGSFDDMRQGFLSGSDDYMVKPVNVNEMVLRVGALLRRAQILNEHKIVIGSTEFDYDAMTVTTDKE
SLVLPKKEFLLLYKLAASPDRTFTKQQLMDEVWGYETEADPHTIEVHIGRIRERFKDNPDFEIVTMRGIGYKVVKK

Sequences:

>Translated_236_residues
MGKVSVLIRRKENVFQILIVEDDKELSQLFQKVLEKNGYQVKSASDGAQALEVLDKEYIDLIISDIMMPVMDGYELVSEL
RSAGYQIPVLMITAKGSFDDMRQGFLSGSDDYMVKPVNVNEMVLRVGALLRRAQILNEHKIVIGSTEFDYDAMTVTTDKE
SLVLPKKEFLLLYKLAASPDRTFTKQQLMDEVWGYETEADPHTIEVHIGRIRERFKDNPDFEIVTMRGIGYKVVKK
>Mature_235_residues
GKVSVLIRRKENVFQILIVEDDKELSQLFQKVLEKNGYQVKSASDGAQALEVLDKEYIDLIISDIMMPVMDGYELVSELR
SAGYQIPVLMITAKGSFDDMRQGFLSGSDDYMVKPVNVNEMVLRVGALLRRAQILNEHKIVIGSTEFDYDAMTVTTDKES
LVLPKKEFLLLYKLAASPDRTFTKQQLMDEVWGYETEADPHTIEVHIGRIRERFKDNPDFEIVTMRGIGYKVVKK

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated hssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=36.1990950226244, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=33.4841628959276, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=32.1888412017167, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=33.0316742081448, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=30.9090909090909, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=34.0909090909091, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=30.6306306306306, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=35.3711790393013, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=30, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=28.8990825688073, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=32.7433628318584, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=28.0542986425339, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI145693157, Length=104, Percent_Identity=39.4230769230769, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1787229, Length=224, Percent_Identity=26.7857142857143, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1790437, Length=161, Percent_Identity=27.3291925465839, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=39.2156862745098, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1790299, Length=117, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788905, Length=103, Percent_Identity=37.8640776699029, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=26.9565217391304, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1788550, Length=113, Percent_Identity=29.2035398230088, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788713, Length=126, Percent_Identity=30.1587301587302, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788191, Length=105, Percent_Identity=33.3333333333333, Blast_Score=60, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322000, Length=102, Percent_Identity=36.2745098039216, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26978; Mature: 26846

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVSVLIRRKENVFQILIVEDDKELSQLFQKVLEKNGYQVKSASDGAQALEVLDKEYID
CCCEEEEEEECCCEEEEEEEECCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHH
LIISDIMMPVMDGYELVSELRSAGYQIPVLMITAKGSFDDMRQGFLSGSDDYMVKPVNVN
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHCCCCCCCEEECCCHH
EMVLRVGALLRRAQILNEHKIVIGSTEFDYDAMTVTTDKESLVLPKKEFLLLYKLAASPD
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCEECCHHHHEEEEEECCCCC
RTFTKQQLMDEVWGYETEADPHTIEVHIGRIRERFKDNPDFEIVTMRGIGYKVVKK
CHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHHHHCCCCCEEEEEEECCCEEECCC
>Mature Secondary Structure 
GKVSVLIRRKENVFQILIVEDDKELSQLFQKVLEKNGYQVKSASDGAQALEVLDKEYID
CCEEEEEEECCCEEEEEEEECCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHH
LIISDIMMPVMDGYELVSELRSAGYQIPVLMITAKGSFDDMRQGFLSGSDDYMVKPVNVN
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHHHHCCCCCCCEEECCCHH
EMVLRVGALLRRAQILNEHKIVIGSTEFDYDAMTVTTDKESLVLPKKEFLLLYKLAASPD
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCEECCHHHHEEEEEECCCCC
RTFTKQQLMDEVWGYETEADPHTIEVHIGRIRERFKDNPDFEIVTMRGIGYKVVKK
CHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHHHHCCCCCEEEEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA