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The map label for this gene is hssS [H]

Identifier: 238922419

GI number: 238922419

Start: 613995

End: 615038

Strand: Reverse

Name: hssS [H]

Synonym: EUBELI_20655

Alternate gene names: 238922419

Gene position: 615038-613995 (Counterclockwise)

Preceding gene: 238922420

Following gene: 238922418

Centisome position: 98.13

GC content: 37.93

Gene sequence:

>1044_bases
ATGGAACAAAAGAAAGAAAAAGGATTGCGGATCCGATCCTGTCTGACTGGTGCAATCTGGCTGGCACTTGTATTTTCAAC
AGTTATATCTGCTTTATTATTTGCTATTTTGAATCATTTTTTTAATCTGCCGGGCAGTATACCTGTGCTTGGCTGGCTTT
TGATTTTCAATACATTGATTGCAGGGCTGATCACTTCCTTTATTAATGCAAAGTTACTGGAACCAATTACTAGGCTTAGT
AAAGCAATGAAGGAAGTTTCTCGGGGAGATTTTGAACAGCATTTGGAAACGAACAGCCGTATAGCAGAAGTTGGAGAATC
TTATCAAAGTTTTAACGTTATGACAAAAGAACTTCGTGCAACAGAGGTGCTGCAGATGGATTTTGTATCTAATGTTTCTC
ATGAGTTTAAGACCCCGATTAATGCCATTGAAGGATATACAATGCTGCTTCAGGGAGAAGAACTGTCTCCGGATCAAGAG
GAATATGTAGAAAAAATCTTATTTAACACCCAAAGACTTTCCGGATTGGTTGGAAATATTTTGCTGTTATCCAAGTTAGA
GAATCAGAATATACCAATGAAAAAAACAGAATATCGTCTGGATGAACAGATCCGCCAGGCATTTCTTTCATTGGAAACAA
AATGGACAGAAAAAGAAATTGGTTTTCAGGTAGAGCTGGAGGAAGTTAAATATACTGGGAATGAAGGACTTTTTATGCAT
ATCTGGATAAATCTTTTGGATAATGCGATTAAGTTCAGCCCATCAAAGGGGACAATTACGATGTTTCTGAAACAAGAACA
GGATTCTGTTAAGTTCATTCTGGAAGATGAAGGACCAGGAATAGAGGATGATGTAAAATCCAGAATATTTGACAAGTTCT
ATCAGGTAGATGGATCTCATAAAGCAGAAGGAAATGGCCTAGGTCTTGCACTTGTAAAACGGATTGTAGATAGTGCCGGA
GGAACAATCAAAGCAGAAAACCGTGAATATGGTGGATGCAGATTTGTTGTAGAGCTTCCAATACAGAAAGATGAGGCCAT
ATAA

Upstream 100 bases:

>100_bases
TAGAGGTACATATAGGAAGAATCAGAGAGCGTTTTAAAGATAACCCTGATTTTGAAATCGTAACAATGCGTGGAATTGGA
TACAAGGTGGTGAAAAAATA

Downstream 100 bases:

>100_bases
GTTTAAGAAAAACAGATAGAGGAGGAATTACATGACATTTTATCAGGAATTGCAGTTAAATCAGGCAGGTTCTAAAAATC
TGTTGAAAAAGAGTGAAACA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MEQKKEKGLRIRSCLTGAIWLALVFSTVISALLFAILNHFFNLPGSIPVLGWLLIFNTLIAGLITSFINAKLLEPITRLS
KAMKEVSRGDFEQHLETNSRIAEVGESYQSFNVMTKELRATEVLQMDFVSNVSHEFKTPINAIEGYTMLLQGEELSPDQE
EYVEKILFNTQRLSGLVGNILLLSKLENQNIPMKKTEYRLDEQIRQAFLSLETKWTEKEIGFQVELEEVKYTGNEGLFMH
IWINLLDNAIKFSPSKGTITMFLKQEQDSVKFILEDEGPGIEDDVKSRIFDKFYQVDGSHKAEGNGLGLALVKRIVDSAG
GTIKAENREYGGCRFVVELPIQKDEAI

Sequences:

>Translated_347_residues
MEQKKEKGLRIRSCLTGAIWLALVFSTVISALLFAILNHFFNLPGSIPVLGWLLIFNTLIAGLITSFINAKLLEPITRLS
KAMKEVSRGDFEQHLETNSRIAEVGESYQSFNVMTKELRATEVLQMDFVSNVSHEFKTPINAIEGYTMLLQGEELSPDQE
EYVEKILFNTQRLSGLVGNILLLSKLENQNIPMKKTEYRLDEQIRQAFLSLETKWTEKEIGFQVELEEVKYTGNEGLFMH
IWINLLDNAIKFSPSKGTITMFLKQEQDSVKFILEDEGPGIEDDVKSRIFDKFYQVDGSHKAEGNGLGLALVKRIVDSAG
GTIKAENREYGGCRFVVELPIQKDEAI
>Mature_347_residues
MEQKKEKGLRIRSCLTGAIWLALVFSTVISALLFAILNHFFNLPGSIPVLGWLLIFNTLIAGLITSFINAKLLEPITRLS
KAMKEVSRGDFEQHLETNSRIAEVGESYQSFNVMTKELRATEVLQMDFVSNVSHEFKTPINAIEGYTMLLQGEELSPDQE
EYVEKILFNTQRLSGLVGNILLLSKLENQNIPMKKTEYRLDEQIRQAFLSLETKWTEKEIGFQVELEEVKYTGNEGLFMH
IWINLLDNAIKFSPSKGTITMFLKQEQDSVKFILEDEGPGIEDDVKSRIFDKFYQVDGSHKAEGNGLGLALVKRIVDSAG
GTIKAENREYGGCRFVVELPIQKDEAI

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=26.978417266187, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786783, Length=298, Percent_Identity=26.8456375838926, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790346, Length=275, Percent_Identity=27.2727272727273, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=29.3859649122807, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1790861, Length=206, Percent_Identity=30.0970873786408, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=30.8370044052863, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789403, Length=290, Percent_Identity=26.8965517241379, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI48994928, Length=223, Percent_Identity=30.9417040358744, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788549, Length=218, Percent_Identity=27.0642201834862, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1788279, Length=256, Percent_Identity=29.296875, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1789149, Length=277, Percent_Identity=27.0758122743682, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI145693157, Length=222, Percent_Identity=28.8288288288288, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788713, Length=240, Percent_Identity=26.25, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787894, Length=319, Percent_Identity=22.884012539185, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1789808, Length=281, Percent_Identity=25.2669039145907, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=25, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787374, Length=266, Percent_Identity=23.6842105263158, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790551, Length=292, Percent_Identity=25, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87081816, Length=280, Percent_Identity=23.5714285714286, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 39293; Mature: 39293

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQKKEKGLRIRSCLTGAIWLALVFSTVISALLFAILNHFFNLPGSIPVLGWLLIFNTLI
CCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AGLITSFINAKLLEPITRLSKAMKEVSRGDFEQHLETNSRIAEVGESYQSFNVMTKELRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
TEVLQMDFVSNVSHEFKTPINAIEGYTMLLQGEELSPDQEEYVEKILFNTQRLSGLVGNI
HHHHHHHHHHHHHHHHCCCHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LLLSKLENQNIPMKKTEYRLDEQIRQAFLSLETKWTEKEIGFQVELEEVKYTGNEGLFMH
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEEHHEEECCCCCEEEH
IWINLLDNAIKFSPSKGTITMFLKQEQDSVKFILEDEGPGIEDDVKSRIFDKFYQVDGSH
HHHHHHHHHHEECCCCCEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCC
KAEGNGLGLALVKRIVDSAGGTIKAENREYGGCRFVVELPIQKDEAI
CCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MEQKKEKGLRIRSCLTGAIWLALVFSTVISALLFAILNHFFNLPGSIPVLGWLLIFNTLI
CCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
AGLITSFINAKLLEPITRLSKAMKEVSRGDFEQHLETNSRIAEVGESYQSFNVMTKELRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
TEVLQMDFVSNVSHEFKTPINAIEGYTMLLQGEELSPDQEEYVEKILFNTQRLSGLVGNI
HHHHHHHHHHHHHHHHCCCHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LLLSKLENQNIPMKKTEYRLDEQIRQAFLSLETKWTEKEIGFQVELEEVKYTGNEGLFMH
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCEEEEEHHEEECCCCCEEEH
IWINLLDNAIKFSPSKGTITMFLKQEQDSVKFILEDEGPGIEDDVKSRIFDKFYQVDGSH
HHHHHHHHHHEECCCCCEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCC
KAEGNGLGLALVKRIVDSAGGTIKAENREYGGCRFVVELPIQKDEAI
CCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA