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The map label for this gene is gabR [H]

Identifier: 238922161

GI number: 238922161

Start: 354391

End: 355791

Strand: Reverse

Name: gabR [H]

Synonym: EUBELI_20396

Alternate gene names: 238922161

Gene position: 355791-354391 (Counterclockwise)

Preceding gene: 238922162

Following gene: 238922160

Centisome position: 56.77

GC content: 36.47

Gene sequence:

>1401_bases
ATGTTGACATACTCGTTTGAAAACATTGGAAAAGAATCAATATATGAATATTTATACAAATGTATCAAAAAAGATATAAT
AGAAGGCAGACTTGTTAAGGGTGAACATCTTCCTTCAAAGAGAACGCTTGCTGTCAATCTTGGAATAAGCACCATAACAG
TAGAGAATTCATATGGACAGCTTATGAGTGAAGGATATATATATTCTGTTCCAAAGAAGGGCTATTATGTATCAGATATT
TCAGGTGTTGCAAGGATAAAGCCGGTAAAATATGAAGTTCCTGAAATAACCGCAAAGAAGAAGACTGGATATAAATCAGA
TTTATCATCAAACAGGACAGATCCTGGAAGCTTTCCATTTGCAACATGGGCTAAGCTTATGAGACGTGTTATAACAGACA
GGCAGGATGATCTTATGAAAATTTCTCCGGGAGAAGGAACATGGGAGTTAAGAAAAGCGATTGCTATGCATCTGGCTTCA
TTTCGTGATATGAAAGTAACACCCGGACAGATAATCATTGGCGCCGGAACGGAATATATGTATAGTCTTCTTATACAGCT
TTTGGGAAGAGATAAAGTGTATTGTGTTGAAGATCCGGGATATTCTAAGATTGCCAGGATATATGCAAGTAATAATGTTA
AATTCTGTTATGCCGGTATGGATGATGAAGGAATGAAACCGGAAGCGGTAAGAGAATGTATGGCAGATATTGTTCATATA
AGTCCTACACATCATTATCCGACAGGTATAACAATGCCGGTAAGCCGGCGATTTGAACTGCTTGCATGGGCTAATGAAAA
GCCGGACAGATATATAATAGAAGATGATTATGATTCAGAATTCCGTATGACAGGAAAGACAATTCCGACTATGAAAAGCA
TAGATATAAGCGAAAAGGTTATATATATGAATACATTTTCAAGAACACTGACACCGACAATCCGAATCAGTTATATGGTT
CTGCCACCACACCTTGCAGCAACATATCAGGAAAAACTTGATTTTTATGCATGTACTGTATCTAATTTCGAGCAGTATGC
ACTTGCTGCATTCATAGAAGAAGGATATTTTGAGAAACATTTAAACAGAATGAGGCTGTATTATACGAAACAGAGAGAGG
CTGTTCTTTCGGTACTTAAAGAGGAGCCGTTCAAATGTGTTGGAAGAGTAAGAGAGGCTGATTCAGGACTGCATTTTATT
CTTGAACTTAATACATTACTTTCTGATAATGAGGTAAAAAGAAAACTTGAGGCAGAAGGCATCCATATAAATGCGTTATC
TGAGTACTATCATAATAATACTGATGAATACAGCCACAGCTTTGTTATCAGCTATTCTGATATGAAGATAGAAAACTTCA
GAATTGCATGCAGTAAAATGTCAGAACTTACACCTTTATGA

Upstream 100 bases:

>100_bases
ATATAATATTTGTAGAATATTTGCTACATTTCATCAGGCATGTTATAATAACTGACATTAATATAAAAGGAGATTTCTGA
AAAAGAAATAAGGTCAGATT

Downstream 100 bases:

>100_bases
TGATTATTTATGATTGATTGTGAATGAATATAACAGTTGCAAAGAATGTAATAAAGCGGTAAAATCTGTTTATGTGATTT
GTAAATAATGTGAGAGGGTA

Product: GntR family transcriptional regulator / MocR family aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MLTYSFENIGKESIYEYLYKCIKKDIIEGRLVKGEHLPSKRTLAVNLGISTITVENSYGQLMSEGYIYSVPKKGYYVSDI
SGVARIKPVKYEVPEITAKKKTGYKSDLSSNRTDPGSFPFATWAKLMRRVITDRQDDLMKISPGEGTWELRKAIAMHLAS
FRDMKVTPGQIIIGAGTEYMYSLLIQLLGRDKVYCVEDPGYSKIARIYASNNVKFCYAGMDDEGMKPEAVRECMADIVHI
SPTHHYPTGITMPVSRRFELLAWANEKPDRYIIEDDYDSEFRMTGKTIPTMKSIDISEKVIYMNTFSRTLTPTIRISYMV
LPPHLAATYQEKLDFYACTVSNFEQYALAAFIEEGYFEKHLNRMRLYYTKQREAVLSVLKEEPFKCVGRVREADSGLHFI
LELNTLLSDNEVKRKLEAEGIHINALSEYYHNNTDEYSHSFVISYSDMKIENFRIACSKMSELTPL

Sequences:

>Translated_466_residues
MLTYSFENIGKESIYEYLYKCIKKDIIEGRLVKGEHLPSKRTLAVNLGISTITVENSYGQLMSEGYIYSVPKKGYYVSDI
SGVARIKPVKYEVPEITAKKKTGYKSDLSSNRTDPGSFPFATWAKLMRRVITDRQDDLMKISPGEGTWELRKAIAMHLAS
FRDMKVTPGQIIIGAGTEYMYSLLIQLLGRDKVYCVEDPGYSKIARIYASNNVKFCYAGMDDEGMKPEAVRECMADIVHI
SPTHHYPTGITMPVSRRFELLAWANEKPDRYIIEDDYDSEFRMTGKTIPTMKSIDISEKVIYMNTFSRTLTPTIRISYMV
LPPHLAATYQEKLDFYACTVSNFEQYALAAFIEEGYFEKHLNRMRLYYTKQREAVLSVLKEEPFKCVGRVREADSGLHFI
LELNTLLSDNEVKRKLEAEGIHINALSEYYHNNTDEYSHSFVISYSDMKIENFRIACSKMSELTPL
>Mature_466_residues
MLTYSFENIGKESIYEYLYKCIKKDIIEGRLVKGEHLPSKRTLAVNLGISTITVENSYGQLMSEGYIYSVPKKGYYVSDI
SGVARIKPVKYEVPEITAKKKTGYKSDLSSNRTDPGSFPFATWAKLMRRVITDRQDDLMKISPGEGTWELRKAIAMHLAS
FRDMKVTPGQIIIGAGTEYMYSLLIQLLGRDKVYCVEDPGYSKIARIYASNNVKFCYAGMDDEGMKPEAVRECMADIVHI
SPTHHYPTGITMPVSRRFELLAWANEKPDRYIIEDDYDSEFRMTGKTIPTMKSIDISEKVIYMNTFSRTLTPTIRISYMV
LPPHLAATYQEKLDFYACTVSNFEQYALAAFIEEGYFEKHLNRMRLYYTKQREAVLSVLKEEPFKCVGRVREADSGLHFI
LELNTLLSDNEVKRKLEAEGIHINALSEYYHNNTDEYSHSFVISYSDMKIENFRIACSKMSELTPL

Specific function: Activates the transcription of the gabTD operon. Is also a repressor of its own expression, both in the presence and absence of GABA. Binds specifically to the DNA region overlapping the -35 region of the gabT promoter and the -10 and +1 regions of the ga

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790797, Length=475, Percent_Identity=24.6315789473684, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1787710, Length=452, Percent_Identity=25.8849557522124, Blast_Score=99, Evalue=8e-22,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000524
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00155 Aminotran_1_2; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 53518; Mature: 53518

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTYSFENIGKESIYEYLYKCIKKDIIEGRLVKGEHLPSKRTLAVNLGISTITVENSYGQ
CEEECHHHCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECEEEEEEECCHHH
LMSEGYIYSVPKKGYYVSDISGVARIKPVKYEVPEITAKKKTGYKSDLSSNRTDPGSFPF
HHHCCEEEECCCCCEEEECCCCCHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCH
ATWAKLMRRVITDRQDDLMKISPGEGTWELRKAIAMHLASFRDMKVTPGQIIIGAGTEYM
HHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHH
YSLLIQLLGRDKVYCVEDPGYSKIARIYASNNVKFCYAGMDDEGMKPEAVRECMADIVHI
HHHHHHHHCCCCEEEECCCCHHHEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHEEC
SPTHHYPTGITMPVSRRFELLAWANEKPDRYIIEDDYDSEFRMTGKTIPTMKSIDISEKV
CCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCEEECCCCCCCEECCCCCCEE
IYMNTFSRTLTPTIRISYMVLPPHLAATYQEKLDFYACTVSNFEQYALAAFIEEGYFEKH
EEEECCCCCCCCEEEEEEEEECCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHH
LNRMRLYYTKQREAVLSVLKEEPFKCVGRVREADSGLHFILELNTLLSDNEVKRKLEAEG
HHHHHEEEEHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEEEECHHHCCHHHHHHHHHCC
IHINALSEYYHNNTDEYSHSFVISYSDMKIENFRIACSKMSELTPL
EEEEEHHHHHCCCCCCCCCEEEEEECCEEEEHHEEEHHHHHHCCCC
>Mature Secondary Structure
MLTYSFENIGKESIYEYLYKCIKKDIIEGRLVKGEHLPSKRTLAVNLGISTITVENSYGQ
CEEECHHHCCHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECEEEEEEECCHHH
LMSEGYIYSVPKKGYYVSDISGVARIKPVKYEVPEITAKKKTGYKSDLSSNRTDPGSFPF
HHHCCEEEECCCCCEEEECCCCCHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCH
ATWAKLMRRVITDRQDDLMKISPGEGTWELRKAIAMHLASFRDMKVTPGQIIIGAGTEYM
HHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHH
YSLLIQLLGRDKVYCVEDPGYSKIARIYASNNVKFCYAGMDDEGMKPEAVRECMADIVHI
HHHHHHHHCCCCEEEECCCCHHHEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHEEC
SPTHHYPTGITMPVSRRFELLAWANEKPDRYIIEDDYDSEFRMTGKTIPTMKSIDISEKV
CCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCEEECCCCCCCEECCCCCCEE
IYMNTFSRTLTPTIRISYMVLPPHLAATYQEKLDFYACTVSNFEQYALAAFIEEGYFEKH
EEEECCCCCCCCEEEEEEEEECCHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHH
LNRMRLYYTKQREAVLSVLKEEPFKCVGRVREADSGLHFILELNTLLSDNEVKRKLEAEG
HHHHHEEEEHHHHHHHHHHHHCHHHHHHHHHHCCCCEEEEEEECHHHCCHHHHHHHHHCC
IHINALSEYYHNNTDEYSHSFVISYSDMKIENFRIACSKMSELTPL
EEEEEHHHHHCCCCCCCCCEEEEEECCEEEEHHEEEHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]