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The map label for this gene is nagB [H]

Identifier: 238921848

GI number: 238921848

Start: 62885

End: 63613

Strand: Reverse

Name: nagB [H]

Synonym: EUBELI_20081

Alternate gene names: 238921848

Gene position: 63613-62885 (Counterclockwise)

Preceding gene: 238921849

Following gene: 238921847

Centisome position: 10.15

GC content: 34.84

Gene sequence:

>729_bases
ATGAAAATATACAAAGCAAAAGATTATGCTGATATGAGTAGAAAGGCAGCTAATATTATATCAGCACAGATTATTATGAA
GCCAGAATGTGTACTTGGACTTGCGACTGGTTCAACGCCAGTTGGGTTATATAAGCAGTTAGTAGAATGGTATAAAAAAG
GTGACTTGGATTTTTCAGCAGTTAAGACTGTTAATCTTGATGAGTATAAGGGACTCAGTCAGGACAATGATCAGAGTTAT
TATTATTTTATGCATAAGAATTTATTTGATAATGTGAATATATCAGTTGAGAATACTCATATTCCTAATGGAATGGAGCA
GGATTCGGAAAAAGAATGTAACAGATATTCTGAACTGATTAAGTCTCTTGGAGGTATTGATTTACAACTTCTAGGAATAG
GCCATAATGGACACATAGGATTTAATGAACCATCAGATTCATTTGAAAAACAGGTTCATTGTGTTGATTTAACAGAATCT
ACAATAGAAGCTAACAAGAGATTTTTTGAATCAGCAGAAGACGTTCCAAGACAGGCATACACAATGGGAATCAAGACAAT
AATGCAGGCAAAGAAGATTCTGGTTGTTGCAAGTGGGGAAGATAAAGCACAGATTGTGAAAGAAGCCTTTTTTGGACATA
TTACACCATATGTTCCTGCATCAGTTTTGCAGCTGCATAATGATGTAACACTGGTAGCAGATGAAGCAGCTCTTAGTAAG
ATTTACTAA

Upstream 100 bases:

>100_bases
ATCAGTACATTTTAGTTAATATAATAAATATTTGTATATCTGGGGAATGTTTATTATTAGAATCTGAGATGGTAGAATAT
GTGAAATGGAGTGATAAGTG

Downstream 100 bases:

>100_bases
AGCTTATTAACTTGGTGGATAGAAGGTTGAGAACATATGATTATAAAGAATGCTGATGTTTATACACAGGACAATGTATT
TGTTAAGGGAGATGTCGTTG

Product: glucosamine-6-phosphate isomerase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MKIYKAKDYADMSRKAANIISAQIIMKPECVLGLATGSTPVGLYKQLVEWYKKGDLDFSAVKTVNLDEYKGLSQDNDQSY
YYFMHKNLFDNVNISVENTHIPNGMEQDSEKECNRYSELIKSLGGIDLQLLGIGHNGHIGFNEPSDSFEKQVHCVDLTES
TIEANKRFFESAEDVPRQAYTMGIKTIMQAKKILVVASGEDKAQIVKEAFFGHITPYVPASVLQLHNDVTLVADEAALSK
IY

Sequences:

>Translated_242_residues
MKIYKAKDYADMSRKAANIISAQIIMKPECVLGLATGSTPVGLYKQLVEWYKKGDLDFSAVKTVNLDEYKGLSQDNDQSY
YYFMHKNLFDNVNISVENTHIPNGMEQDSEKECNRYSELIKSLGGIDLQLLGIGHNGHIGFNEPSDSFEKQVHCVDLTES
TIEANKRFFESAEDVPRQAYTMGIKTIMQAKKILVVASGEDKAQIVKEAFFGHITPYVPASVLQLHNDVTLVADEAALSK
IY
>Mature_242_residues
MKIYKAKDYADMSRKAANIISAQIIMKPECVLGLATGSTPVGLYKQLVEWYKKGDLDFSAVKTVNLDEYKGLSQDNDQSY
YYFMHKNLFDNVNISVENTHIPNGMEQDSEKECNRYSELIKSLGGIDLQLLGIGHNGHIGFNEPSDSFEKQVHCVDLTES
TIEANKRFFESAEDVPRQAYTMGIKTIMQAKKILVVASGEDKAQIVKEAFFGHITPYVPASVLQLHNDVTLVADEAALSK
IY

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily [H]

Homologues:

Organism=Homo sapiens, GI13027378, Length=243, Percent_Identity=41.5637860082305, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI19923881, Length=243, Percent_Identity=37.8600823045267, Blast_Score=162, Evalue=2e-40,
Organism=Escherichia coli, GI1786893, Length=208, Percent_Identity=41.8269230769231, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1789530, Length=226, Percent_Identity=30.5309734513274, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI48994958, Length=243, Percent_Identity=30.8641975308642, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17554876, Length=208, Percent_Identity=44.2307692307692, Blast_Score=185, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24581960, Length=208, Percent_Identity=40.8653846153846, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI19920764, Length=208, Percent_Identity=40.8653846153846, Blast_Score=179, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.5.99.6 [H]

Molecular weight: Translated: 27099; Mature: 27099

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIYKAKDYADMSRKAANIISAQIIMKPECVLGLATGSTPVGLYKQLVEWYKKGDLDFSA
CCCCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCHHH
VKTVNLDEYKGLSQDNDQSYYYFMHKNLFDNVNISVENTHIPNGMEQDSEKECNRYSELI
EEEECHHHHCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
KSLGGIDLQLLGIGHNGHIGFNEPSDSFEKQVHCVDLTESTIEANKRFFESAEDVPRQAY
HHHCCCEEEEEEECCCCCCCCCCCCHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
TMGIKTIMQAKKILVVASGEDKAQIVKEAFFGHITPYVPASVLQLHNDVTLVADEAALSK
HHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEECHHHHHH
IY
CC
>Mature Secondary Structure
MKIYKAKDYADMSRKAANIISAQIIMKPECVLGLATGSTPVGLYKQLVEWYKKGDLDFSA
CCCCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCCHHH
VKTVNLDEYKGLSQDNDQSYYYFMHKNLFDNVNISVENTHIPNGMEQDSEKECNRYSELI
EEEECHHHHCCCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
KSLGGIDLQLLGIGHNGHIGFNEPSDSFEKQVHCVDLTESTIEANKRFFESAEDVPRQAY
HHHCCCEEEEEEECCCCCCCCCCCCHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
TMGIKTIMQAKKILVVASGEDKAQIVKEAFFGHITPYVPASVLQLHNDVTLVADEAALSK
HHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCEEEEECHHHHHH
IY
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA