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The map label for this gene is grxC [C]

Identifier: 238921681

GI number: 238921681

Start: 3722272

End: 3723006

Strand: Direct

Name: grxC [C]

Synonym: NT01EI_3842

Alternate gene names: 238921681

Gene position: 3722272-3723006 (Clockwise)

Preceding gene: 238921679

Following gene: 238921682

Centisome position: 97.64

GC content: 54.83

Gene sequence:

>735_bases
ATGTTTAGCAGCCAAGAGGGCAGAAACGTTCCACCGGTTACCTTCCATACCCGTCAAAGGGATAAATGGCTCGATGTCAC
CAGCGACGCGCTGTTCCGTGACAAAACCGTCATCGTCTTTTCACTGCCGGGCGCCTTCACGCCGACTTGCTCTTCCAGCC
ACCTGCCACGCTACAACGAACTGGCGCCGATATTCCACCAGCACGGTGTGGACAGCATTCTGTGTGTATCGGTAAACGAT
ACCTTTGTTATGAATGCCTGGAAAAATGATCAGAAAGCCGAACATATCACGTTTATTCCCGACGGAAACGGTGAGTTCAC
CCGCGGGATGAACATGCTGGTCGAAAAAACGGATCTGGGCTTTGGGCCACGCTCCTGGCGTTACTCTATGCTGGTACGCA
ACGGCGTGGTCGAGAAGATGTTTGTCGAGCCAAATCTGCCAGGCGATCCGTTTCAGGTCTCCGATGCCGATACCATGCTG
AAATACCTCGCACCGGAGCACAAACTGCAGGCCTCGGTTTCCCTGTTTACCAAACCCGGATGCCCCTACTGCGCCAAGGC
CAAACAGATGCTGCAAGATCGTGGCATCCAGTATGAGGAGATCATCCTGGGTAAAGACGCGACCACCATCAGCCTGCGCG
CCATCAGCGGTCGGGCAACCGTGCCTCAGGTTTACATCGGTGGCCAGCATATCGGCGGCAGCGATGATTTGGAGCACTAC
CTGCAACAGGCTTAA

Upstream 100 bases:

>100_bases
TAGCAATTAACGATTAGAACTATCAAGTAGGAGCAACAATAATGAATAATAAACAGCGGCTCCATCGCAAATTTCGTCTC
AGACAGGAAGATTGTATTAC

Downstream 100 bases:

>100_bases
CAACAATAGGGCCACCCATGGCCCATCAAAGCCAACGTATTGGCGGGCTTGTCCCGCCTTTTTTTCGGTATTCCAGGAAT
CATGTAATGAGAGAATTACA

Product: hybrid peroxiredoxin

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MFSSQEGRNVPPVTFHTRQRDKWLDVTSDALFRDKTVIVFSLPGAFTPTCSSSHLPRYNELAPIFHQHGVDSILCVSVND
TFVMNAWKNDQKAEHITFIPDGNGEFTRGMNMLVEKTDLGFGPRSWRYSMLVRNGVVEKMFVEPNLPGDPFQVSDADTML
KYLAPEHKLQASVSLFTKPGCPYCAKAKQMLQDRGIQYEEIILGKDATTISLRAISGRATVPQVYIGGQHIGGSDDLEHY
LQQA

Sequences:

>Translated_244_residues
MFSSQEGRNVPPVTFHTRQRDKWLDVTSDALFRDKTVIVFSLPGAFTPTCSSSHLPRYNELAPIFHQHGVDSILCVSVND
TFVMNAWKNDQKAEHITFIPDGNGEFTRGMNMLVEKTDLGFGPRSWRYSMLVRNGVVEKMFVEPNLPGDPFQVSDADTML
KYLAPEHKLQASVSLFTKPGCPYCAKAKQMLQDRGIQYEEIILGKDATTISLRAISGRATVPQVYIGGQHIGGSDDLEHY
LQQA
>Mature_244_residues
MFSSQEGRNVPPVTFHTRQRDKWLDVTSDALFRDKTVIVFSLPGAFTPTCSSSHLPRYNELAPIFHQHGVDSILCVSVND
TFVMNAWKNDQKAEHITFIPDGNGEFTRGMNMLVEKTDLGFGPRSWRYSMLVRNGVVEKMFVEPNLPGDPFQVSDADTML
KYLAPEHKLQASVSLFTKPGCPYCAKAKQMLQDRGIQYEEIILGKDATTISLRAISGRATVPQVYIGGQHIGGSDDLEHY
LQQA

Specific function: The Disulfide Bond Functions As An Electron Carrier In The Glutathione-Dependent Synthesis Of Deoxyribonucleotides By The Enzyme Ribonucleotide Reductase. In Addition, It Is Also Involved In Reducing Some Disulfides In A Coupled System With Glutathione R

COG id: COG0678

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI6912238, Length=121, Percent_Identity=38.8429752066116, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1790039, Length=68, Percent_Identity=47.0588235294118, Blast_Score=69, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323138, Length=140, Percent_Identity=32.1428571428571, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI78706776, Length=125, Percent_Identity=44, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI78709078, Length=125, Percent_Identity=44, Blast_Score=101, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR011906
- InterPro:   IPR014025
- InterPro:   IPR013740
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin; PF08534 Redoxin [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 27326; Mature: 27326

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSSQEGRNVPPVTFHTRQRDKWLDVTSDALFRDKTVIVFSLPGAFTPTCSSSHLPRYNE
CCCCCCCCCCCCEEEECCCCCCEECCCCCHHCCCCEEEEEECCCCCCCCCCCCCCCCCHH
LAPIFHQHGVDSILCVSVNDTFVMNAWKNDQKAEHITFIPDGNGEFTRGMNMLVEKTDLG
HHHHHHHCCCCEEEEEECCCEEEEECCCCCCCCCEEEEEECCCCCHHHCHHHEEEECCCC
FGPRSWRYSMLVRNGVVEKMFVEPNLPGDPFQVSDADTMLKYLAPEHKLQASVSLFTKPG
CCCCCHHHHHHHHCCCEEEEEECCCCCCCCEEECCHHHHHHHHCCCHHHEEEEEEEECCC
CPYCAKAKQMLQDRGIQYEEIILGKDATTISLRAISGRATVPQVYIGGQHIGGSDDLEHY
CCHHHHHHHHHHHCCCCCHHEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCHHHHHH
LQQA
HHCC
>Mature Secondary Structure
MFSSQEGRNVPPVTFHTRQRDKWLDVTSDALFRDKTVIVFSLPGAFTPTCSSSHLPRYNE
CCCCCCCCCCCCEEEECCCCCCEECCCCCHHCCCCEEEEEECCCCCCCCCCCCCCCCCHH
LAPIFHQHGVDSILCVSVNDTFVMNAWKNDQKAEHITFIPDGNGEFTRGMNMLVEKTDLG
HHHHHHHCCCCEEEEEECCCEEEEECCCCCCCCCEEEEEECCCCCHHHCHHHEEEECCCC
FGPRSWRYSMLVRNGVVEKMFVEPNLPGDPFQVSDADTMLKYLAPEHKLQASVSLFTKPG
CCCCCHHHHHHHHCCCEEEEEECCCCCCCCEEECCHHHHHHHHCCCHHHEEEEEEEECCC
CPYCAKAKQMLQDRGIQYEEIILGKDATTISLRAISGRATVPQVYIGGQHIGGSDDLEHY
CCHHHHHHHHHHHCCCCCHHEEECCCCCEEEEEEECCCCCCCEEEECCCCCCCCHHHHHH
LQQA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]