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The map label for this gene is cpxA [H]

Identifier: 238921656

GI number: 238921656

Start: 3692929

End: 3694317

Strand: Direct

Name: cpxA [H]

Synonym: NT01EI_3812

Alternate gene names: 238921656

Gene position: 3692929-3694317 (Clockwise)

Preceding gene: 238921655

Following gene: 238921657

Centisome position: 96.87

GC content: 60.33

Gene sequence:

>1389_bases
ATGATCAATAGCCTGACGGCGCGTATTTTTGCCATTTTTTGGCTGACGCTGGCGCTGGTACTGATGGTGGTACTGATGCT
GCCCAAGCTTGACTCACGTCAGATAACCAGTCTGCTGGACAGTGAACGTCGCCAGGGCGTCATGCTGGAGCAGCACGTAG
AAGCCGAGCTGGCCGTCGATCCTCCTAACGATCTACTGTGGTGGCGTCGCCTGTTCCGCGCCATCGATAAATGGTCGCCG
CCGGGGCAGCGCCTGCTGCTGGTGACCAGTGAAGGACGGGTGATCGGAGCGCAGCGCAACGAAATGCAGATCGTGCGTAA
CTTTATCGGCCAATCCGACAATGCCGATCACCCAAAGAAGAAAAAGTATGGGCGCCTGGAGATCCTGGGCCCCTTTCCGA
TCCGCGACGGCGAGGACAACTACCAGCTGTATCTGATCCGGCCCGCTAACAGCCCGCAGTCTGACTTTGTAAACCTGCTG
TTCGATCGCCCGCTACTGCTGCTGCTCGTCACCATGTTGATCAGTTCACCGTTGCTGCTGTGGCTGGCGTGGAGCCTAGC
CAGCCCGGCGCGTAAACTGAAAATGGCGGCGGATGAAGTCGCCAGCGGGAACCTGCGTCAGCACCCTGAGCTGGAGTCGG
GGCCCCAGGAGTTTTTAGCCACCGGAGTCAGCTTCAACCAGATGGTCAATGCCCTTGAGGGGATGGTAAAGGCACAGCAG
CGTCTGATCTCCGATATCTCTCACGAGCTTCGTACACCGTTGACCCGGCTACAGCTGGCCACGGCCCTGATGCGTCGGCG
CCACGGCGAGTATAGCGAGCTGACGCGTATTGAAACTGAAGCTCTGCGGCTGGACAGCATGATCAACGATCTGCTGGCGC
TATCGCGTAACCAGCACAAAACCGAGCTGGAGCGGGAGCCCCTACGGGCGGATGAGCTGTGGTCTGATGTATTGGATAAC
GCCGGCTTCGAAGCCGAACAGCGCGGCAAAAAGCTGGAGGTAACCGCCCCCCCCGGCCCATGGCCGCTATTTGGCAGCCA
CTCGGCGCTGGACAGTGCGTTCGAAAATATCGTGCGCAACGCCCTGCGCTACTCCAACCACCATATCGCTATTCATTTCA
GCTGCGATGGGCAGGGGATCACCATCCACGTGGACGATGACGGTCCGGGCGTTGCCCCCCAAGATCGAGAACAGATCTTC
CGCCCGTTCTACCGTACCGATGAGGCACGTGATCGCGAGTCTGGCGGCACCGGCCTGGGGCTGGCGATAGTCTCTACGGT
GGTGGAACAGCACCACGGCTGGGTGCGGGCTGAAGACAGCCCACTGGGCGGCCTGCGCCTGACGCTGTGGTTACCGCTCT
CCACGCGCAGCAGCGCGGGAAAAGCCTGA

Upstream 100 bases:

>100_bases
TGCATATCTCTAACCTCCGCCGCAAACTGCCGGAGCGCCAGGATGGCCAGCCGTGGTTTAAAACGCTGCGCGGGCGCGGC
TATCTGATGGTATCCGTTTC

Downstream 100 bases:

>100_bases
CGCGCTGCGCTATACTGCGCCCCCTGACATCTGGGGGCGCAAATGCTGAATATCGTACTCTTCGAACCTGAAATTCCACC
CAATACCGGTAACATTATCC

Product: two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MINSLTARIFAIFWLTLALVLMVVLMLPKLDSRQITSLLDSERRQGVMLEQHVEAELAVDPPNDLLWWRRLFRAIDKWSP
PGQRLLLVTSEGRVIGAQRNEMQIVRNFIGQSDNADHPKKKKYGRLEILGPFPIRDGEDNYQLYLIRPANSPQSDFVNLL
FDRPLLLLLVTMLISSPLLLWLAWSLASPARKLKMAADEVASGNLRQHPELESGPQEFLATGVSFNQMVNALEGMVKAQQ
RLISDISHELRTPLTRLQLATALMRRRHGEYSELTRIETEALRLDSMINDLLALSRNQHKTELEREPLRADELWSDVLDN
AGFEAEQRGKKLEVTAPPGPWPLFGSHSALDSAFENIVRNALRYSNHHIAIHFSCDGQGITIHVDDDGPGVAPQDREQIF
RPFYRTDEARDRESGGTGLGLAIVSTVVEQHHGWVRAEDSPLGGLRLTLWLPLSTRSSAGKA

Sequences:

>Translated_462_residues
MINSLTARIFAIFWLTLALVLMVVLMLPKLDSRQITSLLDSERRQGVMLEQHVEAELAVDPPNDLLWWRRLFRAIDKWSP
PGQRLLLVTSEGRVIGAQRNEMQIVRNFIGQSDNADHPKKKKYGRLEILGPFPIRDGEDNYQLYLIRPANSPQSDFVNLL
FDRPLLLLLVTMLISSPLLLWLAWSLASPARKLKMAADEVASGNLRQHPELESGPQEFLATGVSFNQMVNALEGMVKAQQ
RLISDISHELRTPLTRLQLATALMRRRHGEYSELTRIETEALRLDSMINDLLALSRNQHKTELEREPLRADELWSDVLDN
AGFEAEQRGKKLEVTAPPGPWPLFGSHSALDSAFENIVRNALRYSNHHIAIHFSCDGQGITIHVDDDGPGVAPQDREQIF
RPFYRTDEARDRESGGTGLGLAIVSTVVEQHHGWVRAEDSPLGGLRLTLWLPLSTRSSAGKA
>Mature_462_residues
MINSLTARIFAIFWLTLALVLMVVLMLPKLDSRQITSLLDSERRQGVMLEQHVEAELAVDPPNDLLWWRRLFRAIDKWSP
PGQRLLLVTSEGRVIGAQRNEMQIVRNFIGQSDNADHPKKKKYGRLEILGPFPIRDGEDNYQLYLIRPANSPQSDFVNLL
FDRPLLLLLVTMLISSPLLLWLAWSLASPARKLKMAADEVASGNLRQHPELESGPQEFLATGVSFNQMVNALEGMVKAQQ
RLISDISHELRTPLTRLQLATALMRRRHGEYSELTRIETEALRLDSMINDLLALSRNQHKTELEREPLRADELWSDVLDN
AGFEAEQRGKKLEVTAPPGPWPLFGSHSALDSAFENIVRNALRYSNHHIAIHFSCDGQGITIHVDDDGPGVAPQDREQIF
RPFYRTDEARDRESGGTGLGLAIVSTVVEQHHGWVRAEDSPLGGLRLTLWLPLSTRSSAGKA

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=457, Percent_Identity=79.4310722100657, Blast_Score=688, Evalue=0.0,
Organism=Escherichia coli, GI1787894, Length=327, Percent_Identity=33.3333333333333, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1789808, Length=272, Percent_Identity=31.6176470588235, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1788393, Length=280, Percent_Identity=31.0714285714286, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786783, Length=331, Percent_Identity=28.0966767371601, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1786600, Length=259, Percent_Identity=29.7297297297297, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=30.1369863013699, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI145693157, Length=236, Percent_Identity=25, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787374, Length=295, Percent_Identity=26.7796610169492, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790551, Length=239, Percent_Identity=29.7071129707113, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788279, Length=275, Percent_Identity=24.3636363636364, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI87081816, Length=230, Percent_Identity=27.8260869565217, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789149, Length=289, Percent_Identity=26.643598615917, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI48994928, Length=233, Percent_Identity=24.0343347639485, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87082128, Length=273, Percent_Identity=23.0769230769231, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786912, Length=340, Percent_Identity=25.5882352941176, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=293, Percent_Identity=25.2559726962457, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=238, Percent_Identity=27.3109243697479, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=75, Percent_Identity=40, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52104; Mature: 52104

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINSLTARIFAIFWLTLALVLMVVLMLPKLDSRQITSLLDSERRQGVMLEQHVEAELAVD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHCCCEEECC
PPNDLLWWRRLFRAIDKWSPPGQRLLLVTSEGRVIGAQRNEMQIVRNFIGQSDNADHPKK
CCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEECCCHHHHHHHHHHHCCCCCCCCCCH
KKYGRLEILGPFPIRDGEDNYQLYLIRPANSPQSDFVNLLFDRPLLLLLVTMLISSPLLL
HCCCCEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHCHHHH
WLAWSLASPARKLKMAADEVASGNLRQHPELESGPQEFLATGVSFNQMVNALEGMVKAQQ
HHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
RLISDISHELRTPLTRLQLATALMRRRHGEYSELTRIETEALRLDSMINDLLALSRNQHK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
TELEREPLRADELWSDVLDNAGFEAEQRGKKLEVTAPPGPWPLFGSHSALDSAFENIVRN
HHHHHCCCCHHHHHHHHHHCCCCCHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
ALRYSNHHIAIHFSCDGQGITIHVDDDGPGVAPQDREQIFRPFYRTDEARDRESGGTGLG
HHHHCCCEEEEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCHHCCCCCCCCHH
LAIVSTVVEQHHGWVRAEDSPLGGLRLTLWLPLSTRSSAGKA
HHHHHHHHHHHCCEEEECCCCCCCEEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MINSLTARIFAIFWLTLALVLMVVLMLPKLDSRQITSLLDSERRQGVMLEQHVEAELAVD
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHCCCEEECC
PPNDLLWWRRLFRAIDKWSPPGQRLLLVTSEGRVIGAQRNEMQIVRNFIGQSDNADHPKK
CCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEECCCHHHHHHHHHHHCCCCCCCCCCH
KKYGRLEILGPFPIRDGEDNYQLYLIRPANSPQSDFVNLLFDRPLLLLLVTMLISSPLLL
HCCCCEEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHCHHHH
WLAWSLASPARKLKMAADEVASGNLRQHPELESGPQEFLATGVSFNQMVNALEGMVKAQQ
HHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHH
RLISDISHELRTPLTRLQLATALMRRRHGEYSELTRIETEALRLDSMINDLLALSRNQHK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
TELEREPLRADELWSDVLDNAGFEAEQRGKKLEVTAPPGPWPLFGSHSALDSAFENIVRN
HHHHHCCCCHHHHHHHHHHCCCCCHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
ALRYSNHHIAIHFSCDGQGITIHVDDDGPGVAPQDREQIFRPFYRTDEARDRESGGTGLG
HHHHCCCEEEEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCHHCCCCCCCCHH
LAIVSTVVEQHHGWVRAEDSPLGGLRLTLWLPLSTRSSAGKA
HHHHHHHHHHHCCEEEECCCCCCCEEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]