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The map label for this gene is cpxR [H]

Identifier: 238921655

GI number: 238921655

Start: 3692234

End: 3692932

Strand: Direct

Name: cpxR [H]

Synonym: NT01EI_3811

Alternate gene names: 238921655

Gene position: 3692234-3692932 (Clockwise)

Preceding gene: 238921651

Following gene: 238921656

Centisome position: 96.85

GC content: 56.08

Gene sequence:

>699_bases
ATGAATAAGATATTACTGGTTGATGACGATCGCGAACTGACATCGCTTCTGCAAGAGCTTCTTGATCTTGAAGGATTTGA
AGTTATCGTCGCTCACGATGGTGAGCAGGCATTGGCAATACTGGACGCCAGCATCGATCTGCTGCTGCTGGATGTCATGA
TGCCGAAGAAAAACGGTATCGACACTCTCAAAGAGCTGCGTCAACACCACCAGACGCCGGTCATTATGCTCACTGCCCGC
GGCAGCGAGCTCGACAGGGTACTGGGGCTGGAGCTAGGGGCAGACGACTACCTGCCAAAACCCTTCAATGATCGCGAGCT
GGTTGCCCGTATTCGGGCTATCCTGCGCCGCTCTAACTGGAATGAACAACAGCAAAACAGCGATAGCGGTGCGCCGATCC
TACAGGTCGATCGCCTGCAGCTGAATCCCGGCCGCCAAGAGGCCAGCTTTGACGGCCAGCCCCTGGAACTCACCGGCACC
GAATTTACTCTGCTGTACCTGCTGGCACAGCATCTGGGGCAGGTTGTATCGCGCGAACATCTTAGCCAGGAGGTCTTGGG
TAAACGTCTGACCCCCTTCGATCGCGCCATCGACATGCATATCTCTAACCTCCGCCGCAAACTGCCGGAGCGCCAGGATG
GCCAGCCGTGGTTTAAAACGCTGCGCGGGCGCGGCTATCTGATGGTATCCGTTTCATGA

Upstream 100 bases:

>100_bases
ACCCACACAGCTGAAAACATGCGTCAGGGGATGTAAAACTAAGTAAAGTCATGGATTAGCGGCATTTGATATCGTATTTT
GCGTCAGGAGGTAACACCCA

Downstream 100 bases:

>100_bases
TCAATAGCCTGACGGCGCGTATTTTTGCCATTTTTTGGCTGACGCTGGCGCTGGTACTGATGGTGGTACTGATGCTGCCC
AAGCTTGACTCACGTCAGAT

Product: DNA-binding transcriptional regulator CpxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MNKILLVDDDRELTSLLQELLDLEGFEVIVAHDGEQALAILDASIDLLLLDVMMPKKNGIDTLKELRQHHQTPVIMLTAR
GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSNWNEQQQNSDSGAPILQVDRLQLNPGRQEASFDGQPLELTGT
EFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPERQDGQPWFKTLRGRGYLMVSVS

Sequences:

>Translated_232_residues
MNKILLVDDDRELTSLLQELLDLEGFEVIVAHDGEQALAILDASIDLLLLDVMMPKKNGIDTLKELRQHHQTPVIMLTAR
GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSNWNEQQQNSDSGAPILQVDRLQLNPGRQEASFDGQPLELTGT
EFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPERQDGQPWFKTLRGRGYLMVSVS
>Mature_232_residues
MNKILLVDDDRELTSLLQELLDLEGFEVIVAHDGEQALAILDASIDLLLLDVMMPKKNGIDTLKELRQHHQTPVIMLTAR
GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSNWNEQQQNSDSGAPILQVDRLQLNPGRQEASFDGQPLELTGT
EFTLLYLLAQHLGQVVSREHLSQEVLGKRLTPFDRAIDMHISNLRRKLPERQDGQPWFKTLRGRGYLMVSVS

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=90.0862068965517, Blast_Score=399, Evalue=1e-113,
Organism=Escherichia coli, GI1789809, Length=234, Percent_Identity=40.5982905982906, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=38.2222222222222, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=38.8646288209607, Blast_Score=143, Evalue=8e-36,
Organism=Escherichia coli, GI1790860, Length=229, Percent_Identity=37.9912663755458, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=32.8947368421053, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI87082012, Length=234, Percent_Identity=35.8974358974359, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=35.5263157894737, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790552, Length=235, Percent_Identity=38.7234042553192, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786784, Length=234, Percent_Identity=34.6153846153846, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=32.034632034632, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI145693140, Length=238, Percent_Identity=31.9327731092437, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=31.304347826087, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=30.2631578947368, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=41.2844036697248, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1790299, Length=126, Percent_Identity=39.6825396825397, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1790437, Length=118, Percent_Identity=38.9830508474576, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1787487, Length=112, Percent_Identity=35.7142857142857, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26390; Mature: 26390

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKILLVDDDRELTSLLQELLDLEGFEVIVAHDGEQALAILDASIDLLLLDVMMPKKNGI
CCCEEEEECCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHCCCCCCH
DTLKELRQHHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSNW
HHHHHHHHHCCCCEEEEEECCCHHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
NEQQQNSDSGAPILQVDRLQLNPGRQEASFDGQPLELTGTEFTLLYLLAQHLGQVVSREH
CHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
LSQEVLGKRLTPFDRAIDMHISNLRRKLPERQDGQPWFKTLRGRGYLMVSVS
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEEEC
>Mature Secondary Structure
MNKILLVDDDRELTSLLQELLDLEGFEVIVAHDGEQALAILDASIDLLLLDVMMPKKNGI
CCCEEEEECCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEHHHHHHHHHHHHCCCCCCH
DTLKELRQHHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSNW
HHHHHHHHHCCCCEEEEEECCCHHHHHHHCEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
NEQQQNSDSGAPILQVDRLQLNPGRQEASFDGQPLELTGTEFTLLYLLAQHLGQVVSREH
CHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHH
LSQEVLGKRLTPFDRAIDMHISNLRRKLPERQDGQPWFKTLRGRGYLMVSVS
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]