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The map label for this gene is uhpB [H]

Identifier: 238921615

GI number: 238921615

Start: 3654183

End: 3655715

Strand: Reverse

Name: uhpB [H]

Synonym: NT01EI_3770

Alternate gene names: 238921615

Gene position: 3655715-3654183 (Counterclockwise)

Preceding gene: 238921616

Following gene: 238921614

Centisome position: 95.89

GC content: 65.1

Gene sequence:

>1533_bases
ATGCAGCGTCTGATCTCCAGCATTGCCATCTTCTTTTGCTATACCATCGCCGGATTTTGCCTGTGGGCTATTGGTGCGGC
ACTGGTGACGGCGCCCGTCGATGCACTGCTGCTGTTTCCCTTCGGTCTACGGATGGGCATTCTGCTGCAGACGCCGCACC
GCTACTGGCCCGGCATTCTGGTCGGCGACGTGGCTGTGCAGCTGTTTTTGAGCCATCAGCTGGGCGGCGGCAGCTGGCTG
TGGGGAACTCTGGGGGGACTGCTACTGTGCATGGCCCTCGCCTGGGCGTCGGGAGAGTGGCTGCGGCGTCAGCAGCAGCA
AGGGGCTGAATGGCGCTGGCCGCTGCAGCAGGGGGCGCTGGTGGCGCTGGCAGCGCTGCTCCAGGCGCTCTCCTGGTCGC
TGGCGACCGGTACTATGCCGGGGCCACCGCTGCTGCTGGGGCTGTGCGGCGGATTGACGGTAGCACCGACCTGCCTGCTG
ATTTGGCACTATTTGGCGCAGCAGAGGTGGCTGCCGCTGACGCCGGGGATCCTGCATTGCCCGGTCAACCTGCGCCTGCG
TCATATCGGTGGCTATCTGCTGCTGTTCGCGCTGAGCCTATGGCTGCAGCACCTGGCGCAGCACGCCGATTTGCGCCGCT
TTGTCCTTTTCTGCCTGGCGATCCCCATCGTCTTCATGTCGTATCGCTATGGCTGGCAGGGGGCGCTGTTGGCCACGCTG
CTGAACGGCGTGGTGTTGATCGCGACGGAGCCGCAGGGCGATGCCCCGCACCGCGATCTGCTGCTGTCGCTGTTGGCACA
GAGCCTGACCGGGATGCTGCTGGGTGCCGGGATCGAGCGGCAGCGCGATCTGAACCGCCAGCTGAAGCAGCGTCTGGCGG
AGAACCGCTCACTGGCCCGTTCGCTGGTCATGGCGCAGGAGGTGACCCGGCGGGAGATCGCCCGTGAGCTGCACGACGAG
GTCGGGCAGACCATTACGGTGATCCGCACCCAGGCGGGCATTATTCGGCGGCTGAGCGATGAGCCGCGCCTGCTGGCCAG
CGCCGAGGCCATCGAAAACCACGCTCTGCGGGTATATGACGGCGTACACGATCTGCTGGCGCAGCTATGGCCGGCATCGC
TGAGCAATCTGCCGCTGTCGGCAGCGCTCTCGGCGCTGCTGCGCGATCTGGTACCGCCGGAGCAGGGTACCACGGCGCGA
CTAAGCTGGCATATCGACGACGCCGCGTTGGACGACACCCTGAAAATTACGTTGTACCGCCTGTGTCAGGAGGGGGTGAC
AAATGCCTGTCGCCACGCGCGGGCCAGCCATATAGAGGTACAGGGCTGGCAGGATACCGGAGGTCTGCTGCACGTGAATA
TCTGTGATGACGGCTGCGGGGTGGATACGCTCAGCCTGATGCCGGGGTATGGTCTGCGCGGCCTGCGAGAGCGGATCTGC
GCCATGGGTGGGGAGCTGCACCTGGAGAGCCATCAGGGGACCCGACTGGTTGTGATCCTGCCCGCAGTTTTATCCGGTGA
GGCGGGAAACTAG

Upstream 100 bases:

>100_bases
GTCTGTCGCCGAAAACCGTACACGTCCATCGTGCCAATCTGTTCATCAAGTTGGGGGTAAACAACAACGTTGAGCTGGCG
CACCGCCTGTTGGGGCAGTG

Downstream 100 bases:

>100_bases
GAGATTTTCTTAGTGCCAGCGGGAGATTTGTATTAGTTATCCCGTGCGTGCGCGACGCACCATAGCGTCTACAACGATGA
GTTTTCACGCACGAGGTATT

Product: sensory histidine kinase UhpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MQRLISSIAIFFCYTIAGFCLWAIGAALVTAPVDALLLFPFGLRMGILLQTPHRYWPGILVGDVAVQLFLSHQLGGGSWL
WGTLGGLLLCMALAWASGEWLRRQQQQGAEWRWPLQQGALVALAALLQALSWSLATGTMPGPPLLLGLCGGLTVAPTCLL
IWHYLAQQRWLPLTPGILHCPVNLRLRHIGGYLLLFALSLWLQHLAQHADLRRFVLFCLAIPIVFMSYRYGWQGALLATL
LNGVVLIATEPQGDAPHRDLLLSLLAQSLTGMLLGAGIERQRDLNRQLKQRLAENRSLARSLVMAQEVTRREIARELHDE
VGQTITVIRTQAGIIRRLSDEPRLLASAEAIENHALRVYDGVHDLLAQLWPASLSNLPLSAALSALLRDLVPPEQGTTAR
LSWHIDDAALDDTLKITLYRLCQEGVTNACRHARASHIEVQGWQDTGGLLHVNICDDGCGVDTLSLMPGYGLRGLRERIC
AMGGELHLESHQGTRLVVILPAVLSGEAGN

Sequences:

>Translated_510_residues
MQRLISSIAIFFCYTIAGFCLWAIGAALVTAPVDALLLFPFGLRMGILLQTPHRYWPGILVGDVAVQLFLSHQLGGGSWL
WGTLGGLLLCMALAWASGEWLRRQQQQGAEWRWPLQQGALVALAALLQALSWSLATGTMPGPPLLLGLCGGLTVAPTCLL
IWHYLAQQRWLPLTPGILHCPVNLRLRHIGGYLLLFALSLWLQHLAQHADLRRFVLFCLAIPIVFMSYRYGWQGALLATL
LNGVVLIATEPQGDAPHRDLLLSLLAQSLTGMLLGAGIERQRDLNRQLKQRLAENRSLARSLVMAQEVTRREIARELHDE
VGQTITVIRTQAGIIRRLSDEPRLLASAEAIENHALRVYDGVHDLLAQLWPASLSNLPLSAALSALLRDLVPPEQGTTAR
LSWHIDDAALDDTLKITLYRLCQEGVTNACRHARASHIEVQGWQDTGGLLHVNICDDGCGVDTLSLMPGYGLRGLRERIC
AMGGELHLESHQGTRLVVILPAVLSGEAGN
>Mature_510_residues
MQRLISSIAIFFCYTIAGFCLWAIGAALVTAPVDALLLFPFGLRMGILLQTPHRYWPGILVGDVAVQLFLSHQLGGGSWL
WGTLGGLLLCMALAWASGEWLRRQQQQGAEWRWPLQQGALVALAALLQALSWSLATGTMPGPPLLLGLCGGLTVAPTCLL
IWHYLAQQRWLPLTPGILHCPVNLRLRHIGGYLLLFALSLWLQHLAQHADLRRFVLFCLAIPIVFMSYRYGWQGALLATL
LNGVVLIATEPQGDAPHRDLLLSLLAQSLTGMLLGAGIERQRDLNRQLKQRLAENRSLARSLVMAQEVTRREIARELHDE
VGQTITVIRTQAGIIRRLSDEPRLLASAEAIENHALRVYDGVHDLLAQLWPASLSNLPLSAALSALLRDLVPPEQGTTAR
LSWHIDDAALDDTLKITLYRLCQEGVTNACRHARASHIEVQGWQDTGGLLHVNICDDGCGVDTLSLMPGYGLRGLRERIC
AMGGELHLESHQGTRLVVILPAVLSGEAGN

Specific function: Member of the two-component regulatory system uhpB/uhpA involved in the regulation of the uptake of hexose phosphates. UhpB functions as a membrane-associated protein kinase that phosphorylates uhpA in response to environmental signals [H]

COG id: COG3851

COG function: function code T; Signal transduction histidine kinase, glucose-6-phosphate specific

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=502, Percent_Identity=47.808764940239, Blast_Score=355, Evalue=5e-99,
Organism=Escherichia coli, GI1788812, Length=190, Percent_Identity=30.5263157894737, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR007895
- InterPro:   IPR011712
- InterPro:   IPR005467 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3; PF05231 MASE1 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55959; Mature: 55959

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRLISSIAIFFCYTIAGFCLWAIGAALVTAPVDALLLFPFGLRMGILLQTPHRYWPGIL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHH
VGDVAVQLFLSHQLGGGSWLWGTLGGLLLCMALAWASGEWLRRQQQQGAEWRWPLQQGAL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHH
VALAALLQALSWSLATGTMPGPPLLLGLCGGLTVAPTCLLIWHYLAQQRWLPLTPGILHC
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEC
PVNLRLRHIGGYLLLFALSLWLQHLAQHADLRRFVLFCLAIPIVFMSYRYGWQGALLATL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LNGVVLIATEPQGDAPHRDLLLSLLAQSLTGMLLGAGIERQRDLNRQLKQRLAENRSLAR
HCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SLVMAQEVTRREIARELHDEVGQTITVIRTQAGIIRRLSDEPRLLASAEAIENHALRVYD
HHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHH
GVHDLLAQLWPASLSNLPLSAALSALLRDLVPPEQGTTARLSWHIDDAALDDTLKITLYR
HHHHHHHHHCCHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEECHHHHCHHHHHHHHH
LCQEGVTNACRHARASHIEVQGWQDTGGLLHVNICDDGCGVDTLSLMPGYGLRGLRERIC
HHHHHHHHHHHHHHHCCEEEECEECCCCEEEEEECCCCCCCCHHHHCCCCCHHHHHHHHH
AMGGELHLESHQGTRLVVILPAVLSGEAGN
HCCCCEEEECCCCCEEEEEECHHHCCCCCC
>Mature Secondary Structure
MQRLISSIAIFFCYTIAGFCLWAIGAALVTAPVDALLLFPFGLRMGILLQTPHRYWPGIL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHH
VGDVAVQLFLSHQLGGGSWLWGTLGGLLLCMALAWASGEWLRRQQQQGAEWRWPLQQGAL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHH
VALAALLQALSWSLATGTMPGPPLLLGLCGGLTVAPTCLLIWHYLAQQRWLPLTPGILHC
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEC
PVNLRLRHIGGYLLLFALSLWLQHLAQHADLRRFVLFCLAIPIVFMSYRYGWQGALLATL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LNGVVLIATEPQGDAPHRDLLLSLLAQSLTGMLLGAGIERQRDLNRQLKQRLAENRSLAR
HCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SLVMAQEVTRREIARELHDEVGQTITVIRTQAGIIRRLSDEPRLLASAEAIENHALRVYD
HHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHH
GVHDLLAQLWPASLSNLPLSAALSALLRDLVPPEQGTTARLSWHIDDAALDDTLKITLYR
HHHHHHHHHCCHHHCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEECHHHHCHHHHHHHHH
LCQEGVTNACRHARASHIEVQGWQDTGGLLHVNICDDGCGVDTLSLMPGYGLRGLRERIC
HHHHHHHHHHHHHHHCCEEEECEECCCCEEEEEECCCCCCCCHHHHCCCCCHHHHHHHHH
AMGGELHLESHQGTRLVVILPAVLSGEAGN
HCCCCEEEECCCCCEEEEEECHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3301805; 1569007; 7686882; 9278503 [H]