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The map label for this gene is pepB [H]

Identifier: 238921046

GI number: 238921046

Start: 3057441

End: 3058742

Strand: Reverse

Name: pepB [H]

Synonym: NT01EI_3176

Alternate gene names: 238921046

Gene position: 3058742-3057441 (Counterclockwise)

Preceding gene: 238921047

Following gene: 238921045

Centisome position: 80.23

GC content: 62.14

Gene sequence:

>1302_bases
ATGACCAATGAATTGATGTCGGTCCATTTATCAAGTCAGACCGCAGATACGCGCTGGGGCAGCGATGCGCTGCTGAGCGC
GGATACTCAGGGGATGACCATTCACGCGGGAGAATCACTGGACCACGGGGTGATTCAGCGCGCCGCGCGCCGCCTAGATA
CCCAGGGGATGAAGCAGGTCTCTCTGCAGGGGACGTCGTGGAGCCTGAGCGCCTGCTGGGCGTTTTGGCAGGGCTTTCGC
AACCCGAAGGGCGGGCAGTATGTGCAGTGGCCTGCGCTGAGCGTCGCCGATCGCGCTGAGCTGGATCGTCGGCTGCTTAA
TATCGACTGGGTGCGCGATACCATCAATACCCCGGCAGAAAATCTGGGGCCGACTCAGCTGGCGCAGCGCGCGGTCGATC
TGCTGTGCGCGCAGGCCTGCGACAGTATTCACTACCGCATCATTAAGGGCGACGATCTACGCGAGCAGGGCTATATGGGA
CTGCACAGCGTTGGCCGAGGCTCTGCGCGCGCGCCGGCGTTGCTGGAGCTGGATTACAATCCGGGCGGCAAGCCTGATAC
ACCGGTGTTGGCCTGCCTGGTCGGGAAAGGGATCACCTTTGACTCCGGCGGCTATAGTCTGAAGCAGACGGCTTTCATGG
ACTCCATGAAATCGGATATGGGTGGCGCGGCATTGGTGACCGGCGCCCTGGCGCTGGCGATCGCGCAGGGACTGCAGGCA
CGGGTCAAGCTTTACCTGTGCTGCGCGGATAACCTGGTCAGCGGCAATGCGTTCAAGCTGGGTGATATCATTCCGTATCG
CAACGGTAAACGGGTTGAGATTATGAATACCGATGCCGAAGGGCGCCTGGTGCTGGCTGATGGTCTGATCGATGCCTCGC
GTCAGGCACCGCGTATGATCATTGACTGCGCCACCCTGACTGGCGCAGCCAAGACCGCGGTCGGCGGCGACTACCATGCG
TTGCTCTCTTTTGACGATGAGCTGGTGGCGGCGCTGCAAGAGAGCGCGGATCAGGAGGAAGAGCTGTTCTGGCGCCTGCC
GTTGGCGGAGTTTCACCGTAGCCAACTGCCCTCCGCCTTTGCTGATCTCAGCAACGTGGCAGGGGTGGCGCACTCGGCCG
GTGCCAGCACCGCGGCGGCTTTCCTGTCGCACTTCGTCACTGACTACCGGCAGGGCTGGCTACACATTGACTGCAGCGCT
ACCTACCGTAAGGTGGCGGTGGATCAGTGGTCCGCCGGAGCGACCGGTATTGGCGTACGGACGCTGTCGCGCCTGTTGTT
GACACAGGCTGGGCGCTGCTGA

Upstream 100 bases:

>100_bases
GGAGTTGGCCTGGGCAAGCCACCCGTAGGGGTGGCTTTTTACTATAGACCGTCCGCGAAGTCCGTTCGCGGGGGGCCGCG
AAGCAAGCGGGAGAACACGT

Downstream 100 bases:

>100_bases
CGTTGGCATCATGGTTCCGCCGAATGGCGGAGCCTGCATCGGTCAAGGAAACACGGAAATAGGAGAGATGACGGTGAGTA
CCAGTACCCGCGATACCCCC

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MTNELMSVHLSSQTADTRWGSDALLSADTQGMTIHAGESLDHGVIQRAARRLDTQGMKQVSLQGTSWSLSACWAFWQGFR
NPKGGQYVQWPALSVADRAELDRRLLNIDWVRDTINTPAENLGPTQLAQRAVDLLCAQACDSIHYRIIKGDDLREQGYMG
LHSVGRGSARAPALLELDYNPGGKPDTPVLACLVGKGITFDSGGYSLKQTAFMDSMKSDMGGAALVTGALALAIAQGLQA
RVKLYLCCADNLVSGNAFKLGDIIPYRNGKRVEIMNTDAEGRLVLADGLIDASRQAPRMIIDCATLTGAAKTAVGGDYHA
LLSFDDELVAALQESADQEEELFWRLPLAEFHRSQLPSAFADLSNVAGVAHSAGASTAAAFLSHFVTDYRQGWLHIDCSA
TYRKVAVDQWSAGATGIGVRTLSRLLLTQAGRC

Sequences:

>Translated_433_residues
MTNELMSVHLSSQTADTRWGSDALLSADTQGMTIHAGESLDHGVIQRAARRLDTQGMKQVSLQGTSWSLSACWAFWQGFR
NPKGGQYVQWPALSVADRAELDRRLLNIDWVRDTINTPAENLGPTQLAQRAVDLLCAQACDSIHYRIIKGDDLREQGYMG
LHSVGRGSARAPALLELDYNPGGKPDTPVLACLVGKGITFDSGGYSLKQTAFMDSMKSDMGGAALVTGALALAIAQGLQA
RVKLYLCCADNLVSGNAFKLGDIIPYRNGKRVEIMNTDAEGRLVLADGLIDASRQAPRMIIDCATLTGAAKTAVGGDYHA
LLSFDDELVAALQESADQEEELFWRLPLAEFHRSQLPSAFADLSNVAGVAHSAGASTAAAFLSHFVTDYRQGWLHIDCSA
TYRKVAVDQWSAGATGIGVRTLSRLLLTQAGRC
>Mature_432_residues
TNELMSVHLSSQTADTRWGSDALLSADTQGMTIHAGESLDHGVIQRAARRLDTQGMKQVSLQGTSWSLSACWAFWQGFRN
PKGGQYVQWPALSVADRAELDRRLLNIDWVRDTINTPAENLGPTQLAQRAVDLLCAQACDSIHYRIIKGDDLREQGYMGL
HSVGRGSARAPALLELDYNPGGKPDTPVLACLVGKGITFDSGGYSLKQTAFMDSMKSDMGGAALVTGALALAIAQGLQAR
VKLYLCCADNLVSGNAFKLGDIIPYRNGKRVEIMNTDAEGRLVLADGLIDASRQAPRMIIDCATLTGAAKTAVGGDYHAL
LSFDDELVAALQESADQEEELFWRLPLAEFHRSQLPSAFADLSNVAGVAHSAGASTAAAFLSHFVTDYRQGWLHIDCSAT
YRKVAVDQWSAGATGIGVRTLSRLLLTQAGRC

Specific function: Probably plays an important role in intracellular peptide degradation [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=319, Percent_Identity=37.9310344827586, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI47155554, Length=289, Percent_Identity=38.4083044982699, Blast_Score=152, Evalue=7e-37,
Organism=Escherichia coli, GI87082123, Length=423, Percent_Identity=70.4491725768322, Blast_Score=619, Evalue=1e-178,
Organism=Escherichia coli, GI1790710, Length=320, Percent_Identity=36.875, Blast_Score=176, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17556903, Length=298, Percent_Identity=33.5570469798658, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17565172, Length=141, Percent_Identity=36.1702127659575, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21357381, Length=332, Percent_Identity=34.3373493975904, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI221379063, Length=318, Percent_Identity=35.2201257861635, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI221379062, Length=318, Percent_Identity=35.2201257861635, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI20129969, Length=405, Percent_Identity=29.6296296296296, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21355725, Length=321, Percent_Identity=28.3489096573209, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI161077148, Length=397, Percent_Identity=28.7153652392947, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI20130057, Length=397, Percent_Identity=28.7153652392947, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24662227, Length=438, Percent_Identity=27.6255707762557, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24661038, Length=321, Percent_Identity=27.4143302180685, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21355645, Length=408, Percent_Identity=25.9803921568627, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24662223, Length=408, Percent_Identity=25.9803921568627, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI19922386, Length=407, Percent_Identity=27.027027027027, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI20129963, Length=403, Percent_Identity=27.5434243176179, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646701, Length=208, Percent_Identity=29.3269230769231, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646703, Length=208, Percent_Identity=29.3269230769231, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21358201, Length=208, Percent_Identity=29.3269230769231, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.23 [H]

Molecular weight: Translated: 46604; Mature: 46473

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNELMSVHLSSQTADTRWGSDALLSADTQGMTIHAGESLDHGVIQRAARRLDTQGMKQV
CCCCEEEEEECCCCCCCCCCCCCEEECCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCEE
SLQGTSWSLSACWAFWQGFRNPKGGQYVQWPALSVADRAELDRRLLNIDWVRDTINTPAE
EECCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
NLGPTQLAQRAVDLLCAQACDSIHYRIIKGDDLREQGYMGLHSVGRGSARAPALLELDYN
CCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHCCCCHHHCCCCCCCCCEEEEEECC
PGGKPDTPVLACLVGKGITFDSGGYSLKQTAFMDSMKSDMGGAALVTGALALAIAQGLQA
CCCCCCCCEEHHHHCCCCEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RVKLYLCCADNLVSGNAFKLGDIIPYRNGKRVEIMNTDAEGRLVLADGLIDASRQAPRMI
EEEEEEEECCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCEEE
IDCATLTGAAKTAVGGDYHALLSFDDELVAALQESADQEEELFWRLPLAEFHRSQLPSAF
EEEHHHCCCHHHCCCCCEEEEEECCHHHHHHHHHCCCCHHHHEEECCHHHHHHHHCCHHH
ADLSNVAGVAHSAGASTAAAFLSHFVTDYRQGWLHIDCSATYRKVAVDQWSAGATGIGVR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCCCCCCCCHHHH
TLSRLLLTQAGRC
HHHHHHHHHCCCC
>Mature Secondary Structure 
TNELMSVHLSSQTADTRWGSDALLSADTQGMTIHAGESLDHGVIQRAARRLDTQGMKQV
CCCEEEEEECCCCCCCCCCCCCEEECCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCEE
SLQGTSWSLSACWAFWQGFRNPKGGQYVQWPALSVADRAELDRRLLNIDWVRDTINTPAE
EECCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
NLGPTQLAQRAVDLLCAQACDSIHYRIIKGDDLREQGYMGLHSVGRGSARAPALLELDYN
CCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHCCCCHHHCCCCCCCCCEEEEEECC
PGGKPDTPVLACLVGKGITFDSGGYSLKQTAFMDSMKSDMGGAALVTGALALAIAQGLQA
CCCCCCCCEEHHHHCCCCEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
RVKLYLCCADNLVSGNAFKLGDIIPYRNGKRVEIMNTDAEGRLVLADGLIDASRQAPRMI
EEEEEEEECCCCCCCCCEEECCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCEEE
IDCATLTGAAKTAVGGDYHALLSFDDELVAALQESADQEEELFWRLPLAEFHRSQLPSAF
EEEHHHCCCHHHCCCCCEEEEEECCHHHHHHHHHCCCCHHHHEEECCHHHHHHHHCCHHH
ADLSNVAGVAHSAGASTAAAFLSHFVTDYRQGWLHIDCSATYRKVAVDQWSAGATGIGVR
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCCCCCCCCHHHH
TLSRLLLTQAGRC
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA